miRandola

Summary information about hsa-miR-21:


	Mature miRNA ID from article	hsa-miR-21
	miRBase ID	hsa-miR-21-5p
	miRBase Accession	MIMAT0000076
	miRBase family	mir-21
	Organism	Homo sapiens

Results found for hsa-miR-21: 71

1
	First author	Taylor Dd et al.
	Journal	Gynecol Oncol.110(1):13-21.
	Title	Microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
	PubMed ID	18589210
	Year of publication	2008
	Potential biomarker role defined in the article	unknown
	exRNA form	exosome
	Sample	serum
	Sample source	ts
	Diseases, cell lines or normal status	papillary adenocarcinoma of ovary
	Expression	-
	Drug	-
	Methods	467microrna array
	Experiment Description/Results	Microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
	Data imported from external databases?	Yes,

2
	First author	Mitchell Ps et al.
	Journal	Pnas 105(30):10513-8
	Title	Circulating micrornas as stable blood-based markers for cancer detection.
	PubMed ID	18663219
	Year of publication	2008
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	normal
	Expression	-
	Drug	-
	Methods	Taqman low-density array qrt-pcr
	Experiment Description/Results	Mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
	Data imported from external databases?	No

3
	First author	Hunter Mp et al.
	Journal	Plos One. 3(11):e3694.
	Title	Detection of microrna expression in human peripheral blood microvesicles.
	PubMed ID	19002258
	Year of publication	2008
	Potential biomarker role defined in the article	unknown
	exRNA form	exosome
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	normal
	Expression	down
	Drug	-
	Methods	Trizol (invitrogen, carlsbad, ca)\|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)\|real-time pcr using an applied biosystems 7900ht real-time pcr instrument\|bd aria flow cytometer (bd biosciences)
	Experiment Description/Results	Microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
	Data imported from external databases?	No

4
	First author	Rabinowits G et al.
	Journal	Clin Lung Cancer. 10(1):42-6.
	Title	Exosomal microrna: a diagnostic marker for lung cancer.
	PubMed ID	19289371
	Year of publication	2009
	Potential biomarker role defined in the article	unknown
	exRNA form	exosome
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	lung cancer
	Expression	-
	Drug	-
	Methods	Size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)\|mirvana isolation kit (ambion, austin, tx)\|mirvana mirna array labeling kit (ambion)\|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)\|mirna microarray chips
	Experiment Description/Results	The significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
	Data imported from external databases?	No

5
	First author	Hanke M et al.
	Journal	Urol Oncol. 28(6):655-61.
	Title	A robust methodology to study urine microrna as tumor marker: microrna-126 and microrna-182 are related to urinary bladder cancer.
	PubMed ID	19375957
	Year of publication	2010
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	urine
	Sample source	-
	Diseases, cell lines or normal status	urothelial bladder cancer (bca)
	Expression	up
	Drug	-
	Methods	Mirneasy kit (qiagen, hilden, germany)\|quantitative reverse transcriptase-polymerase chain reaction\|taqman microrna assay kits (applied biosystems, darmstadt, germany)\|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)
	Experiment Description/Results	This study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
	Data imported from external databases?	No

6
	First author	Tsujiura M et al.
	Journal	Br J Cancer. 102(7):1174-9
	Title	Circulating micrornas in plasma of patients with gastric cancers.
	PubMed ID	20234369
	Year of publication	2010
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	gastric cancer (gc)
	Expression	up
	Drug	-
	Methods	Qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)\|taqman microrna reverse transcription kit (applied biosystems)
	Experiment Description/Results	Mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
	Data imported from external databases?	No

7
	First author	Zampetaki A et al.
	Journal	Circ Res. 107(6):810-7.
	Title	Plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.
	PubMed ID	20651284
	Year of publication	2010
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	type 2 diabetes
	Expression	down
	Drug	-
	Methods	Quantitative pcr\|mirneasy kit (qiagen)\|taqman mirna arrays a and b (all from applied biosystems)
	Experiment Description/Results	Quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
	Data imported from external databases?	No

8
	First author	Asaga S et al.
	Journal	Clin Chem. 57(1):84-91
	Title	Direct serum assay for microrna-21 concentrations in early and advanced breast cancer
	PubMed ID	21036945
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Breast cancer
	Expression	up
	Drug	-
	Methods	Rt-qpcr applied directly in serum (rt-qpcr-ds) assay
	Experiment Description/Results	The assay was sensitive for detection of mir-21 in 0.625 microliter of serum from breast cancer patients. For differentiation of samples from patients with locoregional breast cancer from those from healthy donors, the odds ratio was 1.796 and the area under the curve was 0.721. In a multivariate analysis that included standard clinicopathologic prognostic factors, high circulating mir-21 concentrations correlated significantly (p < 0.001) with visceral metastasis.
	Data imported from external databases?	No

9
	First author	Xu J et al.
	Journal	Mol Carcinog. 50(2):136-42.
	Title	Circulating micrornas, mir-21, mir-122, and mir-223, in patients with hepatocellular carcinoma or chronic hepatitis.
	PubMed ID	21229610
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Chronic type B hepatitis
	Expression	up
	Drug	-
	Methods	Real-time quantitative rt-pcr
	Experiment Description/Results	Mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
	Data imported from external databases?	No

10
	First author	Xu J et al.
	Journal	Mol Carcinog. 50(2):136-42.
	Title	Circulating micrornas, mir-21, mir-122, and mir-223, in patients with hepatocellular carcinoma or chronic hepatitis.
	PubMed ID	21229610
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	hepatocellular carcinoma (hcc)
	Expression	up
	Drug	-
	Methods	Real-time quantitative rt-pcr
	Experiment Description/Results	Mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
	Data imported from external databases?	No

11
	First author	Arroyo Jd et al.
	Journal	Pnas 108(12):5003-8
	Title	Argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.
	PubMed ID	21383194
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	Ago2
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	normal
	Expression	-
	Drug	-
	Methods	Size-exclusion chromatography\|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)
	Experiment Description/Results	The majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
	Data imported from external databases?	No

12
	First author	Arroyo Jd et al.
	Journal	Pnas 108(12):5003-8
	Title	Argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.
	PubMed ID	21383194
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	Ago2
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	normal
	Expression	-
	Drug	-
	Methods	Size-exclusion chromatography\|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)
	Experiment Description/Results	The majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
	Data imported from external databases?	No

13
	First author	Moussay E et al.
	Journal	Pnas 108(16):6573-8
	Title	Microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.
	PubMed ID	21460253
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	B-CLL
	Expression	-
	Drug	-
	Methods	Mirneasy kit (qiagen)\|taq mirna low-density array from applied biosystems
	Experiment Description/Results	Circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll.
	Data imported from external databases?	No

14
	First author	Moussay E et al.
	Journal	Pnas 108(16):6573-8
	Title	Microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.
	PubMed ID	21460253
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	normal
	Expression	-
	Drug	-
	Methods	Mirneasy kit (qiagen)\|taq mirna low-density array from applied biosystems
	Experiment Description/Results	Circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll.
	Data imported from external databases?	No

15
	First author	Mittelbrunn M et al.
	Journal	Nat Commun.2:282.
	Title	Unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
	PubMed ID	21505438
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	exosome
	Sample	dendritic cells
	Sample source	ts
	Diseases, cell lines or normal status	Dendritic cells
	Expression	-
	Drug	-
	Methods	Human mirna microarray kit
	Experiment Description/Results	Unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
	Data imported from external databases?	Yes,

16
	First author	Mittelbrunn M et al.
	Journal	Nat Commun.2:282.
	Title	Unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
	PubMed ID	21505438
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	exosome
	Sample	t cells
	Sample source	cl
	Diseases, cell lines or normal status	j77
	Expression	-
	Drug	-
	Methods	Human mirna microarray kit
	Experiment Description/Results	Unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
	Data imported from external databases?	Yes,

17
	First author	Zahm Am et al.
	Journal	J Pediatr Gastroenterol Nutr. 53(1):26-33.
	Title	Circulating microrna is a biomarker of pediatric crohn disease.
	PubMed ID	21546856
	Year of publication	2011
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	pediatric crohn disease
	Expression	up
	Drug	-
	Methods	Low-density array qrt-pcr
	Experiment Description/Results	All of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls.
	Data imported from external databases?	No

18
	First author	Rupp Ak et al.
	Journal	Gynecol Oncol. 122(2):437-46.
	Title	Loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
	PubMed ID	21601258
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	exosome
	Sample	pleural effusions
	Sample source	ts
	Diseases, cell lines or normal status	Breast cancer
	Expression	-
	Drug	-
	Methods	Rt-pcr
	Experiment Description/Results	Loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
	Data imported from external databases?	Yes,

19
	First author	Rupp Ak et al.
	Journal	Gynecol Oncol. 122(2):437-46.
	Title	Loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
	PubMed ID	21601258
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	exosome
	Sample	ascites
	Sample source	ts
	Diseases, cell lines or normal status	liver cirrhosis (lc)
	Expression	-
	Drug	-
	Methods	Rt-pcr
	Experiment Description/Results	Loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
	Data imported from external databases?	Yes,

20
	First author	Rupp Ak et al.
	Journal	Gynecol Oncol. 122(2):437-46.
	Title	Loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
	PubMed ID	21601258
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	exosome
	Sample	malignant ascites
	Sample source	ts
	Diseases, cell lines or normal status	ovarian cancer
	Expression	-
	Drug	-
	Methods	Rt-pcr
	Experiment Description/Results	Loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
	Data imported from external databases?	Yes,

21
	First author	Wei J et al.
	Journal	Chin J Cancer. 30(6):407-14.
	Title	Identification of plasma microrna-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer.
	PubMed ID	21627863
	Year of publication	2011
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	non small cell lung cancer (nsclc)
	Expression	up
	Drug	platinum
	Methods	Real-time rt-pcr
	Experiment Description/Results	This study was to investigate whether plasma mirna-21 (mir-21) can be used as a biomarker for the early detection of non-small cell lung cancer (nsclc) and to explore its association with clinicopathologic features and sensitivity to platinum-based chemotherapy.
	Data imported from external databases?	No

22
	First author	Baggish Al et al.
	Journal	J Physiol. 589(pt 16):3983-94.
	Title	Dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.
	PubMed ID	21690193
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	Acute exhaustive exercise
	Expression	up
	Drug	-
	Methods	Microrna extraction kit (benevbio, mission viejo, ca, usa)\|rt-qpcr
	Experiment Description/Results	Authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
	Data imported from external databases?	No

23
	First author	Baggish Al et al.
	Journal	J Physiol. 589(pt 16):3983-94.
	Title	Dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.
	PubMed ID	21690193
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	sustained aerobic exercise
	Expression	-
	Drug	-
	Methods	Microrna extraction kit (benevbio, mission viejo, ca, usa)\|rt-qpcr
	Experiment Description/Results	Authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
	Data imported from external databases?	No

24
	First author	Tomimaru Y et al.
	Journal	J Hepatol. 56(1):167-75.
	Title	Circulating microrna-21 as a novel biomarker for hepatocellular carcinoma.
	PubMed ID	21749846
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	hepatocellular carcinoma (hcc)
	Expression	up
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	In the 10-patient group, plasma microrna-21 levels significantly diminished after surgery compared with the pre-operative values. Plasma microrna-21 level in the 126 patients with hepatocellular carcinoma was significantly higher than in patients with chronic hepatitis and healthy volunteers.
	Data imported from external databases?	No

25
	First author	Shen J et al.
	Journal	Bmc Cancer. 11:374.
	Title	Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microrna biomarkers
	PubMed ID	21864403
	Year of publication	2011
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	solitary pulmonary nodules (spns)
	Expression	up
	Drug	-
	Methods	Mirvana mirna isolation kit (ambion, austin, tx)\|qrt-pcr\|taqman microrna rt kit (applied biosystems, foster city, ca)
	Experiment Description/Results	In the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
	Data imported from external databases?	No

26
	First author	Cermelli S et al.
	Journal	Plos One.6(8):e23937
	Title	Circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.
	PubMed ID	21886843
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Chronic type C hepatitis
	Expression	-
	Drug	-
	Methods	Taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.
	Experiment Description/Results	Serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
	Data imported from external databases?	No

27
	First author	Cermelli S et al.
	Journal	Plos One.6(8):e23937
	Title	Circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.
	PubMed ID	21886843
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	non-alcoholic fatty liver disease (nafld)
	Expression	-
	Drug	-
	Methods	Taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.
	Experiment Description/Results	Serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
	Data imported from external databases?	No

28
	First author	Wulfken Lm et al.
	Journal	Plos One. 6(9):e25787.
	Title	Micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.
	PubMed ID	21984948
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	renal cell carcinoma (rcc)
	Expression	up
	Drug	-
	Methods	Taqman low-density array qrt-pcr
	Experiment Description/Results	Microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
	Data imported from external databases?	No

29
	First author	Bihrer V et al.
	Journal	Plos One 6(10): E26971.
	Title	Serum microrna-21 as marker for necroinflammation in hepatitis c patients with and without hepatocellular carcinoma.
	PubMed ID	22066022
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Chronic type C hepatitis
	Expression	up
	Drug	-
	Methods	Tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)\|taqman mirna reverse transcription kit
	Experiment Description/Results	The serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
	Data imported from external databases?	No

30
	First author	Bihrer V et al.
	Journal	Plos One 6(10): E26971.
	Title	Serum microrna-21 as marker for necroinflammation in hepatitis c patients with and without hepatocellular carcinoma.
	PubMed ID	22066022
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Chronic hepatitis c infection (chc)-associated hcc
	Expression	up
	Drug	-
	Methods	Tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)\|taqman mirna reverse transcription kit
	Experiment Description/Results	The serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
	Data imported from external databases?	No

31
	First author	Goren Y et al.
	Journal	Eur J Heart Fail. 14(2):147-54
	Title	Serum levels of micrornas in patients with heart failure.
	PubMed ID	22120965
	Year of publication	2012
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Chronic systolic heart failure
	Expression	-
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	Elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
	Data imported from external databases?	No

32
	First author	Schwarzenbach H et al.
	Journal	Breast Cancer Res Treat.
	Title	Diagnostic potential of pten-targeting mir-214 in the blood of breast cancer patients.
	PubMed ID	22350790
	Year of publication	2012
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Breast cancer
	Expression	up
	Drug	-
	Methods	Taqman microrna assays
	Experiment Description/Results	The relative concentrations of four circulating micrornas (mir-19a, mir-20a, mir-21, and mir-214) in blood serum were measured by taqman microrna assays. Levels of preoperative serum mir-20a and mir-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum mir-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in roc analysis, respectively.
	Data imported from external databases?	No

33
	First author	Jung Ej et al.
	Journal	Cancer.
	Title	Plasma microrna 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients.
	PubMed ID	22370716
	Year of publication	2011
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	Breast cancer
	Expression	-
	Drug	-
	Methods	Reverse transcriptase-polymerase chain reaction
	Experiment Description/Results	Circulating mir-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma mir-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab.
	Data imported from external databases?	No

34
	First author	Wang B et al.
	Journal	J Cancer Res Clin Oncol.
	Title	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.
	PubMed ID	22638884
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Breast cancer
	Expression	up
	Drug	-
	Methods	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)\|LightCycler 480 Real-Time PCR System (Roche, USA)\|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)
	Experiment Description/Results	MiR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantly higher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
	Data imported from external databases?	No

35
	First author	Wang B et al.
	Journal	J Cancer Res Clin Oncol.
	Title	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.
	PubMed ID	22638884
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Colorectal cancer (crc)
	Expression	up
	Drug	-
	Methods	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)\|LightCycler 480 Real-Time PCR System (Roche, USA)\|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)
	Experiment Description/Results	MiR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantly higher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
	Data imported from external databases?	No

36
	First author	Wang B et al.
	Journal	J Cancer Res Clin Oncol.
	Title	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.
	PubMed ID	22638884
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	lung cancer
	Expression	up
	Drug	-
	Methods	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)\|LightCycler 480 Real-Time PCR System (Roche, USA)\|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)
	Experiment Description/Results	MiR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantly higher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
	Data imported from external databases?	No

37
	First author	Wang B et al.
	Journal	J Cancer Res Clin Oncol.
	Title	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.
	PubMed ID	22638884
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Esophageal cancer
	Expression	up
	Drug	-
	Methods	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)\|LightCycler 480 Real-Time PCR System (Roche, USA)\|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)
	Experiment Description/Results	MiR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantly higher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
	Data imported from external databases?	No

38
	First author	Wang B et al.
	Journal	J Cancer Res Clin Oncol.
	Title	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.
	PubMed ID	22638884
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	gastric cancer (gc)
	Expression	up
	Drug	-
	Methods	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)\|LightCycler 480 Real-Time PCR System (Roche, USA)\|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)
	Experiment Description/Results	MiR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantly higher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
	Data imported from external databases?	No

39
	First author	Martino F et al.
	Journal	Plos One. 7(6): E38269.
	Title	Circulating MicroRNAs Are Not Eliminated by Hemodialysis.
	PubMed ID	22715378
	Year of publication	2012
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	Acute kidney injury
	Expression	-
	Drug	-
	Methods	MasterPure RNA Purification kit (Epicenter Technologies)\|TaqMan microRNA Reverse Transcription kit (Applied Biosystems, Foster City, CA)\|quantitative real-time PCR (qRT-PCR) via TaqMan MicroRNA Assays (Applied Biosystems)
	Experiment Description/Results	In patients with acute kidney injury circulating microRNAs are not removed by dialysis. As only traces of miR-21 and -210 are detected in dialysate and ultrafiltrate, microRNAs in the circulation are likely to be transported by larger structures such as proteins and/or microvesicles. As miRNAs are not affected by dialysis they might be more robust biomarkers of acute kidney injury.
	Data imported from external databases?	No

40
	First author	Villar AV et al.
	Journal	Int J Cardiol.
	Title	Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients.
	PubMed ID	22882958
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	Aortic stenosis (as)
	Expression	up
	Drug	-
	Methods
	Experiment Description/Results	The myocardial and plasma levels of mir-21 were significantly higher in the as patients compared with the controls and correlated directly with the echocardiographic mean transvalvular gradients.
	Data imported from external databases?	No

41
	First author	Ilhan-Mutlu A et al.
	Journal	Cancer Invest. 30(8):615-21
	Title	Plasma MicroRNA-21 Concentration May Be a Useful Biomarker in Glioblastoma Patients.
	PubMed ID	22891879
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	glioblastoma
	Expression	up
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	Microrna-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). one patient with increasing microrna-21 developed a histopathologically proven recurrence after the second sample collection. circulating microrna-21 might be a useful biomarker in glioblastoma.
	Data imported from external databases?	No

42
	First author	Si H et al.
	Journal	J Cancer Res Clin Oncol.
	Title	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.
	PubMed ID	23052693
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Breast cancer
	Expression	up
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	The level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
	Data imported from external databases?	No

43
	First author	Jia SZ et al.
	Journal	Hum Reprod.
	Title	Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis.
	PubMed ID	23203215
	Year of publication	2012
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	endometriosis
	Expression	-
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	Mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
	Data imported from external databases?	No

44
	First author	Ikonomidis JS et al.
	Journal	J Thorac Cardiovasc Surg. Pii: S0022-5223(12)01571
	Title	Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.
	PubMed ID	23312977
	Year of publication	2013
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	thoracic aortic aneurysm (taa)
	Expression	-
	Drug	-
	Methods	Quantitative PCR
	Experiment Description/Results	Significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
	Data imported from external databases?	No

45
	First author	Xie L et al.
	Journal	Bmc Cancer. 10:591.
	Title	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.
	PubMed ID	21029414
	Year of publication	2010
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	malignant effusions
	Sample source	-
	Diseases, cell lines or normal status	lung cancer
	Expression	-
	Drug	-
	Methods	QRT-PCR
	Experiment Description/Results	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
	Data imported from external databases?	No

46
	First author	Jones KL et al.
	Journal	Clin Cancer Res.
	Title	Plasma microRNA are disease response biomarkers in classical Hodgkin lymphoma.
	PubMed ID	24222179
	Year of publication	2013
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	hodgkin lymphoma (chl)
	Expression	up
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	Levels of mir-494, mir-1973 and mir-21 were higher in patients than control (n=20) plasma (p=0.004, p=0.007, p<0.0001, respectively).
	Data imported from external databases?	No

47
	First author	Yaman Agaoglu F et al.
	Journal	Tumour Biol. 32(3):583-8.
	Title	Investigation of miR-21, miR-141, and miR-221 in blood circulation of patients with prostate cancer.
	PubMed ID	21274675
	Year of publication	2011
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	prostate cancer
	Expression	up
	Drug	-
	Methods	Real-time pcr
	Experiment Description/Results	Analysis of mir-21, -141, and -221 in blood of pca patients reveals that mir-21 is more useful to differentiate pca patients from healthy controls, while the mir-141 was a better discriminator of metastatic pca from localized/local advanced disease. these results suggest that analysis of these mirnas might have clinical utility as a supplement to psa testing.
	Data imported from external databases?	No

48
	First author	Sanders I et al.
	Journal	Int J Urol. 19(11):1017-25.
	Title	Evaluation of reference genes for the analysis of serum miRNA in patients with prostate cancer, bladder cancer and renal cell carcinoma.
	PubMed ID	22788411
	Year of publication	2012
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	prostate cancer
	Expression	-
	Drug	-
	Methods	Quantitative real-time pcr
	Experiment Description/Results	The level of mir-21 was similar in cancer patients and healthy controls, irrespective of the normalization strategy.
	Data imported from external databases?	No

49
	First author	Shen J et al.
	Journal	Prostate. 72(13):1469-77.
	Title	Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer.
	PubMed ID	22298119
	Year of publication	2012
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	prostate cancer
	Expression	up
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	These preliminary data suggest that altered plasma mirnas may be useful predictors to distinguish pca patients with varied aggressiveness. further larger studies to validate this promising finding are warranted.
	Data imported from external databases?	No

50
	First author	Watahiki A et al.
	Journal	Int J Mol Sci. 14(4):7757-70.
	Title	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.
	PubMed ID	23574937
	Year of publication	2013
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	prostate cancer
	Expression	up
	Drug	-
	Methods	Exiqon miRNA qPCR panel\|qRT-PCR
	Experiment Description/Results	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
	Data imported from external databases?	No

51
	First author	Zhang HL et al.
	Journal	Prostate. 71(3):326-31.
	Title	Serum miRNA-21: elevated levels in patients with metastatic hormone-refractory prostate cancer and potential predictive factor for the efficacy of docetaxel-based chemotherapy.
	PubMed ID	20842666
	Year of publication	2011
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	prostate cancer
	Expression	up
	Drug	docetaxel
	Methods	Taqman real-time pcr
	Experiment Description/Results	Serum mir-21 levels are elevated in hrpc patients, especially in those resistant to docetaxel-based chemotherapy. it may be applicable as a marker to indicate the transformation to hormone refractory disease, and a potential predictor for the efficacy of docetaxel-based chemotherapy.
	Data imported from external databases?	No

52
	First author	Zhang J et al.
	Journal	Chin Med J (engl). 127(12):2212-7.
	Title	Inflammation induced-endothelial cells release angiogenesis associated-microRNAs into circulation by microparticles.
	PubMed ID	24931230
	Year of publication	2014
	Potential biomarker role defined in the article	unknown
	exRNA form	microparticle
	Sample	atherosclerotic plaques
	Sample source	endothelial cells
	Diseases, cell lines or normal status	Atherosclerosis
	Expression	up
	Drug	-
	Methods	Real-time pcr
	Experiment Description/Results	By comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype (n = 9) and those from normal vascular tissues (n = 9), we found levels of annexin v(+) microparticles and annexin v(+) cd144(+) microparticles were significantly increased in plaques and angiogenesis associated micrornas (106b, 25, 92a and 21) were also significantly increased in microparticles from plaques. inflammation could induce endothelial cells to release angiogenesis associated micrornas into circulation, causing higher levels of circulating endothelial cells derived micrornas in atherosclerosis.
	Data imported from external databases?	No

53
	First author	Basati G et al.
	Journal	Med Oncol. 31(10):205.
	Title	Elevated level of microRNA-21 in the serum of patients with colorectal cancer.
	PubMed ID	25178939
	Year of publication	2014
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Colorectal cancer (crc)
	Expression	up
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	Increased levels of serum mir-21 were associated with clinical stages of tumors in the patients (p=0.01). these results indicated that serum mir-21 levels could serve as a reliable diagnostic and prognostic biomarker for colorectal adenocarcinoma.
	Data imported from external databases?	No

54
	First author	Muller V et al.
	Journal	Breast Cancer Res Treat. 147(1):61-8.
	Title	Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial.
	PubMed ID	25086636
	Year of publication	2014
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Breast cancer
	Expression	up
	Drug	trastuzumab
	Methods	Taqman human microrna arrays
	Experiment Description/Results	Authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
	Data imported from external databases?	No

55
	First author	Jiang R et al.
	Journal	Part Fibre Toxicol. 11(1):71.
	Title	Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics.
	PubMed ID	25487561
	Year of publication	2014
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	blood
	Sample source	-
	Diseases, cell lines or normal status	Asthma
	Expression	up
	Drug	-
	Methods
	Experiment Description/Results	Authors demonstrated that short-term exposure to diesel exhaust resulted in dna methylation changes at cpg sites residing in genes involved in inflammation and oxidative stress response, repetitive elements, and microrna.
	Data imported from external databases?	No

56
	First author	Muller V et al.
	Journal	Breast Cancer Res Treat. 147(1):61-8.
	Title	Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial.
	PubMed ID	25086636
	Year of publication	2014
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Breast cancer
	Expression	up
	Drug	lapatinib
	Methods	Taqman microrna assays
	Experiment Description/Results	Authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
	Data imported from external databases?	No

57
	First author	Kim Y et al.
	Journal	Plos One. 9(2):e86933.
	Title	Serum microRNA-21 as a potential biomarker for response to hypomethylating agents in myelodysplastic syndromes.
	PubMed ID	24503739
	Year of publication	2014
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	myelodysplastic syndromes (mds)
	Expression	down
	Drug	hypomethylating agents (hmas)
	Methods	Mirvana paris kit (ambion inc., austin, tx)\|qrt-pcr
	Experiment Description/Results	Serum mir-21 is a potential biomarker of epigenetic therapy in mds patients.
	Data imported from external databases?	No

58
	First author	Ma GJ et al.
	Journal	Asian Pac J Cancer Prev. 14(12):7551-4.
	Title	Plasma post-operative miR-21 expression in the prognosis of gastric cancers.
	PubMed ID	24460332
	Year of publication	2013
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	gastric cancer (gc)
	Expression	down
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	The results suggested plasma mir-21 could be a novel potential biomarker for gc prognosis and evaluation of surgery outcomes, especially in patients without a family history.
	Data imported from external databases?	No

59
	First author	Song WF et al.
	Journal	Asian Pac J Cancer Prev. 14(12):7529-36.
	Title	MiR-21 upregulation induced by promoter zone histone acetylation is associated with chemoresistance to gemcitabine and enhanced malignancy of pancreatic cancer cells.
	PubMed ID	24460329
	Year of publication	2013
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	pancreatic ductal adenocarcinoma (pdac)
	Expression	up
	Drug	gemcitabine
	Methods	Real-time pcr
	Experiment Description/Results	Serum mir-21 levels were increased in gemcitabine- resistant pdac patients compared with gemcitabine-sensitive subjects.
	Data imported from external databases?	No

60
	First author	Ren W et al.
	Journal	Biomarkers. 19(7):590-6.
	Title	Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma.
	PubMed ID	25174622
	Year of publication	2014
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	blood
	Sample source	-
	Diseases, cell lines or normal status	oral squamous cell carcinoma (oscc)
	Expression	up
	Drug	-
	Methods	E.z.n.a. blood rna kit\|quantitative real-time reverse transcriptionpolymerase chain reaction
	Experiment Description/Results	Authors demonstrate that circulating mir-21 and pten might represent new complementary tumour markers for oscc.
	Data imported from external databases?	No

61
	First author	Chen W et al.
	Journal	Eur J Haematol. 92(5):407-12.
	Title	Clinical significance and detection of microRNA-21 in serum of patients with diffuse large B-cell lymphoma in Chinese population.
	PubMed ID	24400911
	Year of publication	2014
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Diffuse large b-cell lymphoma (dlbcl)
	Expression	up
	Drug	-
	Methods	Fluorescent quantitative pcr
	Experiment Description/Results	Authors show that mir-21 may be served as a biomarker in early diagnosis, genotyping, treatment options, and prognosis estimating of chinese dlbcl.
	Data imported from external databases?	No

62
	First author	Gao J et al.
	Journal	Chin J Cancer Res. 25(6):743-8.
	Title	Clinical significance of serum miR-21 in breast cancer compared with CA153 and CEA.
	PubMed ID	24385703
	Year of publication	2013
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Breast cancer
	Expression	up
	Drug	-
	Methods	Real-time pcr
	Experiment Description/Results	Authors show that serum mir-21 may be a potential diagnostic indicator for bc, especially for the early stage.
	Data imported from external databases?	No

63
	First author	Seeliger C et al.
	Journal	J Bone Miner Res. 29(8):1718-28.
	Title	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.
	PubMed ID	24431276
	Year of publication	2014
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	osteoporosis
	Expression	up
	Drug	-
	Methods	Mirna pcr array
	Experiment Description/Results	Authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
	Data imported from external databases?	No

64
	First author	Song J et al.
	Journal	Oncol Lett. 6(6):1733-1737.
	Title	Serum microRNA-21 levels are related to tumor size in gastric cancer patients but cannot predict prognosis.
	PubMed ID	24260069
	Year of publication	2013
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	gastric cancer (gc)
	Expression	up
	Drug	-
	Methods	Quantitative PCR
	Experiment Description/Results	Authors suggest that serum mir-21 could be exploited as a practical biomarker for monitoring tumor burden in patients with gc.
	Data imported from external databases?	No

65
	First author	He QF et al.
	Journal	Biomed Environ Sci. 2016 May;29(5):385-9
	Title	Circulating MicroRNA-21 is Downregulated in Patients with Metabolic Syndrome.
	PubMed ID	27353714
	Year of publication	2016
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	metabolic syndrome (mets)
	Expression	down
	Drug	-
	Methods	Qrt-pcr
	Experiment Description/Results	Expression levels of mir-21 were significantly decreased in the circulation of mets subjects (or=0.52, 95% ci: 0.29-0.92) compared with that of non-mets subjects. body mass index (bmi) and the number of mets components had a negative correlation with the level of mir-21, whereas age was inversely related to the level of mir-21. no significant difference was detected in mir-21 levels between the sexes (p=0.056). mir-21 might be a negative regulating factor in mets.
	Data imported from external databases?	No

66
	First author	Montagnana M et al.
	Journal	Clin Lab. 62(5):967-70
	Title	Plasma Expression Levels of Circulating miR-21 are not Useful for Diagnosing and Monitoring Colorectal Cancer.
	PubMed ID	27349026
	Year of publication	2016
	Potential biomarker role defined in the article	unknown
	exRNA form	circulating
	Sample	plasma
	Sample source	-
	Diseases, cell lines or normal status	Colorectal cancer (crc)
	Expression	-
	Drug	-
	Methods	Quantitative reverse transcription polymerase chain reaction (rt-qpcr)
	Experiment Description/Results	These results do not support the hypothesis that circulating mir-21 expression is increased in adenoma-carcinoma-advanced carcinoma sequence. accordingly, plasma mir-21 assessment does not appear to be a useful biomarker for diagnosing and staging crc.
	Data imported from external databases?	No

67
	First author	Chien HY et al.
	Journal	Int J Med Sci. 13(6):457-65
	Title	Differential microRNA Profiles Predict Diabetic Nephropathy Progression in Taiwan.
	PubMed ID	27279796
	Year of publication	2016
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	diabetic nephropathy (dn)
	Expression	up
	Drug	-
	Methods	Rt-pcr
	Experiment Description/Results	The levels of mir-21, mir-29a and mir-192 were significantly enriched in the overt proteinuria group compared with microalbuminuria and/or overt proteinuria groups. it was shown that only mir-21 level was significantly up-regulated in low-egfr group compared with high-egfr patients.
	Data imported from external databases?	No

68
	First author	Zhang L et al.
	Journal	Int J Gynecol Cancer. 26(5):810-6
	Title	Circulating MicroRNA-21 Is Involved in Lymph Node Metastasis in Cervical Cancer by Targeting RASA1.
	PubMed ID	27101583
	Year of publication	2016
	Potential biomarker role defined in the article	yes
	exRNA form	circulating
	Sample	serum
	Sample source	-
	Diseases, cell lines or normal status	Cervical cancer
	Expression	up
	Drug	-
	Methods
	Experiment Description/Results	Circulating mir-21 in serum could be a promising biomarker in auxiliary diagnosis of lymph node metastasis in cervical cancer, and inhibition of mir-21/rasa1 axis could be a possible strategy to restrain migration of cervical cancer.
	Data imported from external databases?	No

69
	First author	Collino F et al.
	Journal	Plos One. 5(7):e11803
	Title	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs.
	PubMed ID	20668554
	Year of publication	2010
	Potential biomarker role defined in the article	unknown
	exRNA form	microvesicle
	Sample	mesenchymal stem cells
	Sample source	ts
	Diseases, cell lines or normal status	Mesenchymal stem cells - Normal
	Expression	-
	Drug	-
	Methods	Rt-pcr\|Differential centrifugation\|Ultracentrifugation
	Experiment Description/Results	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
	Data imported from external databases?	Yes,

70
	First author	Skog J et al.
	Journal	Nat Cell Biol. 10(12):1470-6
	Title	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
	PubMed ID	19011622
	Year of publication	2008
	Potential biomarker role defined in the article	unknown
	exRNA form	microvesicle
	Sample	glioblastoma cells
	Sample source	ts
	Diseases, cell lines or normal status	Glioblastoma cells
	Expression	-
	Drug	-
	Methods	Rt-pcr\|Differential centrifugation\|Ultracentrifugation\|Filtration
	Experiment Description/Results	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
	Data imported from external databases?	Yes,

71
	First author	Yuan A et al.
	Journal	Plos One. 4(3):e4722
	Title	Transfer of microRNAs by embryonic stem cell microvesicles.
	PubMed ID	19266099
	Year of publication	2009
	Potential biomarker role defined in the article	unknown
	exRNA form	microvesicle
	Sample	embryonic stem cells
	Sample source	ts
	Diseases, cell lines or normal status	Embryonic stem cells
	Expression	-
	Drug	-
	Methods	Rt-pcr\|Differential centrifugation
	Experiment Description/Results	Transfer of microRNAs by embryonic stem cell microvesicles
	Data imported from external databases?	Yes,