miRandola

You can search for RNAs typing in the text area the molecule of interest (e.g. hsa-miR-21) or you can browse the database. When you start typing the molecule, the system will suggest an entry in our database:


miRandola 2017

miRandola is a comprehensive manually curated classification of different extracellular circulating non-coding RNA types. The first version of the miRandola database was published in 2012. It contained 89 papers and only miRNA data from humans. Now, we have updated the database with 314 papers! We are starting to add more RNA molecules such as lncRNAs and circRNAs.

Extracellular RNAs

Extracellular RNAs (e.g. microRNAs) in serum, plasma, saliva, urine and other body fluids have recently been shown to be associated with various pathological conditions including cancer. RNAs circulate in the bloodstream in a highly stable form, thus they may be used as blood-based biomarkers for many diseases.

The miRandola database 2017 includes (last update February 2017):

  • 314 articles
  • 3283 entries
  • 7 extracellular RNA forms
  • 1032 microRNAs
  • 12 long non-coding RNAs
  • 8 circular RNAs
  • 26 drugs
  • 14 organisms and animal models
  • 197 diseases and cell lines
  • 47 samples
  • integration of Vesiclepedia miRNA data
  • new graphic design
  • new features for browsing and quering the database
  • new visualization section
  • new approach to update the database
  • link to the NIH exrna.org Research Portal

The first version of the miRandola database has been released in April 27, 2012. It appeared for the first time at the annual meeting of the Bioinformatics Italian Society 2012 (Catania, Italy). After less than 5 years, miRandola received 100 citations (source: Google Scholar citations, January 2017).

Awards:
Francesco Russo received the Best Poster and Travel Fellowship Awards presenting miRandola at The Ninth International Biocuration Conference (2016), Geneva, Switzerland (follow the link to the F1000Research channel https://f1000research.com/posters/5-724).

Learn more about Extracellular RNAs! Visit the NIH exRNA Research Portal and watch this video!

References
If you use miRandola please cite the following papers:

Francesco Russo, Sebastiano Di Bella, Giovanni Nigita, Valentina Macca, Alessandro Laganà, Rosalba Giugno, Alfredo Pulvirenti, Alfredo Ferro.
miRandola: Extracellular Circulating microRNAs Database.
PLoS ONE 7(10): e47786 (2012) doi:10.1371/journal.pone.0047786

Francesco Russo*, Sebastiano Di Bella*, Vincenzo Bonnici, Alessandro Laganà, Giuseppe Rainaldi, Marco Pellegrini, Alfredo Pulvirenti, Rosalba Giugno, Alfredo Ferro.
A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs.
BMC Genomics 2014, 15(Suppl 3):S4 doi:10.1186/1471-2164-15-S3-S4