RNA	RNA_class	miRBase_Last_Version	miRBase_accession	miRBase_family	circRNA_accession	organism	exRNA_type	sample	disease_or_cell_line	PubMed_ID	method	description
bta-let-7	miRNA	bta-let-7a-5p	MIMAT0003844	let-7	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-let-7-5p	miRNA	bta-let-7a-5p	MIMAT0003844	let-7	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-let-7a	miRNA	bta-let-7a-5p	MIMAT0003844	let-7	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-let-7b	miRNA	bta-let-7b	MIMAT0004331	let-7	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-let-7c	miRNA	bta-let-7c	MIMAT0004332	let-7	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-let-7d	miRNA	bta-let-7d	MIMAT0003810	let-7	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-let-7e	miRNA	bta-let-7e	MIMAT0004333	let-7	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-let-7f	miRNA	bta-let-7f	MIMAT0003519	let-7		Bos taurus	circulating	plasma	oestrous cycle	27340826	illumina hiseq 2000 platform|illumina truseq small-rna sample preparation kit (illumina, usa)|trizol ls (life technologies, usa)|rt-qpcr	overall, authors identified four mirnas (let-7f, mir-125b, mir-145 and mir-99a-5p), the plasma levels of which distinctly increased (up to 2.2-fold, p < 0.05) during oestrus (day 0) relative to other stages of the cycle (days 8 and 16)
bta-let-7i	miRNA	bta-let-7i	MIMAT0003851	let-7	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-100	miRNA	bta-miR-100	MIMAT0009215	mir-10		Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-100	miRNA	bta-miR-100	MIMAT0009215	mir-10	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-103	miRNA	bta-miR-103	MIMAT0003521	mir-103	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-107	miRNA	bta-miR-107	MIMAT0003785	mir-103	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-10a	miRNA	bta-miR-10a	MIMAT0003786	mir-10	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-125a	miRNA	bta-miR-125a	MIMAT0003538	mir-10	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-mir-125b	miRNA	bta-mir-125b	MIMAT0003539	mir-10		Bos taurus	circulating	plasma	oestrous cycle	27340826	illumina hiseq 2000 platform|illumina truseq small-rna sample preparation kit (illumina, usa)|trizol ls (life technologies, usa)|rt-qpcr	overall, authors identified four mirnas (let-7f, mir-125b, mir-145 and mir-99a-5p), the plasma levels of which distinctly increased (up to 2.2-fold, p < 0.05) during oestrus (day 0) relative to other stages of the cycle (days 8 and 16)
bta-miR-125b	miRNA	bta-miR-125b	MIMAT0003539	mir-10	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-126-3p	miRNA	bta-miR-126-3p	MIMAT0003540	mir-126	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-141	miRNA	bta-miR-141	MIMAT0009232	mir-8	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-143	miRNA	bta-miR-143	MIMAT0009233	mir-143	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-145	miRNA	bta-miR-145	MIMAT0003542	mir-145		Bos taurus	circulating	plasma	oestrous cycle	27340826	illumina hiseq 2000 platform|illumina truseq small-rna sample preparation kit (illumina, usa)|trizol ls (life technologies, usa)|rt-qpcr	overall, authors identified four mirnas (let-7f, mir-125b, mir-145 and mir-99a-5p), the plasma levels of which distinctly increased (up to 2.2-fold, p < 0.05) during oestrus (day 0) relative to other stages of the cycle (days 8 and 16)
bta-miR-145	miRNA	bta-miR-145	MIMAT0003542	mir-145	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-149-5p	miRNA	bta-miR-149-5p	MIMAT0024570	mir-149	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-151-3p	miRNA	bta-miR-151-3p	MIMAT0003524	mir-28	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-151-5p	miRNA	bta-miR-151-5p	MIMAT0003523	mir-28	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-152	miRNA	bta-miR-152	MIMAT0009238	mir-148	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-17-5p	miRNA	bta-miR-17-5p	MIMAT0003815	mir-17	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-181a	miRNA	bta-miR-181a	MIMAT0003543	mir-181	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-182	miRNA	bta-miR-182	MIMAT0009244	mir-181	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-191	miRNA	bta-miR-191	MIMAT0003819	mir-191	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-195	miRNA	bta-miR-195	MIMAT0004335	mir-15	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-19b	miRNA	bta-miR-19b	MIMAT0004337	mir-19	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-200a	miRNA	bta-miR-200a	MIMAT0003822	mir-8	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-200b	miRNA	bta-miR-200b	MIMAT0003842	mir-8	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-200c	miRNA	bta-miR-200c	MIMAT0003823	mir-8	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-205	miRNA	bta-miR-205	MIMAT0003545	mir-205	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-20a	miRNA	bta-miR-20a	MIMAT0003527	mir-17	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-21-5p	miRNA	bta-miR-21-5p	MIMAT0003528	mir-21	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-22-3p	miRNA	bta-miR-22-3p	MIMAT0012536	mir-22	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-221	miRNA	bta-miR-221	MIMAT0003529	mir-221	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-222	miRNA	bta-miR-222	MIMAT0003530	mir-221	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-23a	miRNA	bta-miR-23a	MIMAT0003827	mir-23	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-23b-3p	miRNA	bta-miR-23b-3p	MIMAT0003852	mir-23	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-24	miRNA	bta-miR-24	MIMAT0003840	mir-24	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-24-3p	miRNA	bta-miR-24-3p	MIMAT0003840	mir-24	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-26a	miRNA	bta-miR-26a	MIMAT0003516	mir-26	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-27a-3p	miRNA	bta-miR-27a-3p	MIMAT0003532	mir-27	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-27b	miRNA	bta-miR-27b	MIMAT0003546	mir-27	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-29a	miRNA	bta-miR-29a	MIMAT0003518	mir-29	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-30a-5p	miRNA	bta-miR-30a-5p	MIMAT0003841	mir-30	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-30d	miRNA	bta-miR-30d	MIMAT0003533	mir-30	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-31	miRNA	bta-miR-31	MIMAT0003548	mir-31	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-320a	miRNA	bta-miR-320a	MIMAT0003534	mir-320	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-342	miRNA	bta-miR-342	MIMAT0003846	mir-342	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-361	miRNA	bta-miR-361	MIMAT0003830	mir-361	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-425-3p	miRNA	bta-miR-425-3p	MIMAT0003833	mir-425	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-425-5p	miRNA	bta-miR-425-5p	MIMAT0003832	mir-425	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-429	miRNA	bta-miR-429	MIMAT0009315	mir-8	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-660	miRNA	bta-miR-660	MIMAT0004344	mir-188	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-93	miRNA	bta-miR-93	MIMAT0003837	mir-17	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-miR-99a-5p	miRNA	bta-miR-99a-5p	MIMAT0003537	mir-10	NULL	Bos taurus	membrane vesicle	epithelial cells	Normal-Caput epithelial cells	23803555	microarray	Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis.
bta-mir-99a-5p	miRNA	bta-mir-99a-5p	MIMAT0003537	mir-10		Bos taurus	circulating	plasma	oestrous cycle	27340826	illumina hiseq 2000 platform|illumina truseq small-rna sample preparation kit (illumina, usa)|trizol ls (life technologies, usa)|rt-qpcr	overall, authors identified four mirnas (let-7f, mir-125b, mir-145 and mir-99a-5p), the plasma levels of which distinctly increased (up to 2.2-fold, p < 0.05) during oestrus (day 0) relative to other stages of the cycle (days 8 and 16)
DNAJC6	circRNA	NULL			hsa_circ_0002454	Homo sapiens	circulating	blood	normal	26485708	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
dre-miR-122	miRNA	dre-miR-122	MIMAT0001818	mir-122		Danio rerio	circulating	serum	Acute liver failure	24625211	retro-orbital blood acquisition|mirneasy kit (qiagen, venlo, netherlands)|minelute kit (qiagen, venlo, netherlands)|stem-loop reverse-transcription rt primers (applied biosystems, foster city, ca, usa)|mircury lna microrna detection probes (exiqon a/s, vedbaek, denmark)|	collection of blood by ro bleeding facilitated measurement of mir-122 in a zebrafish model of paracetamol hepatotoxicity. the zebrafish represents a new species for measurement of circulating mirna biomarkers that are translational and can bridge between fish and humans.
ebv-miR-BART1-3p	miRNA	ebv-miR-BART1-3p	MIMAT0003390	mir-BART1	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART1-5p	miRNA	ebv-miR-BART1-5p	MIMAT0000999	mir-BART1	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART10	miRNA	ebv-miR-BART10-3p	MIMAT0003420	mir-BART10	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART12	miRNA	ebv-miR-BART12	MIMAT0003423	mir-BART12	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART13	miRNA	ebv-miR-BART13-3p	MIMAT0003424	mir-BART13	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART2	miRNA	ebv-miR-BART2-5p	MIMAT0001000	mir-BART2	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART3	miRNA	ebv-miR-BART3-3p	MIMAT0003411	mir-BART3	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART4	miRNA	ebv-miR-BART4-5p	MIMAT0003412	mir-BART3	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART5	miRNA	ebv-miR-BART5-5p	MIMAT0003413	mir-BART5	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART6-3p	miRNA	ebv-miR-BART6-3p	MIMAT0003415	NULL	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART6-5p	miRNA	ebv-miR-BART6-5p	MIMAT0003414	NULL	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART7	miRNA	ebv-miR-BART7-3p	MIMAT0003416	mir-BART7	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART8	miRNA	ebv-miR-BART8-5p	MIMAT0003417	NULL	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BART8*	miRNA	ebv-miR-BART8-3p	MIMAT0003418	NULL	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BHRF1-1	miRNA	ebv-miR-BHRF1-1	MIMAT0000995	mir-BHRF1-1	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BHRF1-2	miRNA	ebv-miR-BHRF1-2-3p	MIMAT0000997	mir-BHRF1-2	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BHRF1-2*	miRNA	ebv-miR-BHRF1-2-5p	MIMAT0000996	mir-BHRF1-2	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
ebv-miR-BHRF1-3	miRNA	ebv-miR-BHRF1-3	MIMAT0000998	NULL	NULL	Epstein Barr virus	exosome	B cells	B95-8	20304794	RT-PCR|Differential centrifugation	Functional delivery of viral miRNAs via exosomes
eca-miR-101	miRNA	eca-miR-101	MIMAT0012951	mir-101	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-106a	miRNA	eca-miR-106a	MIMAT0013194	mir-17	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-106b	miRNA	eca-miR-106b	MIMAT0013054	mir-17	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-124	miRNA	eca-miR-124	MIMAT0012906	mir-124	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-125a-5p	miRNA	eca-miR-125a-5p	MIMAT0013008	mir-10	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-132	miRNA	eca-miR-132	MIMAT0013021	mir-132	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-134	miRNA	eca-miR-134	MIMAT0013127	mir-134	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-135a	miRNA	eca-miR-135a	MIMAT0013078	mir-135	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-135b	miRNA	eca-miR-135b	MIMAT0012952	mir-135	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-139-5p	miRNA	eca-miR-139-5p	MIMAT0012983	mir-139	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-149	miRNA	eca-miR-149	MIMAT0012973	mir-149	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-17	miRNA	eca-miR-17	MIMAT0013084	mir-17	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-181a	miRNA	eca-miR-181a	MIMAT0013178	mir-181	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-181b	miRNA	eca-miR-181b	MIMAT0013179	mir-181	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-187	miRNA	eca-miR-187	MIMAT0012999	mir-187	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-188-5p	miRNA	eca-miR-188-5p	MIMAT0013198	mir-188	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-192	miRNA	eca-miR-192	MIMAT0013049	mir-192	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-193b	miRNA	eca-miR-193b	MIMAT0013056	mir-193	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-195	miRNA	eca-miR-195	MIMAT0013027	mir-15	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-197	miRNA	eca-miR-197	MIMAT0012959	mir-197	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-19a	miRNA	eca-miR-19a	MIMAT0013086	mir-19	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-19b	miRNA	eca-miR-19b	MIMAT0013087	mir-19	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-20a	miRNA	eca-miR-20a	MIMAT0013088	mir-17	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-20b	miRNA	eca-miR-20b	MIMAT0013202	mir-17	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-21	miRNA	eca-miR-21	MIMAT0013029	mir-21	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-212	miRNA	eca-miR-212	MIMAT0013030	mir-132	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-214	miRNA	eca-miR-214	MIMAT0012963	mir-214	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-215	miRNA	eca-miR-215	MIMAT0013190	mir-192	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-22	miRNA	eca-miR-22	MIMAT0013031	mir-22	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-222	miRNA	eca-miR-222	MIMAT0013204	mir-221	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-223	miRNA	eca-miR-223	MIMAT0013205	mir-223	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-23a	miRNA	eca-miR-23a	MIMAT0012986	mir-23	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-23b	miRNA	eca-miR-23b	MIMAT0013113	mir-23	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-24	miRNA	eca-miR-24	MIMAT0012987	mir-24	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-25	miRNA	eca-miR-25	MIMAT0013057	mir-25	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-27a	miRNA	eca-miR-27a	MIMAT0012988	mir-27	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-28-3p	miRNA	eca-miR-28-3p	MIMAT0013093	mir-28	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-30b	miRNA	eca-miR-30b	MIMAT0013005	mir-30	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-30e	miRNA	eca-miR-30e	MIMAT0012916	mir-30	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-31	miRNA	eca-miR-31	MIMAT0013115	mir-31	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-323-5p	miRNA	eca-miR-323-5p	MIMAT0013131	mir-154	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-324-3p	miRNA	eca-miR-324-3p	MIMAT0013034	mir-324	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-324-5p	miRNA	eca-miR-324-5p	MIMAT0013033	mir-324	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-326	miRNA	eca-miR-326	MIMAT0012989	mir-326	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-328	miRNA	eca-miR-328	MIMAT0012929	mir-328	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-342-3p	miRNA	eca-miR-342-3p	MIMAT0013137	mir-342	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-346	miRNA	eca-miR-346	MIMAT0012902	mir-346	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-362-5p	miRNA	eca-miR-362-5p	MIMAT0013210	mir-362	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-370	miRNA	eca-miR-370	MIMAT0013142	mir-370	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-372	miRNA	eca-miR-372	MIMAT0034639	mir-290	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-374a	miRNA	eca-miR-374a	MIMAT0013213	mir-374	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-377	miRNA	eca-miR-377	MIMAT0013146	mir-154	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-378	miRNA	eca-miR-378	MIMAT0013068	mir-378	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-409-3p	miRNA	eca-miR-409-3p	MIMAT0013152	mir-154	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-409-5p	miRNA	eca-miR-409-5p	MIMAT0013151	mir-154	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-411	miRNA	eca-miR-411	MIMAT0013154	mir-379	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-421	miRNA	eca-miR-421	MIMAT0013216	mir-95	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-433	miRNA	eca-miR-433	MIMAT0013158	mir-433	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-485-3p	miRNA	eca-miR-485-3p	MIMAT0013160	mir-485	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-486-5p	miRNA	eca-miR-486-5p	MIMAT0013186	mir-486	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-488	miRNA	eca-miR-488	MIMAT0012965	mir-488	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-494	miRNA	eca-miR-494	MIMAT0013164	mir-154	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-499-3p	miRNA	eca-miR-499-3p	MIMAT0013109	mir-499	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-503	miRNA	eca-miR-503	MIMAT0013227	mir-503	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-532-3p	miRNA	eca-miR-532-3p	MIMAT0013236	mir-188	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-539	miRNA	eca-miR-539	MIMAT0013167	mir-154	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-92a	miRNA	eca-miR-92a	MIMAT0013089	mir-25	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-92b	miRNA	eca-miR-92b	MIMAT0012966	mir-25	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
eca-miR-93	miRNA	eca-miR-93	MIMAT0013060	mir-17	NULL	Equus caballus	microvesicle	follicular fluid	Follicular fluid - Ovarian	22116803	rt-pcr	Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
GSE1	circRNA	NULL			hsa_circ_0000722	Homo sapiens	circulating	blood	normal	26485708	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
h19	lncRNA					Homo sapiens	circulating	plasma	gastric cancer (gc)	23898077	rt-pcr	plasma h19 levels were significantly higher in patients than in healthy controls. plasma h19 levels were significantly reduced in postoperative samples. circulating lncrnas can be detectable in plasma, and the detection of circulating lncrnas may provide new complementary tumor markers for gastric cancer.
hnf1a-as1	lncRNA					Homo sapiens	circulating	plasma	esophageal squamous cell carcinoma (escc)	25608466	trizol reagent (invitrogen, carlsbad, ca, usa)|mirvana paris kit (ambion 1556, usa)|sybr premix ex tag ii (takara: rr820a)|abi 7500 real-time pcr system (applied biosystems, usa)	escc-related lncrnas were detectable and stable in plasma of cancer patients, and derived largely from escc tumor cells. furthermore, plasma levels of pou3f3, hnf1a-as1 and spry4-it1 were significantly higher in escc patients compared with normal controls. by receiver operating characteristic curve (roc) analysis, among the three lncrnas investigated, plasma pou3f3 provided the highest diagnostic performance for detection of escc (the area under the roc curve (auc), 0.842; p < 0.001; sensitivity, 72.8%; specificity, 89.4%). plasma pou3f3 could serve as a potential biomarker for diagnosis of escc.
hsa-let-7	miRNA	NULL	NULL	let-7	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-let-7-5p	miRNA	NULL	NULL	let-7	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	circulating	plasma	Multiple sclerosis (MS)	25487315	7900 ht fast real-time pcr system (applied biosystems)	authors studied that significantly changed expression of selected extracellular mirna in plasma of multiple sclerosis (ms) patients may be correlated with clinical parameters.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	serum	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-521	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-p7a	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	lung cancer cells	DMS-53	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	lung cancer cells	nci-h69	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	lung cancer cells	sbc-3	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	colorectal cancer cells	sw480	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	colorectal cancer cells	sw620	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7		Homo sapiens	circulating	plasma	gastric cancer (gc)	20234369	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
hsa-let-7a	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-let-7a*	miRNA	hsa-let-7a-3p	MIMAT0004481	let-7		Homo sapiens	exosome	plasma	type 2 diabetes	24937531	exoquick exosome precipitation solution (system biosciences)| rneasy kit (qiagen)| qrt-pcr	we aimed at studying circulating mirna expression in diabetic patients naïve to treatment and at investigating the influence on this of glycemic control. in diabetic patients, microarray analysis showed that four mirnas are increased, whereas 21 mirnas are decreased. after 12 months of antidiabetic treatment, quantitative rt-pcr data analysis showed that mir-326 levels were unaffected, whereas the levels of let-7a and let-7f were significantly increased.  treatment-naïve, poorly controlled diabetic patients show a significant dysregulation of mirnas involved in the regulation of the adiponectin pathway, a phenomenon that may be reversed, at least in part, by improved glycemic control.
hsa-let-7a*	miRNA	hsa-let-7a-3p	MIMAT0004481	let-7		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-let-7a-5p	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-let-7a-5p	miRNA	hsa-let-7a-5p	MIMAT0000062	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	circulating	serum	Breast cancer	25137071	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	circulating	plasma	Breast cancer	22821209	Quantitative PCR	Potential biomarker microRNAs were identified, including let-7b, let-7g and miR-18b, with higher levels associated with tumours. These microRNAs were over-represented within the more highly expressed microRNAs in matched tumours, suggesting that circulating populations are tumour-derived in part.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	circulating	plasma	Chronic thromboembolic pulmonary hypertension (cteph)	24978044	qrt-pcr	altering let-7b level influenced et-1 and tgfbr1 expression in pulmonary arterial endothelial cells (paecs) as well as the migration of paecs and pulmonary arterial smooth muscle cells (pasmcs). these results suggested that cteph patients had aberrant microrna signature which might provide some clue for pathogenesis study and biomarker screening. reduced let-7b might be involved in the pathogenesis of cteph by affecting et-1 expression and the function of paecs and pasmcs.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-521	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-p7a	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	exosome	lung cancer cells	DMS-53	20949044	human mirna microarray kit	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	exosome	lung cancer cells	nci-h69	20949044	human mirna microarray kit	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	exosome	lung cancer cells	sbc-3	20949044	human mirna microarray kit	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	exosome	colorectal cancer cells	sw480	20949044	human mirna microarray kit	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-let-7b	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-let-7b*	miRNA	hsa-let-7b-3p	MIMAT0004482	let-7		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-let-7b-3p	miRNA	hsa-let-7b-3p	MIMAT0004482	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7b-5p	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-let-7b-5p	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7b-5p	miRNA	hsa-let-7b-5p	MIMAT0000063	let-7		Homo sapiens	circulating	plasma	prostate cancer	27265125	genechip mirna 4.0 array (affymetrix)	in prostatic cancer, significant increase in hsa-mir-619-5p and hsa-mir-1184 microrna expression and significant decrease in hsalet-7b-5p and hsa-let-7c-5p microrna expression were observed.
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-521	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-p7a	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7		Homo sapiens	circulating	plasma	pregnancy	24521639	real-time pcr	analysis of extracellular chromosome 21-derived micrornas has no benefit for screening programmes and non-invasive diagnosis of down syndrome.
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-let-7c	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7		Homo sapiens	circulating	plasma	prostate cancer	22298030	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102 1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followed by qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
hsa-let-7c*	miRNA	hsa-let-7c-3p	MIMAT0026472	let-7	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-let-7c-5p	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-let-7c-5p	miRNA	hsa-let-7c-5p	MIMAT0000064	let-7		Homo sapiens	circulating	plasma	prostate cancer	27265125	genechip mirna 4.0 array (affymetrix)	in prostatic cancer, significant increase in hsa-mir-619-5p and hsa-mir-1184 microrna expression and significant decrease in hsalet-7b-5p and hsa-let-7c-5p microrna expression were observed.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-521	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-p7a	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-let-7d	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-let-7d*	miRNA	hsa-let-7d-3p	MIMAT0004484	let-7		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7d*	miRNA	hsa-let-7d-3p	MIMAT0004484	let-7		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7d*	miRNA	hsa-let-7d-3p	MIMAT0004484	let-7		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7d-3p	miRNA	hsa-let-7d-3p	MIMAT0004484	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7d-5p	miRNA	hsa-let-7d-5p	MIMAT0000065	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	circulating	plasma	essential hypertension	21690488	mircury lna array (version 11.0) system|qrt-pcr mmlv reverse transcriptase (epicenter, madison, wi)|abi prism7500 system (applied biosystems, foster city, ca)	authors report for the first time a circulating mirna profile for hypertensive patients and demonstrate a novel link between hcmv infection and essential hypertension. These findings may reveal important insights into the pathogenesis of essential hypertension.
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-521	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-p7a	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	circulating	serum	osteoarthritis (oa)	24515954	real-time pcr	this is the first study that identifies differentially expressed circulating micrornas in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. among these micrornas, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.
hsa-let-7e	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	circulating	plasma	prostate cancer	22298030	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102-1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followedby qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
hsa-let-7e-5p	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7		Homo sapiens	circulating	plasma	ventricular septal defect (vsd)	25165856	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
hsa-let-7e-5p	miRNA	hsa-let-7e-5p	MIMAT0000066	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-521	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	exosome	plasma	type 2 diabetes	24937531	exoquick exosome precipitation solution (system biosciences)| rneasy kit (qiagen)| qrt-pcr	we aimed at studying circulating mirna expression in diabetic patients naïve to treatment and at investigating the influence on this of glycemic control. in diabetic patients, microarray analysis showed that four mirnas are increased, whereas 21 mirnas are decreased. after 12 months of antidiabetic treatment, quantitative rt-pcr data analysis showed that mir-326 levels were unaffected, whereas the levels of let-7a and let-7f were significantly increased.  treatment-naïve, poorly controlled diabetic patients show a significant dysregulation of mirnas involved in the regulation of the adiponectin pathway, a phenomenon that may be reversed, at least in part, by improved glycemic control.
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-p7a	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-let-7f	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7		Homo sapiens	circulating	plasma	non small cell lung cancer (nsclc)	20595154	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
hsa-let-7f-1*	miRNA	hsa-let-7f-1-3p	MIMAT0004486	let-7		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-let-7f-1*	miRNA	hsa-let-7f-1-3p	MIMAT0004486	let-7		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-let-7f-5p	miRNA	hsa-let-7f-5p	MIMAT0000067	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	circulating	serum	metabolic syndrome (mets)	24093444	qrt-pcr	the circulating levels of let-7 g and mir-221 displayed a female-specific elevation in individuals with metabolic syndrome.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	circulating	plasma	Breast cancer	22821209	Quantitative PCR	Potential biomarker microRNAs were identified, including let-7b, let-7g and miR-18b, with higher levels associated with tumours. These microRNAs were over-represented within the more highly expressed microRNAs in matched tumours, suggesting that circulating populations are tumour-derived in part.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-521	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-p7a	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-let-7g	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-let-7g-5p	miRNA	hsa-let-7g-5p	MIMAT0000414	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	circulating	serum	prostate cancer	21539977	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-521	20949044	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	exosome	stomach cancer cells	AZ-p7a	20949044	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-let-7i	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7i*	miRNA	hsa-let-7i-3p	MIMAT0004585	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-let-7i-5p	miRNA	hsa-let-7i-5p	MIMAT0000415	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-let-7j-5p	miRNA	NULL	NULL	let-7	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	plasma	Acute myocardial infarction (ami)	22719221	TRIzol LS Reagent|ELISA assay|Transcript First-strand cDNA Synthesis Su-perMix (TransGen Biotech, Beijing, China)|Bulge-Loop miRNA qRT-PCR Detection Kit (Ribobio Co., Guangzhou, China)|TransStart Green qPCR SuperMix (TransGen Biotech, Beijing, China)	Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. A remarkable finding in this study is that miR-1, miR-126 and cTnI expression levels exhibited the same trend. Results suggest that the plasma concentrations of miR-1 and miR-126 may be useful indicators for AMI.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	plasma	stable angina (sa) 	24260372	trizol reagent|taqman human microrna card a arrays version 2.0 (life technologies)	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	microvesicle	conditioned medium (cm)	glioblastoma	24310399	trizol (invitrogen)|mir real-time pcr detection kit (applied biosystems)	authors showed how extracellular vesicle signaling promotes the malignant character of glioblastoma and how ectopic expression of mir-1 can mitigate this character, with possible implications for how to develop a unique mirna-based therapy for glioblastoma management.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	plasma	Coronary artery disease	25197382	qrt-pcr	the phenotypes of circulating mirna-1 levels in 34 cases were slightly lower than that of 40 controls but not significantly different (p = 0.090).
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	plasma	unstable angina	24260372	taqman microrna array	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	plasma	tachycardia	25625292	fluorescent quantitative pcr	authors demonstrated that mir-1 may be appropriate marker for pediatric tachycardia. mir-1 levels were decreased in the arrhythmia group compared with those in the healthy controls. in particular, patients with supraventricular tachycardia (svt) had lower mir‑1 expression levels.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	plasma	st elevation myocardial infarction (stemi)	21701171	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	urine	st elevation myocardial infarction (stemi)	21701171	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	plasma	thoracic aortic aneurysm (taa)	23312977	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	plasma	Acute myocardial infarction (ami)	19896465	real-time rt-pcr	in the present study, were recruited 159 patients with or without ami for quantification of mir-1 level in plasma using real-time rt-pcr method. Circulating mir-1 may be a novel, independent biomarker for diagnosis of ami.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-1	miRNA	hsa-miR-1-3p	MIMAT0000416	mir-1		Homo sapiens	circulating	serum	Acute myocardial infarction (ami)	20218970	qrt-pcr with a roche lightcycler 480 detection system	the levels of circulating cell-free mir-1 were significantly increased in patients with ami (acute myocardial infarction) and had a positive correlation with serum ck-mb (creatine kinase-mb) levels.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	circulating	serum	osteoporosis	24431276	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	22937028	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	circulating	plasma	Coronary artery disease	25519160	Quantitative PCR	authors showed that mir-100 might be released into the coronary circulation from vulnerable coronary plaques. this study provides insights into the role of mirnas in coronary atherosclerotic disease.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	25519019	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-100	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-100-5p	miRNA	hsa-miR-100-5p	MIMAT0000098	mir-10	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	circulating	serum	hepatitis b virus (hbv)-associated liver cirrhosis (hbv-lc)	24971953	real-time quantitative pcr	authors suggest that the serum mir-101 level can serve as a potential non-invasive biomarker to differentiate hbv-hcc from hbv-lc.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	exosome	serum	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	circulating	serum	hepatitis b virus-associated hepatocellular carcinoma (hbv-hcc)	24971953	real-time quantitative pcr	authors suggest that the serum mir-101 level can serve as a potential non-invasive biomarker to differentiate hbv-hcc from hbv-lc.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	circulating	serum	hepatitis b virus-associated hepatocellular carcinoma (hbv-hcc)	24260081	real-time pcr	authors demonstrate that circulating mir-101 may serve as a promising biochemical marker for monitoring the progression of tumor development in hbv-related hcc.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-101	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-101-3p	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-101-3p	miRNA	hsa-miR-101-3p	MIMAT0000099	mir-101	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	circulating	serum	triple-negative breast cancers (tnbc)	25547678	real-time pcr	by cox regression analysis, authors identified a four-mirna signature (mir-18b, mir-103, mir-107, and mir-652) that predicted tumor relapse and overall survival for patients with triple-negative breast cancers (tnbc).
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-103	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-103-3p	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-103a-3p	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-103a-3p	miRNA	hsa-miR-103a-3p	MIMAT0000101	mir-103	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-103b	miRNA	hsa-miR-103b	MIMAT0007402	mir-103	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-105	miRNA	hsa-miR-105-5p	MIMAT0000102	mir-105		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-105	miRNA	hsa-miR-105-5p	MIMAT0000102	mir-105		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	blood	Breast cancer	24626163	real-time quantitative pcr	analysis of patient tissue and blood samples revealed mir-138 to be significantly up-regulated in the circulation of patients with breast cancer, with no change observed in the tissue setting. while not significantly changed overall in breast cancer patients compared to controls, circulating mir-106a and mir-191 were significantly decreased in patients with basal breast cancer. in tissue, both mirnas were significantly elevated in breast cancer compared to normal breast tissue. the data demonstrates an impact of tumour epithelial subtype on circulating levels of mirnas, and highlights divergent mirna profiles between tissue and blood samples from breast cancer patients.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	gastric cancer (gc)	20234369	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-106a	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-106a*	miRNA	hsa-miR-106a-3p	MIMAT0004517	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-106a-5p	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-106a-5p	miRNA	hsa-miR-106a-5p	MIMAT0000103	mir-17	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	circulating	serum	Aging	25165030	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	circulating	plasma	gastric cancer (gc)	20234369	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
hsa-miR-106b	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-106b*	miRNA	hsa-miR-106b-3p	MIMAT0004672	mir-17		Homo sapiens	microparticle	atherosclerotic plaques	Atherosclerosis	24931230	rt-pcr	by comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype (n = 9) and those from normal vascular tissues (n = 9), we found levels of annexin v(+) microparticles and annexin v(+) cd144(+) microparticles were significantly increased in plaques and angiogenesis associated micrornas (106b, 25, 92a and 21) were also significantly increased in microparticles from plaques. inflammation could induce endothelial cells to release angiogenesis associated micrornas into circulation, causing higher levels of circulating endothelial cells derived micrornas in atherosclerosis.
hsa-miR-106b-5p	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-106b-5p	miRNA	hsa-miR-106b-5p	MIMAT0000680	mir-17	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	exosome	serum	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	circulating	serum	triple-negative breast cancers (tnbc)	25547678	real-time pcr	by cox regression analysis, authors identified a four-mirna signature (mir-18b, mir-103, mir-107, and mir-652) that predicted tumor relapse and overall survival for patients with triple-negative breast cancers (tnbc).
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	exosome	urine	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-107	miRNA	hsa-miR-107	MIMAT0000104	mir-103		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-107-3p	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-107a	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-107b	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-10a	miRNA	hsa-miR-10a-5p	MIMAT0000253	mir-10		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-10a	miRNA	hsa-miR-10a-5p	MIMAT0000253	mir-10		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-10a	miRNA	hsa-miR-10a-5p	MIMAT0000253	mir-10		Homo sapiens	circulating	breast milk	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-10a	miRNA	hsa-miR-10a-5p	MIMAT0000253	mir-10		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-10a	miRNA	hsa-miR-10a-5p	MIMAT0000253	mir-10		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-10a	miRNA	hsa-miR-10a-5p	MIMAT0000253	mir-10		Homo sapiens	circulating	serum	heart transplant rejection	25176944	real-time pcr	the study demonstrates that a differential expression of mirna occurs in rejecting allograft patients, not only at the tissue level but also in the serum, suggesting their potential relevance as non-invasive biomarkers in heart transplant rejection.
hsa-miR-10a-3p	miRNA	hsa-miR-10a-3p	MIMAT0004555	mir-10	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-10a-5p	miRNA	hsa-miR-10a-5p	MIMAT0000253	mir-10	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-10b	miRNA	hsa-miR-10b-5p	MIMAT0000254	mir-10		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-10b	miRNA	hsa-miR-10b-5p	MIMAT0000254	mir-10		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-10b	miRNA	hsa-miR-10b-5p	MIMAT0000254	mir-10		Homo sapiens	circulating	serum	lung cancer	21398193	picogreen|taqman microrna|caspase-glo 3/7 assay	in lung cancer patients high serum mir10b values associated with lymph node metastasis (p < 0.03) and elevated levels of tpa (tissue polypeptide antigen, p = 0.01), whereas high serum mir141 values associated with elevated levels of upa (urokinase plasminogen activator, p = 0.02).
hsa-miR-10b	miRNA	hsa-miR-10b-5p	MIMAT0000254	mir-10		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-10b	miRNA	hsa-miR-10b-5p	MIMAT0000254	mir-10		Homo sapiens	circulating	serum	Breast cancer	21047409	quantitative real-time pcr taqman microrna assays (applied biosystems)	the relative concentrations of total rna (p = 0.0001) and mir155 (p = 0.0001) in serum significantly discriminated m0-patients (primary breast cancer) from healthy women, whereas mir10b (p = 0.005), mir34a (p = 0.001) and mir155 (p = 0.008) discriminated m1-patients (metastatic disease) from healthy controls.
hsa-miR-10b	miRNA	hsa-miR-10b-5p	MIMAT0000254	mir-10		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-10b*	miRNA	hsa-miR-10b-3p	MIMAT0004556	mir-10		Homo sapiens	circulating	colostrum	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-10b*	miRNA	hsa-miR-10b-3p	MIMAT0004556	mir-10		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-10b*	miRNA	hsa-miR-10b-3p	MIMAT0004556	mir-10		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-10b*	miRNA	hsa-miR-10b-3p	MIMAT0004556	mir-10		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-10b-3p	miRNA	hsa-miR-10b-3p	MIMAT0004556	mir-10	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-10b-5p	miRNA	hsa-miR-10b-5p	MIMAT0000254	mir-10	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-1180	miRNA	hsa-miR-1180-3p	MIMAT0005825	mir-1180	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-1183	miRNA	hsa-miR-1183	MIMAT0005828	mir-1183		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-1184	miRNA	hsa-miR-1184	MIMAT0005829	mir-1184		Homo sapiens	circulating	plasma	prostate cancer	27265125	genechip mirna 4.0 array (affymetrix)	in prostatic cancer, significant increase in hsa-mir-619-5p and hsa-mir-1184 microrna expression and significant decrease in hsalet-7b-5p and hsa-let-7c-5p microrna expression were observed.
hsa-miR-1207-5p	miRNA	hsa-miR-1207-5p	MIMAT0005871	mir-1207		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	liver injury	22427142	real-time reverse transcription pcr	the results showed a positive correlation between serum mir-122 and alanine aminotransferase, a clinical biomarker for liver function. Furthermore, serum mir-122 was assessed in patients with hepatitis b and hepatocarcinoma, resulting in distinct mir-122 profiles in these two closely related diseases.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	exosome	serum	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	plasma	normal	21487102	qrt-pcr	mirna concentrations were higher in plasma than in serum. The mirnas analyzed were stable refrigerated or frozen for up to 72 h and were stable at room temperature for 24 h. Hemolysis increased the apparent concentration of 3 of the mirnas. The total variability of replicate mirna concentrations was <2.0-fold, with most of the variability attributable to the extraction process and interassay imprecision. Normalizing results to those of spiked exogenous control mirnas did not improve this variability.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	plasma	lung adenocarcinoma	24282590	real-time rt-pcr	authors show that circulating mir-195 and mir-122 may have prognostic values in predicting the overall survival as well as predicting egfr mutation status in non-smoking female patients with lung adenocarcinoma.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	plasma	liver injury	20930130	real-time quantitative pcr	circulating mir-122 has potential as a novel, predictive, and reliable blood marker for viral-, alcohol-, and chemical-induced liver injury.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	Chronic type B hepatitis	21229610	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	endometriosis	23118427	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	21229610	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	Chronic type C hepatitis	21886843	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	non-alcoholic fatty liver disease (nafld)	21886843	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	obesity and insulin resistance	25515554		authors demonstrated that elevated circulating mir-122 is positively associated with obesity and insulin resistance in young adults. these findings provide a better understanding regarding the role of mirnas in adiposity and insulin sensitivity.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	Chronic type C hepatitis	23383654		mir-122 is a sensitive marker to distinguish chronic hepatitis c patients from healthy controls.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	plasma	hepatocellular carcinoma (hcc)	27194671	quantitative real-time pcr	high expression levels of plasma mir-122 are associated with early tace refractoriness in hcc patients treated with tace.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	plasma	testosterone abuse	27171140	qrt-pcr	given that testosterone is metabolized by the liver, this observation suggests that mir-122 in cell-free fluids may be used as a sensitive biomarker of testosterone misuse via multiple dosing routes and could therefore be integrated into a blood-based multiparametric follow-up.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	non-alcoholic fatty liver disease (nafld)	24973316	rt-pcr	authors demonstrate that nafld has a distinguishing circulating mirna profile associated with a global dysmetabolic disease state and cardiovascular risk.
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-122	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	Acetaminophen-induced acute liver injury (APAP-ALI)	22045675	miRNeasy kit (Qiagen, Venlo, Netherlands)|Taqman-based quantitative polymerase chain reaction (PCR)|stem-loop reverse-transcription RT primers (Applied Biosystems, Foster City, CA)	Serum miR-122 and miR-192 were substantially higher in APAP-ALI patients, compared to healthy controls.
hsa-miR-1224-5p	miRNA	hsa-miR-1224-5p	MIMAT0005458	mir-1224		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-1225-5p	miRNA	hsa-miR-1225-5p	MIMAT0005572	mir-1225		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-1225-5p	miRNA	hsa-miR-1225-5p	MIMAT0005572	mir-1225		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-1226*	miRNA	hsa-miR-1226-5p	MIMAT0005576	mir-1226		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-1228	miRNA	hsa-miR-1228-3p	MIMAT0005583	mir-1228		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-122a	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-122a	miRNA	hsa-miR-122-5p	MIMAT0000421	mir-122		Homo sapiens	circulating	serum	osteoporosis	24431276	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
hsa-miR-1233	miRNA	hsa-miR-1233	MIMAT0005588	mir-1233		Homo sapiens	circulating	serum	preeclampsia	25017274	taqman low density array chips (human microrna panel v3.0)|quantitative real-time polymerase chain reaction	authors conclude that some circulating mirnas may have potential role in the pathogenesis of preeclampsia. in particular, mir-1233 might represent a potential marker of early spe.
hsa-miR-1233	miRNA	hsa-miR-1233-3p	MIMAT0005588	mir-1233		Homo sapiens	circulating	serum	Acute pulmonary embolism (ape)	27150028	rt-qpcr	this is the first report that identifies a mirna that allows distinguishing acute pe from acute nstemi and healthy individuals with high specificity and sensitivity.
hsa-miR-1233	miRNA	hsa-miR-1233	MIMAT0005588	mir-1233		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-1234	miRNA	hsa-miR-1234	MIMAT0005589	mir-1234		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-1236	miRNA	hsa-miR-1236	MIMAT0005591	mir-1236		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-1238	miRNA	hsa-miR-1238	MIMAT0005593	mir-1238		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-124	miRNA	hsa-miR-124-3p	MIMAT0000422	mir-124		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-124-3p	miRNA	hsa-miR-124-3p	MIMAT0000422	mir-124	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-124-3p	miRNA	hsa-miR-124-3p	MIMAT0000422	mir-124		Homo sapiens	exosome	plasma	sickle cell anemia (sca)	27161653	qrt-pcr	circulating exosomal micrornas may play important roles in predicting the clinical course of sca, and in delineation of individually tailored, mechanistically-based clinical treatment approaches of sca patients in the near future.
hsa-miR-1246	miRNA	hsa-miR-1246	MIMAT0005898	mir-1246		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-1246	miRNA	hsa-miR-1246	MIMAT0005898	mir-1246		Homo sapiens	circulating	serum	multiple myeloma (mm)	23169280	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
hsa-miR-1248	miRNA	hsa-miR-1248	MIMAT0005900	mir-1248		Homo sapiens	circulating	serum	Aging	24088671	next generation sequencing technology|real-time quantitative pcr	of the mirnas that authors found to be present in serum, three were significantly decreased in 20 older individuals compared to 20 younger individuals: mir-151a-5p, mir-181a-5p and mir-1248. consistent with the data in humans, these mirnas are also present at lower levels in the serum of elderly rhesus monkeys.
hsa-miR-1249	miRNA	hsa-miR-1249	MIMAT0005901	mir-1249		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-124a	miRNA	hsa-miR-124-3p	MIMAT0000422	mir-124		Homo sapiens	circulating	serum	osteoporosis	24431276	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
hsa-miR-125	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-1254	miRNA	hsa-miR-1254	MIMAT0005905	mir-1254		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	24515657	microrna array	authors identify two mirnas that are specifically elevated in patients with bevacizumab-induced cardiotoxicity, mir1254 and mirna579, and mirna1254 shows the strongest correlation to the clinical diagnosis of bevacizumab-induced cardiotoxicity.
hsa-miR-125a	miRNA	hsa-miR-125a-5p	MIMAT0000443	mir-125		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-125a	miRNA	hsa-miR-125a-5p	MIMAT0000443	mir-125		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-125a	miRNA	hsa-miR-125a-5p	MIMAT0000443	mir-125	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-125a	miRNA	hsa-miR-125a-5p	MIMAT0000443	mir-125		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-125a-3p	miRNA	hsa-miR-125a-3p	MIMAT0004602	mir-125		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-125a-3p	miRNA	hsa-miR-125a-3p	MIMAT0004602	mir-125		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-125a-5p	miRNA	hsa-miR-125a-5p	MIMAT0000443	mir-125		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-125a-5p	miRNA	hsa-miR-125a-5p	MIMAT0000443	mir-125		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-125a-5p	miRNA	hsa-miR-125a-5p	MIMAT0000443	mir-125		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	plasma	uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	plasma	metastatic uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	serum	osteoporosis	24431276	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	cerebrospinal fluid	Alzheimer disease (AD)	23301201	fluorescent mirna-array-based analysis|led-northern dot-blot assay	the results indicate that mirna-9, mirna-125b, mirna-146a and mirna-155 are csf- and ecf-abundant, nf-кb-sensitive pro-inflammatory mirnas, and their enrichment in circulating csf and ecf suggest that they may be involved in the modulation or proliferation of mirna-triggered pathogenic signaling throughout the brain and central nervous system (cns).
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	plasma	rheumatoid arthritis (ra)	27255643	taqman quantitative pcr	the expression of mir-125b in the pbmcs and plasma of treatment-naïve early ra patients was significantly lower than that of hc and increased significantly after three months of treatment, particularly in responders. however, only the cellular expression of mir-125b was inversely correlated with disease activity.
hsa-miR-125b	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-125b-1*	miRNA	hsa-miR-125b-1-3p	MIMAT0004592	mir-125		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-125b-1*	miRNA	hsa-miR-125b-1-3p	MIMAT0004592	mir-125		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-125b-2	miRNA			mir-10		Homo sapiens	circulating	plasma	pregnancy	24521639	real-time pcr	analysis of extracellular chromosome 21-derived micrornas has no benefit for screening programmes and non-invasive diagnosis of down syndrome.
hsa-miR-125b-2*	miRNA	hsa-miR-125b-2-3p	MIMAT0004603	mir-125		Homo sapiens	circulating	blood	Acute stroke	24447930	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
hsa-miR-125b-2*	miRNA	hsa-miR-125b-2-3p	MIMAT0004603	mir-125		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-125b-5p	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-125b-5p	miRNA	hsa-miR-125b-5p	MIMAT0000423	mir-10		Homo sapiens	circulating	plasma	liver damage in hepatitis b e antigen positive (hbeag-positive) patients	25580300	qrt-pcr	authors demonstrated that three micrornas (mir-28-5p, -30a-5p, and -125b-5p) were significantly upregulated in hbeag-positive children when compared to hbeag-negative and healthy control children. the identified micrornas might impact the progression of chronic hepatitis b in children.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	Breast cancer	22370716	reverse transcriptase-polymerase chain reaction 	circulating mir-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma mir-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab. 
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	type 2 diabetes	24455723	qrt-pcr	mir-126 is the only mirna that showed significantly reduced expression in susceptible individuals and t2dm patients compared to normal individuals, suggesting that mir-126 in circulation may serve as a potential biomarker for early identification of susceptible individuals to t2dm.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	Acute myocardial infarction (ami)	22719221	TRIzol LS Reagent|ELISA assay|Transcript First-strand cDNA Synthesis Su-perMix (TransGen Biotech, Beijing, China)|Bulge-Loop miRNA qRT-PCR Detection Kit (Ribobio Co., Guangzhou, China)|TransStart Green qPCR SuperMix (TransGen Biotech, Beijing, China)	Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. A remarkable finding in this study is that miR-1, miR-126 and cTnI expression levels exhibited the same trend. Results suggest that the plasma concentrations of miR-1 and miR-126 may be useful indicators for AMI.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	Coronary artery disease	22925274	qrt-pcr	mir-126 was not significantly down-regulated or up-regulated in cad patients and was not suitable for discriminating cad patients from patients without cad. the oppositely-directed relationship between mir-126 and ldl cholesterol in patients with or without cad may have significant implications for identifying a potential role of mir-126 in cholesterol metabolism.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	serum	type 2 diabetes	24927146	quantitative real-time pcr	these results encourage the use of serum mir-126 as a biomarker for pre-diabetes and diabetes mellitus, as well as therapeutic response.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	stable angina (sa) 	24260372	taqman microrna array	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	unstable angina	24260372	taqman microrna array	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	metastatic colorectal cancer (mcrc)	25584492	qrt-pcr	authors demonstrated that changes in circulating mirna-126 during chemotherapy and bevacizumab treatment were predictive of  metastatic colorectal cancer (mcrc) response. non-responding patients had a median increase in cir-mirna-126 compared with a median decrease in a responding patients, thus representing a possible biomarker for the resistance to anti-angiogenic containing treatments.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	endurance exercise	23150891	qrt-pcr	different endurance exercise protocols lead to damage of the endothelial cell layer as evident by an increase in mirna-126. on the other hand, resistance exercise has no impact on the endothelial cells, but leads to a destruction of muscular cells.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	solitary pulmonary nodules (spns)	21864403	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	blood	type 2 diabetes	27321479	quantitative real-time pcr	mir-126 strongly associated with t2d and cad, negatively correlated with ldl in cad patients and differentiated between t2d patients, t2d patients with cad and healthy subjects. circulating mir-126 may serve as a biomarker for predicting patients with t2d and diabetic cad.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	urine	urothelial bladder cancer (bca)	19375957	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	type 2 diabetes	23386708	in vitro and in vivo platelet activation	in vitro platelet activation resulted in the transfer of mir-126 from the platelet to the plasma compartment, which was prevented by aspirin. in vivo platelet activation, monitored in patients with dm2 by measuring soluble p-selectin, correlated directly with circulating levels of mir-126. platelets are a major source of circulating mir-126. consequently, in patho-physiological conditions associated with platelet activation, such as diabetes type 2, the administration of aspirin may lead to reduced levels of circulating mir-126.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	troponin-positive acute coronary syndrome	21969012	taqman polymerase chain reaction in edta-plasma 	circulating levels of the muscle-enriched mir-499, mir-133a, and mir-208a were significantly elevated in the aorta of troponin-positive acute coronary syndrome patients compared with patients with coronary artery disease. In contrast, circulating levels of mir-126 decreased during transcoronary passage in patients with evidence of myocardial injury, suggesting consumption during transcoronary passage.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	Coronary artery disease	20595655	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
hsa-miR-126	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-126*	miRNA	hsa-miR-126-5p	MIMAT0000444	mir-126		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-126*	miRNA	hsa-miR-126-5p	MIMAT0000444	mir-126		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-126*	miRNA	hsa-miR-126-5p	MIMAT0000444	mir-126		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-126*	miRNA	hsa-miR-126-5p	MIMAT0000444	mir-126		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-126*	miRNA	hsa-miR-126-5p	MIMAT0000444	mir-126		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-126*	miRNA	hsa-miR-126-5p	MIMAT0000444	mir-126		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-126*	miRNA	hsa-miR-126-5p	MIMAT0000444	mir-126		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-126-3p	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-126-3p	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-126-3p	miRNA	hsa-miR-126-3p	MIMAT0000445	mir-126		Homo sapiens	circulating	serum	subclinical hypothyroidism (sch)	24517143	real-time pcr	mir-21-5p showed the most specific expression patterns in all patients with subclinical hypothyroidism (sch and sch+ath groups). down-regulation of mir-125a-5p, mir-126-3p, mir-221-3p, and mir-222-3p may be a manifestation of atherosclerosis either in sch+ath or in ath-alone patients. mir-126-3p has the most specific expression patterns in all atherosclerosis patients (sch+ath and ath groups).
hsa-miR-1260	miRNA	hsa-miR-1260a	MIMAT0005911	mir-1260		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-1260	miRNA	hsa-miR-1260a	MIMAT0005911	mir-1260		Homo sapiens	circulating	blood	influenza a virus infection	24116168	Quantitative PCR	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
hsa-miR-1260	miRNA	hsa-miR-1260a	MIMAT0005911	mir-1260		Homo sapiens	circulating	blood	influenza a virus infection	24116168	Quantitative PCR	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
hsa-miR-1260	miRNA	hsa-miR-1260a	MIMAT0005911	mir-1260		Homo sapiens	circulating	blood	influenza a virus infection	24116168	Quantitative PCR	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
hsa-miR-1260	miRNA	hsa-miR-1260a	MIMAT0005911	mir-1260		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-1260	miRNA	hsa-miR-1260a	MIMAT0005911	mir-1260		Homo sapiens	circulating	blood	Breast cancer	25179838	qrt-pcr	authors found that mir-1280, mir-1260, and mir-720 were up-regulated in blood from breast cancer patience, mir-1280 may serve as a biomarker for er-positive breast cancer.
hsa-miR-1263	miRNA	hsa-miR-1263	MIMAT0005915	mir-1263		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-1266	miRNA	hsa-miR-1266	MIMAT0005920	mir-1266		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-1268	miRNA	hsa-miR-1268a	MIMAT0005922	mir-1268		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-127	miRNA	hsa-miR-127-3p	MIMAT0000446	mir-127		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-127-3p	miRNA	hsa-miR-127-3p	MIMAT0000446	mir-127		Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-miR-127-3p	miRNA	hsa-miR-127-3p	MIMAT0000446	mir-127		Homo sapiens	circulating	plasma	Breast cancer	24194846	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
hsa-miR-127-3p	miRNA	hsa-miR-127-3p	MIMAT0000446	mir-127		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-1271	miRNA	hsa-miR-1271-5p	MIMAT0005796	mir-1271		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-1272	miRNA	hsa-miR-1272	MIMAT0005925	mir-1272		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-1272	miRNA	hsa-miR-1272	MIMAT0005925	mir-1272		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-1273d	miRNA	hsa-miR-1273d	MIMAT0015090	mir-1273		Homo sapiens	exosome	saliva	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-1274a	miRNA					Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-1274a	miRNA					Homo sapiens	circulating	serum	Breast cancer	25137071	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
hsa-miR-1275	miRNA	hsa-miR-1275	MIMAT0005929	mir-1275		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-1276	miRNA	hsa-miR-1276	MIMAT0005930	mir-1276		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-128	miRNA	hsa-miR-128-3p	MIMAT0000424	mir-128	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-128	miRNA	hsa-miR-128	MIMAT0000424	mir-128		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-128	miRNA	hsa-miR-128	MIMAT0000424	mir-128		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-128	miRNA	hsa-miR-128	MIMAT0000424	mir-128		Homo sapiens	circulating	plasma	mild cognitive impairment (mci)	24368295	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
hsa-miR-128	miRNA	hsa-miR-128	MIMAT0000424	mir-128		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-128	miRNA	hsa-miR-128-3p	MIMAT0000424	mir-128	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-128-3p	miRNA	hsa-miR-128-3p	MIMAT0000424	mir-128		Homo sapiens	circulating	serum	primary progressive multiple sclerosis (ppms) 	27246141	miscript mirna techniques	in comparison with controls, upregulation of mir-191-5p was found in both progressive ms subtypes, while mir-376c-3p was overexpressed only in ppms. additionally, upregulation of mir-128-3p and mir-24-3p was detected in ppms when compared to controls and spms. progression index correlated with mir-128-3p in ppms and mir-375 in spms.
hsa-miR-1280	miRNA					Homo sapiens	circulating	blood	Breast cancer	25179838	qrt-pcr	authors found that mir-1280, mir-1260, and mir-720 were up-regulated in blood from breast cancer patience, mir-1280 may serve as a biomarker for er-positive breast cancer.
hsa-miR-1285	miRNA	hsa-miR-1285-3p	MIMAT0005876	mir-1285		Homo sapiens	circulating	plasma	prostate cancer	22298030	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102 1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followed by qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
hsa-miR-128a	miRNA	hsa-miR-128	MIMAT0000424	mir-128		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-128b	miRNA	hsa-miR-128	MIMAT0000424	mir-128		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-129	miRNA	hsa-miR-129-5p	MIMAT0000242	mir-129		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-129*	miRNA	hsa-miR-129-1-3p	MIMAT0004548	mir-129		Homo sapiens	circulating	peritoneal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-129-5p	miRNA	hsa-miR-129-5p	MIMAT0000242	mir-129		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-1290	miRNA	hsa-miR-1290	MIMAT0005880	mir-1290		Homo sapiens	circulating	serum	Breast cancer	25137071	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
hsa-miR-1290	miRNA	hsa-miR-1290	MIMAT0005880	mir-1290		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-1290	miRNA	hsa-miR-1290	MIMAT0005880	mir-1290		Homo sapiens	exosome	serum	Cervical cancer	27330796	mircury lna array	the expression of circulating mir-1290 was significantly higher in the blood of cervical cancer patients compared with that in controls and may thus serve as a useful biomarker in cervical cancer diagnosis. however, larger studies are required to fully elucidate the role of circulating exosomal mirnas in cervical cancer.
hsa-miR-1290	miRNA	hsa-miR-1290	MIMAT0005880	mir-1290		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-1292	miRNA	hsa-miR-1292	MIMAT0005943	mir-1292		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-1300	miRNA					Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-1305	miRNA	hsa-miR-1305	MIMAT0005893	mir-1305		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-1307-5p	miRNA	hsa-miR-1307-5p	MIMAT0022727	mir-1307	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-1308	miRNA					Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-1308	miRNA					Homo sapiens	circulating	serum	multiple myeloma (mm)	23169280	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
hsa-miR-130a	miRNA	hsa-miR-130a-3p	MIMAT0000425	mir-130		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-130a	miRNA	hsa-miR-130a-3p	MIMAT0000425	mir-130		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-130a	miRNA	hsa-miR-130a-3p	MIMAT0000425	mir-130		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-130a	miRNA	hsa-miR-130a-3p	MIMAT0000425	mir-130		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-130a	miRNA	hsa-miR-130a-3p	MIMAT0000425	mir-130		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-130a	miRNA	hsa-miR-130a-3p	MIMAT0000425	mir-130		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-130a*	miRNA	hsa-miR-130a-5p	MIMAT0004593	mir-130		Homo sapiens	circulating	colostrum	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-130a-3p	miRNA	hsa-miR-130a-3p	MIMAT0000425	mir-130		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-130a-3p	miRNA	hsa-miR-130a-3p	MIMAT0000425	mir-130	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-130b	miRNA	hsa-miR-130b-3p	MIMAT0000691	mir-130		Homo sapiens	circulating	serum	Aging	25165030	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
hsa-miR-130b	miRNA	hsa-miR-130b-3p	MIMAT0000691	mir-130		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-130b	miRNA	hsa-miR-130b-3p	MIMAT0000691	mir-130		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-130b	miRNA	hsa-miR-130b-3p	MIMAT0000691	mir-130		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-130b	miRNA	hsa-miR-130b-3p	MIMAT0000691	mir-130		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-130b	miRNA	hsa-miR-130b-3p	MIMAT0000691	mir-130		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-130b	miRNA	hsa-miR-130b-3p	MIMAT0000691	mir-130		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-130b	miRNA	hsa-miR-130b-3p	MIMAT0000691	mir-130		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-130b	miRNA	hsa-miR-130b-3p	MIMAT0000691	mir-130		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-132	miRNA	hsa-miR-132-3p	MIMAT0000426	mir-132		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-132	miRNA	hsa-miR-132-3p	MIMAT0000426	mir-132		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-132	miRNA	hsa-miR-132-3p	MIMAT0000426	mir-132		Homo sapiens	circulating	plasma	mild cognitive impairment (mci)	24368295	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
hsa-miR-132	miRNA	hsa-miR-132-3p	MIMAT0000426	mir-132		Homo sapiens	circulating	serum	Coronary artery disease	27357355	cox regression analyses	this is the largest study so far evaluating the prognostic value of circulating mirnas in cardiovascular disease. this study shows that single mirnas derived from peripheral blood predict mortality in secondary prevention settings, and thereby represent valuable biomarkers for risk estimation in cad.
hsa-miR-132	miRNA	hsa-miR-132-3p	MIMAT0000426	mir-132		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-132*	miRNA	hsa-miR-132-5p	MIMAT0004594	mir-132		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-1323	miRNA	hsa-miR-1323	MIMAT0005795	mir-1323		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-133	miRNA			mir-133		Homo sapiens	circulating	plasma	ventricular tachycardia (vt)	25625292	fluorescent quantitative pcr	authors demonstrated that mir-133 may be appropriate marker for pediatric tachycardia, in fact patients with ventricular tachycardia (vt) had higher mir‑133 expression levels.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	Breast cancer	25051376	exiqon mircury lna universal rt microrna pcr technology|quantitative real-time pcr	authors suggest that both mir-148b and mir-133a have potential use as biomarkers for breast cancer detection.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	serum	malignant astrocytomas	22674182	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	Acute exhaustive exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	sustained aerobic exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	perioperative myocardial infarction (pmi)	25111390	real-time quantitative rt-pcr	the data analysis revealed that mir-499 had higher sensitivity and specificity than ctni, and indicated that mir-499 could be an independent risk factor for pmi.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	unstable angina	24260372	taqman microrna array	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	st elevation myocardial infarction (stemi)	21701171	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	urine	st elevation myocardial infarction (stemi)	21701171	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	thoracic aortic aneurysm (taa)	23312977	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	Acute myocardial infarction (ami)	27124025	real-time quantitative pcr	in patients undergoing coronary angiography, circulating mir-133a is upregulated in ami patients, but it does not provide enough accuracy for clinical ami diagnosis because it also rises in unstable angina patients. its prognostic value in ami is uncertain mainly for the number of cases with end-point event was small and may be further validated in a larger, better designed study.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	troponin-positive acute coronary syndrome	21969012	taqman polymerase chain reaction in edta-plasma 	circulating levels of the muscle-enriched mir-499, mir-133a, and mir-208a were significantly elevated in the aorta of troponin-positive acute coronary syndrome patients compared with patients with coronary artery disease. In contrast, circulating levels of mir-126 decreased during transcoronary passage in patients with evidence of myocardial injury, suggesting consumption during transcoronary passage.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	circulating	plasma	Coronary artery disease	20595655	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
hsa-miR-133a	miRNA	hsa-miR-133a-3p	MIMAT0000427	mir-133		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-133b	miRNA	hsa-miR-133b	MIMAT0000770	mir-133		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-133b	miRNA	hsa-miR-133b	MIMAT0000770	mir-133		Homo sapiens	circulating	plasma	perioperative myocardial infarction (pmi)	25111390	real-time quantitative rt-pcr	the data analysis revealed that mir-499 had higher sensitivity and specificity than ctni, and indicated that mir-499 could be an independent risk factor for pmi.
hsa-miR-133b	miRNA	hsa-miR-133b	MIMAT0000770	mir-133		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-133b	miRNA	hsa-miR-133b	MIMAT0000770	mir-133		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-133b	miRNA	hsa-miR-133b	MIMAT0000770	mir-133		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-134	miRNA	hsa-miR-134	MIMAT0000447	mir-134		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-134	miRNA	hsa-miR-134	MIMAT0000447	mir-134		Homo sapiens	circulating	plasma	mild cognitive impairment (mci)	24368295	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
hsa-miR-134	miRNA	hsa-miR-134	MIMAT0000447	mir-134		Homo sapiens	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	22937028	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
hsa-miR-134	miRNA	hsa-miR-134	MIMAT0000447	mir-134		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-134	miRNA	hsa-miR-134	MIMAT0000447	mir-134		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-134	miRNA	hsa-miR-134	MIMAT0000447	mir-134		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-134	miRNA	hsa-miR-134	MIMAT0000447	mir-134		Homo sapiens	circulating	plasma	Bipolar disorder (bd)	20546789	real-time rt-pcr	decreased plasma mir-134 levels may be directly associated with the pathophysiology and severity of manic symptoms in bipolar disorder (bd)
hsa-miR-134	miRNA	hsa-miR-134	MIMAT0000447	mir-134		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-1346	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-135a	miRNA	hsa-miR-135a-5p	MIMAT0000428	mir-135		Homo sapiens	HDL	serum	normal	27166305	qrt-pcr	these results demonstrated that high-density lipoprotein-micrornas are relatively resistant to various storage conditions. this study provides new and important information on the stability of high-density lipoprotein-micrornas.
hsa-miR-135a*	miRNA	hsa-miR-135a-3p	MIMAT0004595	mir-135		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-135a*	miRNA	hsa-miR-135a-3p	MIMAT0004595	mir-135	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-135a*	miRNA	hsa-miR-135a-3p	MIMAT0004595	mir-135		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-135a*	miRNA	hsa-miR-135a-3p	MIMAT0004595	mir-135		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-135a*	miRNA	hsa-miR-135a-3p	MIMAT0004595	mir-135		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-135a*	miRNA	hsa-miR-135a-3p	MIMAT0004595	mir-135		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-135a*	miRNA	hsa-miR-135a-3p	MIMAT0004595	mir-135		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-135a-5p	miRNA	hsa-miR-135a-5p	MIMAT0000428	mir-135	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-135b	miRNA	hsa-miR-135b-5p	MIMAT0000758	mir-135		Homo sapiens	circulating	plasma	pregnancy	18218722	mirvana mirna isolation kit (ambion)|taqman microrna assay (applied biosystems) qrt-pcr	the 4 most abundant of the placental mirnas (mir-141, mir-149, mir-299-5p, and mir-135b) were detectable in maternal plasma during pregnancy and showed reduced detection rates in postdelivery plasma. The plasma concentration of mir-141 increased as pregnancy progressed into the third trimester. 
hsa-miR-135b	miRNA	hsa-miR-135b-5p	MIMAT0000758	mir-135		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-135b*	miRNA	hsa-miR-135b-3p	MIMAT0004698	mir-135		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-135b-5p	miRNA	hsa-miR-135b-5p	MIMAT0000758	mir-135	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-136	miRNA	hsa-miR-136-5p	MIMAT0000448	mir-136		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-136	miRNA	hsa-miR-136-5p	MIMAT0000448	mir-136		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-136-5p	miRNA	hsa-miR-136-5p	MIMAT0000448	mir-136		Homo sapiens	circulating	plasma	deep-vein thrombosis (dvt)	27197074	qrt-pcr	the plasma level of mir-424-5p (p=0.01) were significantly higher, whereas the levels of mir-136-5p (p=0.03) were significantly lower in dvt patients compared to patients without dvt.
hsa-miR-137	miRNA	hsa-miR-137	MIMAT0000429	mir-137		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-138	miRNA	hsa-miR-138-5p	MIMAT0000430	mir-138		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-138	miRNA	hsa-miR-138-5p	MIMAT0000430	mir-138		Homo sapiens	circulating	blood	Breast cancer	24626163	real-time quantitative pcr	analysis of patient tissue and blood samples revealed mir-138 to be significantly up-regulated in the circulation of patients with breast cancer, with no change observed in the tissue setting. while not significantly changed overall in breast cancer patients compared to controls, circulating mir-106a and mir-191 were significantly decreased in patients with basal breast cancer. in tissue, both mirnas were significantly elevated in breast cancer compared to normal breast tissue. the data demonstrates an impact of tumour epithelial subtype on circulating levels of mirnas, and highlights divergent mirna profiles between tissue and blood samples from breast cancer patients.
hsa-miR-138	miRNA	hsa-miR-138-5p	MIMAT0000430	mir-138		Homo sapiens	circulating	serum	type 2 diabetes	24204780	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
hsa-miR-138	miRNA	hsa-miR-138-5p	MIMAT0000430	mir-138		Homo sapiens	circulating	serum	obesity	24204780	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
hsa-miR-138-1*	miRNA	hsa-miR-138-1-3p	MIMAT0004607	mir-138		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-138-2*	miRNA	hsa-miR-138-2-3p	MIMAT0004596	mir-138		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-138-5p	miRNA	hsa-miR-138-5p	MIMAT0000430	mir-138	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-139-3p	miRNA	hsa-miR-139-3p	MIMAT0004552	mir-139		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-139-3p	miRNA	hsa-miR-139-3p	MIMAT0004552	mir-139		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-139-3p	miRNA	hsa-miR-139-3p	MIMAT0004552	mir-139		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-139-3p	miRNA	hsa-miR-139-3p	MIMAT0004552	mir-139		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-139-5p	miRNA	hsa-miR-139-5p	MIMAT0000250	mir-139		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-139-5p	miRNA	hsa-miR-139-5p	MIMAT0000250	mir-139		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-139-5p	miRNA	hsa-miR-139-5p	MIMAT0000250	mir-139		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-140	miRNA	hsa-miR-140-5p	MIMAT0000431	mir-140		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-140	miRNA	hsa-miR-140-5p	MIMAT0000431	mir-140		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-140	miRNA	hsa-miR-140-5p	MIMAT0000431	mir-140		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-140	miRNA	hsa-miR-140-5p	MIMAT0000431	mir-140		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-140-3p	miRNA	hsa-miR-140-3p	MIMAT0004597	mir-140		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-140-3p	miRNA	hsa-miR-140-3p	MIMAT0004597	mir-140		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-140-3p	miRNA	hsa-miR-140-3p	MIMAT0004597	mir-140		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-140-3p	miRNA	hsa-miR-140-3p	MIMAT0004597	mir-140		Homo sapiens	circulating	serum	Coronary artery disease	27357355	cox regression analyses	this is the largest study so far evaluating the prognostic value of circulating mirnas in cardiovascular disease. this study shows that single mirnas derived from peripheral blood predict mortality in secondary prevention settings, and thereby represent valuable biomarkers for risk estimation in cad.
hsa-miR-140-3p	miRNA	hsa-miR-140-3p	MIMAT0004597	mir-140		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-140-3p	miRNA	hsa-miR-140-3p	MIMAT0004597	mir-140	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-140-3p	miRNA	hsa-miR-140-3p	MIMAT0004597	mir-140		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-140-5p	miRNA	hsa-miR-140-5p	MIMAT0000431	mir-140		Homo sapiens	circulating	serum	hand-foot-and-mouth disease (hfmd)	22087245	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
hsa-miR-140-5p	miRNA	hsa-miR-140-5p	MIMAT0000431	mir-140		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-140-5p	miRNA	hsa-miR-140-5p	MIMAT0000431	mir-140		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-140-5p	miRNA	hsa-miR-140-5p	MIMAT0000431	mir-140		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-140-5p	miRNA	hsa-miR-140-5p	MIMAT0000431	mir-140	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	plasma	pregnancy	18218722	mirvana mirna isolation kit (ambion)|taqman microrna assay (applied biosystems) qrt-pcr	the 4 most abundant of the placental mirnas (mir-141, mir-149, mir-299-5p, and mir-135b) were detectable in maternal plasma during pregnancy and showed reduced detection rates in postdelivery plasma. The plasma concentration of mir-141 increased as pregnancy progressed into the third trimester. 
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	plasma	prostate cancer	21274675	real-time pcr	analysis of mir-21, -141, and -221 in blood of pca patients reveals that mir-21 is more useful to differentiate pca patients from healthy controls, while the mir-141 was a better discriminator of metastatic pca from localized/local advanced disease. these results suggest that analysis of these mirnas might have clinical utility as a supplement to psa testing.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	prostate cancer	20473869	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	prostate cancer	22052531	qrt-pcr	four mirnas altered in mice, mmu-mir-141, mmu-mir-298, mmu-mir-346 and mmu-mir-375, were also found to be at differential levels in the serum of men with mcrpc. three of these (hsa-mir-141, hsa-mir-298 and hsa-mir-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. moreover, the intra-tumoral expression of hsa-mir-141 and hsa-mir-375 were predictors of biochemical relapse after surgery. this study is the first to demonstrate that specific serum mirnas are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	lung cancer	21398193	picogreen|taqman microrna|caspase-glo 3/7 assay	in lung cancer patients high serum mir10b values associated with lymph node metastasis (p < 0.03) and elevated levels of tpa (tissue polypeptide antigen, p = 0.01), whereas high serum mir141 values associated with elevated levels of upa (urokinase plasminogen activator, p = 0.02).
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	prostate cancer	22887127	taqman human microrna arrays	serum samples from patients of low risk, localized prostate cancer and metastatic crpc patients exhibit distinct circulating mirna signatures. mir-375, mir-378*, and mir-141 were significantly over-expressed in serum from crpc patients compared with serum from low-risk localized patients, while mir-409-3p was significantly under-expressed. in prostate primary tumor samples, mir-375 and mir-141 also had significantly higher expression levels compared with those in normal prostate tissue.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	21445232	mirvana paris rna isolation kit (ambion, austin, tx)|taqman microrna reverse transciption kit (applied biosystems, san diego, ca)	plasma mir-141 may represent a novel biomarker that complements carcinoembryonic antigen (cea) in detecting colon cancer with distant metastasis and high levels of mir-141 in plasma were associated with poor prognosis.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	plasma	metastatic breast cancer (mbc)	22952344	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	plasma	prostate cancer	21723797	qrt-pcr	levels of mir-141 in plasma of 21 patients with cap were measured by using quantitative reverse transcription-polymerase chain reaction. A total of 35 intervals were assessed. Directional changes (increasing or decreasing) in psa, ctc, and mir-141 had sensitivity in predicting clinical outcome (progression vs. nonprogressing) of 78.9%.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	plasma	pregnancy	21806976	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	Bladder cancer	23266581	qrt-pcr	the analysis of mir-141 and mir-639 in the validation cohort demonstrated that microrna levels were similar in bladder cancer patients and control subjects. furthermore, microrna levels were not correlated with clinicopathological parameters (pt-stage, metastasis, grading). the analysis of serum mir-141 and mir-639 levels does not seem to be helpful in the diagnosis or prognosis of bca.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	plasma	prostate cancer	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	exosome	urine	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	circulating	serum	prostate cancer	24510997	real-time pcr	the analysis of circulating micrornas does not seem to help identify patients with cancer undergoing prostate biopsy. however, their levels may be useful to identify patients with high-risk prostate cancer.
hsa-miR-141	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-141*	miRNA	hsa-miR-141-5p	MIMAT0004598	mir-8		Homo sapiens	circulating	serum	Cervical squamous cell carcinoma	24405714	taqman microrna array	authors demonstrated that the circulating mirnas mir-646, mir-141* and mir-542-3p could potentially serve as non-invasive biomarkers for cervical scc. the levels of these specific mirnas might be useful for the post-therapeutic monitoring of disease progression.
hsa-miR-141*	miRNA	hsa-miR-141-5p	MIMAT0004598	mir-8	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-141*	miRNA	hsa-miR-141-5p	MIMAT0004598	mir-8		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-141*	miRNA	hsa-miR-141-5p	MIMAT0004598	mir-8		Homo sapiens	circulating	serum	endometriosis	23118427	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
hsa-miR-141*	miRNA	hsa-miR-141-5p	MIMAT0004598	mir-8		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-141-3p	miRNA	hsa-miR-141-3p	MIMAT0000432	mir-8	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	exosome	serum	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142		Homo sapiens	circulating	serum	nasopharyngeal carcinoma	25450382	quantitative real-time pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
hsa-miR-142-3p	miRNA	hsa-miR-142-3p	MIMAT0000434	mir-142	NULL	Homo sapiens	microvesicle	plasma	Irritable bowel syndrome (IBS)	19951903	Microarray [ArrayExpress]|RT-PCR|Differential centrifugation|Filtration	MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142		Homo sapiens	circulating	serum	Aging	25165030	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-142-5p	miRNA	hsa-miR-142-5p	MIMAT0000433	mir-142		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-143	miRNA	hsa-miR-143-3p	MIMAT0000435	mir-143		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	24993656	probe-based stem-loop quantitative reverse-transcriptase pcr	authors conclude that the expression of mir-143 and mir-215 in serum were significantly up-regulated in patients with chronic hepatitis and hcc, mir-143 and mir-215 could be considered as potential circulating biomarkers.
hsa-miR-143	miRNA	hsa-miR-143-3p	MIMAT0000435	mir-143		Homo sapiens	circulating	serum	hand-foot-and-mouth disease (hfmd)	22087245	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
hsa-miR-143	miRNA	hsa-miR-143-3p	MIMAT0000435	mir-143		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-143	miRNA	hsa-miR-143-3p	MIMAT0000435	mir-143		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-143	miRNA	hsa-miR-143-3p	MIMAT0000435	mir-143		Homo sapiens	circulating	plasma	thoracic aortic aneurysm (taa)	23312977	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
hsa-miR-143	miRNA	hsa-miR-143-3p	MIMAT0000435	mir-143		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-143-3p	miRNA	hsa-miR-143-3p	MIMAT0000435	mir-143		Homo sapiens	microparticle	human coronary artery smooth muscle cells (hcasmc)	Atherosclerosis	27363781	qrt-pcr	authors demonstrated for the first time that microparticles secreted by hcasmc contain micrornas. hypercholesterolemia alters the microrna profile of hcasmc-derived microparticles. the mirna signature of hcasmc-derived microparticles is a source of cardiovascular biomarkers.
hsa-miR-144	miRNA	hsa-miR-144-3p	MIMAT0000436	mir-144		Homo sapiens	circulating	plasma	type 2 diabetes	24497980	real-time pcr	this study suggests that the association between plasma mir-144 expression and t2d differs between swedes and iraqis.
hsa-miR-144	miRNA	hsa-miR-144-3p	MIMAT0000436	mir-144		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-144	miRNA	hsa-miR-144-3p	MIMAT0000436	mir-144		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-144	miRNA	hsa-miR-144-3p	MIMAT0000436	mir-144		Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-miR-144	miRNA	hsa-miR-144-3p	MIMAT0000436	mir-144		Homo sapiens	circulating	serum	preeclampsia	25017274	taqman low density array chips (human microrna panel v3.0)|quantitative real-time polymerase chain reaction	authors conclude that some circulating mirnas may have potential role in the pathogenesis of preeclampsia. in particular, mir-1233 might represent a potential marker of early spe.
hsa-miR-144	miRNA	hsa-miR-144-3p	MIMAT0000436	mir-144		Homo sapiens	circulating	plasma	pregnancy	21806976	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
hsa-miR-144	miRNA	hsa-miR-144-3p	MIMAT0000436	mir-144		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-144*	miRNA	hsa-miR-144-5p	MIMAT0004600	mir-144		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	microvesicle	serum	human colon cancer dld-1 cells	24447928	exomir kit (bioosicentific; austin, tx, usa)|nanosight lm10 nanoparticle characterization system (nanosight, amesbury, uk)|bioopure-mp (bioosicentific, austin, tx, usa)|taqman (applied biosystems, foster city, ca, usa)|rneasy mini kit (qiagen, hilden, germany)	the intra- and extracellular mir-145 and -34a were closely associated with 5-fu resistance, and the resistance was in part due to the enhanced secretion of mir-145 and -34a via mvs, resulting in low intracellular levels of both mirnas.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	circulating	plasma	prostate cancer	22298119	qrt-pcr	these preliminary data suggest that altered plasma mirnas may be useful predictors to distinguish pca patients with varied aggressiveness. further larger studies to validate this promising finding are warranted.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	25519019	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	circulating	serum	Breast cancer	19454029	taqman microrna reverse transcription kit (applied biosystems catalog # 4366596)	the expression of mirnas was similar in samples from healthy women compared to those with breast cancer, women with progesterone receptor (pr, p = 0.016) positive tumors had higher mir-155 expression than tumors that were negative for these receptors.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	circulating	plasma	thoracic aortic aneurysm (taa)	23312977	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-145	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145		Homo sapiens	circulating	plasma	Coronary artery disease	20595655	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
hsa-miR-145*	miRNA	hsa-miR-145-3p	MIMAT0004601	mir-145		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-145*	miRNA	hsa-miR-145-3p	MIMAT0004601	mir-145		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-145*	miRNA	hsa-miR-145-3p	MIMAT0004601	mir-145		Homo sapiens	circulating	serum	endometriosis	23118427	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
hsa-miR-145-5p	miRNA	hsa-miR-145-5p	MIMAT0000437	mir-145	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-146	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-1469	miRNA	hsa-miR-1469	MIMAT0007347	mir-1469		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	metastatic uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	Acute exhaustive exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	sustained aerobic exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	Allogeneic hematopoietic stem cell transplantation (hsct)	25614225	qpcr	authors showed that chemotherapy-induced gi toxicity is associated with reduced levels of mirna- 146a in plasma, indicating that this mirna may have an anti-inflammatory role during immune reconstitution after hsct (allogeneic hematopoietic stem cell transplantation).
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	cerebrospinal fluid	Alzheimer disease (AD)	23301201	fluorescent mirna-array-based analysis|led-northern dot-blot assay	the results indicate that mirna-9, mirna-125b, mirna-146a and mirna-155 are csf- and ecf-abundant, nf-кb-sensitive pro-inflammatory mirnas, and their enrichment in circulating csf and ecf suggest that they may be involved in the modulation or proliferation of mirna-triggered pathogenic signaling throughout the brain and central nervous system (cns).
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-146a	miRNA	hsa-miR-146a-5p	MIMAT0000449	mir-146		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-146b	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-146b	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146		Homo sapiens	circulating	plasma	papillary thyroid carcinomas (ptc)	24301304	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	authors demonstrated that tumor levels of mir-222 and mir-146b are associated with ptc recurrence and that mir-222 and mir-146b levels in the circulation correspond to the presence of ptc.
hsa-miR-146b	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-146b	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-146b-5p	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-146b-5p	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-146b-5p	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-146b-5p	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146		Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-146b-5p	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-146b-5p	miRNA	hsa-miR-146b-5p	MIMAT0002809	mir-146		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-147	miRNA	hsa-miR-147a	MIMAT0000251	mir-147		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	circulating	serum	hand-foot-and-mouth disease (hfmd)	22087245	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	circulating	plasma	multiple myeloma (mm)	22447484	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	circulating	serum	osteoporosis	24431276	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-148a	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-148a*	miRNA	hsa-miR-148a-5p	MIMAT0004549	mir-148	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-148a*	miRNA	hsa-miR-148a-5p	MIMAT0004549	mir-148		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-148a-3p	miRNA	hsa-miR-148a-3p	MIMAT0000243	mir-148	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	circulating	plasma	Breast cancer	25051376	exiqon mircury lna universal rt microrna pcr technology|quantitative real-time pcr	authors suggest that both mir-148b and mir-133a have potential use as biomarkers for breast cancer detection.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	circulating	plasma	Breast cancer	22927033	taqman low-density array qrt-pcr	four mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) were shown to be significantly upregulated in the plasma of breast cancer patients. roc curve analysis showed that the combination of only three mirnas (mir-148b, mir-409-3p and mir-801) had an equal discriminatory power between breast cancer cases and healthy controls as all four mirnas together (auc = 0.69). in conclusion, the identified mirnas might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148		Homo sapiens	circulating	plasma	Breast cancer	24194846	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
hsa-miR-148b	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148	NULL	Homo sapiens	microvesicle	plasma	Irritable bowel syndrome (IBS)	19951903	Microarray [ArrayExpress]|RT-PCR|Differential centrifugation|Filtration	MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome
hsa-miR-148b-3p	miRNA	hsa-miR-148b-3p	MIMAT0000759	mir-148	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-149	miRNA	hsa-miR-149-5p	MIMAT0000450	mir-149		Homo sapiens	circulating	plasma	pregnancy	18218722	mirvana mirna isolation kit (ambion)|taqman microrna assay (applied biosystems) qrt-pcr	the 4 most abundant of the placental mirnas (mir-141, mir-149, mir-299-5p, and mir-135b) were detectable in maternal plasma during pregnancy and showed reduced detection rates in postdelivery plasma. The plasma concentration of mir-141 increased as pregnancy progressed into the third trimester. 
hsa-miR-149	miRNA	hsa-miR-149-5p	MIMAT0000450	mir-149		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-149	miRNA	hsa-miR-149-5p	MIMAT0000450	mir-149		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-149*	miRNA	hsa-miR-149-3p	MIMAT0004609	mir-149		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-149*	miRNA	hsa-miR-149-3p	MIMAT0004609	mir-149		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-149*	miRNA	hsa-miR-149-3p	MIMAT0004609	mir-149		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-149-5p	miRNA	hsa-miR-149-5p	MIMAT0000450	mir-149	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	serum	Chronic lymphocytic leukemia (cll)	25584781	qpcr	authors found that cellular and serum mir-150 levels vary in an opposite manner during chronic lymphocytic leukemia (cll) progression and could be used to molecularly monitor disease evolution as a new prognostic factor in cll.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	chronic lymphocytic leukemia cells	Chronic lymphocytic leukemia (cll)	25584781	qpcr	authors found that cellular and serum mir-150 levels vary in an opposite manner during chronic lymphocytic leukemia (cll) progression and could be used to molecularly monitor disease evolution as a new prognostic factor in cll.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	serum	sepsis	23372743	quantitative real-time pcr	measurements of mir-150 serum concentrations revealed only slightly reduced mir-150 serum levels in critically ill patients compared to healthy controls. furthermore mir-150 levels did not significantly differ in critically ill patients with our without sepsis, indicating that mir-150 serum levels are not suitable for diagnostic establishment of sepsis.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150	miRNA	hsa-miR-150-5p	MIMAT0000451	mir-150		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-150*	miRNA	hsa-miR-150-3p	MIMAT0004610	mir-150	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-150*	miRNA	hsa-miR-150-3p	MIMAT0004610	mir-150		Homo sapiens	circulating	breast milk	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-150*	miRNA	hsa-miR-150-3p	MIMAT0004610	mir-150		Homo sapiens	circulating	serum	malignant astrocytomas	22674182	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
hsa-miR-150*	miRNA	hsa-miR-150-3p	MIMAT0004610	mir-150		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-150*	miRNA	hsa-miR-150-3p	MIMAT0004610	mir-150		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-151	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-151	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	22937028	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
hsa-miR-151	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-151	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-151-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-151-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-151-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-151-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-151-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-151-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-151-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-151-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-151-5p	miRNA	hsa-miR-151a-5p	MIMAT0004697	mir-28		Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-miR-151-5p	miRNA	hsa-miR-151a-5p	MIMAT0004697	mir-28		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-151-5p	miRNA	hsa-miR-151a-5p	MIMAT0004697	mir-28		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-151-5p	miRNA	hsa-miR-151a-5p	MIMAT0004697	mir-28		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-151a-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-151a-3p	miRNA	hsa-miR-151a-3p	MIMAT0000757	mir-28	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-151a-5p	miRNA	hsa-miR-151a-5p	MIMAT0004697	mir-28		Homo sapiens	circulating	serum	Aging	24088671	next generation sequencing technology|real-time quantitative pcr	of the mirnas that authors found to be present in serum, three were significantly decreased in 20 older individuals compared to 20 younger individuals: mir-151a-5p, mir-181a-5p and mir-1248. consistent with the data in humans, these mirnas are also present at lower levels in the serum of elderly rhesus monkeys.
hsa-miR-151a-5p	miRNA	hsa-miR-151a-5p	MIMAT0004697	mir-28	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	circulating	serum	preeclampsia	22095477	trizol (invitrogen, carlsbad, ca)|bioanalyzer agilent rna 6000 picoassay|high-specificity mirna qrt-pcr detection  kit (stratagene-an agilent technologies company, usa-canada)|affinity script rt/rnase block enzyme mixture (stratagene)|bioanalyzer 2100- agilent small rna assay|real-time pcr	authors found up-regulated mir-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. They propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	circulating	urine	urothelial bladder cancer (bca)	19375957	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-152	miRNA	hsa-miR-152-3p	MIMAT0000438	mir-148		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-153	miRNA	hsa-miR-153	MIMAT0000439	mir-153		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-154	miRNA	hsa-miR-154-5p	MIMAT0000452	mir-154		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	serum	heart transplant rejection	25176944	real-time pcr	the study demonstrates that a differential expression of mirna occurs in rejecting allograft patients, not only at the tissue level but also in the serum, suggesting their potential relevance as non-invasive biomarkers in heart transplant rejection.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	metastatic uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	serum	lung cancer	21398193	picogreen|taqman microrna|caspase-glo 3/7 assay	in lung cancer patients high serum mir10b values associated with lymph node metastasis (p < 0.03) and elevated levels of tpa (tissue polypeptide antigen, p = 0.01), whereas high serum mir141 values associated with elevated levels of upa (urokinase plasminogen activator, p = 0.02).
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	serum	Abdominal aortic aneurysm (aaa)	24283299	quantitative real-time pcr	authors suggest that mir-155 is overexpressed in aaa with potential implications in the pathogenesis of the condition.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	serum	Breast cancer	23071695	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	serum mir-155 is a potential biomarker to discriminate breast cancer patients from healthy subjects. for the first time, authors demonstrated a declined trend of mir-155 after surgery and chemotherapy, which raises the possibility to use it as an indicator for treatment response.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	Allogeneic hematopoietic stem cell transplantation (hsct)	25614225	qpcr	authors showed that chemotherapy-induced gi toxicity is associated with increased levels of mirna-155 in plasma, indicating that this mirna may have a pro-inflammatory role during immune reconstitution after hsct (allogeneic hematopoietic stem cell transplantation).
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	serum	Breast cancer	21047409	quantitative real-time pcr taqman microrna assays (applied biosystems)	the relative concentrations of total rna (p = 0.0001) and mir155 (p = 0.0001) in serum significantly discriminated m0-patients (primary breast cancer) from healthy women, whereas mir10b (p = 0.005), mir34a (p = 0.001) and mir155 (p = 0.008) discriminated m1-patients (metastatic disease) from healthy controls.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	pregnancy	24521639	real-time pcr	analysis of extracellular chromosome 21-derived micrornas has no benefit for screening programmes and non-invasive diagnosis of down syndrome.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	lung cancer	21892163	nanopore sensor based on the alpha-hemolysin protein	authors show that a nanopore sensor based on the alpha-hemolysin protein selectively detected micrornas at the single molecular level in plasma samples from lung cancer patients without the need for labelling or amplification.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	cerebrospinal fluid	Alzheimer disease (AD)	23301201	fluorescent mirna-array-based analysis|led-northern dot-blot assay	the results indicate that mirna-9, mirna-125b, mirna-146a and mirna-155 are csf- and ecf-abundant, nf-кb-sensitive pro-inflammatory mirnas, and their enrichment in circulating csf and ecf suggest that they may be involved in the modulation or proliferation of mirna-triggered pathogenic signaling throughout the brain and central nervous system (cns).
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	serum	Breast cancer	19454029	taqman microrna reverse transcription kit (applied biosystems catalog # 4366596)	the expression of mirnas was similar in samples from healthy women compared to those with breast cancer, women with progesterone receptor (pr, p = 0.016) positive tumors had higher mir-155 expression than tumors that were negative for these receptors.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	Coronary artery disease	20595655	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-155	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-155-5p	miRNA	hsa-miR-155-5p	MIMAT0000646	mir-155		Homo sapiens	circulating	plasma	ventricular septal defect (vsd)	25165856	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
hsa-miR-1576	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-15a	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-15a*	miRNA	hsa-miR-15a-3p	MIMAT0004488	mir-15		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-15a*	miRNA	hsa-miR-15a-3p	MIMAT0004488	mir-15		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-15a-5p	miRNA	hsa-miR-15a-5p	MIMAT0000068	mir-15	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	plasma	normal	21487102	qrt-pcr	mirna concentrations were higher in plasma than in serum. The mirnas analyzed were stable refrigerated or frozen for up to 72 h and were stable at room temperature for 24 h. Hemolysis increased the apparent concentration of 3 of the mirnas. The total variability of replicate mirna concentrations was <2.0-fold, with most of the variability attributable to the extraction process and interassay imprecision. Normalizing results to those of spiked exogenous control mirnas did not improve this variability.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	23267864	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	serum	type 2 diabetes	24204780	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	serum	obesity	24204780	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
hsa-miR-15b	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-15b*	miRNA	hsa-miR-15b-3p	MIMAT0004586	mir-15		Homo sapiens	circulating	serum	malignant astrocytomas	22674182	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
hsa-miR-15b*	miRNA	hsa-miR-15b-3p	MIMAT0004586	mir-15		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-15b-5p	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-15b-5p	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-15b-5p	miRNA	hsa-miR-15b-5p	MIMAT0000417	mir-15		Homo sapiens	circulating	plasma	endometriosis	23203215	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	Chronic type C hepatitis	22066022	tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)|taqman mirna reverse transcription kit	the serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	Chronic hepatitis c infection (chc)-associated hcc	22066022	tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)|taqman mirna reverse transcription kit	the serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	prostate cancer	21539977	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	exosome	serum	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	normal	21487102	qrt-pcr	mirna concentrations were higher in plasma than in serum. The mirnas analyzed were stable refrigerated or frozen for up to 72 h and were stable at room temperature for 24 h. Hemolysis increased the apparent concentration of 3 of the mirnas. The total variability of replicate mirna concentrations was <2.0-fold, with most of the variability attributable to the extraction process and interassay imprecision. Normalizing results to those of spiked exogenous control mirnas did not improve this variability.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	traumatic brain injury (tbi)	20883153	qrt-pcr	mir-16, mir-92a, and mir-765 were good markers of severe traumatic brain injury (tbi) (0.89, 0.82, and 0.86 auc values, respectively)
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	gastric cancer (gc)	24595006	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	Chronic type C hepatitis	21886843	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	non-alcoholic fatty liver disease (nafld)	21886843	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	urine	urothelial bladder cancer (bca)	19375957	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	gastric cancer (gc)	22198701	qpcr	authors recommend mir-16 and mir-93 as suitable reference genes for serum mirna analysis for gastric cancer patients and healthy controls.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	Breast cancer	19454029	taqman microrna reverse transcription kit (applied biosystems catalog # 4366596)	the expression of mirnas was similar in samples from healthy women compared to those with breast cancer, women with progesterone receptor (pr, p = 0.016) positive tumors had higher mir-155 expression than tumors that were negative for these receptors.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	nasopharyngeal carcinoma	25450382	real-time quantitative pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15	NULL	Homo sapiens	microvesicle	embryonic stem cells	Embryonic stem cells	19266099	rt-pcr|Differential centrifugation	Transfer of microRNAs by embryonic stem cell microvesicles
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-16	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-16-1	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-16-1*	miRNA	hsa-miR-16-1-3p	MIMAT0004489	mir-15		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-16-1*	miRNA	hsa-miR-16-1-3p	MIMAT0004489	mir-15		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-16-2*	miRNA	hsa-miR-16-2-3p	MIMAT0004518	mir-15		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-16-2*	miRNA	hsa-miR-16-2-3p	MIMAT0004518	mir-15		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-16-5p	miRNA	hsa-miR-16-5p	MIMAT0000069	mir-15		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	seminal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	Coronary artery disease	20595655	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-17	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-17*	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-17*	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-17*	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-17*	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-17*	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-17-3p	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-17-3p	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-17-3p	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-17-3p	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-17-3p	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-17-3p	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-17-3p	miRNA	hsa-miR-17-3p	MIMAT0000071	mir-17		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-17-5p	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-17-5p	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-17-5p	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-17-5p	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-17-5p	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	endometriosis	23203215	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
hsa-miR-17-5p	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	urine	urothelial bladder cancer (bca)	19375957	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems,darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
hsa-miR-17-5p	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	gastric cancer (gc)	20234369	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
hsa-miR-17-5p	miRNA	hsa-miR-17-5p	MIMAT0000070	mir-17		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-1777	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-1777a	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-1777b	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	circulating	plasma	multiple myeloma (mm)	22447484	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	circulating	plasma	uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	circulating	plasma	metastatic uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-181a	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-181a*	miRNA	hsa-miR-181a-3p	MIMAT0000270	mir-181		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-181a-2*	miRNA	hsa-miR-181a-2-3p	MIMAT0004558	mir-181		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-181a-5p	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181		Homo sapiens	circulating	serum	Aging	24088671	next generation sequencing technology|real-time quantitative pcr	of the mirnas that authors found to be present in serum, three were significantly decreased in 20 older individuals compared to 20 younger individuals: mir-151a-5p, mir-181a-5p and mir-1248. consistent with the data in humans, these mirnas are also present at lower levels in the serum of elderly rhesus monkeys.
hsa-miR-181a-5p	miRNA	hsa-miR-181a-5p	MIMAT0000256	mir-181	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-181b	miRNA	hsa-miR-181b-5p	MIMAT0000257	mir-181		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-181b	miRNA	hsa-miR-181b-5p	MIMAT0000257	mir-181		Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-miR-181b	miRNA	hsa-miR-181b-5p	MIMAT0000257	mir-181		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-181b	miRNA	hsa-miR-181b-5p	MIMAT0000257	mir-181		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-181b	miRNA	hsa-miR-181b-5p	MIMAT0000257	mir-181		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-181b-5p	miRNA	hsa-miR-181b-5p	MIMAT0000257	mir-181		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-181b-5p	miRNA	hsa-miR-181b-5p	MIMAT0000257	mir-181	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-181c	miRNA	hsa-miR-181c-5p	MIMAT0000258	mir-181		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-181c	miRNA	hsa-miR-181c-5p	MIMAT0000258	mir-181	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-181c	miRNA	hsa-miR-181c-5p	MIMAT0000258	mir-181		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-181c	miRNA	hsa-miR-181c-5p	MIMAT0000258	mir-181		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-181c	miRNA	hsa-miR-181c-5p	MIMAT0000258	mir-181		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-181c	miRNA	hsa-miR-181c-5p	MIMAT0000258	mir-181		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-181c	miRNA	hsa-miR-181c-5p	MIMAT0000258	mir-181		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-181c*	miRNA	hsa-miR-181c-3p	MIMAT0004559	mir-181		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-181d	miRNA	hsa-miR-181d	MIMAT0002821	mir-181		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-181d	miRNA	hsa-miR-181d	MIMAT0002821	mir-181		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-181d	miRNA	hsa-miR-181d	MIMAT0002821	mir-181		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-181d	miRNA	hsa-miR-181d	MIMAT0002821	mir-181		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-181d	miRNA	hsa-miR-181d	MIMAT0002821	mir-181		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-182	miRNA	hsa-miR-182-5p	MIMAT0000259	mir-182		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-182	miRNA	hsa-miR-182-5p	MIMAT0000259	mir-182		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-182	miRNA	hsa-miR-182-5p	MIMAT0000259	mir-182		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-182	miRNA	hsa-miR-182-5p	MIMAT0000259	mir-182		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-182	miRNA	hsa-miR-182-5p	MIMAT0000259	mir-182		Homo sapiens	circulating	urine	urothelial bladder cancer (bca)	19375957	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
hsa-miR-182	miRNA	hsa-miR-182-5p	MIMAT0000259	mir-182		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-182*	miRNA	hsa-miR-182-3p	MIMAT0000260	mir-182		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-182*	miRNA	hsa-miR-182-3p	MIMAT0000260	mir-182		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-182-5p	miRNA	hsa-miR-182-5p	MIMAT0000259	mir-182	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-1826	miRNA					Homo sapiens	circulating	plasma	Multiple sclerosis (MS)	22231906	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
hsa-miR-183	miRNA	hsa-miR-183-5p	MIMAT0000261	mir-183		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-183	miRNA	hsa-miR-183-5p	MIMAT0000261	mir-183		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-183	miRNA	hsa-miR-183-5p	MIMAT0000261	mir-183		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-183	miRNA	hsa-miR-183-5p	MIMAT0000261	mir-183		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-183-5p	miRNA	hsa-miR-183-5p	MIMAT0000261	mir-183	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-184	miRNA	hsa-miR-184	MIMAT0000454	mir-184		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-184	miRNA	hsa-miR-184	MIMAT0000454	mir-184		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-184	miRNA	hsa-miR-184	MIMAT0000454	mir-184		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-185	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-185-5p	miRNA	hsa-miR-185-5p	MIMAT0000455	mir-185	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-186	miRNA	hsa-miR-186-5p	MIMAT0000456	mir-186		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-186	miRNA	hsa-miR-186-5p	MIMAT0000456	mir-186		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-186	miRNA	hsa-miR-186-5p	MIMAT0000456	mir-186		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-186	miRNA	hsa-miR-186-5p	MIMAT0000456	mir-186		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-186	miRNA	hsa-miR-186-5p	MIMAT0000456	mir-186		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-186	miRNA	hsa-miR-186-5p	MIMAT0000456	mir-186		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-186	miRNA	hsa-miR-186-5p	MIMAT0000456	mir-186		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-186-5p	miRNA	hsa-miR-186-5p	MIMAT0000456	mir-186		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-186-5p	miRNA	hsa-miR-186-5p	MIMAT0000456	mir-186	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-187	miRNA	hsa-miR-187-3p	MIMAT0000262	mir-187		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-187*	miRNA	hsa-miR-187-5p	MIMAT0004561	mir-187		Homo sapiens	circulating	serum	gastric cancer (gc)	22169097	qrt-pcr	genome-wide mirna expression profiles followed with real-time quantitative rt-pcr (qrt-pcr) assays revealed that mir-187(*), mir-371-5p and mir-378 were significantly elevated in gc patients. Further validation indicated that mir-378 alone could yields a roc curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating gc patients from healthy controls.
hsa-miR-187-3p	miRNA	hsa-miR-187-3p	MIMAT0000262	mir-187	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-188	miRNA	hsa-miR-188-5p	MIMAT0000457	mir-188		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-188-3p	miRNA	hsa-miR-188-3p	MIMAT0004613	mir-188		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-188-3p	miRNA	hsa-miR-188-3p	MIMAT0004613	mir-188		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-188-3p	miRNA	hsa-miR-188-3p	MIMAT0004613	mir-188		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-188-5p	miRNA	hsa-miR-188-5p	MIMAT0000457	mir-188		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-188-5p	miRNA	hsa-miR-188-5p	MIMAT0000457	mir-188	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-188-5p	miRNA	hsa-miR-188-5p	MIMAT0000457	mir-188		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-189	miRNA	hsa-miR-24-1-5p	MIMAT0000079	mir-24		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	plasma	gastric cancer (gc)	24626859	qrt-pcr	(1) the mir-18a expressions were significantly higher in gc tissues than in normal gastric tissues (p = 0.0286) and higher in all examined gc cell lines than in the fibroblast cell line. (2) the plasma mir-18a concentrations were significantly higher in gc patients than in healthy controls (p < 0.0001). the value of the area under the receiver-operating characteristic curve was 0.8059. (3) the plasma mir-18a levels were significantly reduced in postoperative samples compared to in preoperative samples (p = 0.0002). in an mir-18a overexpressing cell line, the mir-18a concentration of cultured medium increased in both cell number and time-course dependent manners, suggesting microrna might be released from cancer cells into the surrounding environment. circulating mir-18a could be a useful biomarker for screening gc and monitoring tumor dynamics.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	23267864	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	25519019	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-18a	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-18a*	miRNA	hsa-miR-18a-3p	MIMAT0002891	mir-17		Homo sapiens	circulating	colostrum	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-18a-5p	miRNA	hsa-miR-18a-5p	MIMAT0000072	mir-17	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-18b	miRNA	hsa-miR-18b-5p	MIMAT0001412	mir-17		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-18b	miRNA	hsa-miR-18b-5p	MIMAT0001412	mir-17		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-18b	miRNA	hsa-miR-18b-5p	MIMAT0001412	mir-17		Homo sapiens	circulating	plasma	Breast cancer	22821209	Quantitative PCR	Potential biomarker microRNAs were identified, including let-7b, let-7g and miR-18b, with higher levels associated with tumours. These microRNAs were over-represented within the more highly expressed microRNAs in matched tumours, suggesting that circulating populations are tumour-derived in part.
hsa-miR-18b	miRNA	hsa-miR-18b-5p	MIMAT0001412	mir-17		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-18b	miRNA	hsa-miR-18b-5p	MIMAT0001412	mir-17		Homo sapiens	circulating	serum	triple-negative breast cancers (tnbc)	25547678	real-time pcr	by cox regression analysis, authors identified a four-mirna signature (mir-18b, mir-103, mir-107, and mir-652) that predicted tumor relapse and overall survival for patients with triple-negative breast cancers (tnbc).
hsa-miR-18b	miRNA	hsa-miR-18b-5p	MIMAT0001412	mir-17		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-18b	miRNA	hsa-miR-18b-5p	MIMAT0001412	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-18b-5p	miRNA	hsa-miR-18b-5p	MIMAT0001412	mir-17	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-190	miRNA	hsa-miR-190a-5p	MIMAT0000458	mir-190		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-190	miRNA	hsa-miR-190a-5p	MIMAT0000458	mir-190	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-190	miRNA	hsa-miR-190a-5p	MIMAT0000458	mir-190		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-190	miRNA	hsa-miR-190a-5p	MIMAT0000458	mir-190		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-190	miRNA	hsa-miR-190a-5p	MIMAT0000458	mir-190		Homo sapiens	circulating	serum	thyroid nodules	25057879	qrt-pcr	authors have identified for the first time two mirnas differently expressed in serum of ptc patients who in combination allow the differential diagnosis of thyroid nodules with great accuracy in their study population.
hsa-miR-190	miRNA	hsa-miR-190a-5p	MIMAT0000458	mir-190		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-1908	miRNA	hsa-miR-1908-5p	MIMAT0007881	mir-1908	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-1908	miRNA	hsa-miR-1908-5p	MIMAT0007881	mir-1908	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-190a	miRNA	hsa-miR-190a-5p	MIMAT0000458	mir-190	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-190a	miRNA	hsa-miR-190a-5p	MIMAT0000458	mir-190		Homo sapiens	circulating	plasma	heart failure (hf)	25619197		authors reported specific micrornas as potential biomarkers in distinguishing heart failure (hf) from non-hf controls and in differentiating between hf with reduced vs. preserved left ventricular ejection fraction (hfref and hfpef, respectively). of these, mir-190a distinguished hf from controls and hfref from hfpef.
hsa-miR-190b	miRNA	hsa-miR-190b	MIMAT0004929	mir-190		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-190b	miRNA	hsa-miR-190b	MIMAT0004929	mir-190		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-190b	miRNA	hsa-miR-190b	MIMAT0004929	mir-190		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	blood	Breast cancer	24626163	real-time quantitative pcr	analysis of patient tissue and blood samples revealed mir-138 to be significantly up-regulated in the circulation of patients with breast cancer, with no change observed in the tissue setting. while not significantly changed overall in breast cancer patients compared to controls, circulating mir-106a and mir-191 were significantly decreased in patients with basal breast cancer. in tissue, both mirnas were significantly elevated in breast cancer compared to normal breast tissue. the data demonstrates an impact of tumour epithelial subtype on circulating levels of mirnas, and highlights divergent mirna profiles between tissue and blood samples from breast cancer patients.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-191	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-191*	miRNA	hsa-miR-191-3p	MIMAT0001618	mir-191		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-191-5p	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-191-5p	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-191-5p	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	serum	primary progressive multiple sclerosis (ppms) 	27246141	miscript mirna techniques	in comparison with controls, upregulation of mir-191-5p was found in both progressive ms subtypes, while mir-376c-3p was overexpressed only in ppms. additionally, upregulation of mir-128-3p and mir-24-3p was detected in ppms when compared to controls and spms. progression index correlated with mir-128-3p in ppms and mir-375 in spms.
hsa-miR-191-5p	miRNA	hsa-miR-191-5p	MIMAT0000440	mir-191		Homo sapiens	circulating	serum	secondary progressive multiple sclerosis (spms)	27246141	miscript mirna techniques	in comparison with controls, upregulation of mir-191-5p was found in both progressive ms subtypes, while mir-376c-3p was overexpressed only in ppms. additionally, upregulation of mir-128-3p and mir-24-3p was detected in ppms when compared to controls and spms. progression index correlated with mir-128-3p in ppms and mir-375 in spms.
hsa-miR-1915	miRNA	hsa-miR-1915-3p	MIMAT0007892	mir-1915	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-1915	miRNA	hsa-miR-1915-3p	MIMAT0007892	mir-1915		Homo sapiens	circulating	serum	multiple myeloma (mm)	23169280	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
hsa-miR-1915-3p	miRNA	hsa-miR-1915-3p	MIMAT0007892	mir-1915	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	diabetic nephropathy (dn)	27279796	qrt-pcr	the levels of mir-21, mir-29a and mir-192 were significantly enriched in the overt proteinuria group compared with microalbuminuria and/or overt proteinuria groups. it was shown that only mir-21 level was significantly up-regulated in low-egfr group compared with high-egfr patients.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	Chronic type C hepatitis	23383654		mir-122 is a sensitive marker to distinguish chronic hepatitis c patients from healthy controls.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	Cholangiocarcinoma	25131257	taqman microrna assays	authors indicate that elevated levels of mir-192 may be involved in cca genesis and have a potential utility as a noninvasive prognostic indicator for cca patients.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	non-alcoholic fatty liver disease (nafld)	24973316	rt-pcr	authors demonstrate that nafld has a distinguishing circulating mirna profile associated with a global dysmetabolic disease state and cardiovascular risk.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	Acetaminophen-induced acute liver injury (APAP-ALI)	22045675	miRNeasy kit (Qiagen, Venlo, Netherlands)|Taqman-based quantitative polymerase chain reaction (PCR)|stem-loop reverse-transcription RT primers (Applied Biosystems, Foster City, CA)	Serum miR-122 and miR-192 were substantially higher in APAP-ALI patients, compared to healthy controls.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	serum	nasopharyngeal carcinoma	25450382	real-time quantitative pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
hsa-miR-192	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-192*	miRNA	hsa-miR-192-3p	MIMAT0004543	mir-192		Homo sapiens	circulating	colostrum	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-192-5p	miRNA	hsa-miR-192-5p	MIMAT0000222	mir-192	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-193	miRNA	hsa-miR-193a-3p	MIMAT0000459	mir-193		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-193a	miRNA	hsa-miR-193a-3p	MIMAT0000459	mir-193		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-193a-3p	miRNA	hsa-miR-193a-3p	MIMAT0000459	mir-193		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-193a-3p	miRNA	hsa-miR-193a-3p	MIMAT0000459	mir-193		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-193a-3p	miRNA	hsa-miR-193a-3p	MIMAT0000459	mir-193		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-193a-5p	miRNA	hsa-miR-193a-5p	MIMAT0004614	mir-193		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-193a-5p	miRNA	hsa-miR-193a-5p	MIMAT0004614	mir-193		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-193a-5p	miRNA	hsa-miR-193a-5p	MIMAT0004614	mir-193		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-193a-5p	miRNA	hsa-miR-193a-5p	MIMAT0004614	mir-193	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-193a-5p	miRNA	hsa-miR-193a-5p	MIMAT0004614	mir-193		Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	circulating	breast milk	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-193b	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193		Homo sapiens	circulating	epidermis (epi) and dermal inflammatory infiltrate	psoriasis	25431026	qrt-pcr	authors showed that mir-193b and mir-223 were deregulated in the dermal inflammatory infiltrates (rd) of psoriatic plaque compared with normal psoriatic skin. these altered local mirna changes are reflected in the circulating immune cells, suggesting that mirnas may contribute to the pathogenesis of psoriasis.
hsa-miR-193b*	miRNA	hsa-miR-193b-5p	MIMAT0004767	mir-193		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-193b*	miRNA	hsa-miR-193b-5p	MIMAT0004767	mir-193		Homo sapiens	circulating	colostrum	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-193b-3p	miRNA	hsa-miR-193b-3p	MIMAT0002819	mir-193	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	circulating	serum	Breast cancer	25137071	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-194	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-194-5p	miRNA	hsa-miR-194-5p	MIMAT0000460	mir-194	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	serum	prostate cancer	21539977	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	plasma	lung adenocarcinoma	24282590	real-time rt-pcr	authors show that circulating mir-195 and mir-122 may have prognostic values in predicting the overall survival as well as predicting egfr mutation status in non-smoking female patients with lung adenocarcinoma.
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-195	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-195-5p	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-195-5p	miRNA	hsa-miR-195-5p	MIMAT0000461	mir-15		Homo sapiens	circulating	plasma	gastric cancer (gc)	23212612	high pure mirna isolation kit (roche)|biomark 96.96 dynamic array (fluidigm corporation)|real-time qpcr	in this study, among 740 mirnas that authors analyzed only mir-195-5p was significantly (p < 0.05, fold changes = 13, 3) down-regulated in gastric cancer patients compared with control. authors demonstrated that mir-195-5p is a novel tumor suppressor mirna and may contribute to gastric carcinogenesis.
hsa-miR-196a	miRNA	hsa-miR-196a-5p	MIMAT0000226	mir-196		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-196a	miRNA	hsa-miR-196a-5p	MIMAT0000226	mir-196		Homo sapiens	circulating	serum	gastric cancer (gc)	22420029		extracellular mir-196a detected in conditioned medium was strongly correlated with its cellular expression status and increased circulating mir-196a in patient serum was associated with gastric cancer disease status and relapse. 
hsa-miR-196a	miRNA	hsa-miR-196a-5p	MIMAT0000226	mir-196	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-196a	miRNA	hsa-miR-196a-5p	MIMAT0000226	mir-196		Homo sapiens	circulating	plasma	oral cancer	25485932		authors demonstrated that the combined determination of circulating mir-196a and mir-196b levels may serve as panel plasma biomarkers for the early detection of oral cancer.
hsa-miR-196a	miRNA	hsa-miR-196a-5p	MIMAT0000226	mir-196		Homo sapiens	circulating	serum	pancreatic cancer	24956938	real-time pcr	authors demonstrate that the combination of mir-196a and -196b may be a promising biomarker test for the screening of iar for fpc.
hsa-miR-196a*	miRNA	hsa-miR-196a-3p	MIMAT0004562	mir-196		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-196a-5p	miRNA	hsa-miR-196a-5p	MIMAT0000226	mir-196	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-196b	miRNA	hsa-miR-196b-5p	MIMAT0001080	mir-196		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-196b	miRNA	hsa-miR-196b-5p	MIMAT0001080	mir-196		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-196b	miRNA	hsa-miR-196b-5p	MIMAT0001080	mir-196		Homo sapiens	circulating	plasma	oral cancer	25485932		authors demonstrated that the combined determination of circulating mir-196a and mir-196b levels may serve as panel plasma biomarkers for the early detection of oral cancer.
hsa-miR-196b	miRNA	hsa-miR-196b-5p	MIMAT0001080	mir-196		Homo sapiens	circulating	serum	pancreatic cancer	24956938	real-time pcr	authors demonstrate that the combination of mir-196a and -196b may be a promising biomarker test for the screening of iar for fpc.
hsa-miR-196b	miRNA	hsa-miR-196b-5p	MIMAT0001080	mir-196		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-196b-5p	miRNA	hsa-miR-196b-5p	MIMAT0001080	mir-196	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	circulating	serum	malignant astrocytomas	22674182	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-197	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-197-3p	miRNA	hsa-miR-197-3p	MIMAT0000227	mir-197	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-1973	miRNA	hsa-miR-1973	MIMAT0009448			Homo sapiens	circulating	plasma	hodgkin lymphoma (chl)	24222179	qrt-pcr	levels of mir-494, mir-1973 and mir-21 were higher in patients than control (n=20) plasma (p=0.004, p=0.007, p<0.0001, respectively).
hsa-miR-1974	miRNA					Homo sapiens	circulating	serum	multiple myeloma (mm)	23169280	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
hsa-miR-1975	miRNA					Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-miR-1979	miRNA					Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-1979	miRNA					Homo sapiens	circulating	plasma	Multiple sclerosis (MS)	22231906	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
hsa-miR-1979	miRNA					Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-198	miRNA	hsa-miR-198	MIMAT0000228	mir-198		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-198	miRNA	hsa-miR-198	MIMAT0000228	mir-198		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-198	miRNA	hsa-miR-198	MIMAT0000228	mir-198		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-198	miRNA	hsa-miR-198	MIMAT0000228	mir-198		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-198	miRNA	hsa-miR-198	MIMAT0000228	mir-198		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-199a	miRNA	hsa-miR-199a-5p	MIMAT0000231	mir-199		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-199a	miRNA	hsa-miR-199a-5p	MIMAT0000231	mir-199		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-199a	miRNA	hsa-miR-199a-5p	MIMAT0000231	mir-199		Homo sapiens	circulating	serum	endometriosis	23118427	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
hsa-miR-199a	miRNA	hsa-miR-199a-5p	MIMAT0000231	mir-199		Homo sapiens	circulating	urine	urothelial bladder cancer (bca)	19375957	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
hsa-miR-199a*	miRNA	hsa-miR-199a-3p	MIMAT0000232	mir-199		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-199a-3p	miRNA	hsa-miR-199a-3p	MIMAT0000232	mir-199		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-199a-3p	miRNA	hsa-miR-199a-3p	MIMAT0000232	mir-199		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-199a-5p	miRNA	hsa-miR-199a-5p	MIMAT0000231	mir-199		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-199b	miRNA	hsa-miR-199b-5p	MIMAT0000263	mir-199		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-199b	miRNA	hsa-miR-199b-5p	MIMAT0000263	mir-199	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-199b-5p	miRNA	hsa-miR-199b-5p	MIMAT0000263	mir-199		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-199b-5p	miRNA	hsa-miR-199b-5p	MIMAT0000263	mir-199		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-199b-5p	miRNA	hsa-miR-199b-5p	MIMAT0000263	mir-199		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-199b-5p	miRNA	hsa-miR-199b-5p	MIMAT0000263	mir-199		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	serum	Breast cancer	25137071	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	plasma	pregnancy	21806976	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	serum	plaque psoriasis	21277746	mirneasy rna isolation kit (qiagen, valencia, ca, usa)|mir-x mirna first strand synthesis|sybr qrt-pcr kit (takara bio inc)	authors try to evaluate the possibility that serum levels of these mirnas can be disease markers for psoriasis, reflecting the activation of tnf signaling pathway. Serum levels of mir-19a and -29a, especially mir-19a, can be biomarkers for this disease, reflecting the activation of tnf signaling pathway.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	23267864	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	circulating	serum	Breast cancer	22350790	taqman microrna assays	the relative concentrations of four circulating micrornas (mir-19a, mir-20a, mir-21, and mir-214) in blood serum were measured by taqman microrna assays. Levels of preoperative serum mir-20a and mir-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum mir-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in roc analysis, respectively.
hsa-miR-19a	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19		Homo sapiens	exosome	plasma	lung squamous cell carcinoma (scc)	24130905	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
hsa-miR-19a-3p	miRNA	hsa-miR-19a-3p	MIMAT0000073	mir-19	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	microparticle	plasma	unstable angina	24998411	real-time pcr	the study indicates that in ua patients, the increase of mir-19b wrapped in emps due to endothelial dysfunction may partially contribute to the circulating mir-19b elevation and mir-19b may play an anti-thrombotic role by inhibiting the expression of tf in ecs.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	23267864	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	serum	nasopharyngeal carcinoma	25450382	real-time quantitative pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-19b	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	exosome	plasma	lung squamous cell carcinoma (scc)	24130905	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
hsa-miR-19b-1*	miRNA	hsa-miR-19b-1-5p	MIMAT0004491	mir-19		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-19b-1*	miRNA	hsa-miR-19b-1-5p	MIMAT0004491	mir-19		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-19b-3p	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-19b-3p	miRNA	hsa-miR-19b-3p	MIMAT0000074	mir-19		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-20	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	circulating	plasma	metastatic breast cancer (mbc)	22952344	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	circulating	serum	serous epithelial ovarian cancer (seoc)	23272653	qrt-pcr	individually, mir-200a, mir-200b and mir-200c normalized to serum volume and mir-103 were significantly higher in serum of the seoc cohort (p < 0.05; 0.05; 0.0005 respectively) and in combination, mir-200b + mir-200c normalized to serum volume and mir-103 was the best predictive classifier of seoc (roc-auc = 0.784). this predictive model (mir-200b + mir-200c) was further confirmed by leave one out cross validation (auc = 0.784).
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	25519019	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	circulating	serum	Chronic pancreatitis	20551052	mirvana paris kit (ambion 1556)|taqman microrna assays and taqman microrna reverse transcription kit (applied biosystems)	both mir-200a and mir-200b were significantly elevated in the sera of pancreatic cancer and chronic pancreatitis patients compared with healthy controls (p < 0.0001).
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	circulating	serum	pancreatic cancer	20551052	mirvana paris kit (ambion 1556)|taqman microrna assays and taqman microrna reverse transcription kit (applied biosystems)	both mir-200a and mir-200b were significantly elevated in the sera of pancreatic cancer and chronic pancreatitis patients compared with healthy controls (p < 0.0001).
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	exosome	pleural effusions	Breast cancer	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	exosome	ascites	liver cirrhosis (lc)	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-200a	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8		Homo sapiens	exosome	malignant ascites	ovarian cancer	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-200a*	miRNA	hsa-miR-200a-5p	MIMAT0001620	mir-8		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-200a*	miRNA	hsa-miR-200a-5p	MIMAT0001620	mir-8		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-200a-3p	miRNA	hsa-miR-200a-3p	MIMAT0000682	mir-8	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-200a-5p	miRNA	hsa-miR-200a-5p	MIMAT0001620	mir-8	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	circulating	serum	prostate cancer	20473869	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	circulating	serum	Biliary atresia (BA)	22732895	microfluidic array platform	In this study authors examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia.The miR-200b/429 cluster was significantly increased in the sera of BA patients and has promising diagnostic clinical performance.
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	circulating	plasma	metastatic breast cancer (mbc)	22952344	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	circulating	serum	serous epithelial ovarian cancer (seoc)	23272653	qrt-pcr	individually, mir-200a, mir-200b and mir-200c normalized to serum volume and mir-103 were significantly higher in serum of the seoc cohort (p < 0.05; 0.05; 0.0005 respectively) and in combination, mir-200b + mir-200c normalized to serum volume and mir-103 was the best predictive classifier of seoc (roc-auc = 0.784). this predictive model (mir-200b + mir-200c) was further confirmed by leave one out cross validation (auc = 0.784).
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	circulating	serum	Chronic pancreatitis	20551052	mirvana paris kit (ambion 1556)|taqman microrna assays and taqman microrna reverse transcription kit (applied biosystems)	both mir-200a and mir-200b were significantly elevated in the sera of pancreatic cancer and chronic pancreatitis patients compared with healthy controls (p < 0.0001).
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	circulating	serum	pancreatic cancer	20551052	mirvana paris kit (ambion 1556)|taqman microrna assays and taqman microrna reverse transcription kit (applied biosystems)	both mir-200a and mir-200b were significantly elevated in the sera of pancreatic cancer and chronic pancreatitis patients compared with healthy controls (p < 0.0001).
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-200b	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8		Homo sapiens	exosome	urine	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-200b*	miRNA	hsa-miR-200b-5p	MIMAT0004571	mir-8		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-200b*	miRNA	hsa-miR-200b-5p	MIMAT0004571	mir-8		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-200b-3p	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-200b-3p	miRNA	hsa-miR-200b-3p	MIMAT0000318	mir-8	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-200b-5p	miRNA	hsa-miR-200b-5p	MIMAT0004571	mir-8	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	circulating	plasma	metastatic breast cancer (mbc)	22952344	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	circulating	serum	serous epithelial ovarian cancer (seoc)	23272653	qrt-pcr	individually, mir-200a, mir-200b and mir-200c normalized to serum volume and mir-103 were significantly higher in serum of the seoc cohort (p < 0.05; 0.05; 0.0005 respectively) and in combination, mir-200b + mir-200c normalized to serum volume and mir-103 was the best predictive classifier of seoc (roc-auc = 0.784). this predictive model (mir-200b + mir-200c) was further confirmed by leave one out cross validation (auc = 0.784).
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	exosome	pleural effusions	Breast cancer	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	exosome	ascites	liver cirrhosis (lc)	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-200c	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8		Homo sapiens	exosome	malignant ascites	ovarian cancer	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-200c-3p	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-200c-3p	miRNA	hsa-miR-200c-3p	MIMAT0000617	mir-8	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-202	miRNA	hsa-miR-202-3p	MIMAT0002811	mir-202		Homo sapiens	exosome	saliva	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-202	miRNA	hsa-miR-202-3p	MIMAT0002811	mir-202		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-202	miRNA	hsa-miR-202-3p	MIMAT0002811	mir-202		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-202	miRNA	hsa-miR-202-3p	MIMAT0002811	mir-202		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-202	miRNA	hsa-miR-202-3p	MIMAT0002811	mir-202		Homo sapiens	circulating	serum	pertussis	23073777	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
hsa-miR-203	miRNA	hsa-miR-203a-3p	MIMAT0000264	mir-203	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-203	miRNA	hsa-miR-203a-3p	MIMAT0000264	mir-203		Homo sapiens	exosome	saliva	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-203	miRNA	hsa-miR-203a-3p	MIMAT0000264	mir-203		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-203	miRNA	hsa-miR-203a-3p	MIMAT0000264	mir-203		Homo sapiens	circulating	plasma	metastatic breast cancer (mbc)	22952344	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
hsa-miR-203	miRNA	hsa-miR-203a-3p	MIMAT0000264	mir-203		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-203a	miRNA	hsa-miR-203a-3p	MIMAT0000264	mir-203	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-mir-203a-3p	miRNA	hsa-mir-203a-3p	MIMAT0000264	mir-203		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-204	miRNA	hsa-miR-204-5p	MIMAT0000265	mir-204		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-204	miRNA	hsa-miR-204-5p	MIMAT0000265	mir-204	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-204	miRNA	hsa-miR-204-5p	MIMAT0000265	mir-204		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-204-3p	miRNA	hsa-miR-204-3p	MIMAT0022693	mir-204	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	circulating	serum	Breast cancer	25137071	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	exosome	pleural effusions	Breast cancer	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	exosome	ascites	liver cirrhosis (lc)	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	exosome	malignant ascites	ovarian cancer	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-205	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205		Homo sapiens	exosome	plasma	lung squamous cell carcinoma (scc)	24130905	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
hsa-miR-205-5p	miRNA	hsa-miR-205-5p	MIMAT0000266	mir-205	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-206	miRNA	hsa-miR-206	MIMAT0000462	mir-1		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-206	miRNA	hsa-miR-206	MIMAT0000462	mir-1		Homo sapiens	circulating	serum	Amyotrophic lateral sclerosis (als)	24586506	Quantitative PCR	authors conclude that mir-206 is elevated in the circulation of symptomatic sod1-g93a mice and possibly in human als patients. although larger scale studies on als patients are warranted, mir-206 is a promising candidate biomarker for this motor neuron disease.
hsa-miR-206	miRNA	hsa-miR-206	MIMAT0000462	mir-1		Homo sapiens	circulating	serum	pertussis	23073777	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
hsa-miR-206	miRNA	hsa-miR-206	MIMAT0000462	mir-1		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-206	miRNA	hsa-miR-206	MIMAT0000462	mir-1		Homo sapiens	circulating	serum	rhabdomyosarcoma (rms)	20696132		authors evaluated the feasibility of using muscle-specific mirnas (mir-1, -133a, -133b and -206) as biomarkers of rms. Expression of muscle-specific mirnas, especially mir-206, was significantly higher in rms cell lines than in other tumor cell lines, as well as in rms tumor specimens. Further, serum levels of muscle-specific mirnas were significantly higher in patients with rms tumors than in patients with non-rms tumors.
hsa-miR-208a	miRNA	hsa-miR-208a	MIMAT0000241	mir-208		Homo sapiens	circulating	serum	Acute myocardial infarction (ami)	24482699	qrt-pcr	serum mir-499 and mir-208a might be potential biomarkers for ami. mir-499 might be released from damaged heart to the circulation.
hsa-miR-208a	miRNA	hsa-miR-208a	MIMAT0000241	mir-208		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-208a	miRNA	hsa-miR-208a	MIMAT0000241	mir-208		Homo sapiens	circulating	plasma	Acute myocardial infarction (ami)	20159880	taqman mirna quantitative reverse transcriptase polymerase chain reaction (qrt-pcr) assay	elevated cardiac-specific mir-208a in plasma may be a novel biomarker for early detection of myocardial injury in humans.
hsa-miR-208a	miRNA	hsa-miR-208a	MIMAT0000241	mir-208		Homo sapiens	circulating	plasma	troponin-positive acute coronary syndrome	21969012	taqman polymerase chain reaction in edta-plasma 	circulating levels of the muscle-enriched mir-499, mir-133a, and mir-208a were significantly elevated in the aorta of troponin-positive acute coronary syndrome patients compared with patients with coronary artery disease. In contrast, circulating levels of mir-126 decreased during transcoronary passage in patients with evidence of myocardial injury, suggesting consumption during transcoronary passage.
hsa-miR-208a	miRNA	hsa-miR-208a	MIMAT0000241	mir-208		Homo sapiens	circulating	plasma	Coronary artery disease	20595655	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
hsa-miR-208b	miRNA	hsa-miR-208b	MIMAT0004960	mir-208		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-208b	miRNA	hsa-miR-208b	MIMAT0004960	mir-208		Homo sapiens	circulating	plasma	Acute heart failure	20921333	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
hsa-miR-208b	miRNA	hsa-miR-208b	MIMAT0004960	mir-208		Homo sapiens	circulating	plasma	Acute myocardial infarction (ami)	20921333	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
hsa-miR-208b	miRNA	hsa-miR-208b	MIMAT0004960	mir-208		Homo sapiens	circulating	plasma	Acute viral myocarditis (vm)	20921333	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
hsa-miR-208b	miRNA	hsa-miR-208b	MIMAT0004960	mir-208		Homo sapiens	circulating	plasma	Diastolic dysfunction	20921333	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
hsa-miR-208b	miRNA	hsa-miR-208b	MIMAT0004960	mir-208		Homo sapiens	circulating	plasma	st elevation myocardial infarction (stemi)	21701171	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
hsa-miR-208b	miRNA	hsa-miR-208b	MIMAT0004960	mir-208		Homo sapiens	circulating	urine	st elevation myocardial infarction (stemi)	21701171	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	multiple myeloma (mm)	22447484	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	metastatic uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	prostate cancer	22298119	qrt-pcr	these preliminary data suggest that altered plasma mirnas may be useful predictors to distinguish pca patients with varied aggressiveness. further larger studies to validate this promising finding are warranted.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	Acute exhaustive exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	sustained aerobic exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	endometriosis	23203215	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	Chronic type C hepatitis	23390075		plasma/serum levels of mir-20a and mir-92a have potential as sensitive and cost effective biomarkers for early detection of hcv infection. the circulating mir-20a may serve as a potential for predictive biomarker in hcv mediated fibrosis.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	serum	Chronic type C hepatitis	23390075		plasma/serum levels of mir-20a and mir-92a have potential as sensitive and cost effective biomarkers for early detection of hcv infection. the circulating mir-20a may serve as a potential for predictive biomarker in hcv mediated fibrosis.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	circulating	serum	Breast cancer	22350790	taqman microrna assays	the relative concentrations of four circulating micrornas (mir-19a, mir-20a, mir-21, and mir-214) in blood serum were measured by taqman microrna assays. Levels of preoperative serum mir-20a and mir-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum mir-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in roc analysis, respectively.
hsa-miR-20a	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17		Homo sapiens	exosome	plasma	lung squamous cell carcinoma (scc)	24130905	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
hsa-miR-20a*	miRNA	hsa-miR-20a-3p	MIMAT0004493	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-20a*	miRNA	hsa-miR-20a-3p	MIMAT0004493	mir-17		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-20a*	miRNA	hsa-miR-20a-3p	MIMAT0004493	mir-17		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-20a-5p	miRNA	hsa-miR-20a-5p	MIMAT0000075	mir-17	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	circulating	plasma	non small cell lung cancer (nsclc)	20595154	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
hsa-miR-20b	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-20b-5p	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-20b-5p	miRNA	hsa-miR-20b-5p	MIMAT0001413	mir-17	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	prostate cancer	21274675	real-time pcr	analysis of mir-21, -141, and -221 in blood of pca patients reveals that mir-21 is more useful to differentiate pca patients from healthy controls, while the mir-141 was a better discriminator of metastatic pca from localized/local advanced disease. these results suggest that analysis of these mirnas might have clinical utility as a supplement to psa testing.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	gastric cancer (gc)	24460332	qrt-pcr	the results suggested plasma mir-21 could be a novel potential biomarker for gc prognosis and evaluation of surgery outcomes, especially in patients without a family history.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Chronic type C hepatitis	22066022	tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)|taqman mirna reverse transcription kit	the serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Chronic hepatitis c infection (chc)-associated hcc	22066022	tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)|taqman mirna reverse transcription kit	the serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	pancreatic ductal adenocarcinoma (pdac)	24460329	real-time pcr	serum mir-21 levels were increased in gemcitabine- resistant pdac patients compared with gemcitabine-sensitive subjects.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	blood	oral squamous cell carcinoma (oscc)	25174622	e.z.n.a. blood rna kit|quantitative real-time reverse transcriptionpolymerase chain reaction	authors demonstrate that circulating mir-21 and pten might represent new complementary tumour markers for oscc.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Diffuse large b-cell lymphoma (dlbcl)	24400911	fluorescent quantitative pcr	authors show that mir-21 may be served as a biomarker in early diagnosis, genotyping, treatment options, and prognosis estimating of chinese dlbcl.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Breast cancer	24385703	real-time pcr	authors show that serum mir-21 may be a potential diagnostic indicator for bc, especially for the early stage.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	prostate cancer	22788411	quantitative real-time pcr	the level of mir-21 was similar in cancer patients and healthy controls, irrespective of the normalization strategy.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	prostate cancer	22298119	qrt-pcr	these preliminary data suggest that altered plasma mirnas may be useful predictors to distinguish pca patients with varied aggressiveness. further larger studies to validate this promising finding are warranted.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	osteoporosis	24431276	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Breast cancer	22638884	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Colorectal cancer (crc)	22638884	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	lung cancer	22638884	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Esophageal cancer	22638884	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	prostate cancer	20842666	taqman real-time pcr	serum mir-21 levels are elevated in hrpc patients, especially in those resistant to docetaxel-based chemotherapy. it may be applicable as a marker to indicate the transformation to hormone refractory disease, and a potential predictor for the efficacy of docetaxel-based chemotherapy.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	gastric cancer (gc)	22638884	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	Acute kidney injury	22715378	MasterPure RNA Purification kit (Epicenter Technologies)|TaqMan microRNA Reverse Transcription kit (Applied Biosystems, Foster City, CA)|quantitative real-time PCR (qRT-PCR) via TaqMan MicroRNA Assays (Applied Biosystems)	In patients with acute kidney injury circulating microRNAs are not removed by dialysis. As only traces of miR-21 and -210 are detected in dialysate and ultrafiltrate, microRNAs in the circulation are likely to be transported by larger structures such as proteins and/or microvesicles. As miRNAs are not affected by dialysis they might be more robust biomarkers of acute kidney injury.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	non small cell lung cancer (nsclc)	21627863	real-time rt-pcr	this study was to investigate whether plasma mirna-21 (mir-21) can be used as a biomarker for the early detection of non-small cell lung cancer (nsclc) and to explore its association with clinicopathologic features and sensitivity to platinum-based chemotherapy.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	Acute exhaustive exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	gastric cancer (gc)	24260069	Quantitative PCR	authors suggest that serum mir-21 could be exploited as a practical biomarker for monitoring tumor burden in patients with gc.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	sustained aerobic exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	Aortic stenosis (as)	22882958		the myocardial and plasma levels of mir-21 were significantly higher in the as patients compared with the controls and correlated directly with the echocardiographic mean transvalvular gradients.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	glioblastoma	22891879	qrt-pcr	microrna-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). one patient with increasing microrna-21 developed a histopathologically proven recurrence after the second sample collection. circulating microrna-21 might be a useful biomarker in glioblastoma.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	microparticle	atherosclerotic plaques	Atherosclerosis	24931230	real-time pcr	by comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype (n = 9) and those from normal vascular tissues (n = 9), we found levels of annexin v(+) microparticles and annexin v(+) cd144(+) microparticles were significantly increased in plaques and angiogenesis associated micrornas (106b, 25, 92a and 21) were also significantly increased in microparticles from plaques. inflammation could induce endothelial cells to release angiogenesis associated micrornas into circulation, causing higher levels of circulating endothelial cells derived micrornas in atherosclerosis.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Colorectal cancer (crc)	25178939	qrt-pcr	increased levels of serum mir-21 were associated with clinical stages of tumors in the patients (p=0.01). these results indicated that serum mir-21 levels could serve as a reliable diagnostic and prognostic biomarker for colorectal adenocarcinoma.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	hepatocellular carcinoma (hcc)	21749846	qrt-pcr	in the 10-patient group, plasma microrna-21 levels significantly diminished after surgery compared with the pre-operative values. Plasma microrna-21 level in the 126 patients with hepatocellular carcinoma was significantly higher than in patients with chronic hepatitis and healthy volunteers.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Breast cancer	21036945	rt-qpcr applied directly in serum (rt-qpcr-ds) assay	the assay was sensitive for detection of mir-21 in 0.625 microliter of serum from breast cancer patients. For differentiation of samples from patients with locoregional breast cancer from those from healthy donors, the odds ratio was 1.796 and the area under the curve was 0.721. In a multivariate analysis that included standard clinicopathologic prognostic factors, high circulating mir-21 concentrations correlated significantly (p < 0.001) with visceral metastasis.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Chronic type B hepatitis	21229610	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	21229610	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	endometriosis	23203215	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	metabolic syndrome (mets)	27353714	qrt-pcr	expression levels of mir-21 were significantly decreased in the circulation of mets subjects (or=0.52, 95% ci: 0.29-0.92) compared with that of non-mets subjects. body mass index (bmi) and the number of mets components had a negative correlation with the level of mir-21, whereas age was inversely related to the level of mir-21. no significant difference was detected in mir-21 levels between the sexes (p=0.056). mir-21 might be a negative regulating factor in mets.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	27349026	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	these results do not support the hypothesis that circulating mir-21 expression is increased in adenoma-carcinoma-advanced carcinoma sequence. accordingly, plasma mir-21 assessment does not appear to be a useful biomarker for diagnosing and staging crc.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	solitary pulmonary nodules (spns)	21864403	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Breast cancer	25086636	taqman human microrna arrays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21. 
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Chronic type C hepatitis	21886843	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	diabetic nephropathy (dn)	27279796	rt-pcr	the levels of mir-21, mir-29a and mir-192 were significantly enriched in the overt proteinuria group compared with microalbuminuria and/or overt proteinuria groups. it was shown that only mir-21 level was significantly up-regulated in low-egfr group compared with high-egfr patients.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	non-alcoholic fatty liver disease (nafld)	21886843	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	urine	urothelial bladder cancer (bca)	19375957	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	thoracic aortic aneurysm (taa)	23312977	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	blood	Asthma	25487561		authors demonstrated that short-term exposure to diesel exhaust resulted in dna methylation changes at cpg sites residing in genes involved in inflammation and oxidative stress response, repetitive elements, and microrna.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Breast cancer	25086636	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	gastric cancer (gc)	20234369	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Cervical cancer	27101583		circulating mir-21 in serum could be a promising biomarker in auxiliary diagnosis of lymph node metastasis in cervical cancer, and inhibition of mir-21/rasa1 axis could be a possible strategy to restrain migration of cervical cancer.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	hodgkin lymphoma (chl)	24222179	qrt-pcr	levels of mir-494, mir-1973 and mir-21 were higher in patients than control (n=20) plasma (p=0.004, p=0.007, p<0.0001, respectively).
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	exosome	pleural effusions	Breast cancer	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	myelodysplastic syndromes (mds)	24503739	mirvana paris kit (ambion inc., austin, tx)|qrt-pcr	serum mir-21 is a potential biomarker of epigenetic therapy in mds patients.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	exosome	ascites	liver cirrhosis (lc)	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21	NULL	Homo sapiens	microvesicle	embryonic stem cells	Embryonic stem cells	19266099	rt-pcr|Differential centrifugation	Transfer of microRNAs by embryonic stem cell microvesicles
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	exosome	malignant ascites	ovarian cancer	21601258	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	Breast cancer	22350790	taqman microrna assays	the relative concentrations of four circulating micrornas (mir-19a, mir-20a, mir-21, and mir-214) in blood serum were measured by taqman microrna assays. Levels of preoperative serum mir-20a and mir-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum mir-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in roc analysis, respectively.
hsa-miR-21	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	plasma	Breast cancer	22370716	reverse transcriptase-polymerase chain reaction 	circulating mir-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma mir-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab. 
hsa-miR-21*	miRNA	hsa-miR-21-3p	MIMAT0004494	mir-21		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-21*	miRNA	hsa-miR-21-3p	MIMAT0004494	mir-21	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-21*	miRNA	hsa-miR-21-3p	MIMAT0004494	mir-21		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-21*	miRNA	hsa-miR-21-3p	MIMAT0004494	mir-21		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-21-5p	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-21-5p	miRNA	hsa-miR-21-5p	MIMAT0000076	mir-21		Homo sapiens	circulating	serum	subclinical hypothyroidism (sch)	24517143	real-time pcr	mir-21-5p showed the most specific expression patterns in all patients with subclinical hypothyroidism (sch and sch+ath groups). down-regulation of mir-125a-5p, mir-126-3p, mir-221-3p, and mir-222-3p may be a manifestation of atherosclerosis either in sch+ath or in ath-alone patients. mir-126-3p has the most specific expression patterns in all atherosclerosis patients (sch+ath and ath groups).
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	preeclampsia	22095477	trizol (invitrogen, carlsbad, ca)|bioanalyzer agilent rna 6000 picoassay|high-specificity mirna qrt-pcr detection  kit (stratagene-an agilent technologies company, usa-canada)|affinity script rt/rnase block enzyme mixture (stratagene)|bioanalyzer 2100- agilent small rna assay|real-time pcr	authors found up-regulated mir-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. They propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	plasma	Acute kidney injury	22715378	MasterPure RNA Purification kit (Epicenter Technologies)|TaqMan microRNA Reverse Transcription kit (Applied Biosystems, Foster City, CA)|quantitative real-time PCR (qRT-PCR) via TaqMan MicroRNA Assays (Applied Biosystems)	In patients with acute kidney injury circulating microRNAs are not removed by dialysis. As only traces of miR-21 and -210 are detected in dialysate and ultrafiltrate, microRNAs in the circulation are likely to be transported by larger structures such as proteins and/or microvesicles. As miRNAs are not affected by dialysis they might be more robust biomarkers of acute kidney injury.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	plasma	Acute exhaustive exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	plasma	sustained aerobic exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	Ago2	conditioned medium (cm) of hek293 cell line	hypoxia	24983771	rt-qpcr	authors show that argonaute 2-dependent control of released mir-210 represents a unique communication system that integrates the hypoxic response across anatomically distinct cells, preventing unnecessary activity of delivered mir-210 in normoxia while still preparing recipient tissues for incipient hypoxic stress and accelerating adaptation.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	preeclampsia	25017274	taqman low density array chips (human microrna panel v3.0)|quantitative real-time polymerase chain reaction	authors conclude that some circulating mirnas may have potential role in the pathogenesis of preeclampsia. in particular, mir-1233 might represent a potential marker of early spe.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	plasma	metastatic breast cancer (mbc)	22952344	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	Aortic stenosis (as)	24626394	real-time pcr	circulating mir-210 levels are increased in patients with as and provide independent prognostic information to established risk indices. analytical characteristics were also excellent supporting the potential of micro-rnas as novel cv biomarkers.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	Conventional renal cell cancer (crcc)	23064048	real-time pcr	serum mir-210 may have a potential as a novel noninvasive biomarker for the detection of crcc.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	Coronary artery disease	27357355	cox regression analyses	this is the largest study so far evaluating the prognostic value of circulating mirnas in cardiovascular disease. this study shows that single mirnas derived from peripheral blood predict mortality in secondary prevention settings, and thereby represent valuable biomarkers for risk estimation in cad.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	plasma	solitary pulmonary nodules (spns)	21864403	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	Breast cancer	25086636	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	Breast cancer	25086636	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	plasma	pancreatic cancer	20360935	reverse transcription-pcr (qrt-pcr)|taqman microrna assays (applied biosystems, foster city, ca)	circulating mir-210 levels are elevated in pancreatic cancer patients and may potentially serve as a useful biomarker for pancreatic cancer diagnosis.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-210	miRNA	hsa-miR-210-3p	MIMAT0000267	mir-210		Homo sapiens	circulating	plasma	Breast cancer	22370716	reverse transcriptase-polymerase chain reaction 	circulating mir-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma mir-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab. 
hsa-miR-2110	miRNA	hsa-miR-2110	MIMAT0010133	mir-2110		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-212	miRNA	hsa-miR-212-3p	MIMAT0000269	mir-132		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-212	miRNA	hsa-miR-212-3p	MIMAT0000269	mir-132	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-212	miRNA	hsa-miR-212-3p	MIMAT0000269	mir-132		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-2127	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-2137	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-214	miRNA	hsa-miR-214-3p	MIMAT0000271	mir-214		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-214	miRNA	hsa-miR-214-3p	MIMAT0000271	mir-214		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-214	miRNA	hsa-miR-214-3p	MIMAT0000271	mir-214		Homo sapiens	exosome	plasma	lung cancer	19289371	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
hsa-miR-214	miRNA	hsa-miR-214-3p	MIMAT0000271	mir-214	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-214	miRNA	hsa-miR-214-3p	MIMAT0000271	mir-214		Homo sapiens	circulating	serum	Breast cancer	22350790	taqman microrna assays	the relative concentrations of four circulating micrornas (mir-19a, mir-20a, mir-21, and mir-214) in blood serum were measured by taqman microrna assays. Levels of preoperative serum mir-20a and mir-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum mir-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in roc analysis, respectively.
hsa-miR-214	miRNA	hsa-miR-214-3p	MIMAT0000271	mir-214		Homo sapiens	exosome	hepatic stellate cells	steatotic liver	24122827	rt-pcr	authors show that ccn2 up-regulation in fibrotic or steatotic livers, or in culture-activated or ethanol-treated primary mouse hsc is associated with a reciprocal down-regulation of microrna-214 (mir-214).
hsa-miR-215	miRNA	hsa-miR-215	MIMAT0000272	mir-192		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-215	miRNA	hsa-miR-215	MIMAT0000272	mir-192		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-215	miRNA	hsa-miR-215	MIMAT0000272	mir-192		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	24993656	probe-based stem-loop quantitative reverse-transcriptase pcr	authors conclude that the expression of mir-143 and mir-215 in serum were significantly up-regulated in patients with chronic hepatitis and hcc, mir-143 and mir-215 could be considered as potential circulating biomarkers.
hsa-miR-215	miRNA	hsa-miR-215	MIMAT0000272	mir-192		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-215	miRNA	hsa-miR-215	MIMAT0000272	mir-192		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-215	miRNA	hsa-miR-215	MIMAT0000272	mir-192		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-215	miRNA	hsa-miR-215	MIMAT0000272	mir-192		Homo sapiens	circulating	serum	Breast cancer	22353773	mirvana mirna isolation kit (ambion, austin, tx, usa)|microrna isolation kit (biochain institute inc, hayward, ca, usa)|nanodrop nd1000 (nanodrop technologies, waltham, ma, usa)|taqman microrna reverse transcription kit (applied biosystems)|qrt-pcr	mirna expression in cancerous samples tends to be repressed when compared with mirna expression in healthy controls (p = 0.0685). The four most discriminating mirnas by fold-change (mir-215, mir-299-5p, mir-411, and mir-452) were selected for further analysis on serum samples. All mirnas at least tended to be differentially expressed between serum samples from patients with cancer and serum samples from healthy controls 
hsa-miR-217	miRNA	hsa-miR-217	MIMAT0000274	mir-217		Homo sapiens	circulating	breast milk	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-218	miRNA	hsa-miR-218-5p	MIMAT0000275	mir-218		Homo sapiens	circulating	serum	gastric cancer (gc)	24944481	qrt-pcr	mir-218 is deregulated in gastric cancer patients and is strongly correlated with tumor stage, grade and metastasis. serum expression of mir-218 may be a prognostic marker.
hsa-miR-218	miRNA	hsa-miR-218-5p	MIMAT0000275	mir-218		Homo sapiens	circulating	serum	Cervical cancer	22237456	quantitative real-time pcr	in the cancer group, microrna-218 was reduced significantly in the sera (p < 0.001). Moreover, decreased microrna-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis.
hsa-miR-218-5p	miRNA	hsa-miR-218-5p	MIMAT0000275	mir-218	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-219	miRNA	hsa-miR-219a-5p	MIMAT0000276	mir-219	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-219-5p	miRNA	hsa-miR-219-5p	MIMAT0000276	mir-219		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-219-5p	miRNA	hsa-miR-219-5p	MIMAT0000276	mir-219		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	circulating	saliva	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	circulating	plasma	pancreatic cancer	24578785	microarray|rt-qpcr	three micrornas, mir-642b, mir-885-5p, and mir-22, were confirmed to show consistent expression between microarray and rt-qpcr. these three micrornas were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity (91%) and specificity (91%) with an area under the curve of 0.97 (p < 0.001). compared to the ca19-9 marker at 73%, the three-microrna panel has higher sensitivity although ca19-9 has higher specificity of 100%. the identified panel of three microrna biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	circulating	plasma	endometriosis	23203215	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	exosome	plasma	Multiple sclerosis (MS)	22231906	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-22	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22	NULL	Homo sapiens	microvesicle	embryonic stem cells	Embryonic stem cells	19266099	rt-pcr|Differential centrifugation	Transfer of microRNAs by embryonic stem cell microvesicles
hsa-miR-22*	miRNA	hsa-miR-22-5p	MIMAT0004495	mir-22		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-22*	miRNA	hsa-miR-22-5p	MIMAT0004495	mir-22		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-22*	miRNA	hsa-miR-22-5p	MIMAT0004495	mir-22		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-22*	miRNA	hsa-miR-22-5p	MIMAT0004495	mir-22		Homo sapiens	circulating	serum	hepatitis b virus-infected patients	21567136	taqman low density array|mirvana paris kit (ambion)	this study describes the identification and characterization of an appropriate reference gene for the normalization of circulating mirna levels in hepatitis b virus (hbv)-infected patients and healthy people. The combination of mir-26a, mir-221, and mir-22* is recommended as the most stable set of reference genes for circulating mirna evaluation in hbv patients and healthy people.
hsa-miR-22-3p	miRNA	hsa-miR-22-3p	MIMAT0000077	mir-22	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-22-5p	miRNA	hsa-miR-22-5p	MIMAT0004495	mir-22	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-220	miRNA					Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	serum	metabolic syndrome (mets)	24093444	qrt-pcr	the circulating levels of let-7 g and mir-221 displayed a female-specific elevation in individuals with metabolic syndrome.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	prostate cancer	21274675	real-time pcr	analysis of mir-21, -141, and -221 in blood of pca patients reveals that mir-21 is more useful to differentiate pca patients from healthy controls, while the mir-141 was a better discriminator of metastatic pca from localized/local advanced disease. these results suggest that analysis of these mirnas might have clinical utility as a supplement to psa testing.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	multiple myeloma (mm)	22447484	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	prostate cancer	22298119	qrt-pcr	these preliminary data suggest that altered plasma mirnas may be useful predictors to distinguish pca patients with varied aggressiveness. further larger studies to validate this promising finding are warranted.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	prostate cancer	21487968	taqman real-time pcr	The aim of this study is to evaluate the effect of the variation of miR-221 on the prostate cancer cells' NE differentiation and invasive function and to examine the function of miR-221 in plasma as a blood-based miRNA biomarker candidate for CaP. miR-221 may control the migration of AIPC cells through DVL2, working as a key regulator in advanced CaP. The role of miR-221 in other target mRNA needs to be further investigated.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	Acute exhaustive exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	sustained aerobic exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	extra-nodal natural killer t-cell (nk/t-cell) lymphoma	21206010	real-time pcr	to explore mirnas as potential diagnostic and/or prognostic markers of nk/t-cell lymphoma, were compared circulating mir-221 levels in 79 patients and 37 normal subjects by real-time pcr amplification directly from plasma samples, and correlated patient-s mir-221 levels with their clinic features and treatment outcomes.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	pregnancy	21806976	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	serum	malignant melanoma (mm)	21273047	qrt-pcr	serum levels of mir-221 were significantly increased in mm patients and may be useful not only for the diagnosis of mm, but also for the differentiating mm in situ from stage i-iv mm, and for evaluating tumor progression and monitoring patients during the follow-up period. In addition, considering that the serum levels of mir-221 were correlated with tumor thickness, mir-221 might also be useful as a prognostic marker for patients with mm.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	serum	hepatitis b virus-infected patients	21567136	taqman low density array|mirvana paris kit (ambion)	this study describes the identification and characterization of an appropriate reference gene for the normalization of circulating mirna levels in hepatitis b virus (hbv)-infected patients and healthy people. The combination of mir-26a, mir-221, and mir-22* is recommended as the most stable set of reference genes for circulating mirna evaluation in hbv patients and healthy people.
hsa-miR-221	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221		Homo sapiens	circulating	serum	hepatitis c virus (hcv)-related hepatocellular carcinoma (hcc)	25429320	rt-pcr	authors demonstrated that serum mir-221 has a strong potential to serve as one of the novel non-invasive biomarkers of hcc.
hsa-miR-221*	miRNA	hsa-miR-221-5p	MIMAT0004568	mir-221		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-221*	miRNA	hsa-miR-221-5p	MIMAT0004568	mir-221		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-221-3p	miRNA	hsa-miR-221-3p	MIMAT0000278	mir-221	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	serum	Aging	25165030	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	Acute exhaustive exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	papillary thyroid carcinomas (ptc)	24301304	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	authors demonstrated that tumor levels of mir-222 and mir-146b are associated with ptc recurrence and that mir-222 and mir-146b levels in the circulation correspond to the presence of ptc.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	sustained aerobic exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	25519019	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	gastric cancer (gc)	25129310	qrt-pcr	authors suggest that circulating mir-222 in plasma might be a potential and useful noninvasive biomarker for the early detection and prognosis of gc.
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-222	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	serum	Adenocarcinomas of the gastroesophageal junction	25429911	quantitative real-time pcr	depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction a differential serum microrna profile was identified by the authors. in particular, there was a significant correlation between mir-302c and mir-222 expression with overall survival. 
hsa-miR-222-3p	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	circulating	plasma	ventricular septal defect (vsd)	25165856	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
hsa-miR-222-3p	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-222-3p	miRNA	hsa-miR-222-3p	MIMAT0000279	mir-221		Homo sapiens	microparticle	human coronary artery smooth muscle cells (hcasmc)	Atherosclerosis	27363781	qrt-pcr	authors demonstrated for the first time that microparticles secreted by hcasmc contain micrornas. hypercholesterolemia alters the microrna profile of hcasmc-derived microparticles. the mirna signature of hcasmc-derived microparticles is a source of cardiovascular biomarkers.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	metastatic uveal melanoma	24370793	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	peritoneal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	hepatic schistosomiasis	24330517	mirneasy mini kit (qiagen)|stem-loop rt-pcr	authors suggested that the circulating mir-223 could serve as a potential new biomarker for the detection of schistosome infection and the assessment of the response to chemotherapy.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	hepatic schistosomiasis	24330517	mirneasy mini kit (qiagen)|stem-loop rt-pcr	authors suggested that the circulating mir-223 could serve as a potential new biomarker for the detection of schistosome infection and the assessment of the response to chemotherapy.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	Chronic type B hepatitis	21229610	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	HDL	blood	human coronary artery endothelial cells (hcaec)	24576947	microarray|rt-qpcr	icam-1 is a direct target of hdl-transferred mir-223 and this is the first example of an extracellular mirna regulating gene expression in cells where it is not transcribed.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	microvesicle	plasma	healthy smokers	24573468		despite reduced total pmvs, pmv-derived microrna-profiling of six smoker/control pairs revealed a decrease of only a single microrna, the major platelet-derived microrna mir-223. conversely, mir-29b, a microrna associated with aortic aneurysm and fibrosis, and rnu6-2, a commonly used reference-rna, were significantly up-regulated. smoking leads to alterations in the circulating pmv profile and changes in the pmv-derived microrna signature already in young, healthy adults. these changes may contribute to the development of smoking-related cardiovascular pathologies. moreover, these smoking-related changes have to be considered when microrna or pmv profiles are used as disease-specific biomarkers.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	21229610	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	25519019	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223	NULL	Homo sapiens	microvesicle	macrophages	Macrophages - IL-4 activated	21939504	rt-pcr|Differential centrifugation|Filtration|Ultracentrifugation	Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	HDL	serum	normal	27166305	qrt-pcr	these results demonstrated that high-density lipoprotein-micrornas are relatively resistant to various storage conditions. this study provides new and important information on the stability of high-density lipoprotein-micrornas.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	non small cell lung cancer (nsclc)	20595154	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	troponin-negative non-st elevation acute coronary syndrome (nste-acs)	24202700	real-time pcr	circulating mir-223 may serve as a novel biomarker for assessment of clopidogrel responsiveness in troponin-negative nste-acs patients.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	epidermis (epi) and dermal inflammatory infiltrate	psoriasis	25431026	qrt-pcr	authors showed that mir-193b and mir-223 were deregulated in the dermal inflammatory infiltrates (rd) of psoriatic plaque compared with normal psoriatic skin. these altered local mirna changes are reflected in the circulating immune cells, suggesting that mirnas may contribute to the pathogenesis of psoriasis.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-223	miRNA	hsa-miR-223-3p	MIMAT0000280	mir-223		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-223*	miRNA	hsa-miR-223-5p	MIMAT0004570	mir-223		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-224	miRNA	hsa-miR-224-5p	MIMAT0000281	mir-224		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-224	miRNA	hsa-miR-224-5p	MIMAT0000281	mir-224		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-224	miRNA	hsa-miR-224-5p	MIMAT0000281	mir-224		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-224	miRNA	hsa-miR-224-5p	MIMAT0000281	mir-224		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-224	miRNA	hsa-miR-224-5p	MIMAT0000281	mir-224		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-224	miRNA	hsa-miR-224-5p	MIMAT0000281	mir-224		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-224*	miRNA	hsa-miR-224-3p	MIMAT0009198	mir-224		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-224-5p	miRNA	hsa-miR-224-5p	MIMAT0000281	mir-224		Homo sapiens	circulating	serum	Graves ophthalmopathy	25588771	Quantitative PCR	authors showed that baseline serum mir-224-5p was associated with gc sensitivity in go and in vitro overexpression of mir-224-5p restored gc sensitivity in a resistant cell model. a parameter combined serum mir-224-5p and trab could effectively predict gc sensitivity in go patients.
hsa-miR-2278	miRNA	hsa-miR-2278	MIMAT0011778	mir-2278		Homo sapiens	exosome	plasma	sickle cell anemia (sca)	27161653	qrt-pcr	circulating exosomal micrornas may play important roles in predicting the clinical course of sca, and in delineation of individually tailored, mechanistically-based clinical treatment approaches of sca patients in the near future.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	circulating	serum	osteoporosis	24431276	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	circulating	serum	malignant astrocytomas	22674182	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-23a	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-23a*	miRNA	hsa-miR-23a-5p	MIMAT0004496	mir-23	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-23a*	miRNA	hsa-miR-23a-5p	MIMAT0004496	mir-23		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-23a-3p	miRNA	hsa-miR-23a-3p	MIMAT0000078	mir-23	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-23b	miRNA	hsa-miR-23b-3p	MIMAT0000418	mir-23		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-23b	miRNA	hsa-miR-23b-3p	MIMAT0000418	mir-23		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-23b	miRNA	hsa-miR-23b-3p	MIMAT0000418	mir-23	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-23b	miRNA	hsa-miR-23b-3p	MIMAT0000418	mir-23		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-23b	miRNA	hsa-miR-23b-3p	MIMAT0000418	mir-23		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-23b	miRNA	hsa-miR-23b-3p	MIMAT0000418	mir-23		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-23b	miRNA	hsa-miR-23b-3p	MIMAT0000418	mir-23		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-23b-3p	miRNA	hsa-miR-23b-3p	MIMAT0000418	mir-23	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-23b-3p	miRNA	hsa-miR-23b-3p	MIMAT0000418	mir-26	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	normal	21487102	qrt-pcr	mirna concentrations were higher in plasma than in serum. The mirnas analyzed were stable refrigerated or frozen for up to 72 h and were stable at room temperature for 24 h. Hemolysis increased the apparent concentration of 3 of the mirnas. The total variability of replicate mirna concentrations was <2.0-fold, with most of the variability attributable to the extraction process and interassay imprecision. Normalizing results to those of spiked exogenous control mirnas did not improve this variability.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	serum	osteoporosis	24431276	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	serum	nasopharyngeal carcinoma	25450382	real-time quantitative pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
hsa-miR-24	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-24-3p	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-24-3p	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-24-3p	miRNA	hsa-miR-24-3p	MIMAT0000080	mir-24		Homo sapiens	circulating	serum	primary progressive multiple sclerosis (ppms) 	27246141	miscript mirna techniques	in comparison with controls, upregulation of mir-191-5p was found in both progressive ms subtypes, while mir-376c-3p was overexpressed only in ppms. additionally, upregulation of mir-128-3p and mir-24-3p was detected in ppms when compared to controls and spms. progression index correlated with mir-128-3p in ppms and mir-375 in spms.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	microparticle	atherosclerotic plaques	Atherosclerosis	24931230	real-time pcr	by comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype (n = 9) and those from normal vascular tissues (n = 9), we found levels of annexin v(+) microparticles and annexin v(+) cd144(+) microparticles were significantly increased in plaques and angiogenesis associated micrornas (106b, 25, 92a and 21) were also significantly increased in microparticles from plaques. inflammation could induce endothelial cells to release angiogenesis associated micrornas into circulation, causing higher levels of circulating endothelial cells derived micrornas in atherosclerosis.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	plasma	gastric cancer (gc)	24595006	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-25	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-25-3p	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25		Homo sapiens	circulating	plasma	st elevation myocardial infarction (stemi)	24432306	qrt-pcr	mirnas associated with stemi as compared to nstemi patients included mir-25-3p, mir-221-3p, and mir-374b-5p. mirna 30d-5p was associated with plasma, platelets, and leukocytes in both stemi and nstemi patients; mirnas 221-3p and 483-5p were correlated with plasma and platelets only in nstemi patients.
hsa-miR-25-3p	miRNA	hsa-miR-25-3p	MIMAT0000081	mir-25	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-26	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-26-5p	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	serum	prostate cancer	21539977	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	blood	influenza a virus infection	24116168	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	blood	Atherosclerosis	25613580	qrt-pcr	authors showed that mir-26a is overexpressed in patients with atherosclerosis and associated with epc (circulating endothelial progenitor cells) dysfunction. epha2 was identified as a direct target of mir-26a.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	plasma	endometriosis	23203215	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	serum	hepatitis b virus-infected patients	21567136	taqman low density array|mirvana paris kit (ambion)	this study describes the identification and characterization of an appropriate reference gene for the normalization of circulating mirna levels in hepatitis b virus (hbv)-infected patients and healthy people. The combination of mir-26a, mir-221, and mir-22* is recommended as the most stable set of reference genes for circulating mirna evaluation in hbv patients and healthy people.
hsa-miR-26a	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-26a-1	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	serum	prostate cancer	24510997	real-time pcr	the analysis of circulating micrornas does not seem to help identify patients with cancer undergoing prostate biopsy. however, their levels may be useful to identify patients with high-risk prostate cancer.
hsa-miR-26a-5p	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-26a-5p	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-26a-5p	miRNA	hsa-miR-26a-5p	MIMAT0000082	mir-26		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	circulating	amniotic fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-26b	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-26b*	miRNA	hsa-miR-26b-3p	MIMAT0004500	mir-26		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-26b-5p	miRNA	hsa-miR-26b-5p	MIMAT0000083	mir-26	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-27a	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-27a*	miRNA	hsa-miR-27a-5p	MIMAT0004501	mir-27		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-27a*	miRNA	hsa-miR-27a-5p	MIMAT0004501	mir-27		Homo sapiens	circulating	blood	Acute stroke	24447930	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
hsa-miR-27a-3p	miRNA	hsa-miR-27a-3p	MIMAT0000084	mir-27	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-27b	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-27b	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-27b	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-27b	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-27b	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-27b	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-27b	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-27b	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-27b	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-27b*	miRNA	hsa-miR-27b-5p	MIMAT0004588	mir-27	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-27b-3p	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27		Homo sapiens	circulating	plasma	Acetaminophen-induced acute liver injury (APAP-ALI)	25092309	real-time pcr	authors suggest that mirnas can serve as sensitive diagnostic and prognostic clinical tools for severe liver injury and could be useful for monitoring drug-induced liver injury during drug discovery.
hsa-miR-27b-3p	miRNA	hsa-miR-27b-3p	MIMAT0000419	mir-27	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-28	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-28	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-28-3p	miRNA	hsa-miR-28-3p	MIMAT0004502	mir-28		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-28-3p	miRNA	hsa-miR-28-3p	MIMAT0004502	mir-28		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-28-3p	miRNA	hsa-miR-28-3p	MIMAT0004502	mir-28		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-28-3p	miRNA	hsa-miR-28-3p	MIMAT0004502	mir-28	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-28-3p	miRNA	hsa-miR-28-3p	MIMAT0004502	mir-28		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-28-5p	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-28-5p	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-28-5p	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28		Homo sapiens	circulating	breast milk	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-28-5p	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28		Homo sapiens	circulating	serum	Breast cancer	25137071	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
hsa-miR-28-5p	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-28-5p	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-28-5p	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28		Homo sapiens	circulating	plasma	liver damage in hepatitis b e antigen positive (hbeag-positive) patients	25580300	qrt-pcr	authors demonstrated that three micrornas (mir-28-5p, -30a-5p, and -125b-5p) were significantly upregulated in hbeag-positive children when compared to hbeag-negative and healthy control children. the identified micrornas might impact the progression of chronic hepatitis b in children. 
hsa-miR-28-5p	miRNA	hsa-miR-28-5p	MIMAT0000085	mir-28	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-2861	miRNA	hsa-miR-2861	MIMAT0013802	mir-2861	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-2881	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-29	miRNA			mir-29		Homo sapiens	circulating	human orbital fibroblasts	orbital fibrosis	25550793	real-time pcr	authors demonstrated that mir-29 mediates tgfβ1-induced extracellular matrix synthesis through activation of wnt/β-catenin pathway in human orbital fibroblasts.
hsa-miR-290	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	embryonic stem cells	Embryonic stem cells	19266099	rt-pcr|Differential centrifugation	Transfer of microRNAs by embryonic stem cell microvesicles
hsa-miR-2900	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-291-3p	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	embryonic stem cells	Embryonic stem cells	19266099	rt-pcr|Differential centrifugation	Transfer of microRNAs by embryonic stem cell microvesicles
hsa-miR-292-3p	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	embryonic stem cells	Embryonic stem cells	19266099	rt-pcr|Differential centrifugation	Transfer of microRNAs by embryonic stem cell microvesicles
hsa-miR-294	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	embryonic stem cells	Embryonic stem cells	19266099	rt-pcr|Differential centrifugation	Transfer of microRNAs by embryonic stem cell microvesicles
hsa-miR-295	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	microvesicle	embryonic stem cells	Embryonic stem cells	19266099	rt-pcr|Differential centrifugation	Transfer of microRNAs by embryonic stem cell microvesicles
hsa-miR-296	miRNA	hsa-miR-296-5p	MIMAT0000690	mir-296		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-296-5p	miRNA	hsa-miR-296-5p	MIMAT0000690	mir-296		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-296-5p	miRNA	hsa-miR-296-5p	MIMAT0000690	mir-296		Homo sapiens	circulating	plasma	essential hypertension	21690488	mircury lna array (version 11.0) system|qrt-pcr mmlv reverse transcriptase (epicenter, madison, wi)|abi prism7500 system (applied biosystems, foster city, ca)	authors report for the first time a circulating mirna profile for hypertensive patients and demonstrate a novel link between hcmv infection and essential hypertension. These findings may reveal important insights into the pathogenesis of essential hypertension.
hsa-miR-296-5p	miRNA	hsa-miR-296-5p	MIMAT0000690	mir-296		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-296-5p	miRNA	hsa-miR-296-5p	MIMAT0000690	mir-296		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-298	miRNA	hsa-miR-298	MIMAT0004901	mir-298		Homo sapiens	circulating	serum	prostate cancer	22052531	qrt-pcr	four mirnas altered in mice, mmu-mir-141, mmu-mir-298, mmu-mir-346 and mmu-mir-375, were also found to be at differential levels in the serum of men with mcrpc. three of these (hsa-mir-141, hsa-mir-298 and hsa-mir-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. moreover, the intra-tumoral expression of hsa-mir-141 and hsa-mir-375 were predictors of biochemical relapse after surgery. this study is the first to demonstrate that specific serum mirnas are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers.
hsa-miR-299-5p	miRNA	hsa-miR-299-5p	MIMAT0002890	mir-299		Homo sapiens	circulating	plasma	pregnancy	18218722	mirvana mirna isolation kit (ambion)|taqman microrna assay (applied biosystems) qrt-pcr	the 4 most abundant of the placental mirnas (mir-141, mir-149, mir-299-5p, and mir-135b) were detectable in maternal plasma during pregnancy and showed reduced detection rates in postdelivery plasma. The plasma concentration of mir-141 increased as pregnancy progressed into the third trimester. 
hsa-miR-299-5p	miRNA	hsa-miR-299-5p	MIMAT0002890	mir-299		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-299-5p	miRNA	hsa-miR-299-5p	MIMAT0002890	mir-299		Homo sapiens	circulating	serum	Breast cancer	22353773	mirvana mirna isolation kit (ambion, austin, tx, usa)|microrna isolation kit (biochain institute inc, hayward, ca, usa)|nanodrop nd1000 (nanodrop technologies, waltham, ma, usa)|taqman microrna reverse transcription kit (applied biosystems)|qrt-pcr	mirna expression in cancerous samples tends to be repressed when compared with mirna expression in healthy controls (p = 0.0685). The four most discriminating mirnas by fold-change (mir-215, mir-299-5p, mir-411, and mir-452) were selected for further analysis on serum samples. All mirnas at least tended to be differentially expressed between serum samples from patients with cancer and serum samples from healthy controls 
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	serum	Colorectal liver metastasis (crlm)	22018950	real-time rt-pcr	serum mir-29a was significantly higher in colorectal liver metastasis (crlm) patients than in crc patients.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	serum	plaque psoriasis	21277746	mirneasy rna isolation kit (qiagen, valencia, ca, usa)|mir-x mirna first strand synthesis|sybr qrt-pcr kit (takara bio inc)	authors try to evaluate the possibility that serum levels of these mirnas can be disease markers for psoriasis, reflecting the activation of tnf signaling pathway. Serum levels of mir-19a and -29a, especially mir-19a, can be biomarkers for this disease, reflecting the activation of tnf signaling pathway.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	23267864	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	serum	diabetic nephropathy (dn)	27279796	qrt-pcr	the levels of mir-21, mir-29a and mir-192 were significantly enriched in the overt proteinuria group compared with microalbuminuria and/or overt proteinuria groups. it was shown that only mir-21 level was significantly up-regulated in low-egfr group compared with high-egfr patients.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	plasma	thoracic aortic aneurysm (taa)	23312977	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29	NULL	Homo sapiens	microvesicle	plasma	Irritable bowel syndrome (IBS)	19951903	Microarray [ArrayExpress]|RT-PCR|Differential centrifugation|Filtration	MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome
hsa-miR-29a	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29		Homo sapiens	circulating	plasma	Breast cancer	22370716	reverse transcriptase-polymerase chain reaction 	circulating mir-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma mir-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab. 
hsa-miR-29a-3p	miRNA	hsa-miR-29a-3p	MIMAT0000086	mir-29	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	circulating	serum	Aging	25165030	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	microvesicle	plasma	healthy smokers	24573468		despite reduced total pmvs, pmv-derived microrna-profiling of six smoker/control pairs revealed a decrease of only a single microrna, the major platelet-derived microrna mir-223. conversely, mir-29b, a microrna associated with aortic aneurysm and fibrosis, and rnu6-2, a commonly used reference-rna, were significantly up-regulated. smoking leads to alterations in the circulating pmv profile and changes in the pmv-derived microrna signature already in young, healthy adults. these changes may contribute to the development of smoking-related cardiovascular pathologies. moreover, these smoking-related changes have to be considered when microrna or pmv profiles are used as disease-specific biomarkers.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-29b	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-29b-1*	miRNA	hsa-miR-29b-1-5p	MIMAT0004514	mir-29		Homo sapiens	circulating	peritoneal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-29b-2*	miRNA	hsa-miR-29b-2-5p	MIMAT0004515	mir-29		Homo sapiens	circulating	seminal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-29b-3p	miRNA	hsa-miR-29b-3p	MIMAT0000100	mir-29	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-29c	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-29c	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-29c	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-29c	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-29c	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-29c	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-29c	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-29c	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-29c	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-29c*	miRNA	hsa-miR-29c-5p	MIMAT0004673	mir-29		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-29c*	miRNA	hsa-miR-29c-5p	MIMAT0004673	mir-29		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-29c-3p	miRNA	hsa-miR-29c-3p	MIMAT0000681	mir-29	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-29c-5p	miRNA	hsa-miR-29c-5p	MIMAT0004673	mir-29	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-301	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-301	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-301	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-301	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	circulating	plasma	non small cell lung cancer (nsclc)	20595154	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
hsa-miR-301a	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-301a	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-301a	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-301a	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-301a	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-301a	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-301a	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-301a-3p	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	circulating	serum	neovascular age-related macular degeneration	25203061	qrt-pcr	this is the first study to evaluate the relative abundance of cmirnas in the serum of late stage amd patients. authors identified three cmirnas (hsa-mir-301a-3p, hsa-mir-361-5p, and hsa-mir-424-5p) which were significantly altered in nv amd patients compared to amd-free controls.
hsa-miR-301a-3p	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-301a-3p	miRNA	hsa-miR-301a-3p	MIMAT0000688	mir-130		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-301b	miRNA	hsa-miR-301b	MIMAT0004958	mir-130		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-301b	miRNA	hsa-miR-301b	MIMAT0004958	mir-130		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-302a	miRNA	hsa-miR-302a-3p	MIMAT0000684	mir-302		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-302b	miRNA	hsa-miR-302b-3p	MIMAT0000715	mir-302		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-302c	miRNA	hsa-miR-302c-3p	MIMAT0000717	mir-302	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-302c	miRNA	hsa-miR-302c-3p	MIMAT0000717	mir-302		Homo sapiens	circulating	serum	Adenocarcinomas of the gastroesophageal junction	25429911	quantitative real-time pcr	depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction, a differential serum microrna profile was identified by the authors. in particular, there was a significant correlation between mir-302c and mir-222 expression with overall survival. 
hsa-miR-3065-5p	miRNA	hsa-miR-3065-5p	MIMAT0015066	mir-3065	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-30a	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-30a	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30a	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-30a	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-30a	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-30a	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-30a	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-30a	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-30a	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-30a-3p	miRNA	hsa-miR-30a-3p	MIMAT0000088	mir-30		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-30a-3p	miRNA	hsa-miR-30a-3p	MIMAT0000088	mir-30	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-30a-5p	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-30a-5p	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-30a-5p	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-30a-5p	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-30a-5p	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	serum	type 1 diabetes (t1d)	22829805	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
hsa-miR-30a-5p	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-30a-5p	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-30a-5p	miRNA	hsa-miR-30a-5p	MIMAT0000087	mir-30		Homo sapiens	circulating	plasma	liver damage in hepatitis b e antigen positive (hbeag-positive) patients	25580300	qrt-pcr	authors demonstrated that three micrornas (mir-28-5p, -30a-5p, and -125b-5p) were significantly upregulated in hbeag-positive children when compared to hbeag-negative and healthy control children. the identified micrornas might impact the progression of chronic hepatitis b in children.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	exosome	plasma	lung squamous cell carcinoma (scc)	24130905	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
hsa-miR-30b	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-30b-5p	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-30b-5p	miRNA	hsa-miR-30b-5p	MIMAT0000420	mir-30		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-30c	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30		Homo sapiens	circulating	plasma	prostate cancer	22298030	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102 1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followed by qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
hsa-miR-30c-2*	miRNA	hsa-miR-30c-2-3p	MIMAT0004550	mir-30		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30c-2*	miRNA	hsa-miR-30c-2-3p	MIMAT0004550	mir-30		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30c-2-3p	miRNA	hsa-miR-30c-2-3p	MIMAT0004550	mir-30	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-30c-5p	miRNA	hsa-miR-30c-5p	MIMAT0000244	mir-30	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-30d	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-30d	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-30d	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-30d	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-30d	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-30d	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-30d	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-30d	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-30d	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-30d*	miRNA	hsa-miR-30d-3p	MIMAT0004551	mir-30		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30d*	miRNA	hsa-miR-30d-3p	MIMAT0004551	mir-30		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-30d-5p	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30		Homo sapiens	circulating	plasma	st elevation myocardial infarction (stemi)	24432306	qrt-pcr	mirnas associated with stemi as compared to nstemi patients included mir-25-3p, mir-221-3p, and mir-374b-5p. mirna 30d-5p was associated with plasma, platelets, and leukocytes in both stemi and nstemi patients; mirnas 221-3p and 483-5p were correlated with plasma and platelets only in nstemi patients.
hsa-miR-30d-5p	miRNA	hsa-miR-30d-5p	MIMAT0000245	mir-30	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-30e	miRNA	hsa-miR-30e-5p	MIMAT0000692	mir-30		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30e	miRNA	hsa-miR-30e-5p	MIMAT0000692	mir-30		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-30e	miRNA	hsa-miR-30e-5p	MIMAT0000692	mir-30		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-30e	miRNA	hsa-miR-30e-5p	MIMAT0000692	mir-30		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30e	miRNA	hsa-miR-30e-5p	MIMAT0000692	mir-30		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-30e	miRNA	hsa-miR-30e-5p	MIMAT0000692	mir-30		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-30e*	miRNA	hsa-miR-30e-3p	MIMAT0000693	mir-30		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30e*	miRNA	hsa-miR-30e-3p	MIMAT0000693	mir-30		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-30e*	miRNA	hsa-miR-30e-3p	MIMAT0000693	mir-30		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-30e-3p	miRNA	hsa-miR-30e-3p	MIMAT0000693	mir-30		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-30e-3p	miRNA	hsa-miR-30e-3p	MIMAT0000693	mir-30		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-30e-3p	miRNA	hsa-miR-30e-3p	MIMAT0000693	mir-30	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-30e-3p	miRNA	hsa-miR-30e-3p	MIMAT0000693	mir-30		Homo sapiens	circulating	plasma	non small cell lung cancer (nsclc)	20595154	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
hsa-miR-30e-5p	miRNA	hsa-miR-30e-5p	MIMAT0000692	mir-30		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-30e-5p	miRNA	hsa-miR-30e-5p	MIMAT0000692	mir-30		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-30e-5p	miRNA	hsa-miR-30e-5p	MIMAT0000692	mir-30	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-31	miRNA	hsa-miR-31-5p	MIMAT0000089	mir-31		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-31	miRNA	hsa-miR-31-5p	MIMAT0000089	mir-31		Homo sapiens	circulating	plasma	Coronary artery disease	24558106	real-time pcr	circulating levels of mir-31, mir-720, and vasohibin 1 have the potential to allow early diagnosis of cad and to act as prognosis biomarkers for cad and other epc-related diseases.
hsa-miR-31	miRNA	hsa-miR-31-5p	MIMAT0000089	mir-31	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-31	miRNA	hsa-miR-31-5p	MIMAT0000089	mir-31		Homo sapiens	microvesicle	plasma	osteoporosis	27146333	qpcr	authors suggest that microvesicular mir-31 in the plasma of elderly might play a role in the pathogenesis of age-related impaired bone formation and that mir-31 might be a valuable plasma-based biomarker for aging and for a systemic environment that does not favor cell-based therapies whenever osteogenesis is a limiting factor.
hsa-miR-31	miRNA	hsa-miR-31-5p	MIMAT0000089	mir-31		Homo sapiens	circulating	serum	heart transplant rejection	25176944	real-time pcr	the study demonstrates that a differential expression of mirna occurs in rejecting allograft patients, not only at the tissue level but also in the serum, suggesting their potential relevance as non-invasive biomarkers in heart transplant rejection.
hsa-miR-31-3p	miRNA	hsa-miR-31-3p	MIMAT0004504	mir-31	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-31-5p	miRNA	hsa-miR-31-5p	MIMAT0000089	mir-31	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-3184-3p	miRNA	hsa-miR-3184-3p	MIMAT0022731	NULL	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-32	miRNA	hsa-miR-32-5p	MIMAT0000090	mir-32		Homo sapiens	circulating	serum	prostate cancer	21539977	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
hsa-miR-32	miRNA	hsa-miR-32-5p	MIMAT0000090	mir-32		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-32	miRNA	hsa-miR-32-5p	MIMAT0000090	mir-32		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-32	miRNA	hsa-miR-32-5p	MIMAT0000090	mir-32		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-32	miRNA	hsa-miR-32-5p	MIMAT0000090	mir-32		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-32	miRNA	hsa-miR-32-5p	MIMAT0000090	mir-32		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-32	miRNA	hsa-miR-32-5p	MIMAT0000090	mir-32		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-32	miRNA	hsa-miR-32-5p	MIMAT0000090	mir-32		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-32-5p	miRNA	hsa-miR-32-5p	MIMAT0000090	mir-32	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	malignant effusions	lung cancer	21029414	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-320	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-320	miRNA			mir-320		Homo sapiens	circulating	serum	waldenström macroglobulinemia	25428891	quantitative real-time pcr	authors focused on the role of circulating serum mirnas as biomarkers of waldenström macroglobulinemia (wm). they found that the combination of mir-320a and mir-320b served as the best indicator for wm.
hsa-miR-320a	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-320a	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-320a	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-320a	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-320a	miRNA	hsa-miR-320a	MIMAT0000510	mir-320		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-320b	miRNA	hsa-miR-320b	MIMAT0005792	mir-320	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-320c	miRNA	hsa-miR-320c	MIMAT0005793	mir-320	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-320c	miRNA	hsa-miR-320c	MIMAT0005793	mir-320		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-320d	miRNA	hsa-miR-320d	MIMAT0006764	mir-320	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-323	miRNA	hsa-miR-323a-3p	MIMAT0000755	mir-154	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-323-3p	miRNA	hsa-miR-323a-3p	MIMAT0000755	mir-154		Homo sapiens	circulating	plasma	Acute coronary syndromes	25124998	real-time quantitative pcr	authors identify mir-652 as a novel candidate biomarker for post-acs prognosis beyond existing biomarkers of lvef and nt-probnp. moreover circulating mir-323-3p was markedly elevated in patients for at least a year post-acs and may be a stable biomarker for acs.
hsa-miR-323-3p	miRNA	hsa-miR-323a-3p	MIMAT0000755	mir-154		Homo sapiens	circulating	serum	ectopic pregnancy (ep)	22395025	taqman real-time pcr	the serum concentrations of mirnas mir-323-3p, mir-517a, mir-519d, and mir-525-3p were measured with taqman real-time pcr. Pregnancy-associated mirnas, especially mir-323-3p, added significant diagnostic accuracy to a panel including hcg and progesterone for the diagnosis of ep.
hsa-miR-323-3p	miRNA	hsa-miR-323a-3p	MIMAT0000755	mir-154		Homo sapiens	circulating	plasma	mild cognitive impairment (mci)	24368295	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
hsa-miR-323-3p	miRNA	hsa-miR-323a-3p	MIMAT0000755	mir-154		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-323b-5p	miRNA	hsa-miR-323b-5p	MIMAT0001630	mir-154	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324		Homo sapiens	circulating	serum	hand-foot-and-mouth disease (hfmd)	22087245	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-324-3p	miRNA	hsa-miR-324-3p	MIMAT0000762	mir-324		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-324-5p	miRNA	hsa-miR-324-5p	MIMAT0000761	mir-324		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-324-5p	miRNA	hsa-miR-324-5p	MIMAT0000761	mir-324		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-324-5p	miRNA	hsa-miR-324-5p	MIMAT0000761	mir-324		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-324-5p	miRNA	hsa-miR-324-5p	MIMAT0000761	mir-324		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-324-5p	miRNA	hsa-miR-324-5p	MIMAT0000761	mir-324		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-324-5p	miRNA	hsa-miR-324-5p	MIMAT0000761	mir-324		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-324-5p	miRNA	hsa-miR-324-5p	MIMAT0000761	mir-324	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-326	miRNA	hsa-miR-326	MIMAT0000756	mir-326		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-326	miRNA	hsa-miR-326	MIMAT0000756	mir-326		Homo sapiens	exosome	plasma	type 2 diabetes	24937531	exoquick exosome precipitation solution (system biosciences)| rneasy kit (qiagen)| qrt-pcr	we aimed at studying circulating mirna expression in diabetic patients naïve to treatment and at investigating the influence on this of glycemic control. in diabetic patients, microarray analysis showed that four mirnas are increased, whereas 21 mirnas are decreased. after 12 months of antidiabetic treatment, quantitative rt-pcr data analysis showed that mir-326 levels were unaffected, whereas the levels of let-7a and let-7f were significantly increased.  treatment-naïve, poorly controlled diabetic patients show a significant dysregulation of mirnas involved in the regulation of the adiponectin pathway, a phenomenon that may be reversed, at least in part, by improved glycemic control.
hsa-miR-326	miRNA	hsa-miR-326	MIMAT0000756	mir-326		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-326	miRNA	hsa-miR-326	MIMAT0000756	mir-326		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-326	miRNA	hsa-miR-326	MIMAT0000756	mir-326		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	circulating	blood	Atrial fibrillation (af)	24444445	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	circulating levels of mir-328, a mirna known to promote atrial electrical remodeling by reducing l-type ca(2+) channel density, were associated with prevalent af. adjustment for risk factors that promote atrial remodeling, including hypertension, attenuated the association between mir-328 and af, potentially implicating mir-328 as a potential mediator of atrial remodeling and af vulnerability.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	circulating	plasma	Acute exhaustive exercise	21690193	microrna extraction kit (benevbio,mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	circulating	plasma	sustained aerobic exercise	21690193	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-328	miRNA	hsa-miR-328	MIMAT0000752	mir-328		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-330	miRNA	hsa-miR-330-3p	MIMAT0000751	mir-330		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-330-3p	miRNA	hsa-miR-330-3p	MIMAT0000751	mir-330		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-330-5p	miRNA	hsa-miR-330-5p	MIMAT0004693	mir-330		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-331	miRNA	hsa-miR-331-3p	MIMAT0000760	mir-331		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-331	miRNA	hsa-miR-331-3p	MIMAT0000760	mir-331		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-331	miRNA	hsa-miR-331-3p	MIMAT0000760	mir-331		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-331-3p	miRNA	hsa-miR-331-3p	MIMAT0000760	mir-331		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-331-3p	miRNA	hsa-miR-331-3p	MIMAT0000760	mir-331		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-331-3p	miRNA	hsa-miR-331-3p	MIMAT0000760	mir-331		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-331-3p	miRNA	hsa-miR-331-3p	MIMAT0000760	mir-331		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-331-3p	miRNA	hsa-miR-331-3p	MIMAT0000760	mir-331		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-335	miRNA	hsa-miR-335-5p	MIMAT0000765	mir-335	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-335	miRNA	hsa-miR-335-5p	MIMAT0000765	mir-335		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-335	miRNA	hsa-miR-335-5p	MIMAT0000765	mir-335		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-335	miRNA	hsa-miR-335-5p	MIMAT0000765	mir-335		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-335	miRNA	hsa-miR-335-5p	MIMAT0000765	mir-335		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-335	miRNA	hsa-miR-335-5p	MIMAT0000765	mir-335		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-335	miRNA	hsa-miR-335-5p	MIMAT0000765	mir-335		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	23267864	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
hsa-miR-335*	miRNA	hsa-miR-335-3p	MIMAT0004703	mir-335		Homo sapiens	circulating	blood	influenza a virus infection	24116168	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
hsa-miR-335-5p	miRNA	hsa-miR-335-5p	MIMAT0000765	mir-335	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-337-5p	miRNA	hsa-miR-337-5p	MIMAT0004695	mir-337		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-338-3p	miRNA	hsa-miR-338-3p	MIMAT0000763	mir-338		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-338-3p	miRNA	hsa-miR-338-3p	MIMAT0000763	mir-338		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-338-3p	miRNA	hsa-miR-338-3p	MIMAT0000763	mir-338		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-338-3p	miRNA	hsa-miR-338-3p	MIMAT0000763	mir-338		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-339	miRNA	hsa-miR-339-5p	MIMAT0000764	mir-339		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-339	miRNA	hsa-miR-339-5p	MIMAT0000764	mir-339		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-339-3p	miRNA	hsa-miR-339-3p	MIMAT0004702	mir-339		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-339-3p	miRNA	hsa-miR-339-3p	MIMAT0004702	mir-339		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-339-3p	miRNA	hsa-miR-339-3p	MIMAT0004702	mir-339		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-339-3p	miRNA	hsa-miR-339-3p	MIMAT0004702	mir-339		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-339-5p	miRNA	hsa-miR-339-5p	MIMAT0000764	mir-339		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-339-5p	miRNA	hsa-miR-339-5p	MIMAT0000764	mir-339	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-33a	miRNA	hsa-miR-33a-5p	MIMAT0000091	mir-33		Homo sapiens	circulating	serum	Dialysis	24499083	real-time quantitative pcr	hemodiafiltration (hdf) therapy can downregulate mir-33a expression, and then result in abca1, abcg1 upregulation and an increase in circulating hdl-c, leading to a possible anti-atherosclerosis effect to some extent.
hsa-miR-33a	miRNA	hsa-miR-33a-5p	MIMAT0000091	mir-33		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-33a	miRNA	hsa-miR-33a-5p	MIMAT0000091	mir-33		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-33a	miRNA	hsa-miR-33a-5p	MIMAT0000091	mir-33		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-33a	miRNA	hsa-miR-33a-5p	MIMAT0000091	mir-33		Homo sapiens	circulating	plasma	patients with low hdl-c levels	24591767	quantitative real-time pcr	in patients with low hdl-c levels, xzk therapy raised plasma levels of mir-33a and mir-33b, which may inhibit cellular cholesterol export and limit the hdl-raising effect of xzk.
hsa-miR-33a-5p	miRNA	hsa-miR-33a-5p	MIMAT0000091	mir-33	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-33b	miRNA	hsa-miR-33b-5p	MIMAT0003301	mir-33		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-33b	miRNA	hsa-miR-33b-5p	MIMAT0003301	mir-33		Homo sapiens	circulating	plasma	patients with low hdl-c levels	24591767	quantitative real-time pcr	in patients with low hdl-c levels, xzk therapy raised plasma levels of mir-33a and mir-33b, which may inhibit cellular cholesterol export and limit the hdl-raising effect of xzk.
hsa-miR-340	miRNA	hsa-miR-340-5p	MIMAT0004692	mir-340		Homo sapiens	circulating	serum	Aging	25165030	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
hsa-miR-340	miRNA	hsa-miR-340-5p	MIMAT0004692	mir-340		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-340	miRNA	hsa-miR-340-5p	MIMAT0004692	mir-340		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-340	miRNA	hsa-miR-340-5p	MIMAT0004692	mir-340		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-340	miRNA	hsa-miR-340-5p	MIMAT0004692	mir-340		Homo sapiens	circulating	seminal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-340	miRNA	hsa-miR-340-5p	MIMAT0004692	mir-340		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-340	miRNA	hsa-miR-340-5p	MIMAT0004692	mir-340		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-340	miRNA	hsa-miR-340-5p	MIMAT0004692	mir-340		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-340*	miRNA	hsa-miR-340-3p	MIMAT0000750	mir-340		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-340*	miRNA	hsa-miR-340-3p	MIMAT0000750	mir-340		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-340*	miRNA	hsa-miR-340-3p	MIMAT0000750	mir-340		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-340*	miRNA	hsa-miR-340-3p	MIMAT0000750	mir-340		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-340-5p	miRNA	hsa-miR-340-5p	MIMAT0004692	mir-340	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-342	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-342	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-342	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-342	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-342-3p	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-342-3p	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-342-3p	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-342-3p	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-342-3p	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-342-3p	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-342-3p	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-342-3p	miRNA	hsa-miR-342-3p	MIMAT0000753	mir-342		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-342-5p	miRNA	hsa-miR-342-5p	MIMAT0004694	mir-342		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-342-5p	miRNA	hsa-miR-342-5p	MIMAT0004694	mir-342		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-342-5p	miRNA	hsa-miR-342-5p	MIMAT0004694	mir-342		Homo sapiens	circulating	serum	pertussis	23073777	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
hsa-miR-345	miRNA	hsa-miR-345-5p	MIMAT0000772	mir-345		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-345	miRNA	hsa-miR-345-5p	MIMAT0000772	mir-345		Homo sapiens	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	22937028	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
hsa-miR-345	miRNA	hsa-miR-345-5p	MIMAT0000772	mir-345		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-345	miRNA	hsa-miR-345-5p	MIMAT0000772	mir-345		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-345	miRNA	hsa-miR-345-5p	MIMAT0000772	mir-345		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-345	miRNA	hsa-miR-345-5p	MIMAT0000772	mir-345		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-345	miRNA	hsa-miR-345-5p	MIMAT0000772	mir-345		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-345-5p	miRNA	hsa-miR-345-5p	MIMAT0000772	mir-345	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-346	miRNA	hsa-miR-346	MIMAT0000773	mir-346		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-346	miRNA	hsa-miR-346	MIMAT0000773	mir-346		Homo sapiens	circulating	serum	prostate cancer	22052531	qrt-pcr	four mirnas altered in mice, mmu-mir-141, mmu-mir-298, mmu-mir-346 and mmu-mir-375, were also found to be at differential levels in the serum of men with mcrpc. three of these (hsa-mir-141, hsa-mir-298 and hsa-mir-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. moreover, the intra-tumoral expression of hsa-mir-141 and hsa-mir-375 were predictors of biochemical relapse after surgery. this study is the first to demonstrate that specific serum mirnas are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers.
hsa-miR-346	miRNA	hsa-miR-346	MIMAT0000773	mir-346		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-346	miRNA	hsa-miR-346	MIMAT0000773	mir-346		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	microvesicle	serum	human colon cancer dld-1 cells	24447928	exomir kit (bioosicentific; austin, tx, usa)|nanosight lm10 nanoparticle characterization system (nanosight, amesbury, uk)|bioopure-mp (bioosicentific, austin, tx, usa)|taqman (applied biosystems, foster city, ca, usa)|rneasy mini kit (qiagen, hilden, germany)	the intra- and extracellular mir-145 and -34a were closely associated with 5-fu resistance, and the resistance was in part due to the enhanced secretion of mir-145 and -34a via mvs, resulting in low intracellular levels of both mirnas.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	circulating	serum	Breast cancer	21047409	quantitative real-time pcr taqman microrna assays (applied biosystems)	the relative concentrations of total rna (p = 0.0001) and mir155 (p = 0.0001) in serum significantly discriminated m0-patients (primary breast cancer) from healthy women, whereas mir10b (p = 0.005), mir34a (p = 0.001) and mir155 (p = 0.008) discriminated m1-patients (metastatic disease) from healthy controls.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	circulating	bladder cancer cells	Bladder cancer	25551284	quantitative real-time pcr	authors demonstrated that mir-34a functions as a tumor suppressor in bladder cancer by directly targeting cd44, which would be helpful as a therapeutic approach to block bladder cancer metastasis.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	circulating	serum	Chronic type C hepatitis	21886843	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	circulating	serum	non-alcoholic fatty liver disease (nafld)	21886843	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
hsa-miR-34a	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34		Homo sapiens	circulating	serum	Acute myocardial infarction (ami)	23323620		serum mir-34a levels in acute myocardial infarction (ami) patients and rats were significantly higher than healthy subjects and sham rats. results proved that mir-34a could promote cardiomyocyte apoptosis via negatively regulating aldh2 and circulating mir-34a was increased in the condition of mi. thus, mir-34a may constitute a new therapeutic target and diagnostic marker for patients with mi.
hsa-miR-34a*	miRNA	hsa-miR-34a-3p	MIMAT0004557	mir-34		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-34a-5p	miRNA	hsa-miR-34a-5p	MIMAT0000255	mir-34	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-34b	miRNA	hsa-miR-34b-3p	MIMAT0004676	mir-34		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-34b	miRNA	hsa-miR-34b-3p	MIMAT0004676	mir-34		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-34b	miRNA	hsa-miR-34b-3p	MIMAT0004676	mir-34		Homo sapiens	circulating	serum	malignant pleural mesothelioma (mpm)	24168922	digital methylation specific pcr assay (msp)	authors show that digital msp assay can quantify mir-34b/c methylation in serum-circulating dna. the degree of mir-34b/c methylation in serum-circulating dna is associated with mpm.
hsa-miR-34b	miRNA	hsa-miR-34b-3p	MIMAT0004676	mir-34		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-34b*	miRNA	hsa-miR-34b-5p	MIMAT0000685	mir-34		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-34c	miRNA	hsa-miR-34c-5p	MIMAT0000686	mir-34		Homo sapiens	circulating	plasma	Alzheimer disease (AD)	24550773	quantitative real-time pcr	these data show that plasma levels of microrna 34c are much more prominent in ad than those of its sister, mir-34a, or than its own level in pbmc. transfection studies show that mir-34c, as does its sister mir-34a, represses the expression of several selected genes involved in cell survival and oxidative defense pathways, such as bcl2, sirt1, and others, in cultured cells.
hsa-miR-34c-5p	miRNA	hsa-miR-34c-5p	MIMAT0000686	mir-34		Homo sapiens	circulating	serum	malignant pleural mesothelioma (mpm)	24168922	digital methylation specific pcr assay (msp)	authors show that digital msp assay can quantify mir-34b/c methylation in serum-circulating dna. the degree of mir-34b/c methylation in serum-circulating dna is associated with mpm.
hsa-miR-361	miRNA	hsa-miR-361-5p	MIMAT0000703	mir-361		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-361	miRNA	hsa-miR-361-5p	MIMAT0000703	mir-361		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-361-3p	miRNA	hsa-miR-361-3p	MIMAT0004682	mir-361		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-361-3p	miRNA	hsa-miR-361-3p	MIMAT0004682	mir-361		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22675530	Trizol LS Reagent (Karlsruhe, Germany, Invitrogen)|microfluid biochips (Febit Biomed GmbH, Heidelberg, Germany)|Microfluid Primer Extension Assay|mirVana PARIS kit (Ambion, Darmstadt, Germany)|TaqMan MicroRNA Reverse Transcription Kit (Applied Biosystems)	Microarray profiling showed that miR-361-3p and miR-625* were significantly down-regulated in serum of lung cancer patients. Their further evaluation by quantitative RT-PCR showed that the levels of miR-361-3p and miR-625* were lower in NSCLC than in benign disease (p = 0.0001) and healthy individuals (p = 0.0001, p = 0.0005, respectively).
hsa-miR-361-3p	miRNA	hsa-miR-361-3p	MIMAT0004682	mir-361		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-361-3p	miRNA	hsa-miR-361-3p	MIMAT0004682	mir-361	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-361-5p	miRNA	hsa-miR-361-5p	MIMAT0000703	mir-361		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-361-5p	miRNA	hsa-miR-361-5p	MIMAT0000703	mir-361		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-361-5p	miRNA	hsa-miR-361-5p	MIMAT0000703	mir-361		Homo sapiens	circulating	serum	neovascular age-related macular degeneration	25203061	qrt-pcr	this is the first study to evaluate the relative abundance of cmirnas in the serum of late stage amd patients. authors identified three cmirnas (hsa-mir-301a-3p, hsa-mir-361-5p, and hsa-mir-424-5p) which were significantly altered in nv amd patients compared to amd-free controls.
hsa-miR-361-5p	miRNA	hsa-miR-361-5p	MIMAT0000703	mir-361		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-361-5p	miRNA	hsa-miR-361-5p	MIMAT0000703	mir-361		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-361-5p	miRNA	hsa-miR-361-5p	MIMAT0000703	mir-361	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-362	miRNA	hsa-miR-362-5p	MIMAT0000705	mir-362		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-362	miRNA	hsa-miR-362-5p	MIMAT0000705	mir-362		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-362-3p	miRNA	hsa-miR-362-3p	MIMAT0004683	mir-362		Homo sapiens	circulating	serum	hand-foot-and-mouth disease (hfmd)	22087245	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
hsa-miR-362-3p	miRNA	hsa-miR-362-3p	MIMAT0004683	mir-362		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-362-3p	miRNA	hsa-miR-362-3p	MIMAT0004683	mir-362		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-362-3p	miRNA	hsa-miR-362-3p	MIMAT0004683	mir-362		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-362-3p	miRNA	hsa-miR-362-3p	MIMAT0004683	mir-362		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-362-3p	miRNA	hsa-miR-362-3p	MIMAT0004683	mir-362	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-362-5p	miRNA	hsa-miR-362-5p	MIMAT0000705	mir-362		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-362-5p	miRNA	hsa-miR-362-5p	MIMAT0000705	mir-362		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-362-5p	miRNA	hsa-miR-362-5p	MIMAT0000705	mir-362		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-362-5p	miRNA	hsa-miR-362-5p	MIMAT0000705	mir-362		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-362-5p	miRNA	hsa-miR-362-5p	MIMAT0000705	mir-362	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-363	miRNA	hsa-miR-363-3p	MIMAT0000707	mir-363		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-363	miRNA	hsa-miR-363-3p	MIMAT0000707	mir-363		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-363	miRNA	hsa-miR-363-3p	MIMAT0000707	mir-363		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-363	miRNA	hsa-miR-363-3p	MIMAT0000707	mir-363		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-363-3p	miRNA	hsa-miR-363-3p	MIMAT0000707	mir-363	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-365	miRNA	hsa-miR-365a-3p	MIMAT0000710	mir-365		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-365a-3p	miRNA	hsa-miR-365a-3p	MIMAT0000710	mir-365	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-365b-3p	miRNA	hsa-miR-365b-3p	MIMAT0022834	mir-365	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-367*	miRNA	hsa-miR-367-5p	MIMAT0004686	mir-367	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-369-3p	miRNA	hsa-miR-369-3p	MIMAT0000721	mir-154		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-369-3p	miRNA	hsa-miR-369-3p	MIMAT0000721	mir-154		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-370	miRNA	hsa-miR-370	MIMAT0000722	mir-370		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-370	miRNA	hsa-miR-370	MIMAT0000722	mir-370		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-371	miRNA	hsa-miR-371a-3p	MIMAT0000723	mir-290		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-371-5p	miRNA	hsa-miR-371a-5p	MIMAT0004687	mir-290		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-371-5p	miRNA	hsa-miR-371a-5p	MIMAT0004687	mir-290		Homo sapiens	circulating	serum	gastric cancer (gc)	22169097	qrt-pcr	genome-wide mirna expression profiles followed with real-time quantitative rt-pcr (qrt-pcr) assays revealed that mir-187(*), mir-371-5p and mir-378 were significantly elevated in gc patients. Further validation indicated that mir-378 alone could yields a roc curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating gc patients from healthy controls.
hsa-miR-372	miRNA	hsa-miR-372	MIMAT0000724	mir-290		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-373	miRNA	hsa-miR-373-3p	MIMAT0000726	mir-373	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-373	miRNA	hsa-miR-373-3p	MIMAT0000726	mir-373		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-373	miRNA	hsa-miR-373-3p	MIMAT0000726	mir-373		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-373	miRNA	hsa-miR-373-3p	MIMAT0000726	mir-373		Homo sapiens	circulating	serum	Breast cancer	25086636	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
hsa-miR-373	miRNA	hsa-miR-373-3p	MIMAT0000726	mir-373		Homo sapiens	circulating	serum	Breast cancer	25086636	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
hsa-miR-373*	miRNA	hsa-miR-373-5p	MIMAT0000725	mir-373		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-373*	miRNA	hsa-miR-373-5p	MIMAT0000725	mir-373		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-374	miRNA	hsa-miR-374a-3p	MIMAT0004688	mir-374		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-374	miRNA	hsa-miR-374a-3p	MIMAT0004688	mir-374		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-374a	miRNA	hsa-miR-374a-5p	MIMAT0000727	mir-374		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-374a	miRNA	hsa-miR-374a-5p	MIMAT0000727	mir-374		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-374a	miRNA	hsa-miR-374a-5p	MIMAT0000727	mir-374		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-374a	miRNA	hsa-miR-374a-5p	MIMAT0000727	mir-374		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-374a	miRNA	hsa-miR-374a-5p	MIMAT0000727	mir-374		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-374a-5p	miRNA	hsa-miR-374a-5p	MIMAT0000727	mir-374		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-374a-5p	miRNA	hsa-miR-374a-5p	MIMAT0000727	mir-374	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-374b	miRNA	hsa-miR-374b-5p	MIMAT0004955	mir-374		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-374b	miRNA	hsa-miR-374b-5p	MIMAT0004955	mir-374		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-374b	miRNA	hsa-miR-374b-5p	MIMAT0004955	mir-374		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-374b	miRNA	hsa-miR-374b-5p	MIMAT0004955	mir-374		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-374b-5p	miRNA	hsa-miR-374b-5p	MIMAT0004955	mir-374		Homo sapiens	circulating	plasma	st elevation myocardial infarction (stemi)	24432306	qrt-pcr	mirnas associated with stemi as compared to nstemi patients included mir-25-3p, mir-221-3p, and mir-374b-5p. mirna 30d-5p was associated with plasma, platelets, and leukocytes in both stemi and nstemi patients; mirnas 221-3p and 483-5p were correlated with plasma and platelets only in nstemi patients.
hsa-miR-374b-5p	miRNA	hsa-miR-374b-5p	MIMAT0004955	mir-374	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-374c-3p	miRNA	hsa-miR-374c-3p	MIMAT0022735	mir-374	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	serum	prostate cancer	20473869	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	serum	Aging	25165030	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	serum	prostate cancer	22052531	qrt-pcr	four mirnas altered in mice, mmu-mir-141, mmu-mir-298, mmu-mir-346 and mmu-mir-375, were also found to be at differential levels in the serum of men with mcrpc. three of these (hsa-mir-141, hsa-mir-298 and hsa-mir-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. moreover, the intra-tumoral expression of hsa-mir-141 and hsa-mir-375 were predictors of biochemical relapse after surgery. this study is the first to demonstrate that specific serum mirnas are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	serum	Breast cancer	25137071	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	serum	prostate cancer	22887127	taqman human microrna arrays	serum samples from patients of low risk, localized prostate cancer and metastatic crpc patients exhibit distinct circulating mirna signatures. mir-375, mir-378*, and mir-141 were significantly over-expressed in serum from crpc patients compared with serum from low-risk localized patients, while mir-409-3p was significantly under-expressed. in prostate primary tumor samples, mir-375 and mir-141 also had significantly higher expression levels compared with those in normal prostate tissue.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	plasma	metastatic breast cancer (mbc)	22952344	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	circulating	plasma	solitary pulmonary nodules (spns)	21864403	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-375	miRNA	hsa-miR-375	MIMAT0000728	mir-375		Homo sapiens	exosome	urine	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-375-3p	miRNA	hsa-miR-375	MIMAT0000728	mir-375	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-376a	miRNA	hsa-miR-376a-3p	MIMAT0000729	mir-368		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-376a	miRNA	hsa-miR-376a-3p	MIMAT0000729	mir-368		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-376a	miRNA	hsa-miR-376a-3p	MIMAT0000729	mir-368		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-376a	miRNA	hsa-miR-376a-3p	MIMAT0000729	mir-368		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-376a	miRNA	hsa-miR-376a-3p	MIMAT0000729	mir-368		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-376a	miRNA	hsa-miR-376a-3p	MIMAT0000729	mir-368		Homo sapiens	circulating	serum	type 2 diabetes	24204780	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
hsa-miR-376a	miRNA	hsa-miR-376a-3p	MIMAT0000729	mir-368		Homo sapiens	circulating	serum	obesity	24204780	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
hsa-miR-376a	miRNA	hsa-miR-376a-3p	MIMAT0000729	mir-368		Homo sapiens	circulating	plasma	Breast cancer	24194846	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
hsa-miR-376a	miRNA	hsa-miR-376a-3p	MIMAT0000729	mir-368		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-376b	miRNA	hsa-miR-376b	MIMAT0002172	mir-368		Homo sapiens	circulating	amniotic fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-376c	miRNA	hsa-miR-376c	MIMAT0000720	mir-368		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-376c	miRNA	hsa-miR-376c	MIMAT0000720	mir-368		Homo sapiens	circulating	plasma	Breast cancer	22927033	taqman low-density array qrt-pcr	four mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) were shown to be significantly upregulated in the plasma of breast cancer patients. roc curve analysis showed that the combination of only three mirnas (mir-148b, mir-409-3p and mir-801) had an equal discriminatory power between breast cancer cases and healthy controls as all four mirnas together (auc = 0.69). in conclusion, the identified mirnas might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer.
hsa-miR-376c	miRNA	hsa-miR-376c	MIMAT0000720	mir-368		Homo sapiens	circulating	plasma	Breast cancer	24194846	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
hsa-miR-376c-3p	miRNA	hsa-miR-376c-3p	MIMAT0000720	mir-368		Homo sapiens	circulating	serum	primary progressive multiple sclerosis (ppms) 	27246141	miscript mirna techniques	in comparison with controls, upregulation of mir-191-5p was found in both progressive ms subtypes, while mir-376c-3p was overexpressed only in ppms. additionally, upregulation of mir-128-3p and mir-24-3p was detected in ppms when compared to controls and spms. progression index correlated with mir-128-3p in ppms and mir-375 in spms.
hsa-miR-378	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-378	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-378	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-378	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-378	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-378	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378		Homo sapiens	circulating	serum	gastric cancer (gc)	22169097	qrt-pcr	genome-wide mirna expression profiles followed with real-time quantitative rt-pcr (qrt-pcr) assays revealed that mir-187(*), mir-371-5p and mir-378 were significantly elevated in gc patients. Further validation indicated that mir-378 alone could yields a roc curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating gc patients from healthy controls.
hsa-miR-378	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-378*	miRNA	hsa-miR-378a-5p	MIMAT0000731	mir-378		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-378*	miRNA	hsa-miR-378a-5p	MIMAT0000731	mir-378		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-378*	miRNA	hsa-miR-378a-5p	MIMAT0000731	mir-378		Homo sapiens	circulating	serum	prostate cancer	22887127	taqman human microrna arrays	serum samples from patients of low risk, localized prostate cancer and metastatic crpc patients exhibit distinct circulating mirna signatures. mir-375, mir-378*, and mir-141 were significantly over-expressed in serum from crpc patients compared with serum from low-risk localized patients, while mir-409-3p was significantly under-expressed. in prostate primary tumor samples, mir-375 and mir-141 also had significantly higher expression levels compared with those in normal prostate tissue.
hsa-miR-378*	miRNA	hsa-miR-378a-5p	MIMAT0000731	mir-378		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-378*	miRNA	hsa-miR-378a-5p	MIMAT0000731	mir-378		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-378*	miRNA	hsa-miR-378a-5p	MIMAT0000731	mir-378		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-378a-3p	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-378c	miRNA	hsa-miR-378c	MIMAT0016847	mir-378	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-379	miRNA	hsa-miR-379-5p	MIMAT0000733	mir-379		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-379	miRNA	hsa-miR-379-5p	MIMAT0000733	mir-379		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt-pcr microarray|taqman human mir assays(life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-379	miRNA	hsa-miR-379-5p	MIMAT0000733	mir-379		Homo sapiens	circulating	cell lysates	Dysfunctional lipid homeostasis	25510864	taqman real-time pcr microrna array	authors demonstrated that hepatic mir-379 levels were correlated with glucocorticoid (gc) and triglyceride (tg) levels in human obese patients. the identification of a gc/gr(glucocorticoid receptor)-controlled mirna cluster not only defines a novel layer of hormone-dependent metabolic control but also paves the way to alternative mirna-based therapeutic approaches in metabolic dysfunction.
hsa-miR-379*	miRNA	hsa-miR-379-3p	MIMAT0004690	mir-379	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-379*	miRNA	hsa-miR-379-3p	MIMAT0004690	mir-379		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-379-5p	miRNA	hsa-miR-379-5p	MIMAT0000733	mir-379		Homo sapiens	circulating	plasma	ventricular septal defect (vsd)	25165856	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
hsa-miR-380*	miRNA	hsa-miR-380-5p	MIMAT0000734	mir-379		Homo sapiens	circulating	seminal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-381	miRNA	hsa-miR-381	MIMAT0000736	mir-154		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-381	miRNA	hsa-miR-381	MIMAT0000736	mir-154		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-382	miRNA	hsa-miR-382-5p	MIMAT0000737	mir-154		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-382	miRNA	hsa-miR-382-5p	MIMAT0000737	mir-154	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-382	miRNA	hsa-miR-382-5p	MIMAT0000737	mir-154		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-382	miRNA	hsa-miR-382-5p	MIMAT0000737	mir-154		Homo sapiens	circulating	plasma	mild cognitive impairment (mci)	24368295	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
hsa-miR-382	miRNA	hsa-miR-382-5p	MIMAT0000737	mir-154		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-382	miRNA	hsa-miR-382-5p	MIMAT0000737	mir-154		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-383	miRNA	hsa-miR-383-5p	MIMAT0000738	mir-383		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-383	miRNA	hsa-miR-383-5p	MIMAT0000738	mir-383	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-409-3p	miRNA	hsa-miR-409-3p	MIMAT0001639	mir-154		Homo sapiens	circulating	plasma	ventricular septal defect (vsd)	25165856	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
hsa-miR-409-3p	miRNA	hsa-miR-409-3p	MIMAT0001639	mir-154		Homo sapiens	circulating	serum	prostate cancer	22887127	taqman human microrna arrays	serum samples from patients of low risk, localized prostate cancer and metastatic crpc patients exhibit distinct circulating mirna signatures. mir-375, mir-378*, and mir-141 were significantly over-expressed in serum from crpc patients compared with serum from low-risk localized patients, while mir-409-3p was significantly under-expressed. in prostate primary tumor samples, mir-375 and mir-141 also had significantly higher expression levels compared with those in normal prostate tissue.
hsa-miR-409-3p	miRNA	hsa-miR-409-3p	MIMAT0001639	mir-154		Homo sapiens	circulating	plasma	Breast cancer	22927033	taqman low-density array qrt-pcr	four mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) were shown to be significantly upregulated in the plasma of breast cancer patients. roc curve analysis showed that the combination of only three mirnas (mir-148b, mir-409-3p and mir-801) had an equal discriminatory power between breast cancer cases and healthy controls as all four mirnas together (auc = 0.69). in conclusion, the identified mirnas might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer.
hsa-miR-409-3p	miRNA	hsa-miR-409-3p	MIMAT0001639	mir-154		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-409-3p	miRNA	hsa-miR-409-3p	MIMAT0001639	mir-154		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-409-3p	miRNA	hsa-miR-409-3p	MIMAT0001639	mir-154		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-409-3p	miRNA	hsa-miR-409-3p	MIMAT0001639	mir-154		Homo sapiens	circulating	plasma	Breast cancer	24194846	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
hsa-miR-410	miRNA	hsa-miR-410-3p	MIMAT0002171	mir-154		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-410	miRNA	hsa-miR-410-3p	MIMAT0002171	mir-154		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-410	miRNA	hsa-miR-410-3p	MIMAT0002171	mir-154	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-411	miRNA	hsa-miR-411-5p	MIMAT0003329	mir-379		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-411	miRNA	hsa-miR-411-5p	MIMAT0003329	mir-379		Homo sapiens	circulating	serum	Breast cancer	22353773	mirvana mirna isolation kit (ambion, austin, tx, usa)|microrna isolation kit (biochain institute inc, hayward, ca, usa)|nanodrop nd1000 (nanodrop technologies, waltham, ma, usa)|taqman microrna reverse transcription kit (applied biosystems)|qrt-pcr	mirna expression in cancerous samples tends to be repressed when compared with mirna expression in healthy controls (p = 0.0685). The four most discriminating mirnas by fold-change (mir-215, mir-299-5p, mir-411, and mir-452) were selected for further analysis on serum samples. All mirnas at least tended to be differentially expressed between serum samples from patients with cancer and serum samples from healthy controls 
hsa-miR-412	miRNA	hsa-miR-412	MIMAT0002170	mir-412		Homo sapiens	circulating	plasma	Acetaminophen-induced acute liver injury (APAP-ALI)	25092309	real-time pcr	authors suggest that mirnas can serve as sensitive diagnostic and prognostic clinical tools for severe liver injury and could be useful for monitoring drug-induced liver injury during drug discovery.
hsa-miR-421	miRNA	hsa-miR-421	MIMAT0003339	mir-95		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-421	miRNA	hsa-miR-421	MIMAT0003339	mir-95	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-422a	miRNA	hsa-miR-422a	MIMAT0001339	mir-422		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-422a	miRNA	hsa-miR-422a	MIMAT0001339	mir-422		Homo sapiens	circulating	blood	Acute stroke	24447930	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
hsa-miR-422a	miRNA	hsa-miR-422a	MIMAT0001339	mir-422		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-422a	miRNA	hsa-miR-422a	MIMAT0001339	mir-422		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-422a	miRNA	hsa-miR-422a	MIMAT0001339	mir-422		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-422a	miRNA	hsa-miR-422a	MIMAT0001339	mir-422		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-422a	miRNA	hsa-miR-422a	MIMAT0001339	mir-422		Homo sapiens	circulating	plasma	Multiple sclerosis (MS)	22231906	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
hsa-miR-422b	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-422b	miRNA	hsa-miR-378a-3p	MIMAT0000732	mir-378		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-423	miRNA	hsa-miR-423-3p	MIMAT0001340	mir-423		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-423	miRNA	hsa-miR-423-3p	MIMAT0001340	mir-423	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-423	miRNA	hsa-miR-423-3p	MIMAT0001340	mir-423		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-423	miRNA	hsa-miR-423-3p	MIMAT0001340	mir-423		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-423-3p	miRNA	hsa-miR-423-3p	MIMAT0001340	mir-423		Homo sapiens	circulating	plasma	prostate cancer	23574937	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
hsa-miR-423-3p	miRNA	hsa-miR-423-3p	MIMAT0001340	mir-423	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-423-3p	miRNA	hsa-miR-423-3p	MIMAT0001340	mir-423		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-423-5p	miRNA	hsa-miR-423-5p	MIMAT0004748	mir-423		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-423-5p	miRNA	hsa-miR-423-5p	MIMAT0004748	mir-423		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-423-5p	miRNA	hsa-miR-423-5p	MIMAT0004748	mir-423		Homo sapiens	circulating	plasma	Acute myocardial infarction (ami)	24253456	taqman microrna assays	authors demonstrate that in acute myocardial infarction the expression of mir-423-5p in plasma is significantly increased with subsequent normalization within 6 hours. potentially it is an early marker of myocardial necrosis.
hsa-miR-423-5p	miRNA	hsa-miR-423-5p	MIMAT0004748	mir-423	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-423-5p	miRNA	hsa-miR-423-5p	MIMAT0004748	mir-423		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-423-5p	miRNA	hsa-miR-423-5p	MIMAT0004748	mir-423		Homo sapiens	circulating	plasma	systemic right ventricle and reduced ejection fraction	22188991	quantitative reverse transcription pcr|master pure rna purification kit (epicentre biotechnologies)|iscript select cdna synthesis kit (bio-rad)|mirna-specific stem loop primers (applied biosystems)	levels of circulating mir-423-5p showed no difference between patients and controls. Further, there was no correlation between mir-423-5p and parameters of cardiopulmonary exercise testing or imaging findings. In patients with a systemic right ventricle and reduced ejection fraction mir-423-5p levels are not elevated. Therefore, circulating mir-423-5p is not a useful biomarker for heart failure in this patient group.
hsa-miR-423-5p	miRNA	hsa-miR-423-5p	MIMAT0004748	mir-423		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-424	miRNA	hsa-miR-424-5p	MIMAT0001341	mir-322		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-424	miRNA	hsa-miR-424-5p	MIMAT0001341	mir-322		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-424	miRNA	hsa-miR-424-5p	MIMAT0001341	mir-322		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-424	miRNA	hsa-miR-424-5p	MIMAT0001341	mir-322		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-424	miRNA	hsa-miR-424-5p	MIMAT0001341	mir-322		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-424	miRNA	hsa-miR-424-5p	MIMAT0001341	mir-322		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-424*	miRNA	hsa-miR-424-3p	MIMAT0004749	mir-322		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-424*	miRNA	hsa-miR-424-3p	MIMAT0004749	mir-322		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-424-5p	miRNA	hsa-miR-424-5p	MIMAT0001341	mir-322		Homo sapiens	circulating	serum	neovascular age-related macular degeneration	25203061	qrt-pcr	this is the first study to evaluate the relative abundance of cmirnas in the serum of late stage amd patients. authors identified three cmirnas (hsa-mir-301a-3p, hsa-mir-361-5p, and hsa-mir-424-5p) which were significantly altered in nv amd patients compared to amd-free controls.
hsa-miR-424-5p	miRNA	hsa-miR-424-5p	MIMAT0001341	mir-322	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-424-5p	miRNA	hsa-miR-424-5p	MIMAT0001341	mir-322		Homo sapiens	circulating	plasma	deep-vein thrombosis (dvt)	27197074	qrt-pcr	the plasma level of mir-424-5p (p=0.01) were significantly higher, whereas the levels of mir-136-5p (p=0.03) were significantly lower in dvt patients compared to patients without dvt.
hsa-miR-425	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-425	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-425	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-425	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-425	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-425	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-425*	miRNA	hsa-miR-425-3p	MIMAT0001343	mir-425		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-425*	miRNA	hsa-miR-425-3p	MIMAT0001343	mir-425		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-425*	miRNA	hsa-miR-425-3p	MIMAT0001343	mir-425		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-425*	miRNA	hsa-miR-425-3p	MIMAT0001343	mir-425		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-425-3p	miRNA	hsa-miR-425-3p	MIMAT0001343	mir-425		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-425-3p	miRNA	hsa-miR-425-3p	MIMAT0001343	mir-425		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-425-5p	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-425-5p	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-425-5p	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-425-5p	miRNA	hsa-miR-425-5p	MIMAT0003393	mir-425		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-4286	miRNA	hsa-miR-4286	MIMAT0016916			Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-429	miRNA	hsa-miR-429	MIMAT0001536	mir-8		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-429	miRNA	hsa-miR-429	MIMAT0001536	mir-8		Homo sapiens	circulating	serum	Biliary atresia (BA)	22732895	microfluidic array platform	In this study authors examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia.The miR-200b/429 cluster was significantly increased in the sera of BA patients and has promising diagnostic clinical performance.
hsa-miR-429	miRNA	hsa-miR-429	MIMAT0001536	mir-8	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-429	miRNA	hsa-miR-429	MIMAT0001536	mir-8		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-429	miRNA	hsa-miR-429	MIMAT0001536	mir-8		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-429	miRNA	hsa-miR-429	MIMAT0001536	mir-8		Homo sapiens	circulating	serum	systemic lupus erythematosus (sle)	21372198		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
hsa-miR-431	miRNA	hsa-miR-431-5p	MIMAT0001625	mir-431		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-431*	miRNA	hsa-miR-431-3p	MIMAT0004757	mir-431		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-431*	miRNA	hsa-miR-431-3p	MIMAT0004757	mir-431		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-431*	miRNA	hsa-miR-431-3p	MIMAT0004757	mir-431		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-432	miRNA	hsa-miR-432-5p	MIMAT0002814	mir-432		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-432	miRNA	hsa-miR-432-5p	MIMAT0002814	mir-432		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-432	miRNA	hsa-miR-432-5p	MIMAT0002814	mir-432		Homo sapiens	microvesicle	blood	hepatocellular carcinoma (hcc)	24592541	agilent mirna microarry	mirnas were differentially expressed in hcc-mvs compared with chb and normal controls. aberrant hcc-mvs mirnas may play important roles in the development of hcc.
hsa-miR-432	miRNA	hsa-miR-432-5p	MIMAT0002814	mir-432		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-433	miRNA	hsa-miR-433-3p	MIMAT0001627	mir-433	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-433	miRNA	hsa-miR-433	MIMAT0001627	mir-433		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-433	miRNA	hsa-miR-433	MIMAT0001627	mir-433		Homo sapiens	circulating	plasma	ventricular septal defect (vsd)	25165856	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
hsa-miR-433	miRNA	hsa-miR-433	MIMAT0001627	mir-433		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-4497	miRNA	hsa-miR-4497	MIMAT0019032	NULL	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-449a	miRNA	hsa-miR-449a	MIMAT0001541	mir-449		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-450a	miRNA	hsa-miR-450a-5p	MIMAT0001545	mir-450		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-450a	miRNA	hsa-miR-450a-5p	MIMAT0001545	mir-450		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-450b-5p	miRNA	hsa-miR-450b-5p	MIMAT0004909	mir-450		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	plasma	gastric cancer (gc)	24595006	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	plasma	pregnancy	21806976	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	serum	multiple myeloma (mm)	23169280	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-451	miRNA	hsa-miR-451a	MIMAT0001631	mir-451		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-452	miRNA	hsa-miR-452-5p	MIMAT0001635	mir-452	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-452	miRNA	hsa-miR-452-5p	MIMAT0001635	mir-452		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-452	miRNA	hsa-miR-452-5p	MIMAT0001635	mir-452		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-452	miRNA	hsa-miR-452-5p	MIMAT0001635	mir-452		Homo sapiens	circulating	serum	Breast cancer	22353773	mirvana mirna isolation kit (ambion, austin, tx, usa)|microrna isolation kit (biochain institute inc, hayward, ca, usa)|nanodrop nd1000 (nanodrop technologies, waltham, ma, usa)|taqman microrna reverse transcription kit (applied biosystems)|qrt-pcr	mirna expression in cancerous samples tends to be repressed when compared with mirna expression in healthy controls (p = 0.0685). The four most discriminating mirnas by fold-change (mir-215, mir-299-5p, mir-411, and mir-452) were selected for further analysis on serum samples. All mirnas at least tended to be differentially expressed between serum samples from patients with cancer and serum samples from healthy controls 
hsa-miR-453	miRNA	hsa-miR-323b-5p	MIMAT0001630	mir-154		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-453	miRNA	hsa-miR-323b-5p	MIMAT0001630	mir-154		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-454	miRNA	hsa-miR-454-3p	MIMAT0003885	mir-454	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-454	miRNA	hsa-miR-454-3p	MIMAT0003885	mir-454		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-454	miRNA	hsa-miR-454-3p	MIMAT0003885	mir-454		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-454	miRNA	hsa-miR-454-3p	MIMAT0003885	mir-454		Homo sapiens	circulating	serum	osteoarthritis (oa)	24515954	real-time pcr	this is the first study that identifies differentially expressed circulating micrornas in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. among these micrornas, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.
hsa-miR-454-3p	miRNA	hsa-miR-454-3p	MIMAT0003885	mir-454		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-454-3p	miRNA	hsa-miR-454-3p	MIMAT0003885	mir-454		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-454-3p	miRNA	hsa-miR-454-3p	MIMAT0003885	mir-454	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-454-5p	miRNA	hsa-miR-454-5p	MIMAT0003884	mir-454		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-455-3p	miRNA	hsa-miR-455-3p	MIMAT0004784	mir-455	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-4763-5p	miRNA	hsa-miR-4763-5p	MIMAT0019912	mir-4763		Homo sapiens	exosome	plasma	sickle cell anemia (sca)	27161653	qrt-pcr	circulating exosomal micrornas may play important roles in predicting the clinical course of sca, and in delineation of individually tailored, mechanistically-based clinical treatment approaches of sca patients in the near future.
hsa-miR-483	miRNA	hsa-miR-483-3p	MIMAT0002173	mir-483		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-483-3p	miRNA	hsa-miR-483-3p	MIMAT0002173	mir-483	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-483-3p	miRNA	hsa-miR-483-3p	MIMAT0002173	mir-483		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483		Homo sapiens	circulating	plasma	stable angina (sa) 	24260372	taqman microrna array	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-483-5p	miRNA	hsa-miR-483-5p	MIMAT0004761	mir-483		Homo sapiens	circulating	plasma	hepatocellular carcinoma (hcc)	24127413	qrt-pcr	mir-483-5p was statistically significantly over-expressed in hcc cases compared with controls (3.20 vs. 0.82, p<0.0001). hcc risk factors and clinic-pathological characteristics did not influence mir-483-5p expression.
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-484	miRNA	hsa-miR-484	MIMAT0002174	mir-484		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-485-3p	miRNA	hsa-miR-485-3p	MIMAT0002176	mir-485		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-485-3p	miRNA	hsa-miR-485-3p	MIMAT0002176	mir-485		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-485-3p	miRNA	hsa-miR-485-3p	MIMAT0002176	mir-485		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-485-3p	miRNA	hsa-miR-485-3p	MIMAT0002176	mir-485		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-485-3p	miRNA	hsa-miR-485-3p	MIMAT0002176	mir-485		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-485-5p	miRNA	hsa-miR-485-5p	MIMAT0002175	mir-485		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-485-5p	miRNA	hsa-miR-485-5p	MIMAT0002175	mir-485		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-486	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-486	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	serum	Breast cancer	24980554	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	authors report that circulating levels of the muscle-enriched mir486 is lower in patients with breast cancer compared with healthy individuals.
hsa-miR-486	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-486	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-486	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-486	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	plasma	type 2 diabetes	20651284	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
hsa-miR-486-3p	miRNA	hsa-miR-486-3p	MIMAT0004762	mir-486		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	plasma	gastric cancer (gc)	24595006	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	plasma	solitary pulmonary nodules (spns)	21864403	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	plasma	mercury exposure	27162656	rt-pcr	plasma mir-92a-3p and mir-486-5p might prove to be potential biomarkers to indicate responses to mercury exposure. however, further studies are necessary to prove the causal association between mirnas changes and mercury exposure, and to determine whether these two mirnas are clear biomarkers to mercury exposure.
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-486-5p	miRNA	hsa-miR-486-5p	MIMAT0002177	mir-486		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-487b	miRNA	hsa-miR-487b	MIMAT0003180	mir-154		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-487b	miRNA	hsa-miR-487b	MIMAT0003180	mir-154		Homo sapiens	circulating	plasma	ventricular septal defect (vsd)	25165856	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
hsa-miR-487b	miRNA	hsa-miR-487b	MIMAT0003180	mir-154		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-487b	miRNA	hsa-miR-487b	MIMAT0003180	mir-154		Homo sapiens	circulating	serum	pertussis	23073777	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
hsa-miR-487b	miRNA	hsa-miR-487b	MIMAT0003180	mir-154		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-488	miRNA	hsa-miR-488-3p	MIMAT0004763	mir-488		Homo sapiens	circulating	blood	Acute stroke	24447930	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
hsa-miR-488	miRNA	hsa-miR-488-3p	MIMAT0004763	mir-488	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-489	miRNA	hsa-miR-489-3p	MIMAT0002805	mir-489		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-489	miRNA	hsa-miR-489-3p	MIMAT0002805	mir-489		Homo sapiens	HDL	plasma	familial hypercholesterolemia	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-489	miRNA	hsa-miR-489-3p	MIMAT0002805	mir-489	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-489	miRNA	hsa-miR-489-3p	MIMAT0002805	mir-489		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-490-3p	miRNA	hsa-miR-490-3p	MIMAT0002806	mir-490		Homo sapiens	circulating	plasma	Coronary stenosis	24358814	mirvana paris kit (ambion, austin, tx)|high-throughput biomark real-time pcr system (fluidigm, south san francisco, ca)	authors demonstrate that specific mirnas from circulating plasma are associated with the presence of significant coronary disease.
hsa-miR-490-5p	miRNA	hsa-miR-490-5p	MIMAT0004764	mir-490		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-491	miRNA	hsa-miR-491-5p	MIMAT0002807	mir-491		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-491-3p	miRNA	hsa-miR-491-3p	MIMAT0004765	mir-491		Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-491-5p	miRNA	hsa-miR-491-5p	MIMAT0002807	mir-491		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-492	miRNA	hsa-miR-492	MIMAT0002812	mir-492		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-492	miRNA	hsa-miR-492	MIMAT0002812	mir-492		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-493	miRNA	hsa-miR-493-3p	MIMAT0003161	mir-493		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-494	miRNA	hsa-miR-494	MIMAT0002816	mir-154		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-494	miRNA	hsa-miR-494	MIMAT0002816	mir-154		Homo sapiens	circulating	plasma	Coronary stenosis	24358814	mirvana paris kit (ambion, austin, tx)|high-throughput biomark real-time pcr system (fluidigm, south san francisco, ca)	authors demonstrate that specific mirnas from circulating plasma are associated with the presence of significant coronary disease.
hsa-miR-494	miRNA	hsa-miR-494	MIMAT0002816	mir-154		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-494	miRNA	hsa-miR-494	MIMAT0002816	mir-154		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-494	miRNA	hsa-miR-494	MIMAT0002816	mir-154		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-494	miRNA	hsa-miR-494	MIMAT0002816	mir-154		Homo sapiens	circulating	plasma	hodgkin lymphoma (chl)	24222179	qrt-pcr	levels of mir-494, mir-1973 and mir-21 were higher in patients than control (n=20) plasma (p=0.004, p=0.007, p<0.0001, respectively).
hsa-miR-495	miRNA	hsa-miR-495	MIMAT0002817	mir-329		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-495	miRNA	hsa-miR-495	MIMAT0002817	mir-329		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-495	miRNA	hsa-miR-495	MIMAT0002817	mir-329		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-497	miRNA	hsa-miR-497-5p	MIMAT0002820	mir-497		Homo sapiens	circulating	serum	malignant astrocytomas	22674182	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
hsa-miR-497	miRNA	hsa-miR-497-5p	MIMAT0002820	mir-497		Homo sapiens	circulating	plasma	Acute myocardial infarction (ami)	25110754	qrt-pcr	circulating mir-497 might be a promising biomarker for ami identification and there was high association between human mir-497 and acute myocardial infarction.
hsa-miR-497	miRNA	hsa-miR-497-5p	MIMAT0002820	mir-497		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-498	miRNA	hsa-miR-498	MIMAT0002824	mir-498		Homo sapiens	circulating	plasma	ventricular septal defect (vsd)	25165856	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
hsa-miR-498	miRNA	hsa-miR-498	MIMAT0002824	mir-498		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-498	miRNA	hsa-miR-498	MIMAT0002824	mir-498		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-498	miRNA	hsa-miR-498	MIMAT0002824	mir-498		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-499	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	serum	Acute myocardial infarction (ami)	24482699	qrt-pcr	serum mir-499 and mir-208a might be potential biomarkers for ami. mir-499 might be released from damaged heart to the circulation.
hsa-miR-499	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	plasma	Acute heart failure	20921333	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
hsa-miR-499	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	plasma	Acute myocardial infarction (ami)	20921333	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
hsa-miR-499	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	plasma	Acute viral myocarditis (vm)	20921333	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
hsa-miR-499	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	plasma	Diastolic dysfunction	20921333	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
hsa-miR-499	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	plasma	troponin-positive acute coronary syndrome	21969012	taqman polymerase chain reaction in edta-plasma 	circulating levels of the muscle-enriched mir-499, mir-133a, and mir-208a were significantly elevated in the aorta of troponin-positive acute coronary syndrome patients compared with patients with coronary artery disease. In contrast, circulating levels of mir-126 decreased during transcoronary passage in patients with evidence of myocardial injury, suggesting consumption during transcoronary passage.
hsa-miR-499-3p	miRNA	hsa-miR-499a-3p	MIMAT0004772	mir-499		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-499-5p	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	plasma	perioperative myocardial infarction (pmi)	25111390	real-time quantitative rt-pcr	the data analysis revealed that mir-499 had higher sensitivity and specificity than ctni, and indicated that mir-499 could be an independent risk factor for pmi.
hsa-miR-499-5p	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	plasma	st elevation myocardial infarction (stemi)	21701171	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
hsa-miR-499-5p	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	urine	st elevation myocardial infarction (stemi)	21701171	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
hsa-miR-499-5p	miRNA	hsa-miR-499a-5p	MIMAT0002870	mir-499		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-500	miRNA	hsa-miR-500a-5p	MIMAT0004773	mir-500		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-500	miRNA	hsa-miR-500a-5p	MIMAT0004773	mir-500		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-500*	miRNA	hsa-miR-500a-3p	MIMAT0002871	mir-500		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-500*	miRNA	hsa-miR-500a-3p	MIMAT0002871	mir-500		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-500a*	miRNA	hsa-miR-500a-3p	MIMAT0002871	mir-500		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-500a-3p	miRNA	hsa-miR-500a-3p	MIMAT0002871	mir-500	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-500a-5p	miRNA	hsa-miR-500a-5p	MIMAT0004773	mir-500	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-501	miRNA	hsa-miR-501-5p	MIMAT0002872	mir-500	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-501-3p	miRNA	hsa-miR-501-3p	MIMAT0004774	mir-500		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-501-3p	miRNA	hsa-miR-501-3p	MIMAT0004774	mir-500		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-501-3p	miRNA	hsa-miR-501-3p	MIMAT0004774	mir-500	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-501-5p	miRNA	hsa-miR-501-5p	MIMAT0002872	mir-500	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-501-5p	miRNA	hsa-miR-501-5p	MIMAT0002872	mir-500		Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-502	miRNA	hsa-miR-502-5p	MIMAT0002873	mir-500		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-502-3p	miRNA	hsa-miR-502-3p	MIMAT0004775	mir-500		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-502-3p	miRNA	hsa-miR-502-3p	MIMAT0004775	mir-500		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-502-3p	miRNA	hsa-miR-502-3p	MIMAT0004775	mir-500	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-502-5p	miRNA	hsa-miR-502-5p	MIMAT0002873	mir-500		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-502-5p	miRNA	hsa-miR-502-5p	MIMAT0002873	mir-500		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-503	miRNA	hsa-miR-503	MIMAT0002874	mir-503		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-503	miRNA	hsa-miR-503	MIMAT0002874	mir-503		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-503-5p	miRNA	hsa-miR-503-5p	MIMAT0002874	mir-503	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-505	miRNA	hsa-miR-505-3p	MIMAT0002876	mir-505		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-505	miRNA	hsa-miR-505-3p	MIMAT0002876	mir-505		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-505	miRNA	hsa-miR-505-3p	MIMAT0002876	mir-505		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-505	miRNA	hsa-miR-505-3p	MIMAT0002876	mir-505		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-505	miRNA	hsa-miR-505-3p	MIMAT0002876	mir-505		Homo sapiens	circulating	blood	hypertension	25449503	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	authors showed that hsa-mir-505 is a novel circulating signature of hypertension, which may play a role in angiogenesis.
hsa-miR-505*	miRNA	hsa-miR-505-5p	MIMAT0004776	mir-505		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-508-3p	miRNA	hsa-miR-508-3p	MIMAT0002880	mir-506		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-508-5p	miRNA	hsa-miR-508-5p	MIMAT0004778	mir-506		Homo sapiens	circulating	seminal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-510	miRNA	hsa-miR-510	MIMAT0002882	mir-506		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-510	miRNA	hsa-miR-510	MIMAT0002882	mir-506		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-511	miRNA	hsa-miR-511	MIMAT0002808	mir-506		Homo sapiens	circulating	serum	Combined pituitary hormone deficiency (cphd)	25434367	rt-qpcr	authors demonstrated that the levels of mir-593 and mir-511, whose direct target is the prop1 gene, may serve as a non-invasive diagnostic biomarkers for children with combined pituitary hormone deficiency (cphd).
hsa-miR-512-3p	miRNA	hsa-miR-512-3p	MIMAT0002823	mir-506		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-512-3p	miRNA	hsa-miR-512-3p	MIMAT0002823	mir-506		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-513	miRNA	hsa-miR-513a-5p	MIMAT0002877	mir-506		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-513-3p	miRNA	hsa-miR-513a-3p	MIMAT0004777	mir-506		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-513a-3p	miRNA	hsa-miR-513a-3p	MIMAT0004777	mir-506		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-513a-3p	miRNA	hsa-miR-513a-3p	MIMAT0004777	mir-506		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-513a-5p	miRNA	hsa-miR-513a-5p	MIMAT0002877	mir-506		Homo sapiens	circulating	colostrum	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-513a-5p	miRNA	hsa-miR-513a-5p	MIMAT0002877	mir-506		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-513a-5p	miRNA	hsa-miR-513a-5p	MIMAT0002877	mir-506		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-513a-5p	miRNA	hsa-miR-513a-5p	MIMAT0002877	mir-506		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-513b	miRNA	hsa-miR-513b	MIMAT0005788	mir-506		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-513b	miRNA	hsa-miR-513b	MIMAT0005788	mir-506		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-513c	miRNA	hsa-miR-513c-5p	MIMAT0005789	mir-506		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-513c	miRNA	hsa-miR-513c-5p	MIMAT0005789	mir-506		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-515-5p	miRNA	hsa-miR-515-5p	MIMAT0002826	mir-515	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-515-5p	miRNA	hsa-miR-515-5p	MIMAT0002826	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-516a-3p	miRNA	hsa-miR-516a-3p	MIMAT0006778	mir-515		Homo sapiens	circulating	serum	prostate cancer	20473869	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
hsa-miR-516b	miRNA	hsa-miR-516b-5p	MIMAT0002859	mir-515		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-516b*	miRNA	hsa-miR-516b-3p	MIMAT0002860	mir-515		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-517*	miRNA	hsa-miR-517-5p	MIMAT0002851	mir-515		Homo sapiens	circulating	plasma	preeclampsia	24347821	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	authors demonstrate that the upregulation of mir-516-5p, mir-517*, mir-520a*, mir-525, and mir-526a is a characteristic phenomenon of established preeclampsia.
hsa-miR-517*	miRNA	hsa-miR-517-5p	MIMAT0002851	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-517a	miRNA	hsa-miR-517a-3p	MIMAT0002852	mir-515		Homo sapiens	circulating	serum	ectopic pregnancy (ep)	22395025	taqman real-time pcr	the serum concentrations of mirnas mir-323-3p, mir-517a, mir-519d, and mir-525-3p were measured with taqman real-time pcr. Pregnancy-associated mirnas, especially mir-323-3p, added significant diagnostic accuracy to a panel including hcg and progesterone for the diagnosis of ep.
hsa-miR-517b	miRNA	hsa-miR-517b-3p	MIMAT0002857	mir-515		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-517c	miRNA	hsa-miR-517c-3p	MIMAT0002866	mir-515		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-517c	miRNA	hsa-miR-517c-3p	MIMAT0002866	mir-515		Homo sapiens	circulating	plasma	pregnancy	21806976	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
hsa-miR-517c	miRNA	hsa-miR-517c-3p	MIMAT0002866	mir-515		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-517c	miRNA	hsa-miR-517c-3p	MIMAT0002866	mir-515		Homo sapiens	circulating	plasma	placental abruption	27297699	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	the circulating level of cell-free mir-517c in maternal plasma was increased as a consequence of placental abruption and may be a potential biomedical marker for placental abruption.
hsa-miR-518a-3p	miRNA	hsa-miR-518a-3p	MIMAT0002863	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-518b	miRNA	hsa-miR-518b	MIMAT0002844	mir-515		Homo sapiens	circulating	plasma	gestational hypertension	25502889	real-time pcr	authors demonstrated that mir-518b, particularly in combination with extracellular mir-520h, is associated with a risk of later development of gestational hypertension. 
hsa-miR-518c*	miRNA	hsa-miR-518c-5p	MIMAT0002847	mir-515		Homo sapiens	circulating	breast milk	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-518c*	miRNA	hsa-miR-518c-5p	MIMAT0002847	mir-515		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-518c*	miRNA	hsa-miR-518c-5p	MIMAT0002847	mir-515		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-518d	miRNA	hsa-miR-518d-3p	MIMAT0002864	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-518d-3p	miRNA	hsa-miR-518d-3p	MIMAT0002864	mir-515		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-518e	miRNA	hsa-miR-518e-3p	MIMAT0002861	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-518e	miRNA	hsa-miR-518e-3p	MIMAT0002861	mir-515		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-518e*	miRNA	hsa-miR-518e-5p	MIMAT0005450	mir-515		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-518f	miRNA	hsa-miR-518f-3p	MIMAT0002842	mir-515		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-518f	miRNA	hsa-miR-518f-3p	MIMAT0002842	mir-515		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-518f	miRNA	hsa-miR-518f-3p	MIMAT0002842	mir-515		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-518f*	miRNA	hsa-miR-518f-5p	MIMAT0002841	mir-515		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-519a	miRNA	hsa-miR-519a-3p	MIMAT0002869	mir-515		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-519b	miRNA	hsa-miR-519b-3p	MIMAT0002837	mir-515		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-519d	miRNA	hsa-miR-519d	MIMAT0002853	mir-515		Homo sapiens	circulating	serum	ectopic pregnancy (ep)	22395025	taqman real-time pcr	the serum concentrations of mirnas mir-323-3p, mir-517a, mir-519d, and mir-525-3p were measured with taqman real-time pcr. Pregnancy-associated mirnas, especially mir-323-3p, added significant diagnostic accuracy to a panel including hcg and progesterone for the diagnosis of ep.
hsa-miR-519d	miRNA	hsa-miR-519d	MIMAT0002853	mir-515		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-519d	miRNA	hsa-miR-519d	MIMAT0002853	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-519d	miRNA	hsa-miR-519d	MIMAT0002853	mir-515		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-519e*	miRNA	hsa-miR-519e-5p	MIMAT0002828	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-520a	miRNA	hsa-miR-520a-3p	MIMAT0002834	mir-515		Homo sapiens	circulating	serum	preeclampsia	25017274	taqman low density array chips (human microrna panel v3.0)|quantitative real-time polymerase chain reaction	authors conclude that some circulating mirnas may have potential role in the pathogenesis of preeclampsia. in particular, mir-1233 might represent a potential marker of early spe.
hsa-miR-520b	miRNA	hsa-miR-520b	MIMAT0002843	mir-515		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-520c-3p	miRNA	hsa-miR-520c-3p	MIMAT0002846	mir-515		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-520c-3p	miRNA	hsa-miR-520c-3p	MIMAT0002846	mir-515		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-520c-3p	miRNA	hsa-miR-520c-3p	MIMAT0002846	mir-515		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-520c-3p	miRNA	hsa-miR-520c-3p	MIMAT0002846	mir-515		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-520c-3p	miRNA	hsa-miR-520c-3p	MIMAT0002846	mir-515		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-520c-3p	miRNA	hsa-miR-520c-3p	MIMAT0002846	mir-515		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-520d-5p	miRNA	hsa-miR-520d-5p	MIMAT0002855	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-520e	miRNA	hsa-miR-520e	MIMAT0002825	mir-515		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-520g	miRNA	hsa-miR-520g	MIMAT0002858	mir-515		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-520g	miRNA	hsa-miR-520g	MIMAT0002858	mir-515		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-520h	miRNA	hsa-miR-520h	MIMAT0002867	mir-515		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-520h	miRNA	hsa-miR-520h	MIMAT0002867	mir-515		Homo sapiens	circulating	plasma	gestational hypertension	25502889	real-time pcr	authors demonstrated that the first trimester screening of extracellular mir-520h alone or in combination with mir-518b identified a significant proportion of women with subsequent gestational hypertension.
hsa-miR-521	miRNA	hsa-miR-521	MIMAT0002854	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-521	miRNA	hsa-miR-521	MIMAT0002854	mir-515		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-521	miRNA	hsa-miR-521	MIMAT0002854	mir-515		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-522	miRNA	hsa-miR-522-3p	MIMAT0002868	mir-515		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-523	miRNA	hsa-miR-523-3p	MIMAT0002840	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-524	miRNA	hsa-miR-524-3p	MIMAT0002850	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-524*	miRNA	hsa-miR-524-5p	MIMAT0002849	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-525-3p	miRNA	hsa-miR-525-3p	MIMAT0002839	mir-515		Homo sapiens	circulating	serum	ectopic pregnancy (ep)	22395025	taqman real-time pcr	the serum concentrations of mirnas mir-323-3p, mir-517a, mir-519d, and mir-525-3p were measured with taqman real-time pcr. Pregnancy-associated mirnas, especially mir-323-3p, added significant diagnostic accuracy to a panel including hcg and progesterone for the diagnosis of ep.
hsa-miR-525-3p	miRNA	hsa-miR-525-3p	MIMAT0002839	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-526a	miRNA	hsa-miR-526a	MIMAT0002845	mir-515		Homo sapiens	circulating	plasma	preeclampsia	24347821	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	authors demonstrate that the upregulation of mir-516-5p, mir-517*, mir-520a*, mir-525, and mir-526a is a characteristic phenomenon of established preeclampsia.
hsa-miR-526a	miRNA	hsa-miR-526a	MIMAT0002845	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-526a	miRNA	hsa-miR-526a	MIMAT0002845	mir-515		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-526c	miRNA	hsa-miR-519c-5p	MIMAT0002831	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-527	miRNA	hsa-miR-527	MIMAT0002862	mir-515		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-527	miRNA	hsa-miR-527	MIMAT0002862	mir-515		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-532	miRNA	hsa-miR-532-5p	MIMAT0002888	mir-188		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-532	miRNA	hsa-miR-532-5p	MIMAT0002888	mir-188		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-532	miRNA	hsa-miR-532-5p	MIMAT0002888	mir-188		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-532-3p	miRNA	hsa-miR-532-3p	MIMAT0004780	mir-188		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-532-3p	miRNA	hsa-miR-532-3p	MIMAT0004780	mir-188		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-532-3p	miRNA	hsa-miR-532-3p	MIMAT0004780	mir-188		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-532-3p	miRNA	hsa-miR-532-3p	MIMAT0004780	mir-188	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-532-5p	miRNA	hsa-miR-532-5p	MIMAT0002888	mir-188		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-532-5p	miRNA	hsa-miR-532-5p	MIMAT0002888	mir-188		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-532-5p	miRNA	hsa-miR-532-5p	MIMAT0002888	mir-188		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-532-5p	miRNA	hsa-miR-532-5p	MIMAT0002888	mir-188		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-532-5p	miRNA	hsa-miR-532-5p	MIMAT0002888	mir-188	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-542-3p	miRNA	hsa-miR-542-3p	MIMAT0003389	mir-542		Homo sapiens	circulating	serum	Cervical squamous cell carcinoma	24405714	taqman microrna array	authors demonstrated that the circulating mirnas mir-646, mir-141* and mir-542-3p could potentially serve as non-invasive biomarkers for cervical scc. the levels of these specific mirnas might be useful for the post-therapeutic monitoring of disease progression.
hsa-miR-542-3p	miRNA	hsa-miR-542-3p	MIMAT0003389	mir-542		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-542-3p	miRNA	hsa-miR-542-3p	MIMAT0003389	mir-542		Homo sapiens	circulating	serum	endometriosis	23118427	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
hsa-miR-542-3p	miRNA	hsa-miR-542-3p	MIMAT0003389	mir-542		Homo sapiens	circulating	serum	preeclampsia	21840305	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
hsa-miR-542-3p	miRNA	hsa-miR-542-3p	MIMAT0003389	mir-542		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-542-3p	miRNA	hsa-miR-542-3p	MIMAT0003389	mir-542	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-542-5p	miRNA	hsa-miR-542-5p	MIMAT0003340	mir-542		Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-542-5p	miRNA	hsa-miR-542-5p	MIMAT0003340	mir-542		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-542-5p	miRNA	hsa-miR-542-5p	MIMAT0003340	mir-542		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-543	miRNA	hsa-miR-543	MIMAT0004954	mir-329		Homo sapiens	circulating	serum	papillary thyroid carcinomas (ptc)	22472564	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
hsa-miR-543	miRNA	hsa-miR-543	MIMAT0004954	mir-329		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-545	miRNA	hsa-miR-545-3p	MIMAT0003165	mir-95		Homo sapiens	circulating	serum	hand-foot-and-mouth disease (hfmd)	22087245	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
hsa-miR-548a-3p	miRNA	hsa-miR-548a-3p	MIMAT0003251	mir-548		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-548a-5p	miRNA	hsa-miR-548a-5p	MIMAT0004803	mir-548		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-548b-5p	miRNA	hsa-miR-548b-5p	MIMAT0004798	mir-548		Homo sapiens	circulating	serum	malignant astrocytomas	22674182	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
hsa-miR-548b-5p	miRNA	hsa-miR-548b-5p	MIMAT0004798	mir-548		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-548c-5p	miRNA	hsa-miR-548c-5p	MIMAT0004806	mir-548		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-548d-5p	miRNA	hsa-miR-548d-5p	MIMAT0004812	mir-548		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-550	miRNA	hsa-miR-550a-5p	MIMAT0004800	mir-550		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-550	miRNA	hsa-miR-550a-5p	MIMAT0004800	mir-550		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-550*	miRNA	hsa-miR-550a-3p	MIMAT0003257	mir-550		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-551b	miRNA	hsa-miR-551b-3p	MIMAT0003233	mir-551		Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-551b	miRNA	hsa-miR-551b-3p	MIMAT0003233	mir-551		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-551b	miRNA	hsa-miR-551b-3p	MIMAT0003233	mir-551		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-551b-3p	miRNA	hsa-miR-551b-3p	MIMAT0003233	mir-551	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-556-5p	miRNA	hsa-miR-556-5p	MIMAT0003220	mir-556		Homo sapiens	circulating	amniotic fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-557	miRNA	hsa-miR-557	MIMAT0003221	mir-557		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-557	miRNA	hsa-miR-557	MIMAT0003221	mir-557		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-558	miRNA	hsa-miR-558	MIMAT0003222	mir-558		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-559	miRNA	hsa-miR-559	MIMAT0003223	mir-559		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-564	miRNA	hsa-miR-564	MIMAT0003228	mir-564	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-564	miRNA	hsa-miR-564	MIMAT0003228	mir-564		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-564	miRNA	hsa-miR-564	MIMAT0003228	mir-564	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-565	miRNA					Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-570	miRNA	hsa-miR-570-3p	MIMAT0003235	mir-548		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-571	miRNA	hsa-miR-571	MIMAT0003236	mir-571		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-571	miRNA	hsa-miR-571	MIMAT0003236	mir-571		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-571	miRNA	hsa-miR-571	MIMAT0003236	mir-571		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-572	miRNA	hsa-miR-572	MIMAT0003237	mir-572		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-572	miRNA	hsa-miR-572	MIMAT0003237	mir-572		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-572	miRNA	hsa-miR-572	MIMAT0003237	mir-572		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-572	miRNA	hsa-miR-572	MIMAT0003237	mir-572		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-572	miRNA	hsa-miR-572	MIMAT0003237	mir-572		Homo sapiens	circulating	serum	pregnancy	18773077	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
hsa-miR-572	miRNA	hsa-miR-572	MIMAT0003237	mir-572		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-572	miRNA	hsa-miR-572	MIMAT0003237	mir-572		Homo sapiens	circulating	plasma	Multiple sclerosis (MS)	22231906	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
hsa-miR-572	miRNA	hsa-miR-572	MIMAT0003237	mir-572		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-574	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	exosome	serum	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-574	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-574	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	exosome	urine	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-574-3p	miRNA	hsa-miR-574-3p	MIMAT0003239	mir-574		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-574-5p	miRNA	hsa-miR-574-5p	MIMAT0004795	mir-574		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-574-5p	miRNA	hsa-miR-574-5p	MIMAT0004795	mir-574		Homo sapiens	circulating	serum	multiple myeloma (mm)	23169280	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
hsa-miR-575	miRNA	hsa-miR-575	MIMAT0003240	mir-575		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-575	miRNA	hsa-miR-575	MIMAT0003240	mir-575		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-575	miRNA	hsa-miR-575	MIMAT0003240	mir-575		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-576-3p	miRNA	hsa-miR-576-3p	MIMAT0004796	mir-576		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-576-3p	miRNA	hsa-miR-576-3p	MIMAT0004796	mir-576		Homo sapiens	circulating	blood	influenza a virus infection	24116168	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
hsa-miR-576-5p	miRNA	hsa-miR-576-5p	MIMAT0003241	mir-576		Homo sapiens	circulating	serum	pertussis	23073777	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
hsa-miR-577	miRNA	hsa-miR-577	MIMAT0003242	mir-577		Homo sapiens	circulating	cerebrospinal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-577	miRNA	hsa-miR-577	MIMAT0003242	mir-577		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-578	miRNA	hsa-miR-578	MIMAT0003243	mir-578		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-579	miRNA	hsa-miR-579-3p	MIMAT0003244	mir-548	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-579	miRNA	hsa-miR-579-3p	MIMAT0003244	mir-548		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-579	miRNA	hsa-miR-579-3p	MIMAT0003244	mir-548		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	24515657	microrna array	authors identify two mirnas that are specifically elevated in patients with bevacizumab-induced cardiotoxicity, mir1254 and mirna579, and mirna1254 shows the strongest correlation to the clinical diagnosis of bevacizumab-induced cardiotoxicity.
hsa-miR-580	miRNA	hsa-miR-580	MIMAT0003245	mir-580		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-582	miRNA	hsa-miR-582-5p	MIMAT0003247	mir-582		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-582-3p	miRNA	hsa-miR-582-3p	MIMAT0004797	mir-582		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-582-5p	miRNA	hsa-miR-582-5p	MIMAT0003247	mir-582	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-583	miRNA	hsa-miR-583	MIMAT0003248	mir-583		Homo sapiens	circulating	peritoneal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-583	miRNA	hsa-miR-583	MIMAT0003248	mir-583		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-584	miRNA	hsa-miR-584-5p	MIMAT0003249	mir-584	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-584	miRNA	hsa-miR-584-5p	MIMAT0003249	mir-584		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-584	miRNA	hsa-miR-584-5p	MIMAT0003249	mir-584		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-584	miRNA	hsa-miR-584-5p	MIMAT0003249	mir-584		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-584	miRNA	hsa-miR-584-5p	MIMAT0003249	mir-584		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-584	miRNA	hsa-miR-584-5p	MIMAT0003249	mir-584		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-584-5p	miRNA	hsa-miR-584-5p	MIMAT0003249	mir-584	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-585	miRNA	hsa-miR-585	MIMAT0003250			Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-590	miRNA	hsa-miR-590-5p	MIMAT0003258	mir-590		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-590-5p	miRNA	hsa-miR-590-5p	MIMAT0003258	mir-590		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-590-5p	miRNA	hsa-miR-590-5p	MIMAT0003258	mir-590		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-590-5p	miRNA	hsa-miR-590-5p	MIMAT0003258	mir-590		Homo sapiens	exosome	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-590-5p	miRNA	hsa-miR-590-5p	MIMAT0003258	mir-590		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-590-5p	miRNA	hsa-miR-590-5p	MIMAT0003258	mir-590		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-590-5p	miRNA	hsa-miR-590-5p	MIMAT0003258	mir-590	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-590-5p	miRNA	hsa-miR-590-5p	MIMAT0003258	mir-590		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-591	miRNA	hsa-miR-591	MIMAT0003259	mir-591		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-593	miRNA	hsa-miR-593-3p	MIMAT0004802	mir-593		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-593	miRNA	hsa-miR-593-3p	MIMAT0004802	mir-593		Homo sapiens	circulating	serum	Combined pituitary hormone deficiency (cphd)	25434367	rt-qpcr	authors demonstrated that the levels of mir-593 and mir-511, whose direct target is the prop1 gene, may serve as a non-invasive diagnostic biomarkers for children with combined pituitary hormone deficiency (cphd).
hsa-miR-593*	miRNA	hsa-miR-593-5p	MIMAT0003261	mir-593		Homo sapiens	circulating	amniotic fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-594	miRNA					Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-595	miRNA	hsa-miR-595	MIMAT0003263	mir-595		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-596	miRNA	hsa-miR-596	MIMAT0003264	mir-596		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-598	miRNA	hsa-miR-598	MIMAT0003266	mir-598		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-598	miRNA	hsa-miR-598	MIMAT0003266	mir-598		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-601	miRNA	hsa-miR-601	MIMAT0003269	mir-601		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-601	miRNA	hsa-miR-601	MIMAT0003269	mir-601		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-601	miRNA	hsa-miR-601	MIMAT0003269	mir-601		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-601	miRNA	hsa-miR-601	MIMAT0003269	mir-601		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-601	miRNA	hsa-miR-601	MIMAT0003269	mir-601		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-601	miRNA	hsa-miR-601	MIMAT0003269	mir-601	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-601	miRNA	hsa-miR-601	MIMAT0003269	mir-601		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-603	miRNA	hsa-miR-603	MIMAT0003271	mir-548		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-603	miRNA	hsa-miR-603	MIMAT0003271	mir-548		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-605	miRNA	hsa-miR-605	MIMAT0003273	mir-605		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-608	miRNA	hsa-miR-608	MIMAT0003276	mir-608		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-609	miRNA	hsa-miR-609	MIMAT0003277	mir-609		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-610	miRNA	hsa-miR-610	MIMAT0003278	mir-610		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-610	miRNA	hsa-miR-610	MIMAT0003278	mir-610		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-610	miRNA	hsa-miR-610	MIMAT0003278	mir-610		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-612	miRNA	hsa-miR-612	MIMAT0003280	mir-612		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-614	miRNA	hsa-miR-614	MIMAT0003282	mir-614		Homo sapiens	circulating	plasma	Multiple sclerosis (MS)	22231906	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
hsa-miR-615-3p	miRNA	hsa-miR-615-3p	MIMAT0003283	mir-615	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-616*	miRNA	hsa-miR-616-5p	MIMAT0003284	mir-616		Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-617	miRNA	hsa-miR-617	MIMAT0003286	mir-617		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-618	miRNA	hsa-miR-618	MIMAT0003287	mir-618		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-618	miRNA	hsa-miR-618	MIMAT0003287	mir-618		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-618	miRNA	hsa-miR-618	MIMAT0003287	mir-618		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-619	miRNA	hsa-miR-619	MIMAT0003288	mir-619		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-619-5p	miRNA	hsa-miR-619-5p	MIMAT0026622	mir-619		Homo sapiens	circulating	plasma	prostate cancer	27265125	genechip mirna 4.0 array (affymetrix)	in prostatic cancer, significant increase in hsa-mir-619-5p and hsa-mir-1184 microrna expression and significant decrease in hsalet-7b-5p and hsa-let-7c-5p microrna expression were observed.
hsa-miR-621	miRNA	hsa-miR-621	MIMAT0003290	mir-621	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-622	miRNA	hsa-miR-622	MIMAT0003291	mir-622		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-622	miRNA	hsa-miR-622	MIMAT0003291	mir-622		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-622	miRNA	hsa-miR-622	MIMAT0003291	mir-622		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-622	miRNA	hsa-miR-622	MIMAT0003291	mir-622		Homo sapiens	circulating	plasma	prostate cancer	22298030	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102 1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followed by qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
hsa-miR-624*	miRNA	hsa-miR-624-5p	MIMAT0003293	mir-624		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-624*	miRNA	hsa-miR-624-5p	MIMAT0003293	mir-624		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-625	miRNA	hsa-miR-625-5p	MIMAT0003294	mir-625		Homo sapiens	circulating	plasma	multiple myeloma (mm)	22447484	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
hsa-miR-625	miRNA	hsa-miR-625-5p	MIMAT0003294	mir-625		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-625	miRNA	hsa-miR-625-5p	MIMAT0003294	mir-625		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-625	miRNA	hsa-miR-625-5p	MIMAT0003294	mir-625		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-625*	miRNA	hsa-miR-625-3p	MIMAT0004808	mir-625		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22675530	Trizol LS Reagent (Karlsruhe, Germany, Invitrogen)|microfluid biochips (Febit Biomed GmbH, Heidelberg, Germany)|Microfluid Primer Extension Assay|mirVana PARIS kit (Ambion, Darmstadt, Germany)|TaqMan MicroRNA Reverse Transcription Kit (Applied Biosystems)	Microarray profiling showed that miR-361-3p and miR-625* were significantly down-regulated in serum of lung cancer patients. Their further evaluation by quantitative RT-PCR showed that the levels of miR-361-3p and miR-625* were lower in NSCLC than in benign disease (p = 0.0001) and healthy individuals (p = 0.0001, p = 0.0005, respectively).
hsa-miR-625*	miRNA	hsa-miR-625-3p	MIMAT0004808	mir-625		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-625*	miRNA	hsa-miR-625-3p	MIMAT0004808	mir-625		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-625*	miRNA	hsa-miR-625-3p	MIMAT0004808	mir-625		Homo sapiens	exosome	plasma	prostate cancer	22240788	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
hsa-miR-627	miRNA	hsa-miR-627-5p	MIMAT0003296	mir-627		Homo sapiens	circulating	blood	Acute stroke	24447930	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
hsa-miR-627	miRNA	hsa-miR-627-5p	MIMAT0003296	mir-627		Homo sapiens	circulating	peritoneal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-627	miRNA	hsa-miR-627-5p	MIMAT0003296	mir-627	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-628	miRNA	hsa-miR-628-3p	MIMAT0003297	mir-628		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-628	miRNA	hsa-miR-628-3p	MIMAT0003297	mir-628		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-628-3p	miRNA	hsa-miR-628-3p	MIMAT0003297	mir-628		Homo sapiens	circulating	serum	hand-foot-and-mouth disease (hfmd)	22087245	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
hsa-miR-628-3p	miRNA	hsa-miR-628-3p	MIMAT0003297	mir-628		Homo sapiens	circulating	blood	influenza a virus infection	24116168	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
hsa-miR-628-5p	miRNA	hsa-miR-628-5p	MIMAT0004809	mir-628		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-628-5p	miRNA	hsa-miR-628-5p	MIMAT0004809	mir-628		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-628-5p	miRNA	hsa-miR-628-5p	MIMAT0004809	mir-628		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-628-5p	miRNA	hsa-miR-628-5p	MIMAT0004809	mir-628		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-629	miRNA	hsa-miR-629-5p	MIMAT0004810	mir-629		Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-629	miRNA	hsa-miR-629-5p	MIMAT0004810	mir-629		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-629	miRNA	hsa-miR-629-5p	MIMAT0004810	mir-629		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-629	miRNA	hsa-miR-629-5p	MIMAT0004810	mir-629		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-629*	miRNA	hsa-miR-629-3p	MIMAT0003298	mir-629		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-629*	miRNA	hsa-miR-629-3p	MIMAT0003298	mir-629		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-630	miRNA	hsa-miR-630	MIMAT0003299	mir-630		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-630	miRNA	hsa-miR-630	MIMAT0003299	mir-630		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-630	miRNA	hsa-miR-630	MIMAT0003299	mir-630		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-631	miRNA	hsa-miR-631	MIMAT0003300	mir-631		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-632	miRNA	hsa-miR-632	MIMAT0003302	mir-632		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-632	miRNA	hsa-miR-632	MIMAT0003302	mir-632		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-632	miRNA	hsa-miR-632	MIMAT0003302	mir-632		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-632	miRNA	hsa-miR-632	MIMAT0003302	mir-632		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-634	miRNA	hsa-miR-634	MIMAT0003304	mir-634		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-635	miRNA	hsa-miR-635	MIMAT0003305	mir-635		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-635*	miRNA					Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-636	miRNA	hsa-miR-636	MIMAT0003306	mir-636		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-636	miRNA	hsa-miR-636	MIMAT0003306	mir-636		Homo sapiens	circulating	amniotic fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-637	miRNA	hsa-miR-637	MIMAT0003307	mir-637		Homo sapiens	circulating	tears	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-637	miRNA	hsa-miR-637	MIMAT0003307	mir-637		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-638	miRNA	hsa-miR-638	MIMAT0003308	mir-638	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-638	miRNA	hsa-miR-638	MIMAT0003308	mir-638		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-638	miRNA	hsa-miR-638	MIMAT0003308	mir-638		Homo sapiens	circulating	serum	multiple myeloma (mm)	23169280	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
hsa-miR-638	miRNA	hsa-miR-638	MIMAT0003308	mir-638		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-639	miRNA	hsa-miR-639	MIMAT0003309	mir-639		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-639	miRNA	hsa-miR-639	MIMAT0003309	mir-639		Homo sapiens	circulating	serum	Bladder cancer	23266581	qrt-pcr	the analysis of mir-141 and mir-639 in the validation cohort demonstrated that microrna levels were similar in bladder cancer patients and control subjects. furthermore, microrna levels were not correlated with clinicopathological parameters (pt-stage, metastasis, grading). the analysis of serum mir-141 and mir-639 levels does not seem to be helpful in the diagnosis or prognosis of bca.
hsa-miR-640	miRNA	hsa-miR-640	MIMAT0003310	mir-640		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-642	miRNA	hsa-miR-642a-5p	MIMAT0003312	mir-642		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-642	miRNA	hsa-miR-642a-5p	MIMAT0003312	mir-642		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-642b	miRNA	hsa-miR-642b-3p	MIMAT0018444	mir-642		Homo sapiens	circulating	plasma	pancreatic cancer	24578785	microarray|rt-qpcr	three micrornas, mir-642b, mir-885-5p, and mir-22, were confirmed to show consistent expression between microarray and rt-qpcr. these three micrornas were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity (91%) and specificity (91%) with an area under the curve of 0.97 (p < 0.001). compared to the ca19-9 marker at 73%, the three-microrna panel has higher sensitivity although ca19-9 has higher specificity of 100%. the identified panel of three microrna biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer.
hsa-miR-643	miRNA	hsa-miR-643	MIMAT0003313	mir-643		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-644	miRNA	hsa-miR-644a	MIMAT0003314	mir-644		Homo sapiens	circulating	seminal fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-645	miRNA	hsa-miR-645	MIMAT0003315	mir-645		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-645	miRNA	hsa-miR-645	MIMAT0003315	mir-645		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-646	miRNA	hsa-miR-646	MIMAT0003316	mir-646		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-646	miRNA	hsa-miR-646	MIMAT0003316	mir-646		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-646	miRNA	hsa-miR-646	MIMAT0003316	mir-646		Homo sapiens	circulating	serum	Cervical squamous cell carcinoma	24405714	taqman microrna array	authors demonstrated that the circulating mirnas mir-646, mir-141* and mir-542-3p could potentially serve as non-invasive biomarkers for cervical scc. the levels of these specific mirnas might be useful for the post-therapeutic monitoring of disease progression.
hsa-miR-646	miRNA	hsa-miR-646	MIMAT0003316	mir-646	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-646	miRNA	hsa-miR-646	MIMAT0003316	mir-646		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-646	miRNA	hsa-miR-646	MIMAT0003316	mir-646		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-646	miRNA	hsa-miR-646	MIMAT0003316	mir-646		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-646	miRNA	hsa-miR-646	MIMAT0003316	mir-646		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-646	miRNA	hsa-miR-646	MIMAT0003316	mir-646		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-647	miRNA	hsa-miR-647	MIMAT0003317	mir-647		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-648	miRNA	hsa-miR-648	MIMAT0003318	mir-648	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-648	miRNA	hsa-miR-648	MIMAT0003318	mir-648		Homo sapiens	circulating	plasma	Multiple sclerosis (MS)	22231906	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
hsa-miR-649	miRNA	hsa-miR-649	MIMAT0003319	mir-649		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-652	miRNA	hsa-miR-652-3p	MIMAT0003322	mir-652		Homo sapiens	circulating	plasma	Acute coronary syndromes	25124998	real-time quantitative pcr	authors identify mir-652 as a novel candidate biomarker for post-acs prognosis beyond existing biomarkers of lvef and nt-probnp. moreover circulating mir-323-3p was markedly elevated in patients for at least a year post-acs and may be a stable biomarker for acs.
hsa-miR-652	miRNA	hsa-miR-652-3p	MIMAT0003322	mir-652	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-652	miRNA	hsa-miR-652-3p	MIMAT0003322	mir-652		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-652	miRNA	hsa-miR-652-3p	MIMAT0003322	mir-652		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-652	miRNA	hsa-miR-652-3p	MIMAT0003322	mir-652		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-652	miRNA	hsa-miR-652-3p	MIMAT0003322	mir-652		Homo sapiens	circulating	serum	triple-negative breast cancers (tnbc)	25547678	real-time pcr	by cox regression analysis, authors identified a four-mirna signature (mir-18b, mir-103, mir-107, and mir-652) that predicted tumor relapse and overall survival for patients with triple-negative breast cancers (tnbc).
hsa-miR-652	miRNA	hsa-miR-652-3p	MIMAT0003322	mir-652		Homo sapiens	circulating	plasma	Breast cancer	24194846	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
hsa-miR-652-3p	miRNA	hsa-miR-652-3p	MIMAT0003322	mir-652	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-654-3p	miRNA	hsa-miR-654-3p	MIMAT0004814	mir-654		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-654-3p	miRNA	hsa-miR-654-3p	MIMAT0004814	mir-654		Homo sapiens	circulating	plasma	liver damage in hepatitis b e antigen positive (hbeag-positive) patients	25580300	qrt-pcr	authors demonstrated that 654-3p was downregulated in hbeag-positive children when compared to hbeag-negative and healthy control children. the identified microrna might impact the progression of chronic hepatitis b in children.
hsa-miR-654-5p	miRNA	hsa-miR-654-5p	MIMAT0003330	mir-654		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-654-5p	miRNA	hsa-miR-654-5p	MIMAT0003330	mir-654		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-654-5p	miRNA	hsa-miR-654-5p	MIMAT0003330	mir-654		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-657	miRNA	hsa-miR-657	MIMAT0003335	mir-657		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-658	miRNA	hsa-miR-658	MIMAT0003336	mir-658		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-658	miRNA	hsa-miR-658	MIMAT0003336	mir-658		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-659	miRNA	hsa-miR-659-3p	MIMAT0003337			Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-660	miRNA	hsa-miR-660-5p	MIMAT0003338	mir-188		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-660	miRNA	hsa-miR-660-5p	MIMAT0003338	mir-188		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-660	miRNA	hsa-miR-660-5p	MIMAT0003338	mir-188		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-660	miRNA	hsa-miR-660-5p	MIMAT0003338	mir-188		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-660	miRNA	hsa-miR-660-5p	MIMAT0003338	mir-188		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-660	miRNA	hsa-miR-660-5p	MIMAT0003338	mir-188		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-660-5p	miRNA	hsa-miR-660-5p	MIMAT0003338	mir-188	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-660-5p	miRNA	hsa-miR-660-5p	MIMAT0003338	mir-188		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-662	miRNA	hsa-miR-662	MIMAT0003325	mir-662		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-662	miRNA	hsa-miR-662	MIMAT0003325	mir-662		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-663	miRNA	hsa-miR-663a	MIMAT0003326	mir-663		Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-663	miRNA	hsa-miR-663a	MIMAT0003326	mir-663		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-663a	miRNA	hsa-miR-663a	MIMAT0003326	mir-663		Homo sapiens	circulating	serum	Autism Spectrum Disorder (ASD)	25126405	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
hsa-miR-664	miRNA	hsa-miR-664-3p	MIMAT0005949	mir-664		Homo sapiens	circulating	blood	influenza a virus infection	24116168	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
hsa-miR-664	miRNA	hsa-miR-664-3p	MIMAT0005949	mir-664		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-664a-3p	miRNA	hsa-miR-664a-3p	MIMAT0005949	mir-664	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-664a-5p	miRNA	hsa-miR-664a-5p	MIMAT0005948	mir-664	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-665	miRNA	hsa-miR-665	MIMAT0004952	mir-665		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-668	miRNA	hsa-miR-668	MIMAT0003881	mir-668		Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-671	miRNA	hsa-miR-671-5p	MIMAT0003880	mir-671		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-671-3p	miRNA	hsa-miR-671-3p	MIMAT0004819	mir-671	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-671-5p	miRNA	hsa-miR-671-5p	MIMAT0003880	mir-671	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-671-5p	miRNA	hsa-miR-671-5p	MIMAT0003880	mir-671		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-671-5p	miRNA	hsa-miR-671-5p	MIMAT0003880	mir-671		Homo sapiens	microvesicle	blood	hepatocellular carcinoma (hcc)	24592541	agilent mirna microarry	mirnas were differentially expressed in hcc-mvs compared with chb and normal controls. aberrant hcc-mvs mirnas may play important roles in the development of hcc.
hsa-miR-671-5p	miRNA	hsa-miR-671-5p	MIMAT0003880	mir-671		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-671-5p	miRNA	hsa-miR-671-5p	MIMAT0003880	mir-671		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-675	miRNA	hsa-miR-675-5p	MIMAT0004284	mir-675		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-7	miRNA	hsa-miR-7-5p	MIMAT0000252	mir-7		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-7	miRNA	hsa-miR-7-5p	MIMAT0000252	mir-7		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-7	miRNA	hsa-miR-7-5p	MIMAT0000252	mir-7		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-7	miRNA	hsa-miR-7-5p	MIMAT0000252	mir-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-7	miRNA	hsa-miR-7-5p	MIMAT0000252	mir-7		Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-7-1	miRNA	hsa-miR-7-5p	MIMAT0000252	mir-7		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-7-1*	miRNA	hsa-miR-7-1-3p	MIMAT0004553	mir-7		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-708-5p	miRNA	hsa-miR-708-5p	MIMAT0004926	mir-708	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-720	miRNA	hsa-miR-720	MIMAT0005954	mir-720		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-720	miRNA	hsa-miR-720	MIMAT0005954	mir-720		Homo sapiens	circulating	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-720	miRNA	hsa-miR-720	MIMAT0005954	mir-720		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-720	miRNA	hsa-miR-720	MIMAT0005954	mir-720		Homo sapiens	circulating	serum	multiple myeloma (mm)	23169280	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
hsa-miR-720	miRNA	hsa-miR-720	MIMAT0005954	mir-720		Homo sapiens	circulating	plasma	Coronary artery disease	24558106	real-time pcr	circulating levels of mir-31, mir-720, and vasohibin 1 have the potential to allow early diagnosis of cad and to act as prognosis biomarkers for cad and other epc-related diseases.
hsa-miR-720	miRNA	hsa-miR-720	MIMAT0005954	mir-720		Homo sapiens	circulating	blood	Breast cancer	25179838	qrt-pcr	authors found that mir-1280, mir-1260, and mir-720 were up-regulated in blood from breast cancer patience, mir-1280 may serve as a biomarker for er-positive breast cancer.
hsa-miR-744	miRNA	hsa-miR-744-5p	MIMAT0004945	mir-744		Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-744	miRNA	hsa-miR-744-5p	MIMAT0004945	mir-744		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-744	miRNA	hsa-miR-744-5p	MIMAT0004945	mir-744		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-744	miRNA	hsa-miR-744-5p	MIMAT0004945	mir-744		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-744*	miRNA	hsa-miR-744-3p	MIMAT0004946	mir-744		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-744*	miRNA	hsa-miR-744-3p	MIMAT0004946	mir-744		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-744-5p	miRNA	hsa-miR-744-5p	MIMAT0004945	mir-744	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-760	miRNA	hsa-miR-760	MIMAT0004957	mir-760	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-760	miRNA	hsa-miR-760	MIMAT0004957	mir-760		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-760	miRNA	hsa-miR-760	MIMAT0004957	mir-760		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-760	miRNA	hsa-miR-760	MIMAT0004957	mir-760		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-760	miRNA	hsa-miR-760	MIMAT0004957	mir-760		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-760	miRNA	hsa-miR-760	MIMAT0004957	mir-760		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-762	miRNA	hsa-miR-762	MIMAT0010313	mir-762		Homo sapiens	circulating	serum	multiple myeloma (mm)	23169280	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
hsa-miR-765	miRNA	hsa-miR-765	MIMAT0003945	mir-765		Homo sapiens	circulating	plasma	traumatic brain injury (tbi)	20883153	qrt-pcr	mir-16, mir-92a, and mir-765 were good markers of severe traumatic brain injury (tbi) (0.89, 0.82, and 0.86 auc values, respectively)
hsa-miR-765	miRNA	hsa-miR-765	MIMAT0003945	mir-765		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-765	miRNA	hsa-miR-765	MIMAT0003945	mir-765		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-766	miRNA	hsa-miR-766-3p	MIMAT0003888	mir-766		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-766	miRNA	hsa-miR-766-3p	MIMAT0003888	mir-766		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-766	miRNA	hsa-miR-766-3p	MIMAT0003888	mir-766		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-768	miRNA					Homo sapiens	exosome	serum	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-768-3p	miRNA	NULL	NULL	NULL	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-768-3p	miRNA					Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-768-3p	miRNA					Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-768-3p	miRNA					Homo sapiens	circulating	plasma	metastatic breast cancer (mbc)	22952344	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
hsa-miR-768-3p	miRNA					Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-768-3p	miRNA					Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-768-5p	miRNA					Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-769-3p	miRNA	hsa-miR-769-3p	MIMAT0003887	mir-769		Homo sapiens	circulating	plasma	Coronary stenosis	24358814	mirvana paris kit (ambion, austin, tx)|high-throughput biomark real-time pcr system (fluidigm, south san francisco, ca)	authors demonstrate that specific mirnas from circulating plasma are associated with the presence of significant coronary disease.
hsa-miR-769-3p	miRNA	hsa-miR-769-3p	MIMAT0003887	mir-769		Homo sapiens	circulating	plasma	Coronary artery disease	24358814	mirvana paris kit (ambion, austin, tx)|high-throughput biomark real-time pcr system (fluidigm, south san francisco, ca)	authors demonstrate that specific mirnas from circulating plasma are associated with the presence of significant coronary disease.
hsa-miR-769-3p	miRNA	hsa-miR-769-3p	MIMAT0003887	mir-769		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-769-3p	miRNA	hsa-miR-769-3p	MIMAT0003887	mir-769		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-769-5p	miRNA	hsa-miR-769-5p	MIMAT0003886	mir-769		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-769-5p	miRNA	hsa-miR-769-5p	MIMAT0003886	mir-769		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-769-5p	miRNA	hsa-miR-769-5p	MIMAT0003886	mir-769		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-769-5p	miRNA	hsa-miR-769-5p	MIMAT0003886	mir-769	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-769-5p	miRNA	hsa-miR-769-5p	MIMAT0003886	mir-769		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-770-5p	miRNA	hsa-miR-770-5p	MIMAT0003948	mir-770		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-770-5p	miRNA	hsa-miR-770-5p	MIMAT0003948	mir-770		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-801	miRNA					Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-801	miRNA					Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-801	miRNA					Homo sapiens	circulating	plasma	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-801	miRNA					Homo sapiens	circulating	plasma	Breast cancer	22927033	taqman low-density array qrt-pcr	four mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) were shown to be significantly upregulated in the plasma of breast cancer patients. roc curve analysis showed that the combination of only three mirnas (mir-148b, mir-409-3p and mir-801) had an equal discriminatory power between breast cancer cases and healthy controls as all four mirnas together (auc = 0.69). in conclusion, the identified mirnas might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer.
hsa-miR-801	miRNA					Homo sapiens	circulating	plasma	metastatic breast cancer (mbc)	22952344	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
hsa-miR-801	miRNA					Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-801	miRNA					Homo sapiens	circulating	plasma	Breast cancer	24194846	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
hsa-miR-874	miRNA	hsa-miR-874	MIMAT0004911	mir-874		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-874	miRNA	hsa-miR-874	MIMAT0004911	mir-874		Homo sapiens	circulating	plasma	mild cognitive impairment (mci)	24368295	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
hsa-miR-874	miRNA	hsa-miR-874	MIMAT0004911	mir-874		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-875-5p	miRNA	hsa-miR-875-5p	MIMAT0004922	mir-875		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-875-5p	miRNA	hsa-miR-875-5p	MIMAT0004922	mir-875		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-877	miRNA	hsa-miR-877-5p	MIMAT0004949	mir-877		Homo sapiens	HDL	plasma	normal	21423178	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
hsa-miR-877	miRNA	hsa-miR-877-5p	MIMAT0004949	mir-877		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-877-5p	miRNA	hsa-miR-877-5p	MIMAT0004949	mir-877	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-885-5p	miRNA	hsa-miR-885-5p	MIMAT0004947	mir-885		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-885-5p	miRNA	hsa-miR-885-5p	MIMAT0004947	mir-885		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-885-5p	miRNA	hsa-miR-885-5p	MIMAT0004947	mir-885		Homo sapiens	circulating	plasma	pancreatic cancer	24578785	microarray|rt-qpcr	three micrornas, mir-642b, mir-885-5p, and mir-22, were confirmed to show consistent expression between microarray and rt-qpcr. these three micrornas were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity (91%) and specificity (91%) with an area under the curve of 0.97 (p < 0.001). compared to the ca19-9 marker at 73%, the three-microrna panel has higher sensitivity although ca19-9 has higher specificity of 100%. the identified panel of three microrna biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer.
hsa-miR-885-5p	miRNA	hsa-miR-885-5p	MIMAT0004947	mir-885		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-885-5p	miRNA	hsa-miR-885-5p	MIMAT0004947	mir-885		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-885-5p	miRNA	hsa-miR-885-5p	MIMAT0004947	mir-885		Homo sapiens	circulating	serum	osteoarthritis (oa)	24515954	real-time pcr	this is the first study that identifies differentially expressed circulating micrornas in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. among these micrornas, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.
hsa-miR-885-5p	miRNA	hsa-miR-885-5p	MIMAT0004947	mir-885		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-885-5p	miRNA	hsa-miR-885-5p	MIMAT0004947	mir-885		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-886-3p	miRNA					Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-886-3p	miRNA					Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-886-3p	miRNA					Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-886-3p	miRNA					Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-886-5p	miRNA					Homo sapiens	exosome	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-887	miRNA	hsa-miR-887	MIMAT0004951	mir-887		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-888*	miRNA	hsa-miR-888-3p	MIMAT0004917	mir-743	NULL	Homo sapiens	exosome	saliva	normal	19627513	RT-PCR|Differential centrifugation|Ultracentrifugation	Exosomes from human saliva as a source of microRNA biomarkers.
hsa-miR-891a	miRNA	hsa-miR-891a-5p	MIMAT0004902	mir-891	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-891a-5p	miRNA	hsa-miR-891a-5p	MIMAT0004902	mir-891	NULL	Homo sapiens	microvesicle	seminal fluid	normal	23539611	microarray	microRNA signature is altered in both human epididymis and seminal microvesicles following vasectomy.
hsa-miR-892b	miRNA	hsa-miR-892b	MIMAT0004918	mir-743		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-892b	miRNA	hsa-miR-892b	MIMAT0004918	mir-743		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-9	miRNA	hsa-miR-9-5p	MIMAT0000441	mir-9	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-9	miRNA	hsa-miR-9-5p	MIMAT0000441	mir-9		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-9	miRNA	hsa-miR-9-5p	MIMAT0000441	mir-9		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-9	miRNA	hsa-miR-9-5p	MIMAT0000441	mir-9		Homo sapiens	circulating	cerebrospinal fluid	Alzheimer disease (AD)	23301201	fluorescent mirna-array-based analysis|led-northern dot-blot assay	the results indicate that mirna-9, mirna-125b, mirna-146a and mirna-155 are csf- and ecf-abundant, nf-кb-sensitive pro-inflammatory mirnas, and their enrichment in circulating csf and ecf suggest that they may be involved in the modulation or proliferation of mirna-triggered pathogenic signaling throughout the brain and central nervous system (cns).
hsa-miR-9	miRNA	hsa-miR-9-5p	MIMAT0000441	mir-9		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-9	miRNA	hsa-miR-9-5p	MIMAT0000441	mir-9		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-9*	miRNA	hsa-miR-9-3p	MIMAT0000442	mir-9		Homo sapiens	circulating	serum	prostate cancer	20473869	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
hsa-miR-9*	miRNA	hsa-miR-9-3p	MIMAT0000442	mir-9		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-9*	miRNA	hsa-miR-9-3p	MIMAT0000442	mir-9		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-9*	miRNA	hsa-miR-9-3p	MIMAT0000442	mir-9		Homo sapiens	circulating	serum	endometriosis	23118427	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
hsa-miR-9-5p	miRNA	hsa-miR-9-5p	MIMAT0000441	mir-9	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-92	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	serum	non small cell lung cancer (nsclc)	22389695	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
hsa-miR-92	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-92	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-92	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-92	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-921	miRNA	hsa-miR-921	MIMAT0004971	mir-921		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-921	miRNA	hsa-miR-921	MIMAT0004971	mir-921		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-923	miRNA					Homo sapiens	exosome	mammary epithelial cells	malignant mammary epithelial cells	20976003	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
hsa-miR-923	miRNA					Homo sapiens	circulating	plasma	Acute pulmonary embolism (ape)	21943159	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
hsa-miR-924	miRNA	hsa-miR-924	MIMAT0004974	mir-924		Homo sapiens	circulating	breast milk	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	serum	Aging	25165030	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	Multiple sclerosis (MS)	25487315	7900 ht fast real-time pcr system (applied biosystems)	authors studied that significantly changed expression of selected extracellular mirna in plasma of multiple sclerosis (ms) patients may be correlated with clinical parameters.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	exosome	serum	normal	22427800	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	traumatic brain injury (tbi)	20883153	qrt-pcr	mir-16, mir-92a, and mir-765 are good markers of severe traumatic brain injury (tbi) (0.89, 0.82, and 0.86 auc values, respectively)
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	microparticle	atherosclerotic plaques	Atherosclerosis	24931230	real-time pcr	by comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype (n = 9) and those from normal vascular tissues (n = 9), we found levels of annexin v(+) microparticles and annexin v(+) cd144(+) microparticles were significantly increased in plaques and angiogenesis associated micrornas (106b, 25, 92a and 21) were also significantly increased in microparticles from plaques. inflammation could induce endothelial cells to release angiogenesis associated micrornas into circulation, causing higher levels of circulating endothelial cells derived micrornas in atherosclerosis.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	Colorectal cancer (crc)	22970209	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	hairy cell leukemia	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	gastric cancer (gc)	24595006	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	normal	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage 0)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	19876917	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	aspirin resistance	27208561	rt-qpcr	aspirin resistance can potentially be identified by mir-92a levels in plasma combined with pdw.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	Chronic type C hepatitis	23390075		plasma/serum levels of mir-20a and mir-92a have potential as sensitive and cost effective biomarkers for early detection of hcv infection. the circulating mir-20a may serve as a potential for predictive biomarker in hcv mediated fibrosis.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	serum	Chronic type C hepatitis	23390075		plasma/serum levels of mir-20a and mir-92a have potential as sensitive and cost effective biomarkers for early detection of hcv infection. the circulating mir-20a may serve as a potential for predictive biomarker in hcv mediated fibrosis.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage i-ii)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	serum	endothelial dysfunction	25550450	taqman mirna qpcr	authors demonstrated that oxidative stress induces sterol regulatory element-binding protein 2 (srebp2) and microrna-92a (mir-92a), which in turn activate endothelial innate immune response, leading to dysfunctional endothelium.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	Coronary artery disease	20595655	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
hsa-miR-92a	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	serum	heart transplant rejection	25176944	real-time pcr	the study demonstrates that a differential expression of mirna occurs in rejecting allograft patients, not only at the tissue level but also in the serum, suggesting their potential relevance as non-invasive biomarkers in heart transplant rejection.
hsa-miR-92a-1*	miRNA	hsa-miR-92a-1-5p	MIMAT0004507	mir-25		Homo sapiens	circulating	amniotic fluid	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-92a-2*	miRNA	hsa-miR-92a-2-5p	MIMAT0004508	mir-25		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-92a-3p	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	st elevation myocardial infarction (stemi)	24432306	qrt-pcr	mirnas associated with stemi as compared to nstemi patients included mir-25-3p, mir-221-3p, and mir-374b-5p. mirna 30d-5p was associated with plasma, platelets, and leukocytes in both stemi and nstemi patients; mirnas 221-3p and 483-5p were correlated with plasma and platelets only in nstemi patients.
hsa-miR-92a-3p	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-92a-3p	miRNA	hsa-miR-92a-3p	MIMAT0000092	mir-25		Homo sapiens	circulating	plasma	mercury exposure	27162656	rt-pcr	plasma mir-92a-3p and mir-486-5p might prove to be potential biomarkers to indicate responses to mercury exposure. however, further studies are necessary to prove the causal association between mirnas changes and mercury exposure, and to determine whether these two mirnas are clear biomarkers to mercury exposure.
hsa-miR-92b	miRNA	hsa-miR-92b-3p	MIMAT0003218	mir-25		Homo sapiens	circulating	serum	prostate cancer	19597549	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
hsa-miR-92b	miRNA	hsa-miR-92b-3p	MIMAT0003218	mir-25		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-92b	miRNA	hsa-miR-92b-3p	MIMAT0003218	mir-25		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-92b-3p	miRNA	hsa-miR-92b-3p	MIMAT0003218	mir-25	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-92b-5p	miRNA	hsa-miR-92b-5p	MIMAT0004792	mir-25		Homo sapiens	circulating	plasma	Atrial fibrillation (af)	27138930	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	authors demonstrate that the upregulation of mir-516-5p, mir-517*, mir-520a*, mir-525, and mir-526a is a characteristic phenomenon of established preeclampsia.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	serum	prostate cancer	21098088	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	serum	osteoporosis	24431276	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	Ago2	serum	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	22937028	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	plasma	osteoarthritis (oa)	24901787	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	plasma	B-CLL	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	serum	Breast cancer	23052693	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	plasma	multiple myeloma (mm)	21460253	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	serum	gastric cancer (gc)	22198701	qpcr	authors recommend mir-16 and mir-93 as suitable reference genes for serum mirna analysis for gastric cancer patients and healthy controls.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	blood	Acute kawasaki disease	27089500	rt-pcr	several mirs are highly specific to the acute phase of kd, and may participate in regulating the expression of genes in pathways associated with kd. in particular, mir-93 may participate in regulating expression of vegf-a and contribute to the pathogenesis of arteritis in acute kd.
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17		Homo sapiens	circulating	serum	pediatric crohn disease	21546856	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
hsa-miR-93	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17	NULL	Homo sapiens	microvesicle	glioblastoma cells	Glioblastoma cells	19011622	rt-pcr|Differential centrifugation|Ultracentrifugation|Filtration	Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
hsa-miR-93*	miRNA	hsa-miR-93-3p	MIMAT0004509	mir-17		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-93*	miRNA	hsa-miR-93-3p	MIMAT0004509	mir-17		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-93-5p	miRNA	hsa-miR-93-5p	MIMAT0000093	mir-17	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-934	miRNA	hsa-miR-934	MIMAT0004977	mir-934	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-936	miRNA	hsa-miR-936	MIMAT0004979	mir-936		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-936	miRNA	hsa-miR-936	MIMAT0004979	mir-936		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-939	miRNA	hsa-miR-939-5p	MIMAT0004982	mir-939		Homo sapiens	circulating	serum	Coronary artery disease	28115160	mirneasy mini kit (qiagen, hilden, germany); quantimir rt kit (system biosciences, mountain view, ca) and maxima cdna synthesis kit (thermo scientific); all-inone qpcr mix (genecopoeia, rockville, md)	this study revealed that the expression of circulating mir-939 was down-regulated in cad patients with sufficient ccc. mir-939 abolished vascular integrity and repressed angiogenesis through directly targeting γ-catenin. it provided a potential biomarker and a therapeutic target for cad.
hsa-miR-939	miRNA	hsa-miR-939-5p	MIMAT0004982	mir-939		Homo sapiens	exosome	b cells	raji	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-940	miRNA	hsa-miR-940	MIMAT0004983	mir-940		Homo sapiens	exosome	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-940	miRNA	hsa-miR-940	MIMAT0004983	mir-940		Homo sapiens	circulating	plasma	normal	21698099	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
hsa-miR-942	miRNA	hsa-miR-942	MIMAT0004985	mir-942		Homo sapiens	circulating	serum	renal cell carcinoma (rcc)	21984948	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
hsa-miR-942-5p	miRNA	hsa-miR-942-5p	MIMAT0004985	mir-942		Homo sapiens	circulating	serum	Asthma	27362794	taqman human microrna arrays	circulating micrornas reflect asthma biology and are associated with lung function differences in asthmatics. they may represent biomarkers of asthma severity.
hsa-miR-943	miRNA	hsa-miR-943	MIMAT0004986	mir-943	NULL	Homo sapiens	microvesicle	epithelial cells	A549	20615901	RT-PCR|Differential centrifugation	Export of microRNAs and microRNA-protective protein by mammalian cells
hsa-miR-95	miRNA	hsa-miR-95	MIMAT0000094	mir-95		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-95	miRNA	hsa-miR-95	MIMAT0000094	mir-95		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-95	miRNA	hsa-miR-95	MIMAT0000094	mir-95		Homo sapiens	circulating	serum	thyroid nodules	25057879	qrt-pcr	authors have identified for the first time two mirnas differently expressed in serum of ptc patients who in combination allow the differential diagnosis of thyroid nodules with great accuracy in their study population.
hsa-miR-95	miRNA	hsa-miR-95-3p	MIMAT0000094	mir-95	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-96	miRNA	hsa-miR-96-5p	MIMAT0000095	mir-96		Homo sapiens	exosome	plasma	normal	19002258	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
hsa-miR-96	miRNA	hsa-miR-96-5p	MIMAT0000095	mir-96		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-96	miRNA	hsa-miR-96-5p	MIMAT0000095	mir-96		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-96*	miRNA	hsa-miR-96-3p	MIMAT0004510	mir-96		Homo sapiens	circulating	saliva	normal	20847327	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
hsa-miR-96-5p	miRNA	hsa-miR-96-5p	MIMAT0000095	mir-96	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-98	miRNA	hsa-miR-98	MIMAT0000096	let-7		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-98	miRNA	hsa-miR-98	MIMAT0000096	let-7		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-98	miRNA	hsa-miR-98	MIMAT0000096	let-7		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-98	miRNA	hsa-miR-98	MIMAT0000096	let-7		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-98	miRNA	hsa-miR-98	MIMAT0000096	let-7		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-98-5p	miRNA	hsa-miR-98-5p	MIMAT0000096	let-7	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99		Homo sapiens	Ago2	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99		Homo sapiens	circulating	serum	hepatocellular carcinoma (hcc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99		Homo sapiens	circulating	serum	liver cirrhosis (lc)	20815808	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99		Homo sapiens	circulating	plasma	Bladder cancer	24957100	real-time pcr	mir-99a was significantly down-regulated in bladder cancer tissues, and even the lower expression of mir-99a was correlative with the more aggressive phenotypes of bladder cancer. meanwhile, enforced expression of mir-99a can inhibit the cell proliferation of bladder cancer cells. furthermore, investigation of the expression of mir-99a in plasma of bladder cancer patients showed that mir-99a was also decreased in plasma of bladder cancer patients. the results strongly supported mir-99a as the potential diagnostic marker of bladder cancer.
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99		Homo sapiens	circulating	plasma	pregnancy	24521639	real-time pcr	analysis of extracellular chromosome 21-derived micrornas has no benefit for screening programmes and non-invasive diagnosis of down syndrome.
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99		Homo sapiens	exosome	dendritic cells	Dendritic cells	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-99a	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-99	NULL	Homo sapiens	microvesicle	mesenchymal stem cells	Mesenchymal stem cells - Normal	20668554	rt-pcr|Differential centrifugation|Ultracentrifugation	Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
hsa-miR-99a*	miRNA	hsa-miR-99a-3p	MIMAT0004511	mir-99		Homo sapiens	Ago2	plasma	normal	21609964	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
hsa-miR-99a-5p	miRNA	hsa-miR-99a-5p	MIMAT0000097	mir-10	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hsa-miR-99b	miRNA	hsa-miR-99b-5p	MIMAT0000689	mir-99		Homo sapiens	circulating	plasma	normal	21383194	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
hsa-miR-99b	miRNA	hsa-miR-99b-5p	MIMAT0000689	mir-99		Homo sapiens	circulating	plasma	multiple myeloma (mm)	22447484	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
hsa-miR-99b	miRNA	hsa-miR-99b-5p	MIMAT0000689	mir-99		Homo sapiens	circulating	plasma	normal	18663219	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
hsa-miR-99b	miRNA	hsa-miR-99b-5p	MIMAT0000689	mir-99		Homo sapiens	circulating	serum	Chronic systolic heart failure	22120965	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
hsa-miR-99b	miRNA	hsa-miR-99b-5p	MIMAT0000689	mir-99		Homo sapiens	exosome	serum	papillary adenocarcinoma of ovary	18589210	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
hsa-miR-99b*	miRNA	hsa-miR-99b-3p	MIMAT0004678	mir-99		Homo sapiens	exosome	t cells	j77	21505438	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
hsa-miR-99b-5p	miRNA	hsa-miR-99b-5p	MIMAT0000689	mir-10	NULL	Homo sapiens	exosome	urine	normal	24352158	RNA deep sequencing|Differential centrifugation|Norgen Biotek Exosome kit	Characterization and deep sequencing analysis of  exosomal miRNA in human urine
hulc	lncRNA					Homo sapiens	circulating	blood	hepatocellular carcinoma (hcc)	17241883	quantitative real-time pcr	hulc is the first ncrna with highly specific up-regulation in hcc. because hulc was detected in blood of hcc patients, a potential use as novel biomarker can be envisaged.
linc-ror	lncRNA					Homo sapiens	microvesicle	culture medium	hepatocellular carcinoma (hcc)	24918061	nanosight n-300 (nanosight ltd., amesbury, uk)|trizol (invitrogen)|exoquick-tc (system biosciences, mountain view, ca)|serami exosome rna amplification kit (system biosciences, mountain view, ca)|nanodrop nd-2000 (nano-drop technologies, wilmington, de)|qrt-pcr	these data provide mechanistic insights into primary chemoresistance in hcc by showing that: (a) tgfβ selectively enriches linc-ror within extracellular vesicles, which has a potential role in intercellular signaling in response to tgfβ; (b) expression and enrichment of linc-ror during chemotherapeutic stress plays a functional role in chemoresistance; and (c) the effects of tgfβ on chemoresistance in hcc may involve linc-ror-dependent effects on tumor-initiating cells. these findings implicate extracellular vesicle lncrna as mediators of the chemotherapeutic response, and support targeting linc-ror to enhance chemosensitivity in hcc.
linc00152	lncRNA					Homo sapiens	exosome	plasma	gastric cancer (gc)	25391424	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	the levels of plasma linc00152 were significantly elevated in gastric cancer patients compared with healthy controls.
lipcar	lncRNA					Homo sapiens	circulating	plasma	heart failure (hf)	24663402	mirneasy 96 kit (qiagen)|nanodrop (thermo scientific)|bioanalyzer (agilent)|microarrays (arraystar human lncrna array; version 2.0)|real time pcr	global transcriptomic analyses were done in plasma rna from patients with or without left ventricular remodeling after myocardial infarction. regulated candidates were validated in 3 independent patient cohorts developing cardiac remodeling and heart failure (788 patients). the mitochondrial long noncoding rna uc022bqs.1 (lipcar) was downregulated early after myocardial infarction but upregulated during later stages. lipcar levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths. lipcar is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure.
malat-1	lncRNA					Homo sapiens	circulating	plasma	prostate cancer	23726266	qrt-pcr	plasma metastasis associated in lung adenocarcinoma transcript 1 (malat-1) derived (md) minirna (md-minirna) levels are significantly elevated in pca patients compared to non-pca patients (p<0.001). md-minirna can be used as a novel plasma-based biomarker for pca detection and can improve diagnostic accuracy by predicting prostate biopsy outcomes.
MBOAT2	circRNA	NULL			hsa_circ_0007334	Homo sapiens	circulating	blood	normal	26485708	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
mmu-let-7b	miRNA	mmu-let-7b-5p	MIMAT0000522	let-7	NULL	Mus musculus	exosome	neuronal cells	Prion-infected neuronal cells	22965126	small RNA deep sequencing|RT-PCR|Differential centrifugation|Filtration|Ultracentrifugation	Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.
mmu-let-7i	miRNA	mmu-let-7i-5p	MIMAT0000122	let-7	NULL	Mus musculus	exosome	neuronal cells	Prion-infected neuronal cells	22965126	small RNA deep sequencing|RT-PCR|Differential centrifugation|Filtration|Ultracentrifugation	Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.
mmu-miR-122	miRNA	mmu-miR-122-5p	MIMAT0000246	mir-122		Mus musculus	exosome	serum	non-alcoholic steatohepatitis (NASH)	25040043	taqman microrna assays	authors suggest that decreased liver mir-122 was associated with elevated circulating mir-122, and contributes to upregulation of modulators of tissue remodelling (hif-1α, vimentin and map3k3) and might play a role in nash-induced liver fibrosis.
mmu-miR-122	miRNA	mmu-miR-122-5p	MIMAT0000246	mir-122		Mus musculus	circulating	serum	non-alcoholic steatohepatitis (NASH)	24217942	rt-qpcr	authors demonstrate that serum levels of mir-122 can potentially be used as a sensitive biomarker for the early detection of hepatotoxicity and can aid in monitoring the extent of nafld-associated liver injury in mouse efficacy models.
mmu-miR-122	miRNA	mmu-miR-122-5p	MIMAT0000246	mir-122		mouse xenograft model	exosome	conditioned medium (cm) of breast cell lines	Breast cancer	25621950	real-time pcr	authors demonstrate that, by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular mir-122 is able to reprogram systemic energy metabolism to facilitate disease progression.
mmu-miR-122-5p	miRNA	mmu-miR-122-5p	MIMAT0000246	mir-122		Mus musculus	circulating	serum	perfluorooctanoic acid (pfoa) exposure	24513432	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
mmu-miR-126	miRNA					Mus musculus	circulating	vascular endothelium	kidney ischemia reperfusion injury	25541911	qrt-pcr	authors demonstrated that silencing of mir-126 can enhance renal expression of stromal cell-derived factor 1 (sdf-1) after ischemia/ reperfusion injury (iri), leading to the mobilization of vascular progenitor cells into the circulation.
mmu-miR-128a	miRNA	mmu-miR-128-3p	MIMAT0000140	mir-128	NULL	Mus musculus	exosome	neuronal cells	Prion-infected neuronal cells	22965126	small RNA deep sequencing|RT-PCR|Differential centrifugation|Filtration|Ultracentrifugation	Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.
mmu-miR-146	miRNA	mmu-miR-146a-5p	MIMAT0000158	mir-146	NULL	Mus musculus	exosome	neuronal cells	Prion-infected neuronal cells	22965126	small RNA deep sequencing|RT-PCR|Differential centrifugation|Filtration|Ultracentrifugation	Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.
mmu-mir-146a-5p	miRNA	mmu-miR-146a-5p	MIMAT0000158	mir-146		calsequestrin (csq)-tg mouse	circulating	plasma	heart failure (hf)	27321284	real-time pcr	these results suggest that mirna, especially mir-146a and mir-342-3p, could be used as potential biomarkers for evaluating the efficacy of anti-heart failure drugs.
mmu-miR-192-5p	miRNA	mmu-miR-192-5p	MIMAT0000517	mir-192		Mus musculus	circulating	serum	perfluorooctanoic acid (pfoa) exposure	24513432	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
mmu-miR-199a-3p	miRNA	mmu-miR-199a-3p	MIMAT0000230	mir-199		Mus musculus	circulating	serum	perfluorooctanoic acid (pfoa) exposure	24513432	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
mmu-miR-21	miRNA	mmu-miR-21a-5p	MIMAT0000530	mir-21	NULL	Mus musculus	exosome	neuronal cells	Prion-infected neuronal cells	22965126	small RNA deep sequencing|RT-PCR|Differential centrifugation|Filtration|Ultracentrifugation	Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.
mmu-miR-222	miRNA	mmu-miR-222-3p	MIMAT0000670	mir-221	NULL	Mus musculus	exosome	neuronal cells	Prion-infected neuronal cells	22965126	small RNA deep sequencing|RT-PCR|Differential centrifugation|Filtration|Ultracentrifugation	Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.
mmu-miR-26b-5p	miRNA	mmu-miR-26b-5p	MIMAT0000534	mir-26		Mus musculus	circulating	serum	perfluorooctanoic acid (pfoa) exposure	24513432	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
mmu-miR-26b-5p	miRNA	mmu-miR-26b-5p	MIMAT0000534	mir-26		Mus musculus	circulating	serum	perfluorooctanoic acid (pfoa) exposure	24513432	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
mmu-miR-28-5p	miRNA	mmu-miR-28a-5p	MIMAT0000653	mir-28		Mus musculus	circulating	serum	perfluorooctanoic acid (pfoa) exposure	24513432	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
mmu-miR-29b	miRNA	mmu-miR-29b-3p	MIMAT0000127	mir-29	NULL	Mus musculus	exosome	neuronal cells	Prion-infected neuronal cells	22965126	small RNA deep sequencing|RT-PCR|Differential centrifugation|Filtration|Ultracentrifugation	Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.
mmu-miR-32-5p	miRNA	mmu-miR-32-5p	MIMAT0000654	mir-32		Mus musculus	circulating	serum	perfluorooctanoic acid (pfoa) exposure	24513432	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
mmu-miR-342-3p	miRNA	mmu-miR-342-3p	MIMAT0000590	mir-342	NULL	Mus musculus	exosome	neuronal cells	Prion-infected neuronal cells	22965126	small RNA deep sequencing|RT-PCR|Differential centrifugation|Filtration|Ultracentrifugation	Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.
mmu-miR-342-3p	miRNA	mmu-miR-342-3p	MIMAT0000590	mir-342		calsequestrin (csq)-tg mouse	circulating	plasma	heart failure (hf)	27321284	real-time pcr	these results suggest that mirna, especially mir-146a and mir-342-3p, could be used as potential biomarkers for evaluating the efficacy of anti-heart failure drugs.
mmu-miR-424	miRNA	mmu-miR-322-5p	MIMAT0000548	mir-322	NULL	Mus musculus	exosome	neuronal cells	Prion-infected neuronal cells	22965126	small RNA deep sequencing|RT-PCR|Differential centrifugation|Filtration|Ultracentrifugation	Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells.
mmu-miR-424	miRNA	mmu-miR-322-5p	MIMAT0000548	mir-322		Mus musculus	circulating	peri-infarct cortex	reperfusion injury	25523055	real-time pcr	authors demonstrated that mir-424 protects against transient cerebral ischemia/reperfusion injury by inhibiting oxidative stress.
mmu-miR-424	miRNA	mmu-miR-322-5p	MIMAT0000548	mir-322		Mus musculus	circulating	peri-infarct cortex	Cerebral ischemia	25523055	real-time pcr	authors demonstrated that mir-424 protects against transient cerebral ischemia/reperfusion injury by inhibiting oxidative stress.
MORC3	circRNA	NULL			hsa_circ_0001189	Homo sapiens	circulating	blood	normal	26485708	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
oar-miR-15b	miRNA					Ovis aries	circulating	plasma	maternal alcohol exposure	24588274	Quantitative PCR	shared profiles between pregnant dam and neonate suggest possible maternal-fetal mirna transfer. cir mirnas are biomarkers for alcohol exposure during pregnancy, in both mother and neonate, and may constitute an important shared endocrine biomarker that is vulnerable to the maternal environment.
oar-miR-19b	miRNA	oar-miR-19b	MIMAT0030041	mir-19		Ovis aries	circulating	plasma	maternal alcohol exposure	24588274	Quantitative PCR	shared profiles between pregnant dam and neonate suggest possible maternal-fetal mirna transfer. cir mirnas are biomarkers for alcohol exposure during pregnancy, in both mother and neonate, and may constitute an important shared endocrine biomarker that is vulnerable to the maternal environment.
oar-miR-20a	miRNA					Ovis aries	circulating	plasma	maternal alcohol exposure	24588274	Quantitative PCR	shared profiles between pregnant dam and neonate suggest possible maternal-fetal mirna transfer. cir mirnas are biomarkers for alcohol exposure during pregnancy, in both mother and neonate, and may constitute an important shared endocrine biomarker that is vulnerable to the maternal environment.
oar-miR-9	miRNA					Ovis aries	circulating	plasma	maternal alcohol exposure	24588274	Quantitative PCR	shared profiles between pregnant dam and neonate suggest possible maternal-fetal mirna transfer. cir mirnas are biomarkers for alcohol exposure during pregnancy, in both mother and neonate, and may constitute an important shared endocrine biomarker that is vulnerable to the maternal environment.
pca3	lncRNA					Homo sapiens	circulating	urine	prostate cancer	15245811	isothermic nucleic acid based amplification (nasba)|spectrofluorimeter||nucleic acid sequence based amplification assay (upm3)	serum tpsa lacks specificity. the dd3(pca3) gene is highly specific for prostate cancer and is detectable in prostate cancer cells shed into urine after rectal palpation. a newly developed nucleic acid sequence based amplification assay (upm3) for detecting dd3(pca3) rna in urine samples was evaluated prospectively in patients referred for prostate cancer detection. the upm3 assay showed excellent clinical performances and a specificity far superior to tpsa.
pca3	lncRNA					Homo sapiens	circulating	urine	prostate cancer	12814669	quantitative real-time pcr	the quantitative rt-pcr assay for dd3(pca3) described, bears great promise as a tool for molecular urine analysis. it has great potential in reducing the number of unnecessary biopsies.
PCNT1	circRNA	NULL			hsa_circ_0002903	Homo sapiens	circulating	blood	normal	26485708	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
pou3f3	lncRNA					Homo sapiens	circulating	plasma	esophageal squamous cell carcinoma (escc)	25608466	trizol reagent (invitrogen, carlsbad, ca, usa)|mirvana paris kit (ambion 1556, usa)|sybr premix ex tag ii (takara: rr820a)|abi 7500 real-time pcr system (applied biosystems, usa)	escc-related lncrnas were detectable and stable in plasma of cancer patients, and derived largely from escc tumor cells. furthermore, plasma levels of pou3f3, hnf1a-as1 and spry4-it1 were significantly higher in escc patients compared with normal controls. by receiver operating characteristic curve (roc) analysis, among the three lncrnas investigated, plasma pou3f3 provided the highest diagnostic performance for detection of escc (the area under the roc curve (auc), 0.842; p < 0.001; sensitivity, 72.8%; specificity, 89.4%). plasma pou3f3 could serve as a potential biomarker for diagnosis of escc.
rno-let-7b	miRNA	rno-let-7b-5p	MIMAT0000775	let-7	NULL	Rattus norvegicus	microvesicle	adipocytes	3T3-L1	20621060	RT-PCR|Differential centrifugation|Ultracentrifugation	Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation
rno-miR-103	miRNA	rno-miR-103-3p	MIMAT0000824	mir-103	NULL	Rattus norvegicus	microvesicle	adipocytes	3T3-L1	20621060	RT-PCR|Differential centrifugation|Ultracentrifugation	Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation
rno-miR-133a	miRNA	rno-miR-133a-3p	MIMAT0000839	mir-133		sprague dawley rats	circulating	fibrotic bladder tissues	Bladder outlet obstruction (boo)	25451078	primescript mirna qrt-pcr detection kit (takara, dalian, china)|real-time qpcr with sybr green i	authors showed a novel antifibrotic functional role for mir-133, which may represent a potential target for diagnostic and therapeutic strategies in bladder fibrosis.
rno-miR-133b	miRNA	rno-miR-133b-3p	MIMAT0003126	mir-133	NULL	sprague dawley rats	circulating	fibrotic bladder tissues	Bladder outlet obstruction (boo)	25451078	primescript mirna qrt-pcr detection kit (takara, dalian, china)|real-time qpcr with sybr green i	authors showed a novel antifibrotic functional role for mir-133, which may represent a potential target for diagnostic and therapeutic strategies in bladder fibrosis.
rno-miR-136	miRNA	rno-miR-136-5p	MIMAT0000842	mir-136		rat model	circulating	plasma	ischaemic stroke	24428837	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
rno-miR-142-5p	miRNA	rno-miR-142-5p	MIMAT0000847	mir-142		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
rno-miR-146b	miRNA	rno-miR-148b-3p	MIMAT0000579	mir-146	NULL	Rattus norvegicus	microvesicle	adipocytes	3T3-L1	20621060	RT-PCR|Differential centrifugation|Ultracentrifugation	Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation
rno-miR-148a	miRNA	NULL	NULL	mir-148	NULL	Rattus norvegicus	microvesicle	adipocytes	3T3-L1	20621060	RT-PCR|Differential centrifugation|Ultracentrifugation	Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation
rno-miR-15a	miRNA	rno-miR-15a-5p	MIMAT0035728	mir-15		rat model	circulating	plasma	ischaemic stroke	24428837	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
rno-miR-199a-3p	miRNA	rno-miR-199a-5p	MIMAT0000872	mir-199		rat model	circulating	plasma	ischaemic stroke	24428837	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
rno-miR-19b	miRNA	rno-miR-19b-3p	MIMAT0000788	mir-19		rat model	circulating	plasma	ischaemic stroke	24428837	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
rno-miR-19b-3p	miRNA	rno-miR-19b-3p	MIMAT0000788	mir-19		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
rno-miR-206	miRNA	rno-miR-206-3p	MIMAT0000879	mir-1		male f344 rats model	circulating	serum	lung cancer	24553369	quantitative real-time pcr	the mir-210 was down-regulated and the mir-206 was up-regulated in nnk treatment group. the expression level of circulating mirnas changed from week 1 to week 20 following nnk treatment. the expression level of circulating mirnas is related to nnk-induced early stage lung carcinogenesis in rats and can therefore serve as its potential indicator.
rno-miR-210	miRNA	rno-miR-210-3p	MIMAT0000881	mir-210		male f344 rats model	circulating	serum	lung cancer	24553369	quantitative real-time pcr	the mir-210 was down-regulated and the mir-206 was up-regulated in nnk treatment group. the expression level of circulating mirnas changed from week 1 to week 20 following nnk treatment. the expression level of circulating mirnas is related to nnk-induced early stage lung carcinogenesis in rats and can therefore serve as its potential indicator.
rno-miR-221	miRNA	rno-miR-221-3p	MIMAT0000890	mir-221	NULL	Rattus norvegicus	microvesicle	adipocytes	3T3-L1	20621060	RT-PCR|Differential centrifugation|Ultracentrifugation	Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation
rno-miR-221-3p	miRNA	rno-miR-221-3p	MIMAT0000890	mir-221		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
rno-miR-223-3p	miRNA	rno-miR-223-3p	MIMAT0000892	mir-223		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
rno-miR-223-3p	miRNA	rno-miR-223-3p	MIMAT0000892	mir-223		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
rno-miR-32	miRNA	rno-miR-32-5p	MIMAT0000811	mir-32		rat model	circulating	plasma	ischaemic stroke	24428837	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
rno-miR-322-3p	miRNA	rno-miR-322-3p	MIMAT0000547	mir-322		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
rno-miR-324-3p	miRNA	rno-miR-324-3p	MIMAT0000554	mir-324		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
rno-miR-421-3p	miRNA	rno-miR-421-3p	MIMAT0017175	mir-95		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
rno-miR-463-5p	miRNA	rno-miR-463-5p	MIMAT0017309	mir-463		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
rno-miR-674-3p	miRNA	rno-miR-674-3p	MIMAT0005330	mir-674		male albino sprague 	circulating	serum	posttraumatic stress disorder (ptsd)	24998397	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
spry4-it1	lncRNA					Homo sapiens	circulating	plasma	esophageal squamous cell carcinoma (escc)	25608466	trizol reagent (invitrogen, carlsbad, ca, usa)|mirvana paris kit (ambion 1556, usa)|sybr premix ex tag ii (takara: rr820a)|abi 7500 real-time pcr system (applied biosystems, usa)	escc-related lncrnas were detectable and stable in plasma of cancer patients, and derived largely from escc tumor cells. furthermore, plasma levels of pou3f3, hnf1a-as1 and spry4-it1 were significantly higher in escc patients compared with normal controls. by receiver operating characteristic curve (roc) analysis, among the three lncrnas investigated, plasma pou3f3 provided the highest diagnostic performance for detection of escc (the area under the roc curve (auc), 0.842; p < 0.001; sensitivity, 72.8%; specificity, 89.4%). plasma pou3f3 could serve as a potential biomarker for diagnosis of escc.
tapsaki	lncRNA					Homo sapiens	circulating	plasma	Acute kidney injury	25294924	quantitative real-time pcr	circulating concentrations of the novel intronic antisense lncrna transcript predicting survival in aki (tapsaki) (p < 0.0001) were detectable in kidney biopsies and upregulated in plasma of patients with aki. cox regression and kaplan-meier curve analysis revealed tapsaki as an independent predictor of 28-day survival (p < 0.01). tapsaki was enriched in tubular epithelial cells subjected to atp depletion (p = 0.03). the alteration of circulating concentrations of lncrnas in patients with aki supports tapsaki as a predictor of mortality in this patient cohort.
TMEM56	circRNA	NULL			hsa_circ_0000095	Homo sapiens	circulating	blood	normal	26485708	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
tuc339	lncRNA					Homo sapiens	microvesicle	culture medium	hepatocellular carcinoma (hcc)	24167654	sequential ultracentrifugation and density gradient separation|em208s transmission electron microscope (philips, eindhoven, the netherlands)|nih image j software (national institutes of health, bethesda, md)|pkh67 (sigma-aldrich, st. louis, mo)|applied biosystems 7900ht real-time pcr|qrt-pcr	intercellular transfer of tuc339 represents a unique signaling mechanism by which tumor cells can promote hcc growth and spread. these findings expand the potential roles of ultraconserved lncrna (ucrna) in hcc, support the existence of selective mechanisms for lncrna export from cells, and implicate extracellular vesicle-mediated transfer of lncrna as a mechanism by which tumor cells can modulate their local cellular environment. intercellular transfer of functionally active rna molecules by extracellular vesicles provides a mechanism that enables cells to exert genetic influences on other cells within the microenvironment.
UBXN7	circRNA	NULL			hsa_circ_0001380	Homo sapiens	circulating	blood	normal	26485708	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
XPO1	circRNA	NULL			hsa_circ_0001017	Homo sapiens	circulating	blood	normal	26485708	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.