RNA_class	RNA	mirna_family	mirbase_accession	organism	potential_biomarker	RNA_type	sample	disease	author	journal	title	PubMed_ID	data	method	description
circRNA	MBOAT2	circRNA		Homo sapiens	1	circulating	blood	normal	Memczak S et al.	PLoS One. 10(10):e0141214.	Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood.	26485708	2015	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
circRNA	TMEM56	circRNA		Homo sapiens	1	circulating	blood	normal	Memczak S et al.	PLoS One. 10(10):e0141214.	Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood.	26485708	2015	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
circRNA	DNAJC6	circRNA		Homo sapiens	1	circulating	blood	normal	Memczak S et al.	PLoS One. 10(10):e0141214.	Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood.	26485708	2015	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
circRNA	UBXN7	circRNA		Homo sapiens	1	circulating	blood	normal	Memczak S et al.	PLoS One. 10(10):e0141214.	Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood.	26485708	2015	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
circRNA	PCNT1	circRNA		Homo sapiens	1	circulating	blood	normal	Memczak S et al.	PLoS One. 10(10):e0141214.	Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood.	26485708	2015	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
circRNA	MORC3	circRNA		Homo sapiens	1	circulating	blood	normal	Memczak S et al.	PLoS One. 10(10):e0141214.	Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood.	26485708	2015	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
circRNA	XPO1	circRNA		Homo sapiens	1	circulating	blood	normal	Memczak S et al.	PLoS One. 10(10):e0141214.	Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood.	26485708	2015	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
circRNA	GSE1	circRNA		Homo sapiens	1	circulating	blood	normal	Memczak S et al.	PLoS One. 10(10):e0141214.	Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood.	26485708	2015	Illumina TruSeq protocol (Illumina, San Diego, USA)|Illumina HiSeq2000|qPCR	The authors sequenced RNA in human peripheral whole blood to determine the potential of circRNAs as biomarkers in an easily accessible body fluid. They reported the reproducible detection of thousands of circRNAs. Importantly, they observed that hundreds of circRNAs are much higher expressed than corresponding linear mRNAs. CircRNAs could be used as biomarker molecules in standard clinical blood samples.
lncRNA	pou3f3	lncrna		Homo sapiens	1	circulating	plasma	esophageal squamous cell carcinoma (escc)	Tong YS et al.	Mol Cancer. 14(1):3.	Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma.	25608466	2015	trizol reagent (invitrogen, carlsbad, ca, usa)|mirvana paris kit (ambion 1556, usa)|sybr premix ex tag ii (takara: rr820a)|abi 7500 real-time pcr system (applied biosystems, usa)	escc-related lncrnas were detectable and stable in plasma of cancer patients, and derived largely from escc tumor cells. furthermore, plasma levels of pou3f3, hnf1a-as1 and spry4-it1 were significantly higher in escc patients compared with normal controls. by receiver operating characteristic curve (roc) analysis, among the three lncrnas investigated, plasma pou3f3 provided the highest diagnostic performance for detection of escc (the area under the roc curve (auc), 0.842; p < 0.001; sensitivity, 72.8%; specificity, 89.4%). plasma pou3f3 could serve as a potential biomarker for diagnosis of escc.
lncRNA	hnf1a-as1	lncrna		Homo sapiens	0	circulating	plasma	esophageal squamous cell carcinoma (escc)	Tong YS et al.	Mol Cancer. 14(1):3.	Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma.	25608466	2015	trizol reagent (invitrogen, carlsbad, ca, usa)|mirvana paris kit (ambion 1556, usa)|sybr premix ex tag ii (takara: rr820a)|abi 7500 real-time pcr system (applied biosystems, usa)	escc-related lncrnas were detectable and stable in plasma of cancer patients, and derived largely from escc tumor cells. furthermore, plasma levels of pou3f3, hnf1a-as1 and spry4-it1 were significantly higher in escc patients compared with normal controls. by receiver operating characteristic curve (roc) analysis, among the three lncrnas investigated, plasma pou3f3 provided the highest diagnostic performance for detection of escc (the area under the roc curve (auc), 0.842; p < 0.001; sensitivity, 72.8%; specificity, 89.4%). plasma pou3f3 could serve as a potential biomarker for diagnosis of escc.
lncRNA	spry4-it1	lncrna		Homo sapiens	0	circulating	plasma	esophageal squamous cell carcinoma (escc)	Tong YS et al.	Mol Cancer. 14(1):3.	Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma.	25608466	2015	trizol reagent (invitrogen, carlsbad, ca, usa)|mirvana paris kit (ambion 1556, usa)|sybr premix ex tag ii (takara: rr820a)|abi 7500 real-time pcr system (applied biosystems, usa)	escc-related lncrnas were detectable and stable in plasma of cancer patients, and derived largely from escc tumor cells. furthermore, plasma levels of pou3f3, hnf1a-as1 and spry4-it1 were significantly higher in escc patients compared with normal controls. by receiver operating characteristic curve (roc) analysis, among the three lncrnas investigated, plasma pou3f3 provided the highest diagnostic performance for detection of escc (the area under the roc curve (auc), 0.842; p < 0.001; sensitivity, 72.8%; specificity, 89.4%). plasma pou3f3 could serve as a potential biomarker for diagnosis of escc.
lncRNA	tapsaki	lncrna		Homo sapiens	1	circulating	plasma	Acute kidney injury	Lorenzen JM et al.	Clin Chem. 61(1):191-201.	Circulating long noncoding RNATapSaki is a predictor of mortality in critically ill patients with acute kidney injury.	25294924	2015	quantitative real-time pcr	circulating concentrations of the novel intronic antisense lncrna transcript predicting survival in aki (tapsaki) (p < 0.0001) were detectable in kidney biopsies and upregulated in plasma of patients with aki. cox regression and kaplan-meier curve analysis revealed tapsaki as an independent predictor of 28-day survival (p < 0.01). tapsaki was enriched in tubular epithelial cells subjected to atp depletion (p = 0.03). the alteration of circulating concentrations of lncrnas in patients with aki supports tapsaki as a predictor of mortality in this patient cohort.
lncRNA	lipcar	lncrna		Homo sapiens	1	circulating	plasma	heart failure (hf)	Kumarswamy R et al.	Circ Res. 114(10):1569-75.	Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.	24663402	2014	mirneasy 96 kit (qiagen)|nanodrop (thermo scientific)|bioanalyzer (agilent)|microarrays (arraystar human lncrna array; version 2.0)|real time pcr	global transcriptomic analyses were done in plasma rna from patients with or without left ventricular remodeling after myocardial infarction. regulated candidates were validated in 3 independent patient cohorts developing cardiac remodeling and heart failure (788 patients). the mitochondrial long noncoding rna uc022bqs.1 (lipcar) was downregulated early after myocardial infarction but upregulated during later stages. lipcar levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths. lipcar is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure.
lncRNA	h19	lncrna		Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Arita T et al.	Anticancer Res. 33(8):3185-93.	Circulating long non-coding RNAs in plasma of patients with gastric cancer.	23898077	2013	rt-pcr	plasma h19 levels were significantly higher in patients than in healthy controls. plasma h19 levels were significantly reduced in postoperative samples. circulating lncrnas can be detectable in plasma, and the detection of circulating lncrnas may provide new complementary tumor markers for gastric cancer.
lncRNA	pca3	lncrna		Homo sapiens	1	circulating	urine	prostate cancer	Tinzl M et al.	Eur Urol. 46(2):182-6	DD3PCA3 RNA analysis in urine--a new perspective for detecting prostate cancer.	15245811	2004	isothermic nucleic acid based amplification (nasba)|spectrofluorimeter||nucleic acid sequence based amplification assay (upm3)	serum tpsa lacks specificity. the dd3(pca3) gene is highly specific for prostate cancer and is detectable in prostate cancer cells shed into urine after rectal palpation. a newly developed nucleic acid sequence based amplification assay (upm3) for detecting dd3(pca3) rna in urine samples was evaluated prospectively in patients referred for prostate cancer detection. the upm3 assay showed excellent clinical performances and a specificity far superior to tpsa.
lncRNA	pca3	lncrna		Homo sapiens	1	circulating	urine	prostate cancer	Hessels D et al.	Eur Urol. 44(1):8-15	DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer.	12814669	2003	quantitative real-time pcr	the quantitative rt-pcr assay for dd3(pca3) described, bears great promise as a tool for molecular urine analysis. it has great potential in reducing the number of unnecessary biopsies.
lncRNA	hulc	lncrna		Homo sapiens	0	circulating	blood	hepatocellular carcinoma (hcc)	Panzitt K et al.	Gastroenterology. 132(1):330-42.	Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA.	17241883	2007	quantitative real-time pcr	hulc is the first ncrna with highly specific up-regulation in hcc. because hulc was detected in blood of hcc patients, a potential use as novel biomarker can be envisaged.
lncRNA	tuc339	lncrna		Homo sapiens	0	microvesicle	culture medium	hepatocellular carcinoma (hcc)	Kogure T et al.	Genes Cancer. 4(7-8):261-72.	Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer.	24167654	2013	sequential ultracentrifugation and density gradient separation|em208s transmission electron microscope (philips, eindhoven, the netherlands)|nih image j software (national institutes of health, bethesda, md)|pkh67 (sigma-aldrich, st. louis, mo)|applied biosystems 7900ht real-time pcr|qrt-pcr	intercellular transfer of tuc339 represents a unique signaling mechanism by which tumor cells can promote hcc growth and spread. these findings expand the potential roles of ultraconserved lncrna (ucrna) in hcc, support the existence of selective mechanisms for lncrna export from cells, and implicate extracellular vesicle-mediated transfer of lncrna as a mechanism by which tumor cells can modulate their local cellular environment. intercellular transfer of functionally active rna molecules by extracellular vesicles provides a mechanism that enables cells to exert genetic influences on other cells within the microenvironment.
lncRNA	linc-ror	lncrna		Homo sapiens	1	microvesicle	culture medium	hepatocellular carcinoma (hcc)	Takahashi K et al.	FEBS Open Bio. 4:458-67.	Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer.	24918061	2014	nanosight n-300 (nanosight ltd., amesbury, uk)|trizol (invitrogen)|exoquick-tc (system biosciences, mountain view, ca)|serami exosome rna amplification kit (system biosciences, mountain view, ca)|nanodrop nd-2000 (nano-drop technologies, wilmington, de)|qrt-pcr	these data provide mechanistic insights into primary chemoresistance in hcc by showing that: (a) tgfβ selectively enriches linc-ror within extracellular vesicles, which has a potential role in intercellular signaling in response to tgfβ; (b) expression and enrichment of linc-ror during chemotherapeutic stress plays a functional role in chemoresistance; and (c) the effects of tgfβ on chemoresistance in hcc may involve linc-ror-dependent effects on tumor-initiating cells. these findings implicate extracellular vesicle lncrna as mediators of the chemotherapeutic response, and support targeting linc-ror to enhance chemosensitivity in hcc.
lncRNA	linc00152	lncrna		Homo sapiens	1	exosome	plasma	gastric cancer (gc)	Li Q et al.	Tumour Biol. 36(3):2007-12.	Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer.	25391424	2015	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	the levels of plasma linc00152 were significantly elevated in gastric cancer patients compared with healthy controls.
lncRNA	malat-1	lncrna		Homo sapiens	1	circulating	plasma	prostate cancer	Ren S et al.	Eur J Cancer. 49(13):2949-59.	Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer.	23726266	2013	qrt-pcr	plasma metastasis associated in lung adenocarcinoma transcript 1 (malat-1) derived (md) minirna (md-minirna) levels are significantly elevated in pca patients compared to non-pca patients (p<0.001). md-minirna can be used as a novel plasma-based biomarker for pca detection and can improve diagnostic accuracy by predicting prostate biopsy outcomes.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-590-5p	mir-590	MIMAT0003258	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-145*	mir-145	MIMAT0004601	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-34b	mir-34	MIMAT0004676	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	Breast cancer	jung ej et al.	cancer. 	plasma microrna 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients.	22370716	2011	reverse transcriptase-polymerase chain reaction 	circulating mir-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma mir-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab. 
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	1	circulating	serum	metabolic syndrome (mets)	Wang YT et al.	J Biomed Sci. 20(1):72.	Circulating microRNAs have a sex-specific association with metabolic syndrome.	24093444	2013	qrt-pcr	the circulating levels of let-7 g and mir-221 displayed a female-specific elevation in individuals with metabolic syndrome.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	1	circulating	serum	heart transplant rejection	Duong Van Huyen JP et al.	Eur Heart J. 35(45):3194-202.	MicroRNAs as non-invasive biomarkers of heart transplant rejection.	25176944	2014	real-time pcr	the study demonstrates that a differential expression of mirna occurs in rejecting allograft patients, not only at the tissue level but also in the serum, suggesting their potential relevance as non-invasive biomarkers in heart transplant rejection.
miRNA	hsa-miR-135b	mir-135	MIMAT0000758	Homo sapiens	0	circulating	plasma	pregnancy	chim ss et al.	clin chem. 54(3):482-90 	detection and characterization of placental micrornas in maternal plasma.	18218722	2008	mirvana mirna isolation kit (ambion)|taqman microrna assay (applied biosystems) qrt-pcr	the 4 most abundant of the placental mirnas (mir-141, mir-149, mir-299-5p, and mir-135b) were detectable in maternal plasma during pregnancy and showed reduced detection rates in postdelivery plasma. The plasma concentration of mir-141 increased as pregnancy progressed into the third trimester. 
miRNA	hsa-miR-199a	mir-199	MIMAT0000231	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-598	mir-598	MIMAT0003266	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-193a-3p	mir-193	MIMAT0000459	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-374a	mir-374	MIMAT0000727	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	1	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	1	circulating	serum	metabolic syndrome (mets)	Wang YT et al.	J Biomed Sci. 20(1):72.	Circulating microRNAs have a sex-specific association with metabolic syndrome.	24093444	2013	qrt-pcr	the circulating levels of let-7 g and mir-221 displayed a female-specific elevation in individuals with metabolic syndrome.
miRNA	hsa-miR-33a	mir-33	MIMAT0000091	Homo sapiens	0	circulating	serum	Dialysis	Wang JM et al.	Ther Apher Dial. 18(1):44-50.	Dialysis method alters the expression of microRNA-33a and its target genes ABCA1, ABCG1 in THP-1 macrophages.	24499083	2014	real-time quantitative pcr	hemodiafiltration (hdf) therapy can downregulate mir-33a expression, and then result in abca1, abcg1 upregulation and an increase in circulating hdl-c, leading to a possible anti-atherosclerosis effect to some extent.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	plasma	pregnancy	chim ss et al.	clin chem. 54(3):482-90 	detection and characterization of placental micrornas in maternal plasma.	18218722	2008	mirvana mirna isolation kit (ambion)|taqman microrna assay (applied biosystems) qrt-pcr	the 4 most abundant of the placental mirnas (mir-141, mir-149, mir-299-5p, and mir-135b) were detectable in maternal plasma during pregnancy and showed reduced detection rates in postdelivery plasma. The plasma concentration of mir-141 increased as pregnancy progressed into the third trimester. 
miRNA	hsa-miR-199a	mir-199	MIMAT0000231	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-622	mir-622	MIMAT0003291	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-193a-5p	mir-193	MIMAT0004614	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-425*	mir-425	MIMAT0001343	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-27b	mir-27	MIMAT0000419	Homo sapiens	1	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-151a-5p	mir-28	MIMAT0004697	Homo sapiens	1	circulating	serum	Aging	Hooten NN et al.	Aging (Albany NY).	Age-related changes in microRNA levels in serum.	24088671	2013	next generation sequencing technology|real-time quantitative pcr	of the mirnas that authors found to be present in serum, three were significantly decreased in 20 older individuals compared to 20 younger individuals: mir-151a-5p, mir-181a-5p and mir-1248. consistent with the data in humans, these mirnas are also present at lower levels in the serum of elderly rhesus monkeys.
miRNA	hsa-miR-144	mir-144	MIMAT0000436	Homo sapiens	0	circulating	plasma	type 2 diabetes	Wang X et al.	PLoS One. 9(1):e86792.	Determination of 14 circulating microRNAs in Swedes and Iraqis with and without diabetes mellitus type 2.	24497980	2014	real-time pcr	this study suggests that the association between plasma mir-144 expression and t2d differs between swedes and iraqis.
miRNA	hsa-miR-149	mir-149	MIMAT0000450	Homo sapiens	0	circulating	plasma	pregnancy	chim ss et al.	clin chem. 54(3):482-90 	detection and characterization of placental micrornas in maternal plasma.	18218722	2008	mirvana mirna isolation kit (ambion)|taqman microrna assay (applied biosystems) qrt-pcr	the 4 most abundant of the placental mirnas (mir-141, mir-149, mir-299-5p, and mir-135b) were detectable in maternal plasma during pregnancy and showed reduced detection rates in postdelivery plasma. The plasma concentration of mir-141 increased as pregnancy progressed into the third trimester. 
miRNA	hsa-miR-199b	mir-199	MIMAT0000263	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-629	mir-629	MIMAT0004810	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-15a*	mir-15	MIMAT0004488	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-590-5p	mir-590	MIMAT0003258	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-181a-5p	mir-181	MIMAT0000256	Homo sapiens	1	circulating	serum	Aging	Hooten NN et al.	Aging (Albany NY).	Age-related changes in microRNA levels in serum.	24088671	2013	next generation sequencing technology|real-time quantitative pcr	of the mirnas that authors found to be present in serum, three were significantly decreased in 20 older individuals compared to 20 younger individuals: mir-151a-5p, mir-181a-5p and mir-1248. consistent with the data in humans, these mirnas are also present at lower levels in the serum of elderly rhesus monkeys.
miRNA	hsa-miR-499	mir-499	MIMAT0002870	Homo sapiens	1	circulating	serum	Acute myocardial infarction (ami)	Xiao J et al.	Int J Clin Exp Med. 7(1):136-41.	Serum microRNA-499 and microRNA-208a as biomarkers of acute myocardial infarction.	24482699	2014	qrt-pcr	serum mir-499 and mir-208a might be potential biomarkers for ami. mir-499 might be released from damaged heart to the circulation.
miRNA	hsa-miR-299-5p	mir-299	MIMAT0002890	Homo sapiens	0	circulating	plasma	pregnancy	chim ss et al.	clin chem. 54(3):482-90 	detection and characterization of placental micrornas in maternal plasma.	18218722	2008	mirvana mirna isolation kit (ambion)|taqman microrna assay (applied biosystems) qrt-pcr	the 4 most abundant of the placental mirnas (mir-141, mir-149, mir-299-5p, and mir-135b) were detectable in maternal plasma during pregnancy and showed reduced detection rates in postdelivery plasma. The plasma concentration of mir-141 increased as pregnancy progressed into the third trimester. 
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-668	mir-668	MIMAT0003881	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-151-3p	mir-28	MIMAT0000757	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-193b*	mir-193	MIMAT0004767	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-629	mir-629	MIMAT0004810	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-1248	mir-1248	MIMAT0005900	Homo sapiens	1	circulating	serum	Aging	Hooten NN et al.	Aging (Albany NY).	Age-related changes in microRNA levels in serum.	24088671	2013	next generation sequencing technology|real-time quantitative pcr	of the mirnas that authors found to be present in serum, three were significantly decreased in 20 older individuals compared to 20 younger individuals: mir-151a-5p, mir-181a-5p and mir-1248. consistent with the data in humans, these mirnas are also present at lower levels in the serum of elderly rhesus monkeys.
miRNA	hsa-miR-208a	mir-208	MIMAT0000241	Homo sapiens	1	circulating	serum	Acute myocardial infarction (ami)	Xiao J et al.	Int J Clin Exp Med. 7(1):136-41.	Serum microRNA-499 and microRNA-208a as biomarkers of acute myocardial infarction.	24482699	2014	qrt-pcr	serum mir-499 and mir-208a might be potential biomarkers for ami. mir-499 might be released from damaged heart to the circulation.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-720	mir-720	MIMAT0005954	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-629*	mir-629	MIMAT0003298	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	prostate cancer	Yaman Agaoglu F et al.	Tumour Biol. 32(3):583-8.	Investigation of miR-21, miR-141, and miR-221 in blood circulation of patients with prostate cancer.	21274675	2011	real-time pcr	analysis of mir-21, -141, and -221 in blood of pca patients reveals that mir-21 is more useful to differentiate pca patients from healthy controls, while the mir-141 was a better discriminator of metastatic pca from localized/local advanced disease. these results suggest that analysis of these mirnas might have clinical utility as a supplement to psa testing.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Ma GJ et al.	Asian Pac J Cancer Prev. 14(12):7551-4.	Plasma post-operative miR-21 expression in the prognosis of gastric cancers.	24460332	2013	qrt-pcr	the results suggested plasma mir-21 could be a novel potential biomarker for gc prognosis and evaluation of surgery outcomes, especially in patients without a family history.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-134	mir-134	MIMAT0000447	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-744	mir-744	MIMAT0004945	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-190	mir-190	MIMAT0000458	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-635*			Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	circulating	plasma	prostate cancer	Yaman Agaoglu F et al.	Tumour Biol. 32(3):583-8.	Investigation of miR-21, miR-141, and miR-221 in blood circulation of patients with prostate cancer.	21274675	2011	real-time pcr	analysis of mir-21, -141, and -221 in blood of pca patients reveals that mir-21 is more useful to differentiate pca patients from healthy controls, while the mir-141 was a better discriminator of metastatic pca from localized/local advanced disease. these results suggest that analysis of these mirnas might have clinical utility as a supplement to psa testing.
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	1	circulating	serum	Aging	Zhang H et al.	J Gerontol A Biol Sci Med Sci. 70(1):102-9. 	Investigation of microRNA expression in human serum during the aging process.	25165030	2015	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
miRNA	hsa-let-7c	let-7	MIMAT0000064	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-886-3p		MIMAT0004906	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-196a	mir-196	MIMAT0000226	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-190b	mir-190	MIMAT0004929	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-642	mir-642	MIMAT0003312	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	1	circulating	plasma	prostate cancer	Yaman Agaoglu F et al.	Tumour Biol. 32(3):583-8.	Investigation of miR-21, miR-141, and miR-221 in blood circulation of patients with prostate cancer.	21274675	2011	real-time pcr	analysis of mir-21, -141, and -221 in blood of pca patients reveals that mir-21 is more useful to differentiate pca patients from healthy controls, while the mir-141 was a better discriminator of metastatic pca from localized/local advanced disease. these results suggest that analysis of these mirnas might have clinical utility as a supplement to psa testing.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	1	circulating	serum	Aging	Zhang H et al.	J Gerontol A Biol Sci Med Sci. 70(1):102-9. 	Investigation of microRNA expression in human serum during the aging process.	25165030	2015	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-193a-5p	mir-193	MIMAT0004614	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-7-1	mir-7	MIMAT0000252	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-126*	mir-126	MIMAT0000444	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	1	circulating	serum	prostate cancer	Brase JC et al.	Int J Cancer. 128(3):608-16.	Circulating miRNAs are correlated with tumor progression in prostate cancer.	20473869	2011	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
miRNA	hsa-miR-130b	mir-130	MIMAT0000691	Homo sapiens	1	circulating	serum	Aging	Zhang H et al.	J Gerontol A Biol Sci Med Sci. 70(1):102-9. 	Investigation of microRNA expression in human serum during the aging process.	25165030	2015	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-198	mir-198	MIMAT0000228	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-9*	mir-9	MIMAT0000442	Homo sapiens	0	circulating	serum	prostate cancer	Brase JC et al.	Int J Cancer. 128(3):608-16.	Circulating miRNAs are correlated with tumor progression in prostate cancer.	20473869	2011	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
miRNA	hsa-miR-142-5p	mir-142	MIMAT0000433	Homo sapiens	1	circulating	serum	Aging	Zhang H et al.	J Gerontol A Biol Sci Med Sci. 70(1):102-9. 	Investigation of microRNA expression in human serum during the aging process.	25165030	2015	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-940	mir-940	MIMAT0004983	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-199b-5p	mir-199	MIMAT0000263	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-19b-1*	mir-19	MIMAT0004491	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-942	mir-942	MIMAT0004985	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	circulating	serum	prostate cancer	Brase JC et al.	Int J Cancer. 128(3):608-16.	Circulating miRNAs are correlated with tumor progression in prostate cancer.	20473869	2011	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
miRNA	hsa-miR-340	mir-340	MIMAT0004692	Homo sapiens	1	circulating	serum	Aging	Zhang H et al.	J Gerontol A Biol Sci Med Sci. 70(1):102-9. 	Investigation of microRNA expression in human serum during the aging process.	25165030	2015	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-99a	mir-99	MIMAT0000097	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	1	circulating	serum	Colorectal liver metastasis (crlm)	wang lg et al.	cancer epidemiol. 36(1):e61-7.	serum microrna-29a is a promising novel marker for early detection of colorectal liver metastasis.	22018950	2012	real-time rt-pcr	serum mir-29a was significantly higher in colorectal liver metastasis (crlm) patients than in crc patients.
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	0	circulating	serum	prostate cancer	Brase JC et al.	Int J Cancer. 128(3):608-16.	Circulating miRNAs are correlated with tumor progression in prostate cancer.	20473869	2011	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	1	circulating	serum	Aging	Zhang H et al.	J Gerontol A Biol Sci Med Sci. 70(1):102-9. 	Investigation of microRNA expression in human serum during the aging process.	25165030	2015	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-99b	mir-99	MIMAT0000689	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-378	mir-378	MIMAT0000732	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	Chronic type C hepatitis	bihrer v et al.	plos one 6(10): e26971.	serum microrna-21 as marker for necroinflammation in hepatitis c patients with and without hepatocellular carcinoma.	22066022	2011	tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)|taqman mirna reverse transcription kit	the serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
miRNA	hsa-miR-181c	mir-181	MIMAT0000258	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-516a-3p	mir-515	MIMAT0006778	Homo sapiens	0	circulating	serum	prostate cancer	Brase JC et al.	Int J Cancer. 128(3):608-16.	Circulating miRNAs are correlated with tumor progression in prostate cancer.	20473869	2011	quantitative real-time pcr	various mirnas were highly abundant in the sera of patients with metastatic disease, and five upregulated mirnas (mirna-375, mirna-9*, mirna-141, mirna-200b and mirna-516a-3p). mirna-375 and mirna-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	1	circulating	serum	Aging	Zhang H et al.	J Gerontol A Biol Sci Med Sci. 70(1):102-9. 	Investigation of microRNA expression in human serum during the aging process.	25165030	2015	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-19b-1*	mir-19	MIMAT0004491	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-204	mir-204	MIMAT0000265	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	Chronic type C hepatitis	bihrer v et al.	plos one 6(10): e26971.	serum microrna-21 as marker for necroinflammation in hepatitis c patients with and without hepatocellular carcinoma.	22066022	2011	tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)|taqman mirna reverse transcription kit	the serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
miRNA	hsa-miR-182	mir-182	MIMAT0000259	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	1	circulating	serum	Aging	Zhang H et al.	J Gerontol A Biol Sci Med Sci. 70(1):102-9. 	Investigation of microRNA expression in human serum during the aging process.	25165030	2015	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	authors conclude that the measurement of mirnas in serum provides a novel, noninvasive approach for the identification of the aging process.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-200a*	mir-8	MIMAT0001620	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	Chronic hepatitis c infection (chc)-associated hcc	bihrer v et al.	plos one 6(10): e26971.	serum microrna-21 as marker for necroinflammation in hepatitis c patients with and without hepatocellular carcinoma.	22066022	2011	tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)|taqman mirna reverse transcription kit	the serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	microparticle	plasma	unstable angina	Li S et al.	J Mol Cell Cardiol. 75:49-57.	MicroRNA-19b functions as potential anti-thrombotic protector in patients with unstable angina by targeting tissue factor.	24998411	2014	real-time pcr	the study indicates that in ua patients, the increase of mir-19b wrapped in emps due to endothelial dysfunction may partially contribute to the circulating mir-19b elevation and mir-19b may play an anti-thrombotic role by inhibiting the expression of tf in ecs.
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-224	mir-224	MIMAT0000281	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-215	mir-192	MIMAT0000272	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-let-7d*	let-7	MIMAT0004484	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-518f	mir-515	MIMAT0002842	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-200b*	mir-8	MIMAT0004571	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-212	mir-132	MIMAT0000269	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	Chronic hepatitis c infection (chc)-associated hcc	bihrer v et al.	plos one 6(10): e26971.	serum microrna-21 as marker for necroinflammation in hepatitis c patients with and without hepatocellular carcinoma.	22066022	2011	tri reagentls (sigma-aldrich, st. louis, mo), chloroform and the mirvana rna isolation kit (ambion-abi, austin, tx)|taqman mirna reverse transcription kit	the serum mir-21 level is a marker for necroinflammatory activity, but does not differ between patients with hcv and hcv-induced hcc.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	pancreatic ductal adenocarcinoma (pdac)	Song WF et al.	Asian Pac J Cancer Prev. 14(12):7529-36.	MiR-21 upregulation induced by promoter zone histone acetylation is associated with chemoresistance to gemcitabine and enhanced malignancy of pancreatic cancer cells.	24460329	2013	real-time pcr	serum mir-21 levels were increased in gemcitabine- resistant pdac patients compared with gemcitabine-sensitive subjects.
miRNA	hsa-miR-105	mir-105	MIMAT0000102	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-520c-3p	mir-515	MIMAT0002846	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-215	mir-192	MIMAT0000272	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	1	circulating	serum	hand-foot-and-mouth disease (hfmd)	cui l et al.	plos one. 6(11):e27071.	serum microrna expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease.	22087245	2011	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-143	mir-143	MIMAT0000435	Homo sapiens	1	circulating	serum	hepatocellular carcinoma (hcc)	Zhang ZQ et al.	Diagn Pathol. 9:135.	Serum microRNA 143 and microRNA 215 as potential biomarkers for the diagnosis of chronic hepatitis and hepatocellular carcinoma.	24993656	2014	probe-based stem-loop quantitative reverse-transcriptase pcr	authors conclude that the expression of mir-143 and mir-215 in serum were significantly up-regulated in patients with chronic hepatitis and hcc, mir-143 and mir-215 could be considered as potential circulating biomarkers.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-23b	mir-23	MIMAT0000418	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-224	mir-224	MIMAT0000281	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-628-5p	mir-628	MIMAT0004809	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-22*	mir-22	MIMAT0004495	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-143	mir-143	MIMAT0000435	Homo sapiens	1	circulating	serum	hand-foot-and-mouth disease (hfmd)	cui l et al.	plos one. 6(11):e27071.	serum microrna expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease.	22087245	2011	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
miRNA	hsa-miR-301	mir-130	MIMAT0000688	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-215	mir-192	MIMAT0000272	Homo sapiens	1	circulating	serum	hepatocellular carcinoma (hcc)	Zhang ZQ et al.	Diagn Pathol. 9:135.	Serum microRNA 143 and microRNA 215 as potential biomarkers for the diagnosis of chronic hepatitis and hepatocellular carcinoma.	24993656	2014	probe-based stem-loop quantitative reverse-transcriptase pcr	authors conclude that the expression of mir-143 and mir-215 in serum were significantly up-regulated in patients with chronic hepatitis and hcc, mir-143 and mir-215 could be considered as potential circulating biomarkers.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-483-5p	mir-483	MIMAT0004761	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-646	mir-646	MIMAT0003316	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-20a*	mir-17	MIMAT0004493	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-324-3p	mir-324	MIMAT0000762	Homo sapiens	1	circulating	serum	hand-foot-and-mouth disease (hfmd)	cui l et al.	plos one. 6(11):e27071.	serum microrna expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease.	22087245	2011	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
miRNA	hsa-miR-30a-5p	mir-30	MIMAT0000087	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-34b	mir-34	MIMAT0004676	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	type 2 diabetes	Zhang T et al.	Biomed Res Int. 2013:761617.	Plasma miR-126 is a potential biomarker for early prediction of type 2 diabetes mellitus in susceptible individuals.	24455723	2013	qrt-pcr	mir-126 is the only mirna that showed significantly reduced expression in susceptible individuals and t2dm patients compared to normal individuals, suggesting that mir-126 in circulation may serve as a potential biomarker for early identification of susceptible individuals to t2dm.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-875-5p	mir-875	MIMAT0004922	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-224	mir-224	MIMAT0000281	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-628-3p	mir-628	MIMAT0003297	Homo sapiens	1	circulating	serum	hand-foot-and-mouth disease (hfmd)	cui l et al.	plos one. 6(11):e27071.	serum microrna expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease.	22087245	2011	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	circulating	plasma	Multiple sclerosis (MS)	Kacperska MJ et al.	J Mol Neurosci. 56(1):154-63.	Selected Extracellular microRNA as Potential Biomarkers of Multiple Sclerosis Activity-Preliminary Study.	25487315	2015	7900 ht fast real-time pcr system (applied biosystems)	authors studied that significantly changed expression of selected extracellular mirna in plasma of multiple sclerosis (ms) patients may be correlated with clinical parameters.
miRNA	hsa-miR-10a	mir-10	MIMAT0000253	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-26b*	mir-26	MIMAT0004500	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-140-5p	mir-140	MIMAT0000431	Homo sapiens	1	circulating	serum	hand-foot-and-mouth disease (hfmd)	cui l et al.	plos one. 6(11):e27071.	serum microrna expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease.	22087245	2011	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
miRNA	hsa-miR-30d	mir-30	MIMAT0000245	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-485-3p	mir-485	MIMAT0002176	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-1233	mir-1233	MIMAT0005588	Homo sapiens	1	circulating	serum	preeclampsia	Ura B et al.	Taiwan J Obstet Gynecol. 53(2):232-4.	Potential role of circulating microRNAs as early markers of preeclampsia.	25017274	2014	taqman low density array chips (human microrna panel v3.0)|quantitative real-time polymerase chain reaction	authors conclude that some circulating mirnas may have potential role in the pathogenesis of preeclampsia. in particular, mir-1233 might represent a potential marker of early spe.
miRNA	hsa-miR-10b	mir-10	MIMAT0000254	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-886-3p		MIMAT0004906	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-21*	mir-21	MIMAT0004494	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-27a*	mir-27	MIMAT0004501	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-362-3p	mir-362	MIMAT0004683	Homo sapiens	1	circulating	serum	hand-foot-and-mouth disease (hfmd)	cui l et al.	plos one. 6(11):e27071.	serum microrna expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease.	22087245	2011	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
miRNA	hsa-miR-30e-5p	mir-30	MIMAT0000692	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-485-3p	mir-485	MIMAT0002176	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	Multiple sclerosis (MS)	Kacperska MJ et al.	J Mol Neurosci. 56(1):154-63.	Selected Extracellular microRNA as Potential Biomarkers of Multiple Sclerosis Activity-Preliminary Study.	25487315	2015	7900 ht fast real-time pcr system (applied biosystems)	authors studied that significantly changed expression of selected extracellular mirna in plasma of multiple sclerosis (ms) patients may be correlated with clinical parameters.
miRNA	hsa-miR-122a	mir-122	MIMAT0000421	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-28-5p	mir-28	MIMAT0000085	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-545	mir-95	MIMAT0003165	Homo sapiens	1	circulating	serum	hand-foot-and-mouth disease (hfmd)	cui l et al.	plos one. 6(11):e27071.	serum microrna expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease.	22087245	2011	taqman array human mirna panel a+b (applied biosystems, ca)|mirvana paris kit (ambion, austin, tx)|taqman mirna reverse transcription kit (applied biosystems)|qrt-pcr	a receiver operating characteristic (roc) curve analysis revealed that six mirnas (mir-148a, mir-143, mir-324-3p, mir-628-3p, mir-140-5p, and mir-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (auc) values ranged from 0.828 to 0.934. Expression levels of five mirnas (mir-148a, mir-143, mir-324-3p, mir-545, and mir-140-5p) were significantly increased in patients with cva16 versus those with ev71 (p<0.05). 
miRNA	hsa-miR-324-3p	mir-324	MIMAT0000762	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-92b	mir-25	MIMAT0003218	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-323-3p	mir-154	MIMAT0000755	Homo sapiens	1	circulating	plasma	Acute coronary syndromes	Pilbrow AP et al.	Int J Cardiol. 176(2):375-85.	Circulating miR-323-3p and miR-652: candidate markers for the presence and progression of acute coronary syndromes.	25124998	2014	real-time quantitative pcr	authors identify mir-652 as a novel candidate biomarker for post-acs prognosis beyond existing biomarkers of lvef and nt-probnp. moreover circulating mir-323-3p was markedly elevated in patients for at least a year post-acs and may be a stable biomarker for acs.
miRNA	hsa-miR-125a	mir-125	MIMAT0000443	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-27b	mir-27	MIMAT0000419	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-95	mir-95	MIMAT0000094	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-126*	mir-126	MIMAT0000444	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-219-5p	mir-219	MIMAT0000276	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-296-5p	mir-296	MIMAT0000690	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	1	circulating	serum	preeclampsia	gunel t et al.	genet mol res. 10(4).	serum microrna expression in pregnancies with preeclampsia.	22095477	2011	trizol (invitrogen, carlsbad, ca)|bioanalyzer agilent rna 6000 picoassay|high-specificity mirna qrt-pcr detection  kit (stratagene-an agilent technologies company, usa-canada)|affinity script rt/rnase block enzyme mixture (stratagene)|bioanalyzer 2100- agilent small rna assay|real-time pcr	authors found up-regulated mir-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. They propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.
miRNA	hsa-miR-422a	mir-422	MIMAT0001339	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-652	mir-652	MIMAT0003322	Homo sapiens	1	circulating	plasma	Acute coronary syndromes	Pilbrow AP et al.	Int J Cardiol. 176(2):375-85.	Circulating miR-323-3p and miR-652: candidate markers for the presence and progression of acute coronary syndromes.	25124998	2014	real-time quantitative pcr	authors identify mir-652 as a novel candidate biomarker for post-acs prognosis beyond existing biomarkers of lvef and nt-probnp. moreover circulating mir-323-3p was markedly elevated in patients for at least a year post-acs and may be a stable biomarker for acs.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-28	mir-28	MIMAT0000085	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-99a	mir-99	MIMAT0000097	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-140-3p	mir-140	MIMAT0004597	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-29c	mir-29	MIMAT0000681	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	0	circulating	serum	preeclampsia	gunel t et al.	genet mol res. 10(4).	serum microrna expression in pregnancies with preeclampsia.	22095477	2011	trizol (invitrogen, carlsbad, ca)|bioanalyzer agilent rna 6000 picoassay|high-specificity mirna qrt-pcr detection  kit (stratagene-an agilent technologies company, usa-canada)|affinity script rt/rnase block enzyme mixture (stratagene)|bioanalyzer 2100- agilent small rna assay|real-time pcr	authors found up-regulated mir-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. They propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.
miRNA	hsa-miR-422b	mir-378	MIMAT0000732	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-636	mir-636	MIMAT0003306	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	mmu-miR-122	mir-122	MIMAT0000246	Mus musculus	0	exosome	serum	non-alcoholic steatohepatitis (NASH)	Csak T et al.	Liver Int. 35(2):532-41.	microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis.	25040043	2015	taqman microrna assays	authors suggest that decreased liver mir-122 was associated with elevated circulating mir-122, and contributes to upregulation of modulators of tissue remodelling (hif-1α, vimentin and map3k3) and might play a role in nash-induced liver fibrosis.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-324-3p	mir-324	MIMAT0000762	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-660	mir-188	MIMAT0003338	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-640	mir-640	MIMAT0003310	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	1	circulating	plasma	Breast cancer	Shen J et al.	Oncotarget. 5(14):5284-94.	Circulating miR-148b and miR-133a as biomarkers for breast cancer detection.	25051376	2014	exiqon mircury lna universal rt microrna pcr technology|quantitative real-time pcr	authors suggest that both mir-148b and mir-133a have potential use as biomarkers for breast cancer detection.
miRNA	hsa-miR-128a	mir-128	MIMAT0000424	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-29c	mir-29	MIMAT0000681	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-142-5p	mir-142	MIMAT0000433	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-221*	mir-221	MIMAT0004568	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-324-5p	mir-324	MIMAT0000761	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-92	mir-25	MIMAT0000092	Homo sapiens	0	circulating	serum	non small cell lung cancer (nsclc)	hennessey pt et al.	plos one 7(2): e32307. 	serum microrna biomarkers for detection of non-small cell lung cancer	22389695	2012	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	examination of mirna expression levels in serum from a multi-institutional cohort of 50 subjects (30 nsclc patients and 20 healthy controls) identified differentially expressed mirnas. A combination of two differentially expressed mirnas mir-15b and mir-27b, was able to discriminate nsclc from healthy controls with sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) of 100% in the training set.
miRNA	hsa-miR-766	mir-766	MIMAT0003888	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	1	circulating	plasma	Breast cancer	Shen J et al.	Oncotarget. 5(14):5284-94.	Circulating miR-148b and miR-133a as biomarkers for breast cancer detection.	25051376	2014	exiqon mircury lna universal rt microrna pcr technology|quantitative real-time pcr	authors suggest that both mir-148b and mir-133a have potential use as biomarkers for breast cancer detection.
miRNA	hsa-miR-128b	mir-128	MIMAT0000424	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-301	mir-130	MIMAT0000688	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-144	mir-144	MIMAT0000436	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-339-3p	mir-339	MIMAT0004702	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-let-7c	let-7	MIMAT0000064	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-323-3p	mir-154	MIMAT0000755	Homo sapiens	1	circulating	serum	ectopic pregnancy (ep)	zhao z et al.	clin chem.	circulating microrna mir-323-3p as a biomarker of ectopic pregnancy.	22395025	2012	taqman real-time pcr	the serum concentrations of mirnas mir-323-3p, mir-517a, mir-519d, and mir-525-3p were measured with taqman real-time pcr. Pregnancy-associated mirnas, especially mir-323-3p, added significant diagnostic accuracy to a panel including hcg and progesterone for the diagnosis of ep.
miRNA	hsa-miR-885-5p	mir-885	MIMAT0004947	Homo sapiens	0	circulating	serum	prostate cancer	Lodes MJ et al.	PLoS One. 4(7):e6229.	Detection of cancer with serum miRNAs on an oligonucleotide microarray.	19597549	2009	pan-human microrna high density microarray	this study is focused on the evaluation of mirna expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microrna, high density microarray.
miRNA	hsa-miR-125b-2*	mir-125	MIMAT0004603	Homo sapiens	1	circulating	blood	Acute stroke	Sepramaniam S et al.	Int J Mol Sci. 15(1):1418-32.	Circulating microRNAs as biomarkers of acute stroke.	24447930	2014	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
miRNA	hsa-miR-129	mir-129	MIMAT0000242	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30a-5p	mir-30	MIMAT0000087	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-128	mir-128	MIMAT0000424	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-340	mir-340	MIMAT0004692	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-517a	mir-515	MIMAT0002852	Homo sapiens	0	circulating	serum	ectopic pregnancy (ep)	zhao z et al.	clin chem.	circulating microrna mir-323-3p as a biomarker of ectopic pregnancy.	22395025	2012	taqman real-time pcr	the serum concentrations of mirnas mir-323-3p, mir-517a, mir-519d, and mir-525-3p were measured with taqman real-time pcr. Pregnancy-associated mirnas, especially mir-323-3p, added significant diagnostic accuracy to a panel including hcg and progesterone for the diagnosis of ep.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	1	circulating	serum	prostate cancer	Mahn R et al.	Urology. 77(5):1265.e9-16.	Circulating microRNAs (miRNA) in serum of patients with prostate cancer.	21539977	2011	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
miRNA	hsa-miR-27a*	mir-27	MIMAT0004501	Homo sapiens	1	circulating	blood	Acute stroke	Sepramaniam S et al.	Int J Mol Sci. 15(1):1418-32.	Circulating microRNAs as biomarkers of acute stroke.	24447930	2014	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
miRNA	hsa-miR-130a	mir-130	MIMAT0000425	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-23b	mir-23	MIMAT0000418	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-340*	mir-340	MIMAT0000750	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-519d	mir-515	MIMAT0002853	Homo sapiens	0	circulating	serum	ectopic pregnancy (ep)	zhao z et al.	clin chem.	circulating microrna mir-323-3p as a biomarker of ectopic pregnancy.	22395025	2012	taqman real-time pcr	the serum concentrations of mirnas mir-323-3p, mir-517a, mir-519d, and mir-525-3p were measured with taqman real-time pcr. Pregnancy-associated mirnas, especially mir-323-3p, added significant diagnostic accuracy to a panel including hcg and progesterone for the diagnosis of ep.
miRNA	hsa-miR-32	mir-32	MIMAT0000090	Homo sapiens	0	circulating	serum	prostate cancer	Mahn R et al.	Urology. 77(5):1265.e9-16.	Circulating microRNAs (miRNA) in serum of patients with prostate cancer.	21539977	2011	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
miRNA	hsa-miR-422a	mir-422	MIMAT0001339	Homo sapiens	1	circulating	blood	Acute stroke	Sepramaniam S et al.	Int J Mol Sci. 15(1):1418-32.	Circulating microRNAs as biomarkers of acute stroke.	24447930	2014	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
miRNA	hsa-miR-130b	mir-130	MIMAT0000691	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-346	mir-346	MIMAT0000773	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-525-3p	mir-515	MIMAT0002839	Homo sapiens	0	circulating	serum	ectopic pregnancy (ep)	zhao z et al.	clin chem.	circulating microrna mir-323-3p as a biomarker of ectopic pregnancy.	22395025	2012	taqman real-time pcr	the serum concentrations of mirnas mir-323-3p, mir-517a, mir-519d, and mir-525-3p were measured with taqman real-time pcr. Pregnancy-associated mirnas, especially mir-323-3p, added significant diagnostic accuracy to a panel including hcg and progesterone for the diagnosis of ep.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	1	circulating	serum	prostate cancer	Mahn R et al.	Urology. 77(5):1265.e9-16.	Circulating microRNAs (miRNA) in serum of patients with prostate cancer.	21539977	2011	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
miRNA	hsa-miR-488	mir-488	MIMAT0004763	Homo sapiens	1	circulating	blood	Acute stroke	Sepramaniam S et al.	Int J Mol Sci. 15(1):1418-32.	Circulating microRNAs as biomarkers of acute stroke.	24447930	2014	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30d	mir-30	MIMAT0000245	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-151-3p	mir-28	MIMAT0000757	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-196a	mir-196	MIMAT0000226	Homo sapiens	1	circulating	serum	gastric cancer (gc)	tsai kw et al.	genes chromosomes cancer. 51(4):394-401.	aberrant expression of mir-196a in gastric cancers and correlation with recurrence.	22420029	2012		extracellular mir-196a detected in conditioned medium was strongly correlated with its cellular expression status and increased circulating mir-196a in patient serum was associated with gastric cancer disease status and relapse. 
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	1	circulating	serum	prostate cancer	Mahn R et al.	Urology. 77(5):1265.e9-16.	Circulating microRNAs (miRNA) in serum of patients with prostate cancer.	21539977	2011	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
miRNA	hsa-miR-627	mir-627	MIMAT0003296	Homo sapiens	1	circulating	blood	Acute stroke	Sepramaniam S et al.	Int J Mol Sci. 15(1):1418-32.	Circulating microRNAs as biomarkers of acute stroke.	24447930	2014	taqman low density array (tlda)	authors found 5 micrornas, mir-125b-2*, -27a*, -422a, -488 and -627 to be consistently altered in acute stroke irrespective of age or severity or confounding metabolic complications. differential expression of these 5 micrornas was also observed in rat stroke models. hence, their specificity to the stroke pathology emphasizes the possibility of developing these micrornas into accurate and useful tools for diagnosis of stroke.
miRNA	hsa-miR-135b	mir-135	MIMAT0000758	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30e-3p	mir-30	MIMAT0000693	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-483-5p	mir-483	MIMAT0004761	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-34a*	mir-34	MIMAT0004557	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	1	circulating	serum	liver injury	ding x et al.	mol med report. 5(6):1428-32.	circulating microrna-122 as a potential biomarker for liver injury.	22427142	2012	real-time reverse transcription pcr	the results showed a positive correlation between serum mir-122 and alanine aminotransferase, a clinical biomarker for liver function. Furthermore, serum mir-122 was assessed in patients with hepatitis b and hepatocarcinoma, resulting in distinct mir-122 profiles in these two closely related diseases.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	1	circulating	serum	prostate cancer	Mahn R et al.	Urology. 77(5):1265.e9-16.	Circulating microRNAs (miRNA) in serum of patients with prostate cancer.	21539977	2011	quantitative real-time pcr	circulating oncogenic mirna levels were different, and especially the mir-26a level allowed sensitive (89%) discrimination of pca and bph patients at a moderate specificity (56%; area under the curve [auc]: 0.703); the analysis of oncogenic mirnas in combination increased the diagnostic accuracy (sensitivity: 78.4%; specificity: 66.7%; auc: 0.758). despite the low number of patients limiting the statistical power of the study, authors observed correlations with clinical-pathologic parameters: mir-16, mir-195, and mir-26a were significantly correlated with surgical margin positivity; mir-195 and mir-let7i were significantly correlated with the gleason score.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	blood	oral squamous cell carcinoma (oscc)	Ren W et al.	Biomarkers. 19(7):590-6.	Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma.	25174622	2014	e.z.n.a. blood rna kit|quantitative real-time reverse transcriptionpolymerase chain reaction	authors demonstrate that circulating mir-21 and pten might represent new complementary tumour markers for oscc.
miRNA	hsa-miR-136	mir-136	MIMAT0000448	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30e-5p	mir-30	MIMAT0000692	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-361-5p	mir-361	MIMAT0000703	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	serum	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	1	circulating	serum	hepatitis b virus (hbv)-associated liver cirrhosis (hbv-lc)	Xie Y et al.	Cancer Biol Ther. 15(9):1248-55.	Expression profiling of serum microRNA-101 in HBV-associated chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.	24971953	2014	real-time quantitative pcr	authors suggest that the serum mir-101 level can serve as a potential non-invasive biomarker to differentiate hbv-hcc from hbv-lc.
miRNA	hsa-miR-137	mir-137	MIMAT0000429	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-32	mir-32	MIMAT0000090	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-362-3p	mir-362	MIMAT0004683	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	0	exosome	serum	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	1	circulating	serum	hepatitis b virus-associated hepatocellular carcinoma (hbv-hcc)	Xie Y et al.	Cancer Biol Ther. 15(9):1248-55.	Expression profiling of serum microRNA-101 in HBV-associated chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.	24971953	2014	real-time quantitative pcr	authors suggest that the serum mir-101 level can serve as a potential non-invasive biomarker to differentiate hbv-hcc from hbv-lc.
miRNA	hsa-miR-138	mir-138	MIMAT0000430	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-520c-3p	mir-515	MIMAT0002846	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-27b	mir-27	MIMAT0000419	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-362-5p	mir-362	MIMAT0000705	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	exosome	serum	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	0	microvesicle	serum	human colon cancer dld-1 cells	Akao Y et al.	Int J Mol Sci. 15(1):1392-401.	Extracellular disposal of tumor-suppressor miRs-145 and -34a via microvesicles and 5-FU resistance of human colon cancer cells.	24447928	2014	exomir kit (bioosicentific; austin, tx, usa)|nanosight lm10 nanoparticle characterization system (nanosight, amesbury, uk)|bioopure-mp (bioosicentific, austin, tx, usa)|taqman (applied biosystems, foster city, ca, usa)|rneasy mini kit (qiagen, hilden, germany)	the intra- and extracellular mir-145 and -34a were closely associated with 5-fu resistance, and the resistance was in part due to the enhanced secretion of mir-145 and -34a via mvs, resulting in low intracellular levels of both mirnas.
miRNA	hsa-miR-140	mir-140	MIMAT0000431	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-324-3p	mir-324	MIMAT0000762	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-186	mir-186	MIMAT0000456	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-601	mir-601	MIMAT0003269	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-28-3p	mir-28	MIMAT0004502	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	exosome	serum	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	0	microvesicle	serum	human colon cancer dld-1 cells	Akao Y et al.	Int J Mol Sci. 15(1):1392-401.	Extracellular disposal of tumor-suppressor miRs-145 and -34a via microvesicles and 5-FU resistance of human colon cancer cells.	24447928	2014	exomir kit (bioosicentific; austin, tx, usa)|nanosight lm10 nanoparticle characterization system (nanosight, amesbury, uk)|bioopure-mp (bioosicentific, austin, tx, usa)|taqman (applied biosystems, foster city, ca, usa)|rneasy mini kit (qiagen, hilden, germany)	the intra- and extracellular mir-145 and -34a were closely associated with 5-fu resistance, and the resistance was in part due to the enhanced secretion of mir-145 and -34a via mvs, resulting in low intracellular levels of both mirnas.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-326	mir-326	MIMAT0000756	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-618	mir-618	MIMAT0003287	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-28-5p	mir-28	MIMAT0000085	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-376a	mir-368	MIMAT0000729	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-1273d	mir-1273	MIMAT0015090	Homo sapiens	0	exosome	saliva	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	circulating	blood	Atrial fibrillation (af)	McManus DD et al.	Heart Rhythm. 11(4):663-9.	Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study.	24444445	2014	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	circulating levels of mir-328, a mirna known to promote atrial electrical remodeling by reducing l-type ca(2+) channel density, were associated with prevalent af. adjustment for risk factors that promote atrial remodeling, including hypertension, attenuated the association between mir-328 and af, potentially implicating mir-328 as a potential mediator of atrial remodeling and af vulnerability.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-215	mir-192	MIMAT0000272	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-646	mir-646	MIMAT0003316	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-376c	mir-368	MIMAT0000720	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	exosome	serum	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-874	mir-874	MIMAT0004911	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-646	mir-646	MIMAT0003316	Homo sapiens	1	circulating	serum	Cervical squamous cell carcinoma	Wang WT et al.	J Hematol Oncol. 7:6.	Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery.	24405714	2014	taqman microrna array	authors demonstrated that the circulating mirnas mir-646, mir-141* and mir-542-3p could potentially serve as non-invasive biomarkers for cervical scc. the levels of these specific mirnas might be useful for the post-therapeutic monitoring of disease progression.
miRNA	hsa-miR-146b	mir-146	MIMAT0002809	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-330	mir-330	MIMAT0000751	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-224	mir-224	MIMAT0000281	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-892b	mir-743	MIMAT0004918	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-378*	mir-378	MIMAT0000731	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-10a	mir-10	MIMAT0000253	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	exosome	serum	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-1274a		MIMAT0005927	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-141*	mir-8	MIMAT0004598	Homo sapiens	1	circulating	serum	Cervical squamous cell carcinoma	Wang WT et al.	J Hematol Oncol. 7:6.	Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery.	24405714	2014	taqman microrna array	authors demonstrated that the circulating mirnas mir-646, mir-141* and mir-542-3p could potentially serve as non-invasive biomarkers for cervical scc. the levels of these specific mirnas might be useful for the post-therapeutic monitoring of disease progression.
miRNA	hsa-miR-147	mir-147	MIMAT0000251	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-331	mir-331	MIMAT0000760	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-29c	mir-29	MIMAT0000681	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-422a	mir-422	MIMAT0001339	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-10b	mir-10	MIMAT0000254	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-202	mir-202	MIMAT0002811	Homo sapiens	0	exosome	saliva	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-1207-5p	mir-1207	MIMAT0005871	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-542-3p	mir-542	MIMAT0003389	Homo sapiens	1	circulating	serum	Cervical squamous cell carcinoma	Wang WT et al.	J Hematol Oncol. 7:6.	Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery.	24405714	2014	taqman microrna array	authors demonstrated that the circulating mirnas mir-646, mir-141* and mir-542-3p could potentially serve as non-invasive biomarkers for cervical scc. the levels of these specific mirnas might be useful for the post-therapeutic monitoring of disease progression.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-335	mir-335	MIMAT0000765	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	plasma	normal	mcdonald js et al.	clin chem. 57(6):833-40	analysis of circulating microrna: preanalytical and analytical challenges.	21487102	2011	qrt-pcr	mirna concentrations were higher in plasma than in serum. The mirnas analyzed were stable refrigerated or frozen for up to 72 h and were stable at room temperature for 24 h. Hemolysis increased the apparent concentration of 3 of the mirnas. The total variability of replicate mirna concentrations was <2.0-fold, with most of the variability attributable to the extraction process and interassay imprecision. Normalizing results to those of spiked exogenous control mirnas did not improve this variability.
miRNA	hsa-miR-29c*	mir-29	MIMAT0004673	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-423-5p	mir-423	MIMAT0004748	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-203	mir-203	MIMAT0000264	Homo sapiens	0	exosome	saliva	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	Diffuse large b-cell lymphoma (dlbcl)	Chen W et al.	Eur J Haematol. 92(5):407-12.	Clinical significance and detection of microRNA-21 in serum of patients with diffuse large B-cell lymphoma in Chinese population.	24400911	2014	fluorescent quantitative pcr	authors show that mir-21 may be served as a biomarker in early diagnosis, genotyping, treatment options, and prognosis estimating of chinese dlbcl.
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-339	mir-339	MIMAT0000764	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-1979		MIMAT0009454	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	circulating	plasma	normal	mcdonald js et al.	clin chem. 57(6):833-40	analysis of circulating microrna: preanalytical and analytical challenges.	21487102	2011	qrt-pcr	mirna concentrations were higher in plasma than in serum. The mirnas analyzed were stable refrigerated or frozen for up to 72 h and were stable at room temperature for 24 h. Hemolysis increased the apparent concentration of 3 of the mirnas. The total variability of replicate mirna concentrations was <2.0-fold, with most of the variability attributable to the extraction process and interassay imprecision. Normalizing results to those of spiked exogenous control mirnas did not improve this variability.
miRNA	hsa-miR-301a	mir-130	MIMAT0000688	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-425	mir-425	MIMAT0003393	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-124	mir-124	MIMAT0000422	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	0	circulating	saliva	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	Breast cancer	Gao J et al.	Chin J Cancer Res. 25(6):743-8.	Clinical significance of serum miR-21 in breast cancer compared with CA153 and CEA.	24385703	2013	real-time pcr	authors show that serum mir-21 may be a potential diagnostic indicator for bc, especially for the early stage.
miRNA	hsa-miR-149	mir-149	MIMAT0000450	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-340	mir-340	MIMAT0004692	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-423-5p	mir-423	MIMAT0004748	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-199a-3p	mir-199	MIMAT0000232	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	normal	mcdonald js et al.	clin chem. 57(6):833-40	analysis of circulating microrna: preanalytical and analytical challenges.	21487102	2011	qrt-pcr	mirna concentrations were higher in plasma than in serum. The mirnas analyzed were stable refrigerated or frozen for up to 72 h and were stable at room temperature for 24 h. Hemolysis increased the apparent concentration of 3 of the mirnas. The total variability of replicate mirna concentrations was <2.0-fold, with most of the variability attributable to the extraction process and interassay imprecision. Normalizing results to those of spiked exogenous control mirnas did not improve this variability.
miRNA	hsa-miR-301b	mir-130	MIMAT0004958	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-425*	mir-425	MIMAT0001343	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-125a-5p	mir-125	MIMAT0000443	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-574	mir-574	MIMAT0003239	Homo sapiens	0	exosome	serum	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	1	circulating	plasma	uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-342	mir-342	MIMAT0000753	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	normal	mcdonald js et al.	clin chem. 57(6):833-40	analysis of circulating microrna: preanalytical and analytical challenges.	21487102	2011	qrt-pcr	mirna concentrations were higher in plasma than in serum. The mirnas analyzed were stable refrigerated or frozen for up to 72 h and were stable at room temperature for 24 h. Hemolysis increased the apparent concentration of 3 of the mirnas. The total variability of replicate mirna concentrations was <2.0-fold, with most of the variability attributable to the extraction process and interassay imprecision. Normalizing results to those of spiked exogenous control mirnas did not improve this variability.
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-429	mir-8	MIMAT0001536	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-768			Homo sapiens	0	exosome	serum	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	serum	prostate cancer	Moltzahn F et al.	Cancer Res. 71(2):550-60.	Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.	21098088	2011	microfluidic-based multiplex qrt-pcr	ten micrornas (mir-20b, -24, -26b, -30c, -93, -106a, -223, -874, -1207-5p and mir-1274a) were significantly different between the healthy and all the malignant samples. four were downregulated in the cancer group (mir- 223, -26b, -30c and mir-24) and six were upregulated in the cancer group (mir-20b, -874, -1274a, -1207-5p, -93 and mir-106a). mir-19a and -451 were significantly different between healthy vs. high-risk.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	1	circulating	plasma	uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-151	mir-28	MIMAT0000757	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-345	mir-345	MIMAT0000772	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-99a	mir-99	MIMAT0000097	Homo sapiens	0	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-485-3p	mir-485	MIMAT0002176	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	exosome	serum	normal	Gallo A et al.	PLoS One. 7(3):e30679.	The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes.	22427800	2012	TRIZOL reagent (Invitrogen, Carlsbad, CA)|Nanodrop ND-1000 (Thermo Scientific, Worcester, MA)|TaqManH MicroRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA)|TaqMan MicroRNA Assay, PN 4427975, Applied Biosystems|TaqMan Universal PCR Master Mix (PN 4324018, Applied Biosystems)	Exosome isolation improves the sensitivity of miRNA amplification from human biologic fluids. Exosomal miRNA should be the starting point for early biomarker studies to reduce the probability of false negative results involving low abundance miRNAs that may be missed by using unfractionated serum or saliva.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	prostate cancer	Sanders I et al.	Int J Urol. 19(11):1017-25.	Evaluation of reference genes for the analysis of serum miRNA in patients with prostate cancer, bladder cancer and renal cell carcinoma.	22788411	2012	quantitative real-time pcr	the level of mir-21 was similar in cancer patients and healthy controls, irrespective of the normalization strategy.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	1	circulating	plasma	uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-361	mir-361	MIMAT0000703	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-10a	mir-10	MIMAT0000253	Homo sapiens	0	circulating	breast milk	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30c-2*	mir-30	MIMAT0004550	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-505*	mir-505	MIMAT0004776	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-126*	mir-126	MIMAT0000444	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	1	circulating	plasma	multiple myeloma (mm)	huang jj et al.	med oncol. 	circulating microrna expression is associated with genetic subtype and survival of multiple myeloma.	22447484	2012	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	circulating	serum	prostate cancer	Selth LA et al.	Int J Cancer. 131(3):652-61.	Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease.	22052531	2012	qrt-pcr	four mirnas altered in mice, mmu-mir-141, mmu-mir-298, mmu-mir-346 and mmu-mir-375, were also found to be at differential levels in the serum of men with mcrpc. three of these (hsa-mir-141, hsa-mir-298 and hsa-mir-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. moreover, the intra-tumoral expression of hsa-mir-141 and hsa-mir-375 were predictors of biochemical relapse after surgery. this study is the first to demonstrate that specific serum mirnas are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	1	circulating	plasma	uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-362	mir-362	MIMAT0000705	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-10b*	mir-10	MIMAT0004556	Homo sapiens	0	circulating	colostrum	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-let-7c	let-7	MIMAT0000064	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30d*	mir-30	MIMAT0004551	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-513-3p	mir-506	MIMAT0004777	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-130a	mir-130	MIMAT0000425	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	1	circulating	plasma	multiple myeloma (mm)	huang jj et al.	med oncol. 	circulating microrna expression is associated with genetic subtype and survival of multiple myeloma.	22447484	2012	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
miRNA	hsa-miR-298	mir-298	MIMAT0004901	Homo sapiens	1	circulating	serum	prostate cancer	Selth LA et al.	Int J Cancer. 131(3):652-61.	Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease.	22052531	2012	qrt-pcr	four mirnas altered in mice, mmu-mir-141, mmu-mir-298, mmu-mir-346 and mmu-mir-375, were also found to be at differential levels in the serum of men with mcrpc. three of these (hsa-mir-141, hsa-mir-298 and hsa-mir-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. moreover, the intra-tumoral expression of hsa-mir-141 and hsa-mir-375 were predictors of biochemical relapse after surgery. this study is the first to demonstrate that specific serum mirnas are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers.
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	1	circulating	plasma	uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-374	mir-374	MIMAT0004688	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-1228	mir-1228	MIMAT0005583	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-215	mir-192	MIMAT0000272	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30e	mir-30	MIMAT0000692	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-532-5p	mir-188	MIMAT0002888	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-130b	mir-130	MIMAT0000691	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	1	circulating	plasma	multiple myeloma (mm)	huang jj et al.	med oncol. 	circulating microrna expression is associated with genetic subtype and survival of multiple myeloma.	22447484	2012	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
miRNA	hsa-miR-346	mir-346	MIMAT0000773	Homo sapiens	1	circulating	serum	prostate cancer	Selth LA et al.	Int J Cancer. 131(3):652-61.	Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease.	22052531	2012	qrt-pcr	four mirnas altered in mice, mmu-mir-141, mmu-mir-298, mmu-mir-346 and mmu-mir-375, were also found to be at differential levels in the serum of men with mcrpc. three of these (hsa-mir-141, hsa-mir-298 and hsa-mir-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. moreover, the intra-tumoral expression of hsa-mir-141 and hsa-mir-375 were predictors of biochemical relapse after surgery. this study is the first to demonstrate that specific serum mirnas are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	1	circulating	plasma	uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-17-3p	mir-17	MIMAT0000071	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-129*	mir-129	MIMAT0004548	Homo sapiens	0	circulating	peritoneal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30e*	mir-30	MIMAT0000693	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-571	mir-571	MIMAT0003236	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-132	mir-132	MIMAT0000426	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	1	circulating	plasma	multiple myeloma (mm)	huang jj et al.	med oncol. 	circulating microrna expression is associated with genetic subtype and survival of multiple myeloma.	22447484	2012	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	1	circulating	serum	prostate cancer	Selth LA et al.	Int J Cancer. 131(3):652-61.	Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease.	22052531	2012	qrt-pcr	four mirnas altered in mice, mmu-mir-141, mmu-mir-298, mmu-mir-346 and mmu-mir-375, were also found to be at differential levels in the serum of men with mcrpc. three of these (hsa-mir-141, hsa-mir-298 and hsa-mir-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. moreover, the intra-tumoral expression of hsa-mir-141 and hsa-mir-375 were predictors of biochemical relapse after surgery. this study is the first to demonstrate that specific serum mirnas are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	1	circulating	plasma	metastatic uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-17-5p	mir-17	MIMAT0000070	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-376a	mir-368	MIMAT0000729	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-130a*	mir-130	MIMAT0004593	Homo sapiens	0	circulating	colostrum	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-32	mir-32	MIMAT0000090	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-571	mir-571	MIMAT0003236	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-133b	mir-133	MIMAT0000770	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-625	mir-625	MIMAT0003294	Homo sapiens	1	circulating	plasma	multiple myeloma (mm)	huang jj et al.	med oncol. 	circulating microrna expression is associated with genetic subtype and survival of multiple myeloma.	22447484	2012	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	1	circulating	plasma	prostate cancer	Shen J et al.	Prostate. 72(13):1469-77.	Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer.	22298119	2012	qrt-pcr	these preliminary data suggest that altered plasma mirnas may be useful predictors to distinguish pca patients with varied aggressiveness. further larger studies to validate this promising finding are warranted.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	1	circulating	plasma	metastatic uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-378	mir-378	MIMAT0000732	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-135a*	mir-135	MIMAT0004595	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-324-3p	mir-324	MIMAT0000762	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-572	mir-572	MIMAT0003237	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-139-5p	mir-139	MIMAT0000250	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-99b	mir-99	MIMAT0000689	Homo sapiens	1	circulating	plasma	multiple myeloma (mm)	huang jj et al.	med oncol. 	circulating microrna expression is associated with genetic subtype and survival of multiple myeloma.	22447484	2012	taqman low-density arrays|reverse transcription pcr	authors have identified aberrant expression of particular circulating mirnas that are associated with the genetic subtype and survival of mm. These plasma mirnas have potential as clinical biomarkers in mm.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	prostate cancer	Shen J et al.	Prostate. 72(13):1469-77.	Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer.	22298119	2012	qrt-pcr	these preliminary data suggest that altered plasma mirnas may be useful predictors to distinguish pca patients with varied aggressiveness. further larger studies to validate this promising finding are warranted.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	1	circulating	plasma	metastatic uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-181b	mir-181	MIMAT0000257	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-379	mir-379	MIMAT0000733	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-135b*	mir-135	MIMAT0004698	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-23b	mir-23	MIMAT0000418	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-324-5p	mir-324	MIMAT0000761	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-572	mir-572	MIMAT0003237	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-140-3p	mir-140	MIMAT0004597	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	1	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	1	circulating	plasma	prostate cancer	Shen J et al.	Prostate. 72(13):1469-77.	Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer.	22298119	2012	qrt-pcr	these preliminary data suggest that altered plasma mirnas may be useful predictors to distinguish pca patients with varied aggressiveness. further larger studies to validate this promising finding are warranted.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	1	circulating	plasma	metastatic uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-181c	mir-181	MIMAT0000258	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-382	mir-154	MIMAT0000737	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-139-3p	mir-139	MIMAT0004552	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-let-7i*	let-7	MIMAT0004585	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-331-3p	mir-331	MIMAT0000760	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-576-3p	mir-576	MIMAT0004796	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-140-5p	mir-140	MIMAT0000431	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-151-5p	mir-28	MIMAT0004697	Homo sapiens	1	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	1	circulating	plasma	prostate cancer	Shen J et al.	Prostate. 72(13):1469-77.	Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer.	22298119	2012	qrt-pcr	these preliminary data suggest that altered plasma mirnas may be useful predictors to distinguish pca patients with varied aggressiveness. further larger studies to validate this promising finding are warranted.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	1	circulating	plasma	metastatic uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-181d	mir-181	MIMAT0002821	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-383	mir-383	MIMAT0000738	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-339-3p	mir-339	MIMAT0004702	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-579	mir-548	MIMAT0003244	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	1	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	1	circulating	plasma	metastatic uveal melanoma	Achberger S et al.	Mol Immunol. 58(2):182-6.	Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.	24370793	2014	taqman microrna assays	authors demonstrated that the development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. these changes are associated with changes in plasma and cellular levels of immune regulatory mirs.
miRNA	hsa-miR-182	mir-182	MIMAT0000259	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-410	mir-154	MIMAT0002171	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-145*	mir-145	MIMAT0004601	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-33a	mir-33	MIMAT0000091	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-580	mir-580	MIMAT0003245	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-142-5p	mir-142	MIMAT0000433	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-181b	mir-181	MIMAT0000257	Homo sapiens	0	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-92a-3p	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	st elevation myocardial infarction (stemi)	Ward JA et al.	Fam Med Med Sci Res. 2(2):108.	Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction.	24432306	2013	qrt-pcr	mirnas associated with stemi as compared to nstemi patients included mir-25-3p, mir-221-3p, and mir-374b-5p. mirna 30d-5p was associated with plasma, platelets, and leukocytes in both stemi and nstemi patients; mirnas 221-3p and 483-5p were correlated with plasma and platelets only in nstemi patients.
miRNA	hsa-miR-183	mir-183	MIMAT0000261	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-411	mir-379	MIMAT0003329	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-150*	mir-150	MIMAT0004610	Homo sapiens	0	circulating	breast milk	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-33b	mir-33	MIMAT0003301	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-584	mir-584	MIMAT0003249	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-143	mir-143	MIMAT0000435	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-1975		MIMAT0009450	Homo sapiens	0	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	1	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-30d-5p	mir-30	MIMAT0000245	Homo sapiens	0	circulating	plasma	st elevation myocardial infarction (stemi)	Ward JA et al.	Fam Med Med Sci Res. 2(2):108.	Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction.	24432306	2013	qrt-pcr	mirnas associated with stemi as compared to nstemi patients included mir-25-3p, mir-221-3p, and mir-374b-5p. mirna 30d-5p was associated with plasma, platelets, and leukocytes in both stemi and nstemi patients; mirnas 221-3p and 483-5p were correlated with plasma and platelets only in nstemi patients.
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-423	mir-423	MIMAT0001340	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	seminal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-340	mir-340	MIMAT0004692	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-591	mir-591	MIMAT0003259	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-144	mir-144	MIMAT0000436	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-144	mir-144	MIMAT0000436	Homo sapiens	0	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	1	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-134	mir-134	MIMAT0000447	Homo sapiens	1	circulating	plasma	mild cognitive impairment (mci)	Sheinerman KS et al.	Aging (Albany NY). 5(12):925-38.	Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study.	24368295	2013	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
miRNA	hsa-miR-186	mir-186	MIMAT0000456	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-424	mir-322	MIMAT0001341	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-182	mir-182	MIMAT0000259	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-27b	mir-27	MIMAT0000419	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-340*	mir-340	MIMAT0000750	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-598	mir-598	MIMAT0003266	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-144*	mir-144	MIMAT0004600	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	0	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-25-3p	mir-25	MIMAT0000081	Homo sapiens	0	circulating	plasma	st elevation myocardial infarction (stemi)	Ward JA et al.	Fam Med Med Sci Res. 2(2):108.	Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction.	24432306	2013	qrt-pcr	mirnas associated with stemi as compared to nstemi patients included mir-25-3p, mir-221-3p, and mir-374b-5p. mirna 30d-5p was associated with plasma, platelets, and leukocytes in both stemi and nstemi patients; mirnas 221-3p and 483-5p were correlated with plasma and platelets only in nstemi patients.
miRNA	hsa-miR-187	mir-187	MIMAT0000262	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-425	mir-425	MIMAT0003393	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-182*	mir-182	MIMAT0000260	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-342-3p	mir-342	MIMAT0000753	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-601	mir-601	MIMAT0003269	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-543	mir-329	MIMAT0004954	Homo sapiens	0	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-374b-5p	mir-374	MIMAT0004955	Homo sapiens	0	circulating	plasma	st elevation myocardial infarction (stemi)	Ward JA et al.	Fam Med Med Sci Res. 2(2):108.	Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction.	24432306	2013	qrt-pcr	mirnas associated with stemi as compared to nstemi patients included mir-25-3p, mir-221-3p, and mir-374b-5p. mirna 30d-5p was associated with plasma, platelets, and leukocytes in both stemi and nstemi patients; mirnas 221-3p and 483-5p were correlated with plasma and platelets only in nstemi patients.
miRNA	hsa-miR-188	mir-188	MIMAT0000457	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-425-5p	mir-425	MIMAT0003393	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-18a*	mir-17	MIMAT0002891	Homo sapiens	0	circulating	colostrum	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-128	mir-128	MIMAT0000424	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-361-3p	mir-361	MIMAT0004682	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-616*	mir-616	MIMAT0003284	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-127-3p	mir-127	MIMAT0000446	Homo sapiens	0	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-151-3p	mir-28	MIMAT0000757	Homo sapiens	1	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	osteoporosis	Seeliger C et al.	J Bone Miner Res. 29(8):1718-28.	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.	24431276	2014	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-432	mir-432	MIMAT0002814	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-192*	mir-192	MIMAT0004543	Homo sapiens	0	circulating	colostrum	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-29c	mir-29	MIMAT0000681	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-130a	mir-130	MIMAT0000425	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-361-5p	mir-361	MIMAT0000703	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-629*	mir-629	MIMAT0003298	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-146b-5p	mir-146	MIMAT0002809	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	papillary thyroid carcinomas (ptc)	yu s et al.	j clin endocrinol metab.	circulating microrna profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.	22472564	2012	solexa sequencing|quantitative rt-pcr	the expression of serum let-7e, mir-151-5p, and mir-222 was significantly increased in ptc cases relative to benign cases and healthy controls. Expression of serum mir-151-5p and mir-222 in a subset of ptc patients decreased significantly after tumor excision. Increased expression of mir-151-5p and mir-222 was also found in the tissue of ptc patients.
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	1	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	1	circulating	serum	osteoporosis	Seeliger C et al.	J Bone Miner Res. 29(8):1718-28.	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.	24431276	2014	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
miRNA	hsa-miR-18b	mir-17	MIMAT0001412	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-433	mir-433	MIMAT0001627	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	circulating	breast milk	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-301a	mir-130	MIMAT0000688	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-130b	mir-130	MIMAT0000691	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-362-3p	mir-362	MIMAT0004683	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-630	mir-630	MIMAT0003299	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	Breast cancer	Wang B et al.	J Cancer Res Clin Oncol.	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.	22638884	2012	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
miRNA	hsa-miR-423-3p	mir-423	MIMAT0001340	Homo sapiens	1	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	1	circulating	serum	osteoporosis	Seeliger C et al.	J Bone Miner Res. 29(8):1718-28.	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.	24431276	2014	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
miRNA	hsa-miR-190	mir-190	MIMAT0000458	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-193b*	mir-193	MIMAT0004767	Homo sapiens	0	circulating	colostrum	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-132	mir-132	MIMAT0000426	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-362-5p	mir-362	MIMAT0000705	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-639	mir-639	MIMAT0003309	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	Colorectal cancer (crc)	Wang B et al.	J Cancer Res Clin Oncol.	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.	22638884	2012	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	1	circulating	serum	osteoporosis	Seeliger C et al.	J Bone Miner Res. 29(8):1718-28.	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.	24431276	2014	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-217	mir-217	MIMAT0000274	Homo sapiens	0	circulating	breast milk	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-132*	mir-132	MIMAT0004594	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-363	mir-363	MIMAT0000707	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-654-3p	mir-654	MIMAT0004814	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	lung cancer	Wang B et al.	J Cancer Res Clin Oncol.	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.	22638884	2012	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	0	circulating	plasma	prostate cancer	Watahiki A et al.	Int J Mol Sci. 14(4):7757-70.	Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.	23574937	2013	Exiqon miRNA qPCR panel|qRT-PCR	Authors identified 63 miRNAs upregulated in mCRPC versus localized PCa, while only four were downregulated. Pearson's correlation analysis revealed two highly correlated groups: one consisting of miR-141, miR375 and miR-200c and the other including miR151-3p, miR423-3p, miR-126, miR152 and miR-21. A third group, containing miR-16 and miR-205, showed less correlation. One miRNA from each group (miR-141, miR151-3p and miR-16) was used for logistic regression analysis and proved to increase the sensitivity of the prostate-specific antigen (PSA) test alone.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	1	circulating	serum	osteoporosis	Seeliger C et al.	J Bone Miner Res. 29(8):1718-28.	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.	24431276	2014	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-485-3p	mir-485	MIMAT0002176	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	peritoneal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-30e	mir-30	MIMAT0000692	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-139-3p	mir-139	MIMAT0004552	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-370	mir-370	MIMAT0000722	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-660	mir-188	MIMAT0003338	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-151-3p	mir-28	MIMAT0000757	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	Esophageal cancer	Wang B et al.	J Cancer Res Clin Oncol.	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.	22638884	2012	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	prostate cancer	Zhang HL et al.	Prostate. 71(3):326-31.	Serum miRNA-21: elevated levels in patients with metastatic hormone-refractory prostate cancer and potential predictive factor for the efficacy of docetaxel-based chemotherapy.	20842666	2011	taqman real-time pcr	serum mir-21 levels are elevated in hrpc patients, especially in those resistant to docetaxel-based chemotherapy. it may be applicable as a marker to indicate the transformation to hormone refractory disease, and a potential predictor for the efficacy of docetaxel-based chemotherapy.
miRNA	hsa-miR-122a	mir-122	MIMAT0000421	Homo sapiens	1	circulating	serum	osteoporosis	Seeliger C et al.	J Bone Miner Res. 29(8):1718-28.	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.	24431276	2014	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
miRNA	hsa-miR-193a	mir-193	MIMAT0000459	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-485-5p	mir-485	MIMAT0002175	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-224	mir-224	MIMAT0000281	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-320a	mir-320	MIMAT0000510	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-140-3p	mir-140	MIMAT0004597	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-373*	mir-373	MIMAT0000725	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-7	mir-7	MIMAT0000252	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-151-5p	mir-28	MIMAT0004697	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	gastric cancer (gc)	Wang B et al.	J Cancer Res Clin Oncol.	The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors.	22638884	2012	TRIzol LS Reagent (Invitrogen, Carlsbad, CA, SA)|LightCycler  480 Real-Time PCR System (Roche, USA)|FastStart Universal SYBR Green Master (Rox) mix kit (Roche, USA)	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control, and its sensitivity and specificity were significantlyhigher than the currently used tumor markers. High miR-21 expression was not correlated with gender, age, clinical stage, and lymph node metastasis status.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	plasma	prostate cancer	Zheng C et al.	Med Oncol. 29(2):815-22.	MiR-221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2.	21487968	2012	taqman real-time pcr	The aim of this study is to evaluate the effect of the variation of miR-221 on the prostate cancer cells' NE differentiation and invasive function and to examine the function of miR-221 in plasma as a blood-based miRNA biomarker candidate for CaP. miR-221 may control the migration of AIPC cells through DVL2, working as a key regulator in advanced CaP. The role of miR-221 in other target mRNA needs to be further investigated.
miRNA	hsa-miR-124a	mir-124	MIMAT0000422	Homo sapiens	1	circulating	serum	osteoporosis	Seeliger C et al.	J Bone Miner Res. 29(8):1718-28.	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.	24431276	2014	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-486	mir-486	MIMAT0002177	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-335	mir-335	MIMAT0000765	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-140-5p	mir-140	MIMAT0000431	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-374a	mir-374	MIMAT0000727	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-766	mir-766	MIMAT0003888	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	1	circulating	serum	malignant astrocytomas	Yang C et al.	Int J Cancer. doi:10.1002/ijc.27657.	Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas.	22674182	2012	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
miRNA	hsa-miR-409-3p	mir-154	MIMAT0001639	Homo sapiens	0	circulating	plasma	ventricular septal defect (vsd)	Li D et al.	PLoS One. 9(8):e106318	Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect.	25165856	2014	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	1	circulating	serum	osteoporosis	Seeliger C et al.	J Bone Miner Res. 29(8):1718-28.	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.	24431276	2014	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-487b	mir-154	MIMAT0003180	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	circulating	amniotic fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-338-3p	mir-338	MIMAT0000763	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-374b	mir-374	MIMAT0004955	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-768-3p			Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-154	mir-154	MIMAT0000452	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-150*	mir-150	MIMAT0004610	Homo sapiens	1	circulating	serum	malignant astrocytomas	Yang C et al.	Int J Cancer. doi:10.1002/ijc.27657.	Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas.	22674182	2012	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
miRNA	hsa-miR-487b	mir-154	MIMAT0003180	Homo sapiens	0	circulating	plasma	ventricular septal defect (vsd)	Li D et al.	PLoS One. 9(8):e106318	Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect.	25165856	2014	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
miRNA	hsa-miR-132	mir-132	MIMAT0000426	Homo sapiens	1	circulating	plasma	mild cognitive impairment (mci)	Sheinerman KS et al.	Aging (Albany NY). 5(12):925-38.	Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study.	24368295	2013	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
miRNA	hsa-miR-196b	mir-196	MIMAT0001080	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-491	mir-491	MIMAT0002807	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-28-5p	mir-28	MIMAT0000085	Homo sapiens	0	circulating	breast milk	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-374b	mir-374	MIMAT0004955	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-378	mir-378	MIMAT0000732	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-768-3p			Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-15b*	mir-15	MIMAT0004586	Homo sapiens	1	circulating	serum	malignant astrocytomas	Yang C et al.	Int J Cancer. doi:10.1002/ijc.27657.	Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas.	22674182	2012	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
miRNA	hsa-miR-155-5p	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	ventricular septal defect (vsd)	Li D et al.	PLoS One. 9(8):e106318	Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect.	25165856	2014	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	1	circulating	serum	osteoporosis	Seeliger C et al.	J Bone Miner Res. 29(8):1718-28.	Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures.	24431276	2014	mirna pcr array	authors identified 9 mirnas, namely mir-21, mir-23a, mir-24, mir-93, mir-100, mir-122a, mir-124a, mir-125b, and mir-148a, that were significantly upregulated in the serum of patients with osteoporosis.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-493	mir-493	MIMAT0003161	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-299-5p	mir-299	MIMAT0002890	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-142-5p	mir-142	MIMAT0000433	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-378*	mir-378	MIMAT0000731	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-770-5p	mir-770	MIMAT0003948	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	1	circulating	serum	malignant astrocytomas	Yang C et al.	Int J Cancer. doi:10.1002/ijc.27657.	Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas.	22674182	2012	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
miRNA	hsa-miR-379-5p	mir-379	MIMAT0000733	Homo sapiens	0	circulating	plasma	ventricular septal defect (vsd)	Li D et al.	PLoS One. 9(8):e106318	Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect.	25165856	2014	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
miRNA	rno-miR-15a	mir-15	MIMAT0035728	rat model	1	circulating	plasma	ischaemic stroke	Selvamani A et al.	Clin Sci (Lond). 127(2):77-89.	Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model.	24428837	2014	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
miRNA	hsa-miR-198	mir-198	MIMAT0000228	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-494	mir-154	MIMAT0002816	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-29b-1*	mir-29	MIMAT0004514	Homo sapiens	0	circulating	peritoneal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-382	mir-154	MIMAT0000737	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-801			Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	1	circulating	serum	malignant astrocytomas	Yang C et al.	Int J Cancer. doi:10.1002/ijc.27657.	Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas.	22674182	2012	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
miRNA	hsa-miR-222-3p	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	ventricular septal defect (vsd)	Li D et al.	PLoS One. 9(8):e106318	Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect.	25165856	2014	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
miRNA	rno-miR-19b	mir-19	MIMAT0000788	rat model	1	circulating	plasma	ischaemic stroke	Selvamani A et al.	Clin Sci (Lond). 127(2):77-89.	Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model.	24428837	2014	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-532	mir-188	MIMAT0002888	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-29b-2*	mir-29	MIMAT0004515	Homo sapiens	0	circulating	seminal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-542-5p	mir-542	MIMAT0003340	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-146b-5p	mir-146	MIMAT0002809	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-422a	mir-422	MIMAT0001339	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-801			Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-497	mir-497	MIMAT0002820	Homo sapiens	1	circulating	serum	malignant astrocytomas	Yang C et al.	Int J Cancer. doi:10.1002/ijc.27657.	Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas.	22674182	2012	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
miRNA	hsa-let-7e-5p	let-7	MIMAT0000066	Homo sapiens	0	circulating	plasma	ventricular septal defect (vsd)	Li D et al.	PLoS One. 9(8):e106318	Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect.	25165856	2014	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
miRNA	rno-miR-32	mir-32	MIMAT0000811	rat model	1	circulating	plasma	ischaemic stroke	Selvamani A et al.	Clin Sci (Lond). 127(2):77-89.	Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model.	24428837	2014	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-550	mir-550	MIMAT0004800	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-330-5p	mir-330	MIMAT0004693	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-424	mir-322	MIMAT0001341	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-875-5p	mir-875	MIMAT0004922	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-17*	mir-17	MIMAT0000071	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-548b-5p	mir-548	MIMAT0004798	Homo sapiens	1	circulating	serum	malignant astrocytomas	Yang C et al.	Int J Cancer. doi:10.1002/ijc.27657.	Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas.	22674182	2012	Solexa sequencing|stem-loop quantitative reverse-transcription PCR (RT-qPCR) assay	Seven miRNAs were validated by RT-qPCR assay to be significantly decreased in grades II-IV patients (p < 0.001), including miR-15b(*) , miR-23a, miR-133a, miR-150(*) , miR-197, miR-497 and miR-548b-5p, and the seven-miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction.
miRNA	hsa-miR-433	mir-433	MIMAT0001627	Homo sapiens	0	circulating	plasma	ventricular septal defect (vsd)	Li D et al.	PLoS One. 9(8):e106318	Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect.	25165856	2014	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
miRNA	rno-miR-136	mir-136	MIMAT0000842	rat model	1	circulating	plasma	ischaemic stroke	Selvamani A et al.	Clin Sci (Lond). 127(2):77-89.	Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model.	24428837	2014	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-572	mir-572	MIMAT0003237	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-340	mir-340	MIMAT0004692	Homo sapiens	0	circulating	seminal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-590-5p	mir-590	MIMAT0003258	Homo sapiens	0	exosome	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-424*	mir-322	MIMAT0004749	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-886-3p		MIMAT0004906	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-361-3p	mir-361	MIMAT0004682	Homo sapiens	1	circulating	serum	non small cell lung cancer (nsclc)	Roth C et al.	PLoS One. 7(6):e38248.	Low Levels of Cell-Free Circulating miR-361-3p and miR-625* as Blood-Based Markers for Discriminating Malignant from Benign Lung Tumors.	22675530	2012	Trizol LS Reagent (Karlsruhe, Germany, Invitrogen)|microfluid biochips (Febit Biomed GmbH, Heidelberg, Germany)|Microfluid Primer Extension Assay|mirVana PARIS kit (Ambion, Darmstadt, Germany)|TaqMan MicroRNA Reverse Transcription Kit (Applied Biosystems)	Microarray profiling showed that miR-361-3p and miR-625* were significantly down-regulated in serum of lung cancer patients. Their further evaluation by quantitative RT-PCR showed that the levels of miR-361-3p and miR-625* were lower in NSCLC than in benign disease (p = 0.0001) and healthy individuals (p = 0.0001, p = 0.0005, respectively).
miRNA	hsa-miR-498	mir-498	MIMAT0002824	Homo sapiens	0	circulating	plasma	ventricular septal defect (vsd)	Li D et al.	PLoS One. 9(8):e106318	Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect.	25165856	2014	reverse transcriptase-polymerase chain reaction 	authors report for the first time the circulating mirna profile for patients with vsd and showed that 7 mirnas were downregulated and 1 upregulated when matched to vsd-free controls. analysis revealed target genes involved in cardiac development were probably regulated by these mirnas.
miRNA	rno-miR-199a-3p	mir-199	MIMAT0000872	rat model	1	circulating	plasma	ischaemic stroke	Selvamani A et al.	Clin Sci (Lond). 127(2):77-89.	Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model.	24428837	2014	qpcr	at 5 days post-stroke, 78 circulating mirnas exhibited significantly different regulation, and most of the variance was associated with sex. a small cohort (five) of mirnas, mir-15a, mir-19b, mir-32 mir-136 and mir-199a-3p, were found to be highly expressed exclusively in adult females compared with middle-aged females, adult males and middle-aged males.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-657	mir-657	MIMAT0003335	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-369-3p	mir-154	MIMAT0000721	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-596	mir-596	MIMAT0003264	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-151-3p	mir-28	MIMAT0000757	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-425	mir-425	MIMAT0003393	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-886-5p		MIMAT0004905	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-181c	mir-181	MIMAT0000258	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-625*	mir-625	MIMAT0004808	Homo sapiens	1	circulating	serum	non small cell lung cancer (nsclc)	Roth C et al.	PLoS One. 7(6):e38248.	Low Levels of Cell-Free Circulating miR-361-3p and miR-625* as Blood-Based Markers for Discriminating Malignant from Benign Lung Tumors.	22675530	2012	Trizol LS Reagent (Karlsruhe, Germany, Invitrogen)|microfluid biochips (Febit Biomed GmbH, Heidelberg, Germany)|Microfluid Primer Extension Assay|mirVana PARIS kit (Ambion, Darmstadt, Germany)|TaqMan MicroRNA Reverse Transcription Kit (Applied Biosystems)	Microarray profiling showed that miR-361-3p and miR-625* were significantly down-regulated in serum of lung cancer patients. Their further evaluation by quantitative RT-PCR showed that the levels of miR-361-3p and miR-625* were lower in NSCLC than in benign disease (p = 0.0001) and healthy individuals (p = 0.0001, p = 0.0005, respectively).
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	1	circulating	serum	Breast cancer	Li Q et al.	PLoS One. 9(8):e104870	Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel.	25137071	2014	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
miRNA	hsa-miR-494	mir-154	MIMAT0002816	Homo sapiens	1	circulating	plasma	Coronary stenosis	Freedman JE et al.	F1000Res. 1:50.	The distribution of circulating microRNA and their relation to coronary disease.	24358814	2012	mirvana paris kit (ambion, austin, tx)|high-throughput biomark real-time pcr system (fluidigm, south san francisco, ca)	authors demonstrate that specific mirnas from circulating plasma are associated with the presence of significant coronary disease.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-660	mir-188	MIMAT0003338	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-373	mir-373	MIMAT0000726	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-720	mir-720	MIMAT0005954	Homo sapiens	0	circulating	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-151-5p	mir-28	MIMAT0004697	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-431*	mir-431	MIMAT0004757	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-9*	mir-9	MIMAT0000442	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-182	mir-182	MIMAT0000259	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	Acute kidney injury	Martino F et al.	PLoS One. 7(6): e38269.	Circulating MicroRNAs Are Not Eliminated by Hemodialysis.	22715378	2012	MasterPure RNA Purification kit (Epicenter Technologies)|TaqMan microRNA Reverse Transcription kit (Applied Biosystems, Foster City, CA)|quantitative real-time PCR (qRT-PCR) via TaqMan MicroRNA Assays (Applied Biosystems)	In patients with acute kidney injury circulating microRNAs are not removed by dialysis. As only traces of miR-21 and -210 are detected in dialysate and ultrafiltrate, microRNAs in the circulation are likely to be transported by larger structures such as proteins and/or microvesicles. As miRNAs are not affected by dialysis they might be more robust biomarkers of acute kidney injury.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	1	circulating	serum	Breast cancer	Li Q et al.	PLoS One. 9(8):e104870	Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel.	25137071	2014	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
miRNA	hsa-miR-769-3p	mir-769	MIMAT0003887	Homo sapiens	1	circulating	plasma	Coronary stenosis	Freedman JE et al.	F1000Res. 1:50.	The distribution of circulating microRNA and their relation to coronary disease.	24358814	2012	mirvana paris kit (ambion, austin, tx)|high-throughput biomark real-time pcr system (fluidigm, south san francisco, ca)	authors demonstrate that specific mirnas from circulating plasma are associated with the presence of significant coronary disease.
miRNA	hsa-miR-202	mir-202	MIMAT0002811	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-7	mir-7	MIMAT0000252	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-376b	mir-368	MIMAT0002172	Homo sapiens	0	circulating	amniotic fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-449a	mir-449	MIMAT0001541	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-93*	mir-17	MIMAT0004509	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	plasma	Acute kidney injury	Martino F et al.	PLoS One. 7(6): e38269.	Circulating MicroRNAs Are Not Eliminated by Hemodialysis.	22715378	2012	MasterPure RNA Purification kit (Epicenter Technologies)|TaqMan microRNA Reverse Transcription kit (Applied Biosystems, Foster City, CA)|quantitative real-time PCR (qRT-PCR) via TaqMan MicroRNA Assays (Applied Biosystems)	In patients with acute kidney injury circulating microRNAs are not removed by dialysis. As only traces of miR-21 and -210 are detected in dialysate and ultrafiltrate, microRNAs in the circulation are likely to be transported by larger structures such as proteins and/or microvesicles. As miRNAs are not affected by dialysis they might be more robust biomarkers of acute kidney injury.
miRNA	hsa-miR-28-5p	mir-28	MIMAT0000085	Homo sapiens	0	circulating	serum	Breast cancer	Li Q et al.	PLoS One. 9(8):e104870	Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel.	25137071	2014	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
miRNA	hsa-miR-490-3p	mir-490	MIMAT0002806	Homo sapiens	1	circulating	plasma	Coronary stenosis	Freedman JE et al.	F1000Res. 1:50.	The distribution of circulating microRNA and their relation to coronary disease.	24358814	2012	mirvana paris kit (ambion, austin, tx)|high-throughput biomark real-time pcr system (fluidigm, south san francisco, ca)	authors demonstrate that specific mirnas from circulating plasma are associated with the presence of significant coronary disease.
miRNA	hsa-miR-203	mir-203	MIMAT0000264	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-92	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-380*	mir-379	MIMAT0000734	Homo sapiens	0	circulating	seminal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	Ago2	serum	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-450a	mir-450	MIMAT0001545	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-99a*	mir-99	MIMAT0004511	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	1	circulating	plasma	Acute myocardial infarction (ami)	Long G et al.	Int J Biol Sci. 8(6):811-8.	Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction.	22719221	2012	TRIzol LS Reagent|ELISA assay|Transcript First-strand cDNA Synthesis Su-perMix (TransGen Biotech, Beijing, China)|Bulge-Loop miRNA qRT-PCR Detection Kit (Ribobio Co., Guangzhou, China)|TransStart Green qPCR SuperMix (TransGen Biotech, Beijing, China)	Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. A remarkable finding in this study is that miR-1, miR-126 and cTnI expression levels exhibited the same trend. Results suggest that the plasma concentrations of miR-1 and miR-126 may be useful indicators for AMI.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	circulating	serum	Breast cancer	Li Q et al.	PLoS One. 9(8):e104870	Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel.	25137071	2014	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
miRNA	hsa-miR-769-3p	mir-769	MIMAT0003887	Homo sapiens	1	circulating	plasma	Coronary artery disease	Freedman JE et al.	F1000Res. 1:50.	The distribution of circulating microRNA and their relation to coronary disease.	24358814	2012	mirvana paris kit (ambion, austin, tx)|high-throughput biomark real-time pcr system (fluidigm, south san francisco, ca)	authors demonstrate that specific mirnas from circulating plasma are associated with the presence of significant coronary disease.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-381	mir-154	MIMAT0000736	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-10b	mir-10	MIMAT0000254	Homo sapiens	0	circulating	serum	lung cancer	roth c et al.	mol oncol. 5(3):281-91. 	screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer.	21398193	2011	picogreen|taqman microrna|caspase-glo 3/7 assay	in lung cancer patients high serum mir10b values associated with lymph node metastasis (p < 0.03) and elevated levels of tpa (tissue polypeptide antigen, p = 0.01), whereas high serum mir141 values associated with elevated levels of upa (urokinase plasminogen activator, p = 0.02).
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	non small cell lung cancer (nsclc)	wei j et al.	chin j cancer. 30(6):407-14.	identification of plasma microrna-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer.	21627863	2011	real-time rt-pcr	this study was to investigate whether plasma mirna-21 (mir-21) can be used as a biomarker for the early detection of non-small cell lung cancer (nsclc) and to explore its association with clinicopathologic features and sensitivity to platinum-based chemotherapy.
miRNA	hsa-miR-18b	mir-17	MIMAT0001412	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	Acute myocardial infarction (ami)	Long G et al.	Int J Biol Sci. 8(6):811-8.	Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction.	22719221	2012	TRIzol LS Reagent|ELISA assay|Transcript First-strand cDNA Synthesis Su-perMix (TransGen Biotech, Beijing, China)|Bulge-Loop miRNA qRT-PCR Detection Kit (Ribobio Co., Guangzhou, China)|TransStart Green qPCR SuperMix (TransGen Biotech, Beijing, China)	Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. A remarkable finding in this study is that miR-1, miR-126 and cTnI expression levels exhibited the same trend. Results suggest that the plasma concentrations of miR-1 and miR-126 may be useful indicators for AMI.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	circulating	serum	Breast cancer	Li Q et al.	PLoS One. 9(8):e104870	Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel.	25137071	2014	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
miRNA	hsa-miR-517*	mir-515	MIMAT0002851	Homo sapiens	0	circulating	plasma	preeclampsia	Hromadnikova I et al.	Mediators Inflamm. 2013:186041.	Circulating C19MC microRNAs in preeclampsia, gestational hypertension, and fetal growth restriction.	24347821	2013	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	authors demonstrate that the upregulation of mir-516-5p, mir-517*, mir-520a*, mir-525, and mir-526a is a characteristic phenomenon of established preeclampsia.
miRNA	hsa-miR-206	mir-1	MIMAT0000462	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-98	let-7	MIMAT0000096	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-431*	mir-431	MIMAT0004757	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	serum	lung cancer	roth c et al.	mol oncol. 5(3):281-91. 	screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer.	21398193	2011	picogreen|taqman microrna|caspase-glo 3/7 assay	in lung cancer patients high serum mir10b values associated with lymph node metastasis (p < 0.03) and elevated levels of tpa (tissue polypeptide antigen, p = 0.01), whereas high serum mir141 values associated with elevated levels of upa (urokinase plasminogen activator, p = 0.02).
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-452	mir-452	MIMAT0001635	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	Acute exhaustive exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	1	circulating	serum	Biliary atresia (BA)	Zahm AM et al.	J Pediatr Gastroenterol Nutr.	Circulating MicroRNA is a Biomarker of Biliary Atresia.	22732895	2012	microfluidic array platform	In this study authors examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia.The miR-200b/429 cluster was significantly increased in the sera of BA patients and has promising diagnostic clinical performance.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	circulating	serum	Breast cancer	Li Q et al.	PLoS One. 9(8):e104870	Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel.	25137071	2014	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
miRNA	hsa-miR-526a	mir-515	MIMAT0002845	Homo sapiens	1	circulating	plasma	preeclampsia	Hromadnikova I et al.	Mediators Inflamm. 2013:186041.	Circulating C19MC microRNAs in preeclampsia, gestational hypertension, and fetal growth restriction.	24347821	2013	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	authors demonstrate that the upregulation of mir-516-5p, mir-517*, mir-520a*, mir-525, and mir-526a is a characteristic phenomenon of established preeclampsia.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-99a	mir-99	MIMAT0000097	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-450b-5p	mir-450	MIMAT0004909	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	serum	lung cancer	roth c et al.	mol oncol. 5(3):281-91. 	screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer.	21398193	2011	picogreen|taqman microrna|caspase-glo 3/7 assay	in lung cancer patients high serum mir10b values associated with lymph node metastasis (p < 0.03) and elevated levels of tpa (tissue polypeptide antigen, p = 0.01), whereas high serum mir141 values associated with elevated levels of upa (urokinase plasminogen activator, p = 0.02).
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-453	mir-154	MIMAT0001630	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	Acute exhaustive exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-429	mir-8	MIMAT0001536	Homo sapiens	1	circulating	serum	Biliary atresia (BA)	Zahm AM et al.	J Pediatr Gastroenterol Nutr.	Circulating MicroRNA is a Biomarker of Biliary Atresia.	22732895	2012	microfluidic array platform	In this study authors examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia.The miR-200b/429 cluster was significantly increased in the sera of BA patients and has promising diagnostic clinical performance.
miRNA	hsa-miR-1290	mir-1290	MIMAT0005880	Homo sapiens	0	circulating	serum	Breast cancer	Li Q et al.	PLoS One. 9(8):e104870	Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel.	25137071	2014	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	1	circulating	serum	hepatic schistosomiasis	He X et al.	Parasit Vectors. 6:272.	Host serum miR-223 is a potential new biomarker for Schistosoma japonicum infection and the response to chemotherapy.	24330517	2013	mirneasy mini kit (qiagen)|stem-loop rt-pcr	authors suggested that the circulating mir-223 could serve as a potential new biomarker for the detection of schistosome infection and the assessment of the response to chemotherapy.
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-99b	mir-99	MIMAT0000689	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-483-3p	mir-483	MIMAT0002173	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-135a*	mir-135	MIMAT0004595	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-454	mir-454	MIMAT0003885	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	Acute exhaustive exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-193a-5p	mir-193	MIMAT0004614	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	1	circulating	plasma	Breast cancer	Cookson VJ et al.	Cell Oncol (Dordr).	Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours.	22821209	2012	Quantitative PCR	Potential biomarker microRNAs were identified, including let-7b, let-7g and miR-18b, with higher levels associated with tumours. These microRNAs were over-represented within the more highly expressed microRNAs in matched tumours, suggesting that circulating populations are tumour-derived in part.
miRNA	hsa-miR-1274a		MIMAT0005927	Homo sapiens	0	circulating	serum	Breast cancer	Li Q et al.	PLoS One. 9(8):e104870	Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel.	25137071	2014	taqman real-time pcr microrna array	the combination of mir-19a and mir-205 in the serum may predict the chemosensitivity of luminal a subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	1	circulating	serum	hepatic schistosomiasis	He X et al.	Parasit Vectors. 6:272.	Host serum miR-223 is a potential new biomarker for Schistosoma japonicum infection and the response to chemotherapy.	24330517	2013	mirneasy mini kit (qiagen)|stem-loop rt-pcr	authors suggested that the circulating mir-223 could serve as a potential new biomarker for the detection of schistosome infection and the assessment of the response to chemotherapy.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-508-3p	mir-506	MIMAT0002880	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-188-5p	mir-188	MIMAT0000457	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-17*	mir-17	MIMAT0000071	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-483-5p	mir-483	MIMAT0004761	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	plasma	Acute exhaustive exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	1	circulating	plasma	Breast cancer	Cookson VJ et al.	Cell Oncol (Dordr).	Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours.	22821209	2012	Quantitative PCR	Potential biomarker microRNAs were identified, including let-7b, let-7g and miR-18b, with higher levels associated with tumours. These microRNAs were over-represented within the more highly expressed microRNAs in matched tumours, suggesting that circulating populations are tumour-derived in part.
miRNA	hsa-miR-151a-3p	mir-28	MIMAT0000757	Homo sapiens	0	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	1	circulating	plasma	papillary thyroid carcinomas (ptc)	Lee JC et al.	Cancer. 119(24):4358-65.	MicroRNA-222 and microRNA-146b are tissue and circulating biomarkers of recurrent papillary thyroid cancer.	24301304	2013	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	authors demonstrated that tumor levels of mir-222 and mir-146b are associated with ptc recurrence and that mir-222 and mir-146b levels in the circulation correspond to the presence of ptc.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-508-5p	mir-506	MIMAT0004778	Homo sapiens	0	circulating	seminal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-877	mir-877	MIMAT0004949	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	plasma	Acute exhaustive exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-18b	mir-17	MIMAT0001412	Homo sapiens	1	circulating	plasma	Breast cancer	Cookson VJ et al.	Cell Oncol (Dordr).	Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours.	22821209	2012	Quantitative PCR	Potential biomarker microRNAs were identified, including let-7b, let-7g and miR-18b, with higher levels associated with tumours. These microRNAs were over-represented within the more highly expressed microRNAs in matched tumours, suggesting that circulating populations are tumour-derived in part.
miRNA	hsa-miR-181b-5p	mir-181	MIMAT0000257	Homo sapiens	1	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-146b	mir-146	MIMAT0002809	Homo sapiens	1	circulating	plasma	papillary thyroid carcinomas (ptc)	Lee JC et al.	Cancer. 119(24):4358-65.	MicroRNA-222 and microRNA-146b are tissue and circulating biomarkers of recurrent papillary thyroid cancer.	24301304	2013	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	authors demonstrated that tumor levels of mir-222 and mir-146b are associated with ptc recurrence and that mir-222 and mir-146b levels in the circulation correspond to the presence of ptc.
miRNA	hsa-miR-214	mir-214	MIMAT0000271	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-513a-5p	mir-506	MIMAT0002877	Homo sapiens	0	circulating	colostrum	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-181b	mir-181	MIMAT0000257	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	circulating	plasma	Acute exhaustive exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	1	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-320a	mir-320	MIMAT0000510	Homo sapiens	1	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	1	circulating	serum	Abdominal aortic aneurysm (aaa)	Biros E et al.	Clin Sci (Lond). 126(11):795-803.	microRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155.	24283299	2014	quantitative real-time pcr	authors suggest that mir-155 is overexpressed in aaa with potential implications in the pathogenesis of the condition.
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-518c*	mir-515	MIMAT0002847	Homo sapiens	0	circulating	breast milk	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-760	mir-760	MIMAT0004957	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-181c	mir-181	MIMAT0000258	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-490-5p	mir-490	MIMAT0004764	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	plasma	Acute exhaustive exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	1	circulating	plasma	stable angina (sa) 	D'Alessandra Y et al.	PLoS One. 8(11):e80345.	Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina.	24260372	2013	trizol reagent|taqman human microrna card a arrays version 2.0 (life technologies)	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
miRNA	hsa-miR-220			Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-149	mir-149	MIMAT0000450	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-518f*	mir-515	MIMAT0002841	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-491-5p	mir-491	MIMAT0002807	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	circulating	plasma	Acute exhaustive exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio,mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-199a-3p	mir-199	MIMAT0000232	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-30a-5p	mir-30	MIMAT0000087	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-433	mir-433	MIMAT0001627	Homo sapiens	0	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	1	circulating	serum	hepatitis b virus-associated hepatocellular carcinoma (hbv-hcc)	Fu Y et al.	Oncol Lett. 6(6):1811-1815.	Circulating microRNA-101 as a potential biomarker for hepatitis B virus-related hepatocellular carcinoma.	24260081	2013	real-time pcr	authors demonstrate that circulating mir-101 may serve as a promising biochemical marker for monitoring the progression of tumor development in hbv-related hcc.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-519d	mir-515	MIMAT0002853	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-186	mir-186	MIMAT0000456	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-492	mir-492	MIMAT0002812	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	sustained aerobic exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-199a-5p	mir-199	MIMAT0000231	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-489	mir-489	MIMAT0002805	Homo sapiens	0	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	gastric cancer (gc)	Song J et al.	Oncol Lett. 6(6):1733-1737.	Serum microRNA-21 levels are related to tumor size in gastric cancer patients but cannot predict prognosis.	24260069	2013	Quantitative PCR	authors suggest that serum mir-21 could be exploited as a practical biomarker for monitoring tumor burden in patients with gc.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-202	mir-202	MIMAT0002811	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-551b	mir-551	MIMAT0003233	Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-138-1*	mir-138	MIMAT0004607	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-188-3p	mir-188	MIMAT0004613	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-498	mir-498	MIMAT0002824	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	sustained aerobic exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-199b-5p	mir-199	MIMAT0000263	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-572	mir-572	MIMAT0003237	Homo sapiens	1	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-423-5p	mir-423	MIMAT0004748	Homo sapiens	1	circulating	plasma	Acute myocardial infarction (ami)	Nabiałek E et al.	Minerva Cardioangiol. 61(6):627-37.	Circulating microRNAs (miR-423-5p, miR-208a and miR-1) in acute myocardial infarction and stable coronary heart disease.	24253456	2013	taqman microrna assays	authors demonstrate that in acute myocardial infarction the expression of mir-423-5p in plasma is significantly increased with subsequent normalization within 6 hours. potentially it is an early marker of myocardial necrosis.
miRNA	hsa-miR-224	mir-224	MIMAT0000281	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-556-5p	mir-556	MIMAT0003220	Homo sapiens	0	circulating	amniotic fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-625*	mir-625	MIMAT0004808	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-502-5p	mir-500	MIMAT0002873	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	sustained aerobic exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-663a	mir-663	MIMAT0003326	Homo sapiens	0	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	mmu-miR-122	mir-122	MIMAT0000246	Mus musculus	1	circulating	serum	non-alcoholic steatohepatitis (NASH)	Clarke JD et al.	J Appl Toxicol. 34(6):726-32.	Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis.	24217942	2014	rt-qpcr	authors demonstrate that serum levels of mir-122 can potentially be used as a sensitive biomarker for the early detection of hepatotoxicity and can aid in monitoring the extent of nafld-associated liver injury in mouse efficacy models.
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-512-3p	mir-506	MIMAT0002823	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-577	mir-577	MIMAT0003242	Homo sapiens	0	circulating	cerebrospinal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	HDL	plasma	normal	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-18b	mir-17	MIMAT0001412	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-503	mir-503	MIMAT0002874	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	plasma	sustained aerobic exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-101-3p	mir-101	MIMAT0000099	Homo sapiens	0	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-34b	mir-34	MIMAT0004676	Homo sapiens	1	circulating	serum	malignant pleural mesothelioma (mpm)	Muraoka T et al.	Lung Cancer. 82(3):485-90.	The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma.	24168922	2013	digital methylation specific pcr assay (msp)	authors show that digital msp assay can quantify mir-34b/c methylation in serum-circulating dna. the degree of mir-34b/c methylation in serum-circulating dna is associated with mpm.
miRNA	hsa-miR-23b	mir-23	MIMAT0000418	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-515-5p	mir-515	MIMAT0002826	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-583	mir-583	MIMAT0003248	Homo sapiens	0	circulating	peritoneal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-193a-3p	mir-193	MIMAT0000459	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-505	mir-505	MIMAT0002876	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	plasma	sustained aerobic exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-204	mir-204	MIMAT0000265	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-106b-5p	mir-17	MIMAT0000680	Homo sapiens	0	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-34c-5p	mir-34	MIMAT0000686	Homo sapiens	1	circulating	serum	malignant pleural mesothelioma (mpm)	Muraoka T et al.	Lung Cancer. 82(3):485-90.	The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma.	24168922	2013	digital methylation specific pcr assay (msp)	authors show that digital msp assay can quantify mir-34b/c methylation in serum-circulating dna. the degree of mir-34b/c methylation in serum-circulating dna is associated with mpm.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-517*	mir-515	MIMAT0002851	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-593*	mir-593	MIMAT0003261	Homo sapiens	0	circulating	amniotic fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-105	mir-105	MIMAT0000102	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-510	mir-506	MIMAT0002882	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	circulating	plasma	sustained aerobic exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-208a	mir-208	MIMAT0000241	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-130a-3p	mir-130	MIMAT0000425	Homo sapiens	1	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	0	microvesicle	conditioned medium (cm)	glioblastoma	Bronisz A et al.	Cancer Res. 74(3):738-50.	Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1.	24310399	2014	trizol (invitrogen)|mir real-time pcr detection kit (applied biosystems)	authors showed how extracellular vesicle signaling promotes the malignant character of glioblastoma and how ectopic expression of mir-1 can mitigate this character, with possible implications for how to develop a unique mirna-based therapy for glioblastoma management.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-518a-3p	mir-515	MIMAT0002863	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-622	mir-622	MIMAT0003291	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-513a-3p	mir-506	MIMAT0004777	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	plasma	sustained aerobic exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-208b	mir-208	MIMAT0004960	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-195-5p	mir-15	MIMAT0000461	Homo sapiens	0	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	1	circulating	plasma	lung adenocarcinoma	Zhang H et al.	PLoS One. 8(11):e81408.	Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.	24282590	2013	real-time rt-pcr	authors show that circulating mir-195 and mir-122 may have prognostic values in predicting the overall survival as well as predicting egfr mutation status in non-smoking female patients with lung adenocarcinoma.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-518d	mir-515	MIMAT0002864	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-627	mir-627	MIMAT0003296	Homo sapiens	0	circulating	peritoneal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-199b-5p	mir-199	MIMAT0000263	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-513a-5p	mir-506	MIMAT0002877	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	circulating	plasma	sustained aerobic exercise	baggish al et al.	j physiol. 589(pt 16):3983-94.	dynamic regulation of circulating microrna during acute exhaustive exercise and sustained aerobic exercise training.	21690193	2011	microrna extraction kit (benevbio, mission viejo, ca, usa)|rt-qpcr	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-27b	mir-27	MIMAT0000419	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-19b-3p	mir-19	MIMAT0000074	Homo sapiens	1	circulating	serum	Autism Spectrum Disorder (ASD)	Mundalil Vasu M et al.	Mol Autism. 5:40	Serum microRNA profiles in children with autism.	25126405	2014	sybr green quantitative pcr	thirteen mirnas were differentially expressed in asd individuals compared to the controls. mir-151a-3p, mir-181b-5p, mir-320a, mir-328, mir-433, mir-489, mir-572, and mir-663a were downregulated, while mir-101-3p, mir-106b-5p, mir-130a-3p, mir-195-5p, and mir-19b-3p were upregulated. five mirnas showed good predictive power for distinguishing individuals with asd.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	1	circulating	plasma	lung adenocarcinoma	Zhang H et al.	PLoS One. 8(11):e81408.	Circulating microRNAs in relation to EGFR status and survival of lung adenocarcinoma in female non-smokers.	24282590	2013	real-time rt-pcr	authors show that circulating mir-195 and mir-122 may have prognostic values in predicting the overall survival as well as predicting egfr mutation status in non-smoking female patients with lung adenocarcinoma.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-518e	mir-515	MIMAT0002861	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-636	mir-636	MIMAT0003306	Homo sapiens	0	circulating	amniotic fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-135a*	mir-135	MIMAT0004595	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-513b	mir-506	MIMAT0005788	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	0	circulating	plasma	essential hypertension	li s et al.	circulation. 124(2):175-84.	signature microrna expression profile of essential hypertension and its novel link to human cytomegalovirus infection.	21690488	2011	mircury lna array (version 11.0) system|qrt-pcr mmlv reverse transcriptase (epicenter, madison, wi)|abi prism7500 system (applied biosystems, foster city, ca)	authors report for the first time a circulating mirna profile for hypertensive patients and demonstrate a novel link between hcmv infection and essential hypertension. These findings may reveal important insights into the pathogenesis of essential hypertension.
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	circulating	serum	type 1 diabetes (t1d)	Nielsen LB et al.	Exp Diabetes Res. 2012:896362	Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.	22829805	2012	solexa sequencing|quantitative rt-pcr	this study shows that 12 mirnas have increased expression levels in children with new onset t1d compared to age-matched healthy controls. furthermore, the residual beta-cell function and glycaemic control after 3 months of clinical disease associate with mir-25 expression level present soon after diagnosis.
miRNA	hsa-miR-499-5p	mir-499	MIMAT0002870	Homo sapiens	1	circulating	plasma	perioperative myocardial infarction (pmi)	Yao Y et al.	PLoS One. 9(8):e104618	Plasma Levels of MicroRNA-499 Provide an Early Indication of Perioperative Myocardial Infarction in Coronary Artery Bypass Graft Patients.	25111390	2014	real-time quantitative rt-pcr	the data analysis revealed that mir-499 had higher sensitivity and specificity than ctni, and indicated that mir-499 could be an independent risk factor for pmi.
miRNA	hsa-miR-412	mir-412	MIMAT0002170	Homo sapiens	1	circulating	plasma	Acetaminophen-induced acute liver injury (APAP-ALI)	Ward J et al.	Proc Natl Acad Sci U S A. 111(33):12169-74.	Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.	25092309	2014	real-time pcr	authors suggest that mirnas can serve as sensitive diagnostic and prognostic clinical tools for severe liver injury and could be useful for monitoring drug-induced liver injury during drug discovery.
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-519d	mir-515	MIMAT0002853	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-637	mir-637	MIMAT0003307	Homo sapiens	0	circulating	tears	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-372	mir-290	MIMAT0000724	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-513c	mir-506	MIMAT0005789	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-296-5p	mir-296	MIMAT0000690	Homo sapiens	0	circulating	plasma	essential hypertension	li s et al.	circulation. 124(2):175-84.	signature microrna expression profile of essential hypertension and its novel link to human cytomegalovirus infection.	21690488	2011	mircury lna array (version 11.0) system|qrt-pcr mmlv reverse transcriptase (epicenter, madison, wi)|abi prism7500 system (applied biosystems, foster city, ca)	authors report for the first time a circulating mirna profile for hypertensive patients and demonstrate a novel link between hcmv infection and essential hypertension. These findings may reveal important insights into the pathogenesis of essential hypertension.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	Aortic stenosis (as)	Villar AV et al.	Int J Cardiol.	Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients.	22882958	2012		the myocardial and plasma levels of mir-21 were significantly higher in the as patients compared with the controls and correlated directly with the echocardiographic mean transvalvular gradients.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	circulating	plasma	perioperative myocardial infarction (pmi)	Yao Y et al.	PLoS One. 9(8):e104618	Plasma Levels of MicroRNA-499 Provide an Early Indication of Perioperative Myocardial Infarction in Coronary Artery Bypass Graft Patients.	25111390	2014	real-time quantitative rt-pcr	the data analysis revealed that mir-499 had higher sensitivity and specificity than ctni, and indicated that mir-499 could be an independent risk factor for pmi.
miRNA	hsa-miR-27b-3p	mir-27	MIMAT0000419	Homo sapiens	1	circulating	plasma	Acetaminophen-induced acute liver injury (APAP-ALI)	Ward J et al.	Proc Natl Acad Sci U S A. 111(33):12169-74.	Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.	25092309	2014	real-time pcr	authors suggest that mirnas can serve as sensitive diagnostic and prognostic clinical tools for severe liver injury and could be useful for monitoring drug-induced liver injury during drug discovery.
miRNA	hsa-miR-27b	mir-27	MIMAT0000419	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-519e*	mir-515	MIMAT0002828	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-644	mir-644	MIMAT0003314	Homo sapiens	0	circulating	seminal fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-489	mir-489	MIMAT0002805	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-516b	mir-515	MIMAT0002859	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7b*	let-7	MIMAT0004482	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-21*	mir-21	MIMAT0004494	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	1	circulating	serum	prostate cancer	Nguyen HC et al.	Prostate.	Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer.	22887127	2012	taqman human microrna arrays	serum samples from patients of low risk, localized prostate cancer and metastatic crpc patients exhibit distinct circulating mirna signatures. mir-375, mir-378*, and mir-141 were significantly over-expressed in serum from crpc patients compared with serum from low-risk localized patients, while mir-409-3p was significantly under-expressed. in prostate primary tumor samples, mir-375 and mir-141 also had significantly higher expression levels compared with those in normal prostate tissue.
miRNA	hsa-miR-133b	mir-133	MIMAT0000770	Homo sapiens	0	circulating	plasma	perioperative myocardial infarction (pmi)	Yao Y et al.	PLoS One. 9(8):e104618	Plasma Levels of MicroRNA-499 Provide an Early Indication of Perioperative Myocardial Infarction in Coronary Artery Bypass Graft Patients.	25111390	2014	real-time quantitative rt-pcr	the data analysis revealed that mir-499 had higher sensitivity and specificity than ctni, and indicated that mir-499 could be an independent risk factor for pmi.
miRNA	hsa-miR-486	mir-486		Homo sapiens	1	circulating	serum	Breast cancer	Chen D et al.	Cancer Res. 74(16):4270-81.	Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle.	24980554	2014	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	authors report that circulating levels of the muscle-enriched mir486 is lower in patients with breast cancer compared with healthy individuals.
miRNA	hsa-miR-28	mir-28	MIMAT0000085	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-520d-5p	mir-515	MIMAT0002855	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-801			Homo sapiens	0	circulating	plasma	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-518c*	mir-515	MIMAT0002847	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7f-1*	let-7	MIMAT0004486	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	circulating	serum	prostate cancer	Nguyen HC et al.	Prostate.	Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer.	22887127	2012	taqman human microrna arrays	serum samples from patients of low risk, localized prostate cancer and metastatic crpc patients exhibit distinct circulating mirna signatures. mir-375, mir-378*, and mir-141 were significantly over-expressed in serum from crpc patients compared with serum from low-risk localized patients, while mir-409-3p was significantly under-expressed. in prostate primary tumor samples, mir-375 and mir-141 also had significantly higher expression levels compared with those in normal prostate tissue.
miRNA	hsa-miR-497	mir-497	MIMAT0002820	Homo sapiens	1	circulating	plasma	Acute myocardial infarction (ami)	Li Z et al.	ScientificWorldJournal. 2014:931845.	High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction.	25110754	2014	qrt-pcr	circulating mir-497 might be a promising biomarker for ami identification and there was high association between human mir-497 and acute myocardial infarction.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	Ago2	conditioned medium (cm) of hek293 cell line	hypoxia	Hale A et al.	Biochim Biophys Acta. 1843(11):2528-42.	An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells.	24983771	2014	rt-qpcr	authors show that argonaute 2-dependent control of released mir-210 represents a unique communication system that integrates the hypoxic response across anatomically distinct cells, preventing unnecessary activity of delivered mir-210 in normoxia while still preparing recipient tissues for incipient hypoxic stress and accelerating adaptation.
miRNA	hsa-miR-296	mir-296	MIMAT0000690	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-521	mir-515	MIMAT0002854	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-924	mir-924	MIMAT0004974	Homo sapiens	0	circulating	breast milk	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-518d-3p	mir-515	MIMAT0002864	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1183	mir-1183	MIMAT0005828	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-214	mir-214	MIMAT0000271	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-378*	mir-378	MIMAT0000731	Homo sapiens	1	circulating	serum	prostate cancer	Nguyen HC et al.	Prostate.	Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer.	22887127	2012	taqman human microrna arrays	serum samples from patients of low risk, localized prostate cancer and metastatic crpc patients exhibit distinct circulating mirna signatures. mir-375, mir-378*, and mir-141 were significantly over-expressed in serum from crpc patients compared with serum from low-risk localized patients, while mir-409-3p was significantly under-expressed. in prostate primary tumor samples, mir-375 and mir-141 also had significantly higher expression levels compared with those in normal prostate tissue.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	1	circulating	plasma	Chronic thromboembolic pulmonary hypertension (cteph)	Guo L et al.	PLoS One. 9(6):e101055	Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension.	24978044	2014	qrt-pcr	altering let-7b level influenced et-1 and tgfbr1 expression in pulmonary arterial endothelial cells (paecs) as well as the migration of paecs and pulmonary arterial smooth muscle cells (pasmcs). these results suggested that cteph patients had aberrant microrna signature which might provide some clue for pathogenesis study and biomarker screening. reduced let-7b might be involved in the pathogenesis of cteph by affecting et-1 expression and the function of paecs and pasmcs.
miRNA	rno-miR-142-5p	mir-142	MIMAT0000847	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-523	mir-515	MIMAT0002840	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-92a-1*	mir-25	MIMAT0004507	Homo sapiens	0	circulating	amniotic fluid	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	HDL	plasma	familial hypercholesterolemia	vickers kc et al.	nat cell biol. 13(4):423-33.	micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins	21423178	2011	qiazol and mirnaeasy kits (qiagen)|spectrophotometry (nanodrop) and fluorometry (qubit, invitrogen)|riboquant fluorescent rna detection methods (quant-it, invitrogen)|affymetrix genechip microarray|real-time pcr|taqman array microrna assays (applied biosystems)	authors present evidence that high-density lipoprotein (hdl) transports endogenous mirnas and delivers them to recipient cells with functional targeting capabilities.
miRNA	hsa-miR-21*	mir-21	MIMAT0004494	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-518e*	mir-515	MIMAT0005450	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-409-3p	mir-154	MIMAT0001639	Homo sapiens	1	circulating	serum	prostate cancer	Nguyen HC et al.	Prostate.	Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer.	22887127	2012	taqman human microrna arrays	serum samples from patients of low risk, localized prostate cancer and metastatic crpc patients exhibit distinct circulating mirna signatures. mir-375, mir-378*, and mir-141 were significantly over-expressed in serum from crpc patients compared with serum from low-risk localized patients, while mir-409-3p was significantly under-expressed. in prostate primary tumor samples, mir-375 and mir-141 also had significantly higher expression levels compared with those in normal prostate tissue.
miRNA	hsa-miR-99a	mir-99	MIMAT0000097	Homo sapiens	1	circulating	plasma	Bladder cancer	Feng Y et al.	BMC Urol. 14:50	microRNA-99a acts as a tumor suppressor and is down-regulated in bladder cancer.	24957100	2014	real-time pcr	mir-99a was significantly down-regulated in bladder cancer tissues, and even the lower expression of mir-99a was correlative with the more aggressive phenotypes of bladder cancer. meanwhile, enforced expression of mir-99a can inhibit the cell proliferation of bladder cancer cells. furthermore, investigation of the expression of mir-99a in plasma of bladder cancer patients showed that mir-99a was also decreased in plasma of bladder cancer patients. the results strongly supported mir-99a as the potential diagnostic marker of bladder cancer.
miRNA	rno-miR-19b-3p	mir-19	MIMAT0000788	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-524	mir-515	MIMAT0002850	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-96*	mir-96	MIMAT0004510	Homo sapiens	0	circulating	saliva	normal	weber ja et al.	clin chem. 56(11):1733-41.	the microrna spectrum in 12 body fluids.	20847327	2010	qpcr miscript reverse transcription kit (qiagen)	mirnas were present in all fluids tested and showed distinct compositions in different fluid types. Several of the highly abundant mirnas in these fluids were common among multiple fluid types, and some of the mirnas were enriched in specific fluids.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	cheng h et al.	plos one.6(3):e17745.	circulating plasma mir-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis.	21445232	2011	mirvana paris rna isolation kit (ambion, austin, tx)|taqman microrna reverse transciption kit (applied biosystems, san diego, ca)	plasma mir-141 may represent a novel biomarker that complements carcinoembryonic antigen (cea) in detecting colon cancer with distant metastasis and high levels of mir-141 in plasma were associated with poor prognosis.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-518f	mir-515	MIMAT0002842	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1234	mir-1234	MIMAT0005589	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	glioblastoma	Ilhan-Mutlu A et al.	Cancer Invest. 30(8):615-21	Plasma MicroRNA-21 Concentration May Be a Useful Biomarker in Glioblastoma Patients.	22891879	2012	qrt-pcr	microrna-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). one patient with increasing microrna-21 developed a histopathologically proven recurrence after the second sample collection. circulating microrna-21 might be a useful biomarker in glioblastoma.
miRNA	hsa-miR-218	mir-218	MIMAT0000275	Homo sapiens	1	circulating	serum	gastric cancer (gc)	Xin SY et al.	World J Gastroenterol. 20(22):6906-11	Reduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis.	24944481	2014	qrt-pcr	mir-218 is deregulated in gastric cancer patients and is strongly correlated with tumor stage, grade and metastasis. serum expression of mir-218 may be a prognostic marker.
miRNA	rno-miR-221-3p	mir-221	MIMAT0000890	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-301	mir-130	MIMAT0000688	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-524*	mir-515	MIMAT0002849	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	traumatic brain injury (tbi)	redell jb et al.	j neurotrauma. 27(12):2147-56.	human traumatic brain injury alters plasma microrna levels.	20883153	2010	qrt-pcr	mir-16, mir-92a, and mir-765 were good markers of severe traumatic brain injury (tbi) (0.89, 0.82, and 0.86 auc values, respectively)
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-520b	mir-515	MIMAT0002843	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1238	mir-1238	MIMAT0005593	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	Coronary artery disease	Sun X et al.	Thromb J. 10(1):16	Circulating microRNA-126 in patients with coronary artery disease: correlation with LDL cholesterol.	22925274	2012	qrt-pcr	mir-126 was not significantly down-regulated or up-regulated in cad patients and was not suitable for discriminating cad patients from patients without cad. the oppositely-directed relationship between mir-126 and ldl cholesterol in patients with or without cad may have significant implications for identifying a potential role of mir-126 in cholesterol metabolism.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	serum	type 2 diabetes	Liu Y et al.	Int J Mol Sci. 15(6):10567-77	The role of circulating microRNA-126 (miR-126): a novel biomarker for screening prediabetes and newly diagnosed type 2 diabetes mellitus.	24927146	2014	quantitative real-time pcr	these results encourage the use of serum mir-126 as a biomarker for pre-diabetes and diabetes mellitus, as well as therapeutic response.
miRNA	rno-miR-223-3p	mir-223	MIMAT0000892	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-302a	mir-302	MIMAT0000684	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-525-3p	mir-515	MIMAT0002839	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-765	mir-765	MIMAT0003945	Homo sapiens	0	circulating	plasma	traumatic brain injury (tbi)	redell jb et al.	j neurotrauma. 27(12):2147-56.	human traumatic brain injury alters plasma microrna levels.	20883153	2010	qrt-pcr	mir-16, mir-92a, and mir-765 were good markers of severe traumatic brain injury (tbi) (0.89, 0.82, and 0.86 auc values, respectively)
miRNA	hsa-miR-135a*	mir-135	MIMAT0004595	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-22*	mir-22	MIMAT0004495	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-520e	mir-515	MIMAT0002825	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1249	mir-1249	MIMAT0005901	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	Int J Cancer. 132(7):1602-12.	Circulating microRNAs in plasma as early detection markers for breast cancer.	22927033	2013	taqman low-density array qrt-pcr	four mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) were shown to be significantly upregulated in the plasma of breast cancer patients. roc curve analysis showed that the combination of only three mirnas (mir-148b, mir-409-3p and mir-801) had an equal discriminatory power between breast cancer cases and healthy controls as all four mirnas together (auc = 0.69). in conclusion, the identified mirnas might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer.
miRNA	hsa-miR-301a-3p	mir-130	MIMAT0000688	Homo sapiens	1	circulating	serum	neovascular age-related macular degeneration	Grassmann F et al.	PLoS One. 9(9):e107461	A Circulating MicroRNA Profile Is Associated with Late-Stage Neovascular Age-Related Macular Degeneration.	25203061	2014	qrt-pcr	this is the first study to evaluate the relative abundance of cmirnas in the serum of late stage amd patients. authors identified three cmirnas (hsa-mir-301a-3p, hsa-mir-361-5p, and hsa-mir-424-5p) which were significantly altered in nv amd patients compared to amd-free controls.
miRNA	rno-miR-223-3p	mir-223	MIMAT0000892	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-30a-3p	mir-30	MIMAT0000088	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-526a	mir-515	MIMAT0002845	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	traumatic brain injury (tbi)	redell jb et al.	j neurotrauma. 27(12):2147-56.	human traumatic brain injury alters plasma microrna levels.	20883153	2010	qrt-pcr	mir-16, mir-92a, and mir-765 are good markers of severe traumatic brain injury (tbi) (0.89, 0.82, and 0.86 auc values, respectively)
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-532-3p	mir-188	MIMAT0004780	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1260	mir-1260	MIMAT0005911	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-23b	mir-23	MIMAT0000418	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-376c	mir-368	MIMAT0000720	Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	Int J Cancer. 132(7):1602-12.	Circulating microRNAs in plasma as early detection markers for breast cancer.	22927033	2013	taqman low-density array qrt-pcr	four mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) were shown to be significantly upregulated in the plasma of breast cancer patients. roc curve analysis showed that the combination of only three mirnas (mir-148b, mir-409-3p and mir-801) had an equal discriminatory power between breast cancer cases and healthy controls as all four mirnas together (auc = 0.69). in conclusion, the identified mirnas might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer.
miRNA	hsa-miR-361-5p	mir-361	MIMAT0000703	Homo sapiens	1	circulating	serum	neovascular age-related macular degeneration	Grassmann F et al.	PLoS One. 9(9):e107461	A Circulating MicroRNA Profile Is Associated with Late-Stage Neovascular Age-Related Macular Degeneration.	25203061	2014	qrt-pcr	this is the first study to evaluate the relative abundance of cmirnas in the serum of late stage amd patients. authors identified three cmirnas (hsa-mir-301a-3p, hsa-mir-361-5p, and hsa-mir-424-5p) which were significantly altered in nv amd patients compared to amd-free controls.
miRNA	rno-miR-322-3p	mir-322	MIMAT0000547	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-30a-5p	mir-30	MIMAT0000087	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-526c	mir-515	MIMAT0002831	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-208b	mir-208	MIMAT0004960	Homo sapiens	1	circulating	plasma	Acute heart failure	corsten mf et al.	circ cardiovasc genet. 3(6):499-506.	circulating microrna-208b and microrna-499 reflect myocardial damage in cardiovascular disease.	20921333	2010	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
miRNA	hsa-miR-150*	mir-150	MIMAT0004610	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-221*	mir-221	MIMAT0004568	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-532-5p	mir-188	MIMAT0002888	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1263	mir-1263	MIMAT0005915	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-409-3p	mir-154	MIMAT0001639	Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	Int J Cancer. 132(7):1602-12.	Circulating microRNAs in plasma as early detection markers for breast cancer.	22927033	2013	taqman low-density array qrt-pcr	four mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) were shown to be significantly upregulated in the plasma of breast cancer patients. roc curve analysis showed that the combination of only three mirnas (mir-148b, mir-409-3p and mir-801) had an equal discriminatory power between breast cancer cases and healthy controls as all four mirnas together (auc = 0.69). in conclusion, the identified mirnas might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer.
miRNA	hsa-miR-424-5p	mir-322	MIMAT0001341	Homo sapiens	1	circulating	serum	neovascular age-related macular degeneration	Grassmann F et al.	PLoS One. 9(9):e107461	A Circulating MicroRNA Profile Is Associated with Late-Stage Neovascular Age-Related Macular Degeneration.	25203061	2014	qrt-pcr	this is the first study to evaluate the relative abundance of cmirnas in the serum of late stage amd patients. authors identified three cmirnas (hsa-mir-301a-3p, hsa-mir-361-5p, and hsa-mir-424-5p) which were significantly altered in nv amd patients compared to amd-free controls.
miRNA	rno-miR-324-3p	mir-324	MIMAT0000554	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-527	mir-515	MIMAT0002862	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-499	mir-499	MIMAT0002870	Homo sapiens	1	circulating	plasma	Acute heart failure	corsten mf et al.	circ cardiovasc genet. 3(6):499-506.	circulating microrna-208b and microrna-499 reflect myocardial damage in cardiovascular disease.	20921333	2010	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-542-3p	mir-542	MIMAT0003389	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1266	mir-1266	MIMAT0005920	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-801			Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	Int J Cancer. 132(7):1602-12.	Circulating microRNAs in plasma as early detection markers for breast cancer.	22927033	2013	taqman low-density array qrt-pcr	four mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) were shown to be significantly upregulated in the plasma of breast cancer patients. roc curve analysis showed that the combination of only three mirnas (mir-148b, mir-409-3p and mir-801) had an equal discriminatory power between breast cancer cases and healthy controls as all four mirnas together (auc = 0.69). in conclusion, the identified mirnas might be of potential use in the development of a multimarker blood-based test to complement and improve early detection of breast cancer.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	0	circulating	plasma	Coronary artery disease	Wang L et al.	Int J Clin Exp Pathol. 7(8):5093-102	Polymorphism in miRNA-1 target site and circulating miRNA-1 phenotype are associated with the decreased risk and prognosis of coronary artery disease.	25197382	2014	qrt-pcr	the phenotypes of circulating mirna-1 levels in 34 cases were slightly lower than that of 40 controls but not significantly different (p = 0.090).
miRNA	rno-miR-421-3p	mir-95	MIMAT0017175	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-572	mir-572	MIMAT0003237	Homo sapiens	0	circulating	serum	pregnancy	gilad s et al.	plos one. 3(9):e3148 	serum micrornas are promising novel biomarkers.	18773077	2008	superscript ii rt (invitrogen)	to address the possibility that the abundance of specific micrornas might change during physiological or pathological conditions, serum microrna levels in pregnant and non pregnant women were compared. In sera from pregnant women, micrornas associated with human placenta were significantly elevated and their levels correlated with pregnancy stage.
miRNA	hsa-miR-208b	mir-208	MIMAT0004960	Homo sapiens	1	circulating	plasma	Acute myocardial infarction (ami)	corsten mf et al.	circ cardiovasc genet. 3(6):499-506.	circulating microrna-208b and microrna-499 reflect myocardial damage in cardiovascular disease.	20921333	2010	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
miRNA	hsa-miR-16-1	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-548a-5p	mir-548	MIMAT0004803	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1272	mir-1272	MIMAT0005925	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	1	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	Wang T et al.	PLoS One. 7(8):e43268	Cell-Free MicroRNA Expression Profiles in Malignant Effusion Associated with Patient Survival in Non-Small Cell Lung Cancer.	22937028	2012	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	rno-miR-463-5p	mir-463	MIMAT0017309	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-30d	mir-30	MIMAT0000245	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-499	mir-499	MIMAT0002870	Homo sapiens	1	circulating	plasma	Acute myocardial infarction (ami)	corsten mf et al.	circ cardiovasc genet. 3(6):499-506.	circulating microrna-208b and microrna-499 reflect myocardial damage in cardiovascular disease.	20921333	2010	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-223*	mir-223	MIMAT0004570	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-548c-5p	mir-548	MIMAT0004806	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1276	mir-1276	MIMAT0005930	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	1	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	Wang T et al.	PLoS One. 7(8):e43268	Cell-Free MicroRNA Expression Profiles in Malignant Effusion Associated with Patient Survival in Non-Small Cell Lung Cancer.	22937028	2012	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	rno-miR-674-3p	mir-674	MIMAT0005330	male albino sprague 	1	circulating	serum	posttraumatic stress disorder (ptsd)	Balakathiresan NS et al.	J Psychiatr Res. 57:65-73.	Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.	24998397	2014	taqman microrna assays	authors suggest the plausibility of using circulating mirnas as biomarkers of ptsd.
miRNA	hsa-miR-30e-3p	mir-30	MIMAT0000693	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-208b	mir-208	MIMAT0004960	Homo sapiens	1	circulating	plasma	Acute viral myocarditis (vm)	corsten mf et al.	circ cardiovasc genet. 3(6):499-506.	circulating microrna-208b and microrna-499 reflect myocardial damage in cardiovascular disease.	20921333	2010	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-548d-5p	mir-548	MIMAT0004812	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1292	mir-1292	MIMAT0005943	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-134	mir-134	MIMAT0000447	Homo sapiens	1	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	Wang T et al.	PLoS One. 7(8):e43268	Cell-Free MicroRNA Expression Profiles in Malignant Effusion Associated with Patient Survival in Non-Small Cell Lung Cancer.	22937028	2012	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
miRNA	hsa-miR-29c	mir-29	MIMAT0000681	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-520a	mir-515	MIMAT0002834	Homo sapiens	1	circulating	serum	preeclampsia	Ura B et al.	Taiwan J Obstet Gynecol. 53(2):232-4.	Potential role of circulating microRNAs as early markers of preeclampsia.	25017274	2014	taqman low density array chips (human microrna panel v3.0)|quantitative real-time polymerase chain reaction	authors conclude that some circulating mirnas may have potential role in the pathogenesis of preeclampsia. in particular, mir-1233 might represent a potential marker of early spe.
miRNA	hsa-miR-31	mir-31	MIMAT0000089	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-499	mir-499	MIMAT0002870	Homo sapiens	1	circulating	plasma	Acute viral myocarditis (vm)	corsten mf et al.	circ cardiovasc genet. 3(6):499-506.	circulating microrna-208b and microrna-499 reflect myocardial damage in cardiovascular disease.	20921333	2010	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-23b	mir-23	MIMAT0000418	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-550*	mir-550	MIMAT0003257	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1300		MIMAT0005888	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-27b	mir-27	MIMAT0000419	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-151	mir-28	MIMAT0000757	Homo sapiens	1	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	Wang T et al.	PLoS One. 7(8):e43268	Cell-Free MicroRNA Expression Profiles in Malignant Effusion Associated with Patient Survival in Non-Small Cell Lung Cancer.	22937028	2012	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	1	circulating	serum	preeclampsia	Ura B et al.	Taiwan J Obstet Gynecol. 53(2):232-4.	Potential role of circulating microRNAs as early markers of preeclampsia.	25017274	2014	taqman low density array chips (human microrna panel v3.0)|quantitative real-time polymerase chain reaction	authors conclude that some circulating mirnas may have potential role in the pathogenesis of preeclampsia. in particular, mir-1233 might represent a potential marker of early spe.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-208b	mir-208	MIMAT0004960	Homo sapiens	1	circulating	plasma	Diastolic dysfunction	corsten mf et al.	circ cardiovasc genet. 3(6):499-506.	circulating microrna-208b and microrna-499 reflect myocardial damage in cardiovascular disease.	20921333	2010	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-557	mir-557	MIMAT0003221	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1323	mir-1323	MIMAT0005795	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-28-3p	mir-28	MIMAT0004502	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-345	mir-345	MIMAT0000772	Homo sapiens	1	circulating	malignant pleural effusion (mpe)	non small cell lung cancer (nsclc)	Wang T et al.	PLoS One. 7(8):e43268	Cell-Free MicroRNA Expression Profiles in Malignant Effusion Associated with Patient Survival in Non-Small Cell Lung Cancer.	22937028	2012	qrt-pcr	expression patterns of mirnas are systematically altered in mpe of patient with nsclc. the five mirna signature from the effusion may serve as a predictor for the overall survival of patients with lung cancers.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-144	mir-144	MIMAT0000436	Homo sapiens	1	circulating	serum	preeclampsia	Ura B et al.	Taiwan J Obstet Gynecol. 53(2):232-4.	Potential role of circulating microRNAs as early markers of preeclampsia.	25017274	2014	taqman low density array chips (human microrna panel v3.0)|quantitative real-time polymerase chain reaction	authors conclude that some circulating mirnas may have potential role in the pathogenesis of preeclampsia. in particular, mir-1233 might represent a potential marker of early spe.
miRNA	hsa-miR-324-3p	mir-324	MIMAT0000762	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-499	mir-499	MIMAT0002870	Homo sapiens	1	circulating	plasma	Diastolic dysfunction	corsten mf et al.	circ cardiovasc genet. 3(6):499-506.	circulating microrna-208b and microrna-499 reflect myocardial damage in cardiovascular disease.	20921333	2010	mirvana paris kit (ambion, warrington, united kingdom)|miscript kit (qiagen, venlo, the netherlands)|reverse transcriptase polymerase chain reaction, using br sybr-green supermix for iq (quanta biosciences, amsterdam, the netherlands) in a myiq icycler (bio-rad, veenendal, the netherlands) device using miscript primers sets (qiagen)	micrornas were isolated from plasmas from well-characterized patients with varying degrees of cardiac damage: (1) acute myocardial infarction, (2) viral myocarditis, (3) diastolic dysfunction, and (4) acute heart failure. Plasma levels of selected micrornas, including heart-associated (mir-1, -133a, -208b, and -499), fibrosis-associated (mir-21 and mir-29b), and leukocyte-associated (mir-146, -155, and -223) candidates, were subsequently assessed using real-time polymerase chain reaction. Cardiac damage initiates the detectable release of cardiomyocyte-specific micrornas-208b and -499 into the circulation.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-133b	mir-133	MIMAT0000770	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-28-5p	mir-28	MIMAT0000085	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	1	circulating	plasma	metastatic breast cancer (mbc)	Madhavan D et al.	Clin Cancer Res. 18(21):5972-82	Circulating microRNAs as Surrogate Markers for Circulating Tumour Cells and Prognostic Markers in Metastatic Breast Cancer.	22952344	2012	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	stable angina (sa) 	D'Alessandra Y et al.	PLoS One. 8(11):e80345.	Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina.	24260372	2013	taqman microrna array	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
miRNA	hsa-miR-324-5p	mir-324	MIMAT0000761	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	plasma	liver injury	zhang y et al.	clin chem. 56(12):1830-8.	plasma microrna-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases.	20930130	2010	real-time quantitative pcr	circulating mir-122 has potential as a novel, predictive, and reliable blood marker for viral-, alcohol-, and chemical-induced liver injury.
miRNA	hsa-miR-483-5p	mir-483	MIMAT0004761	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-575	mir-575	MIMAT0003240	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-135a*	mir-135	MIMAT0004595	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-296-5p	mir-296	MIMAT0000690	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	plasma	metastatic breast cancer (mbc)	Madhavan D et al.	Clin Cancer Res. 18(21):5972-82	Circulating microRNAs as Surrogate Markers for Circulating Tumour Cells and Prognostic Markers in Metastatic Breast Cancer.	22952344	2012	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-483-5p	mir-483	MIMAT0004761	Homo sapiens	1	circulating	plasma	stable angina (sa) 	D'Alessandra Y et al.	PLoS One. 8(11):e80345.	Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina.	24260372	2013	taqman microrna array	authors sought to determine whether c-mirnas are dynamically regulated in response to acute exhaustive cycling exercise and sustained rowing exercise training using a longitudinal, repeated measures study design.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-17-5p	mir-17	MIMAT0000070	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	stomach cancer cells	AZ-521	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-583	mir-583	MIMAT0003248	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-139-3p	mir-139	MIMAT0004552	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	circulating	plasma	metastatic breast cancer (mbc)	Madhavan D et al.	Clin Cancer Res. 18(21):5972-82	Circulating microRNAs as Surrogate Markers for Circulating Tumour Cells and Prognostic Markers in Metastatic Breast Cancer.	22952344	2012	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
miRNA	hsa-miR-184	mir-184	MIMAT0000454	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	1	circulating	plasma	unstable angina	D'Alessandra Y et al.	PLoS One. 8(11):e80345.	Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina.	24260372	2013	taqman microrna array	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
miRNA	hsa-miR-331	mir-331	MIMAT0000760	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	exosome	stomach cancer cells	AZ-521	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	circulating	plasma	B-CLL	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-584	mir-584	MIMAT0003249	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-16-1*	mir-15	MIMAT0004489	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	circulating	plasma	metastatic breast cancer (mbc)	Madhavan D et al.	Clin Cancer Res. 18(21):5972-82	Circulating microRNAs as Surrogate Markers for Circulating Tumour Cells and Prognostic Markers in Metastatic Breast Cancer.	22952344	2012	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
miRNA	hsa-miR-186	mir-186	MIMAT0000456	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	unstable angina	D'Alessandra Y et al.	PLoS One. 8(11):e80345.	Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina.	24260372	2013	taqman microrna array	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
miRNA	hsa-miR-335	mir-335	MIMAT0000765	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7c	let-7	MIMAT0000064	Homo sapiens	0	exosome	stomach cancer cells	AZ-521	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-27b	mir-27	MIMAT0000419	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-590-5p	mir-590	MIMAT0003258	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-16-2*	mir-15	MIMAT0004518	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-29c	mir-29	MIMAT0000681	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-203	mir-203	MIMAT0000264	Homo sapiens	0	circulating	plasma	metastatic breast cancer (mbc)	Madhavan D et al.	Clin Cancer Res. 18(21):5972-82	Circulating microRNAs as Surrogate Markers for Circulating Tumour Cells and Prognostic Markers in Metastatic Breast Cancer.	22952344	2012	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	1	circulating	plasma	unstable angina	D'Alessandra Y et al.	PLoS One. 8(11):e80345.	Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina.	24260372	2013	taqman microrna array	authors showed that specific plasmatic mirna signatures have the potential to accurately discriminate patients with angiographically documented cad from matched controls.
miRNA	hsa-miR-339	mir-339	MIMAT0000764	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	exosome	stomach cancer cells	AZ-521	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-28-3p	mir-28	MIMAT0004502	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-601	mir-601	MIMAT0003269	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-191*	mir-191	MIMAT0001618	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-29c*	mir-29	MIMAT0004673	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	plasma	metastatic breast cancer (mbc)	Madhavan D et al.	Clin Cancer Res. 18(21):5972-82	Circulating microRNAs as Surrogate Markers for Circulating Tumour Cells and Prognostic Markers in Metastatic Breast Cancer.	22952344	2012	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
miRNA	hsa-miR-345	mir-345	MIMAT0000772	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-128	mir-128	MIMAT0000424	Homo sapiens	1	circulating	plasma	mild cognitive impairment (mci)	Sheinerman KS et al.	Aging (Albany NY). 5(12):925-38.	Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study.	24368295	2013	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
miRNA	hsa-miR-342	mir-342	MIMAT0000753	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	0	exosome	stomach cancer cells	AZ-521	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-28-5p	mir-28	MIMAT0000085	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-610	mir-610	MIMAT0003278	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-196a*	mir-196	MIMAT0004562	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-301a	mir-130	MIMAT0000688	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	circulating	plasma	metastatic breast cancer (mbc)	Madhavan D et al.	Clin Cancer Res. 18(21):5972-82	Circulating microRNAs as Surrogate Markers for Circulating Tumour Cells and Prognostic Markers in Metastatic Breast Cancer.	22952344	2012	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
miRNA	hsa-miR-885-5p	mir-885	MIMAT0004947	Homo sapiens	1	circulating	plasma	osteoarthritis (oa)	Borgonio Cuadra VM et al.	PLoS One. 9(6):e97690	Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways.	24901787	2014	qpcr	authors identified 12 mirna in the plasma of patients with primary oa. specific mirna that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. several mirna could regulate genes and pathways related with development of the disease; eight of these circulating mirna are described for first time in oa.
miRNA	hsa-miR-874	mir-874	MIMAT0004911	Homo sapiens	1	circulating	plasma	mild cognitive impairment (mci)	Sheinerman KS et al.	Aging (Albany NY). 5(12):925-38.	Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study.	24368295	2013	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
miRNA	hsa-miR-345	mir-345	MIMAT0000772	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	0	exosome	stomach cancer cells	AZ-521	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-617	mir-617	MIMAT0003286	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-198	mir-198	MIMAT0000228	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-30a	mir-30	MIMAT0000087	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-801			Homo sapiens	0	circulating	plasma	metastatic breast cancer (mbc)	Madhavan D et al.	Clin Cancer Res. 18(21):5972-82	Circulating microRNAs as Surrogate Markers for Circulating Tumour Cells and Prognostic Markers in Metastatic Breast Cancer.	22952344	2012	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
miRNA	hsa-miR-323-3p	mir-154	MIMAT0000755	Homo sapiens	1	circulating	plasma	mild cognitive impairment (mci)	Sheinerman KS et al.	Aging (Albany NY). 5(12):925-38.	Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study.	24368295	2013	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
miRNA	hsa-miR-346	mir-346	MIMAT0000773	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	exosome	stomach cancer cells	AZ-521	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-622	mir-622	MIMAT0003291	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200b*	mir-8	MIMAT0004571	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-768-3p			Homo sapiens	0	circulating	plasma	metastatic breast cancer (mbc)	Madhavan D et al.	Clin Cancer Res. 18(21):5972-82	Circulating microRNAs as Surrogate Markers for Circulating Tumour Cells and Prognostic Markers in Metastatic Breast Cancer.	22952344	2012	taqman human microrna arrays	ctc-positive had significantly higher levels of mir-141, mir-200a, mir-200b, mir-200c, mir-203, mir-210, mir-375, and mir-801 than ctc-negative mbc and controls (p < 0.00001), whereas mir-768-3p was present in lower amounts in mbc cases (p < 0.05). mir-200b was singled out as the best marker for distinguishing ctc-positive from ctc-negative patients (auc 0.88). combinations of mirnas and mir-200b alone were found to be promising prognostic marker for progression-free and overall survival. this is the first study to document the capacity of circulating mirnas to indicate ctc status and their potential as prognostic markers in patients with mbc.
miRNA	hsa-miR-326	mir-326	MIMAT0000756	Homo sapiens	0	exosome	plasma	type 2 diabetes	Santovito T et al.	J Clin Endocrinol Metab. 99(9):E1681-5.	Plasma Exosome MicroRNA Profiling Unravels a New Potential Modulator of Adiponectin Pathway in Diabetes: Effect of Glycemic Control	24937531	2014	exoquick exosome precipitation solution (system biosciences)| rneasy kit (qiagen)| qrt-pcr	we aimed at studying circulating mirna expression in diabetic patients naïve to treatment and at investigating the influence on this of glycemic control. in diabetic patients, microarray analysis showed that four mirnas are increased, whereas 21 mirnas are decreased. after 12 months of antidiabetic treatment, quantitative rt-pcr data analysis showed that mir-326 levels were unaffected, whereas the levels of let-7a and let-7f were significantly increased.  treatment-naïve, poorly controlled diabetic patients show a significant dysregulation of mirnas involved in the regulation of the adiponectin pathway, a phenomenon that may be reversed, at least in part, by improved glycemic control.
miRNA	hsa-miR-382	mir-154	MIMAT0000737	Homo sapiens	1	circulating	plasma	mild cognitive impairment (mci)	Sheinerman KS et al.	Aging (Albany NY). 5(12):925-38.	Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study.	24368295	2013	qrt-pcr	authors demonstrate that the mir-132 family biomarkers and the mir-134 family biomarkers may differentiate mci from  amc.
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	0	exosome	stomach cancer cells	AZ-521	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-29c	mir-29	MIMAT0000681	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-624*	mir-624	MIMAT0003293	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-202	mir-202	MIMAT0002811	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-601	mir-601	MIMAT0003269	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-let-7a*	let-7	MIMAT0004481	Homo sapiens	0	exosome	plasma	type 2 diabetes	Santovito T et al.	J Clin Endocrinol Metab. 99(9):E1681-5.	Plasma Exosome MicroRNA Profiling Unravels a New Potential Modulator of Adiponectin Pathway in Diabetes: Effect of Glycemic Control	24937531	2014	exoquick exosome precipitation solution (system biosciences)| rneasy kit (qiagen)| qrt-pcr	we aimed at studying circulating mirna expression in diabetic patients naïve to treatment and at investigating the influence on this of glycemic control. in diabetic patients, microarray analysis showed that four mirnas are increased, whereas 21 mirnas are decreased. after 12 months of antidiabetic treatment, quantitative rt-pcr data analysis showed that mir-326 levels were unaffected, whereas the levels of let-7a and let-7f were significantly increased.  treatment-naïve, poorly controlled diabetic patients show a significant dysregulation of mirnas involved in the regulation of the adiponectin pathway, a phenomenon that may be reversed, at least in part, by improved glycemic control.
miRNA	hsa-miR-1260	mir-1260	MIMAT0005911	Homo sapiens	1	circulating	blood	influenza a virus infection	Tambyah PA et al.	PLoS One. 8(10):e76811.	microRNAs in circulation are altered in response to influenza A virus infection in humans.	24116168	2013	Quantitative PCR	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
miRNA	hsa-miR-361	mir-361	MIMAT0000703	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	stomach cancer cells	AZ-p7a	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-301a	mir-130	MIMAT0000688	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-625	mir-625	MIMAT0003294	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-296-5p	mir-296	MIMAT0000690	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-30d	mir-30	MIMAT0000245	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-760	mir-760	MIMAT0004957	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	0	exosome	plasma	type 2 diabetes	Santovito T et al.	J Clin Endocrinol Metab. 99(9):E1681-5.	Plasma Exosome MicroRNA Profiling Unravels a New Potential Modulator of Adiponectin Pathway in Diabetes: Effect of Glycemic Control	24937531	2014	exoquick exosome precipitation solution (system biosciences)| rneasy kit (qiagen)| qrt-pcr	we aimed at studying circulating mirna expression in diabetic patients naïve to treatment and at investigating the influence on this of glycemic control. in diabetic patients, microarray analysis showed that four mirnas are increased, whereas 21 mirnas are decreased. after 12 months of antidiabetic treatment, quantitative rt-pcr data analysis showed that mir-326 levels were unaffected, whereas the levels of let-7a and let-7f were significantly increased.  treatment-naïve, poorly controlled diabetic patients show a significant dysregulation of mirnas involved in the regulation of the adiponectin pathway, a phenomenon that may be reversed, at least in part, by improved glycemic control.
miRNA	hsa-miR-1260	mir-1260	MIMAT0005911	Homo sapiens	1	circulating	blood	influenza a virus infection	Tambyah PA et al.	PLoS One. 8(10):e76811.	microRNAs in circulation are altered in response to influenza A virus infection in humans.	24116168	2013	Quantitative PCR	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
miRNA	hsa-miR-362	mir-362	MIMAT0000705	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	exosome	stomach cancer cells	AZ-p7a	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-30a	mir-30	MIMAT0000087	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-628-5p	mir-628	MIMAT0004809	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-34b	mir-34	MIMAT0004676	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-30e	mir-30	MIMAT0000692	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-10a	mir-10	MIMAT0000253	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-106b*	mir-17	MIMAT0004672	Homo sapiens	0	microparticle	atherosclerotic plaques	Atherosclerosis	Zhang J et al.	Chin Med J (Engl). 127(12):2212-7.	Inflammation induced-endothelial cells release angiogenesis associated-microRNAs into circulation by microparticles.	24931230	2014	rt-pcr	by comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype (n = 9) and those from normal vascular tissues (n = 9), we found levels of annexin v(+) microparticles and annexin v(+) cd144(+) microparticles were significantly increased in plaques and angiogenesis associated micrornas (106b, 25, 92a and 21) were also significantly increased in microparticles from plaques. inflammation could induce endothelial cells to release angiogenesis associated micrornas into circulation, causing higher levels of circulating endothelial cells derived micrornas in atherosclerosis.
miRNA	hsa-miR-1260	mir-1260	MIMAT0005911	Homo sapiens	1	circulating	blood	influenza a virus infection	Tambyah PA et al.	PLoS One. 8(10):e76811.	microRNAs in circulation are altered in response to influenza A virus infection in humans.	24116168	2013	Quantitative PCR	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
miRNA	hsa-miR-365	mir-365	MIMAT0000710	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7c	let-7	MIMAT0000064	Homo sapiens	0	exosome	stomach cancer cells	AZ-p7a	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-630	mir-630	MIMAT0003299	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-371-5p	mir-290	MIMAT0004687	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-30e*	mir-30	MIMAT0000693	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	microparticle	atherosclerotic plaques	Atherosclerosis	Zhang J et al.	Chin Med J (Engl). 127(12):2212-7.	Inflammation induced-endothelial cells release angiogenesis associated-microRNAs into circulation by microparticles.	24931230	2014	real-time pcr	by comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype (n = 9) and those from normal vascular tissues (n = 9), we found levels of annexin v(+) microparticles and annexin v(+) cd144(+) microparticles were significantly increased in plaques and angiogenesis associated micrornas (106b, 25, 92a and 21) were also significantly increased in microparticles from plaques. inflammation could induce endothelial cells to release angiogenesis associated micrornas into circulation, causing higher levels of circulating endothelial cells derived micrornas in atherosclerosis.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	1	circulating	blood	influenza a virus infection	Tambyah PA et al.	PLoS One. 8(10):e76811.	microRNAs in circulation are altered in response to influenza A virus infection in humans.	24116168	2013	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
miRNA	hsa-miR-369-3p	mir-154	MIMAT0000721	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-27b	mir-27	MIMAT0000419	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	exosome	stomach cancer cells	AZ-p7a	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-631	mir-631	MIMAT0003300	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-379*	mir-379	MIMAT0004690	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-32	mir-32	MIMAT0000090	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-22*	mir-22	MIMAT0004495	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	microparticle	atherosclerotic plaques	Atherosclerosis	Zhang J et al.	Chin Med J (Engl). 127(12):2212-7.	Inflammation induced-endothelial cells release angiogenesis associated-microRNAs into circulation by microparticles.	24931230	2014	real-time pcr	by comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype (n = 9) and those from normal vascular tissues (n = 9), we found levels of annexin v(+) microparticles and annexin v(+) cd144(+) microparticles were significantly increased in plaques and angiogenesis associated micrornas (106b, 25, 92a and 21) were also significantly increased in microparticles from plaques. inflammation could induce endothelial cells to release angiogenesis associated micrornas into circulation, causing higher levels of circulating endothelial cells derived micrornas in atherosclerosis.
miRNA	hsa-miR-335*	mir-335	MIMAT0004703	Homo sapiens	1	circulating	blood	influenza a virus infection	Tambyah PA et al.	PLoS One. 8(10):e76811.	microRNAs in circulation are altered in response to influenza A virus infection in humans.	24116168	2013	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
miRNA	hsa-miR-370	mir-370	MIMAT0000722	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	0	exosome	stomach cancer cells	AZ-p7a	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-30e	mir-30	MIMAT0000692	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-632	mir-632	MIMAT0003302	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-483-5p	mir-483	MIMAT0004761	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-323-3p	mir-154	MIMAT0000755	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	microparticle	atherosclerotic plaques	Atherosclerosis	Zhang J et al.	Chin Med J (Engl). 127(12):2212-7.	Inflammation induced-endothelial cells release angiogenesis associated-microRNAs into circulation by microparticles.	24931230	2014	real-time pcr	by comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype (n = 9) and those from normal vascular tissues (n = 9), we found levels of annexin v(+) microparticles and annexin v(+) cd144(+) microparticles were significantly increased in plaques and angiogenesis associated micrornas (106b, 25, 92a and 21) were also significantly increased in microparticles from plaques. inflammation could induce endothelial cells to release angiogenesis associated micrornas into circulation, causing higher levels of circulating endothelial cells derived micrornas in atherosclerosis.
miRNA	hsa-miR-576-3p	mir-576	MIMAT0004796	Homo sapiens	1	circulating	blood	influenza a virus infection	Tambyah PA et al.	PLoS One. 8(10):e76811.	microRNAs in circulation are altered in response to influenza A virus infection in humans.	24116168	2013	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
miRNA	hsa-miR-371	mir-290	MIMAT0000723	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30a-5p	mir-30	MIMAT0000087	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	0	exosome	stomach cancer cells	AZ-p7a	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-30e*	mir-30	MIMAT0000693	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-638	mir-638	MIMAT0003308	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-495	mir-329	MIMAT0002817	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-324-3p	mir-324	MIMAT0000762	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-628-3p	mir-628	MIMAT0003297	Homo sapiens	1	circulating	blood	influenza a virus infection	Tambyah PA et al.	PLoS One. 8(10):e76811.	microRNAs in circulation are altered in response to influenza A virus infection in humans.	24116168	2013	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
miRNA	hsa-miR-373	mir-373	MIMAT0000726	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	exosome	stomach cancer cells	AZ-p7a	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-32	mir-32	MIMAT0000090	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-652	mir-652	MIMAT0003322	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-498	mir-498	MIMAT0002824	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-324-5p	mir-324	MIMAT0000761	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-125a-5p	mir-125	MIMAT0000443	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	Colorectal cancer (crc)	Basati G et al.	Med Oncol. 31(10):205.	Elevated level of microRNA-21 in the serum of patients with colorectal cancer.	25178939	2014	qrt-pcr	increased levels of serum mir-21 were associated with clinical stages of tumors in the patients (p=0.01). these results indicated that serum mir-21 levels could serve as a reliable diagnostic and prognostic biomarker for colorectal adenocarcinoma.
miRNA	hsa-miR-664	mir-664	MIMAT0005949	Homo sapiens	1	circulating	blood	influenza a virus infection	Tambyah PA et al.	PLoS One. 8(10):e76811.	microRNAs in circulation are altered in response to influenza A virus infection in humans.	24116168	2013	taqman real-time pcr	authors demonstrated that mir-1260, -26a, -335*, -576-3p, -628-3p and -664 were highly dysregulated in the blood of influenza infected patients and these micrornas may be potential biomarkers of influenza.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	0	exosome	stomach cancer cells	AZ-p7a	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit|rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-324-3p	mir-324	MIMAT0000762	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-654-5p	mir-654	MIMAT0003330	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-510	mir-506	MIMAT0002882	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-326	mir-326	MIMAT0000756	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-421	mir-95	MIMAT0003339	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-30d	mir-30	MIMAT0000245	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	lung cancer cells	DMS-53	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-324-5p	mir-324	MIMAT0000761	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-660	mir-188	MIMAT0003338	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-516b*	mir-515	MIMAT0002860	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Tsujiura M et al.	Gastric Cancer. 18(2):271-9.	Circulating miR-18a in plasma contributes to cancer detection and monitoring in patients with gastric cancer.	24626859	2015	qrt-pcr	(1) the mir-18a expressions were significantly higher in gc tissues than in normal gastric tissues (p = 0.0286) and higher in all examined gc cell lines than in the fibroblast cell line. (2) the plasma mir-18a concentrations were significantly higher in gc patients than in healthy controls (p < 0.0001). the value of the area under the receiver-operating characteristic curve was 0.8059. (3) the plasma mir-18a levels were significantly reduced in postoperative samples compared to in preoperative samples (p = 0.0002). in an mir-18a overexpressing cell line, the mir-18a concentration of cultured medium increased in both cell number and time-course dependent manners, suggesting microrna might be released from cancer cells into the surrounding environment. circulating mir-18a could be a useful biomarker for screening gc and monitoring tumor dynamics.
miRNA	hsa-miR-422a	mir-422	MIMAT0001339	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-32	mir-32	MIMAT0000090	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	exosome	lung cancer cells	DMS-53	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-409-3p	mir-154	MIMAT0001639	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-326	mir-326	MIMAT0000756	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-662	mir-662	MIMAT0003325	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-548a-3p	mir-548	MIMAT0003251	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-331-3p	mir-331	MIMAT0000760	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-188-3p	mir-188	MIMAT0004613	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	1	circulating	serum	Aortic stenosis (as)	Rosjo H et al.	PLoS One. 9(3):e91812.	Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis.	24626394	2014	real-time pcr	circulating mir-210 levels are increased in patients with as and provide independent prognostic information to established risk indices. analytical characteristics were also excellent supporting the potential of micro-rnas as novel cv biomarkers.
miRNA	hsa-miR-422b	mir-378	MIMAT0000732	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-92	mir-25	MIMAT0000092	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	lung cancer cells	nci-h69	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-330-3p	mir-330	MIMAT0000751	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-671-5p	mir-671	MIMAT0003880	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-559	mir-559	MIMAT0003223	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-335	mir-335	MIMAT0000765	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-138	mir-138	MIMAT0000430	Homo sapiens	0	circulating	blood	Breast cancer	Waters PS et al.	PLoS One. 9(3):e90605.	Impact of tumour epithelial subtype on circulating microRNAs in breast cancer patients.	24626163	2014	real-time quantitative pcr	analysis of patient tissue and blood samples revealed mir-138 to be significantly up-regulated in the circulation of patients with breast cancer, with no change observed in the tissue setting. while not significantly changed overall in breast cancer patients compared to controls, circulating mir-106a and mir-191 were significantly decreased in patients with basal breast cancer. in tissue, both mirnas were significantly elevated in breast cancer compared to normal breast tissue. the data demonstrates an impact of tumour epithelial subtype on circulating levels of mirnas, and highlights divergent mirna profiles between tissue and blood samples from breast cancer patients.
miRNA	hsa-miR-423	mir-423	MIMAT0001340	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	exosome	lung cancer cells	nci-h69	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-331-3p	mir-331	MIMAT0000760	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-7	mir-7	MIMAT0000252	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-570	mir-548	MIMAT0003235	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-337-5p	mir-337	MIMAT0004695	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	blood	Breast cancer	Waters PS et al.	PLoS One. 9(3):e90605.	Impact of tumour epithelial subtype on circulating microRNAs in breast cancer patients.	24626163	2014	real-time quantitative pcr	analysis of patient tissue and blood samples revealed mir-138 to be significantly up-regulated in the circulation of patients with breast cancer, with no change observed in the tissue setting. while not significantly changed overall in breast cancer patients compared to controls, circulating mir-106a and mir-191 were significantly decreased in patients with basal breast cancer. in tissue, both mirnas were significantly elevated in breast cancer compared to normal breast tissue. the data demonstrates an impact of tumour epithelial subtype on circulating levels of mirnas, and highlights divergent mirna profiles between tissue and blood samples from breast cancer patients.
miRNA	hsa-miR-424	mir-322	MIMAT0001341	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-96	mir-96	MIMAT0000095	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	lung cancer cells	sbc-3	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-646	mir-646	MIMAT0003316	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-335	mir-335	MIMAT0000765	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-7-1*	mir-7	MIMAT0004553	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-603	mir-548	MIMAT0003271	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-338-3p	mir-338	MIMAT0000763	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	blood	Breast cancer	Waters PS et al.	PLoS One. 9(3):e90605.	Impact of tumour epithelial subtype on circulating microRNAs in breast cancer patients.	24626163	2014	real-time quantitative pcr	analysis of patient tissue and blood samples revealed mir-138 to be significantly up-regulated in the circulation of patients with breast cancer, with no change observed in the tissue setting. while not significantly changed overall in breast cancer patients compared to controls, circulating mir-106a and mir-191 were significantly decreased in patients with basal breast cancer. in tissue, both mirnas were significantly elevated in breast cancer compared to normal breast tissue. the data demonstrates an impact of tumour epithelial subtype on circulating levels of mirnas, and highlights divergent mirna profiles between tissue and blood samples from breast cancer patients.
miRNA	hsa-miR-425-3p	mir-425	MIMAT0001343	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	exosome	lung cancer cells	sbc-3	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	hairy cell leukemia	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-338-3p	mir-338	MIMAT0000763	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-744	mir-744	MIMAT0004945	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-605	mir-605	MIMAT0003273	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-339-3p	mir-339	MIMAT0004702	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-224*	mir-224	MIMAT0009198	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	dre-miR-122	mir-122	MIMAT0001818	Danio rerio	1	circulating	serum	Acute liver failure	Vliegenthart AD et al.	Zebrafish. 11(3):219-26.	Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity.	24625211	2014	retro-orbital blood acquisition|mirneasy kit (qiagen, venlo, netherlands)|minelute kit (qiagen, venlo, netherlands)|stem-loop reverse-transcription rt primers (applied biosystems, foster city, ca, usa)|mircury lna microrna detection probes (exiqon a/s, vedbaek, denmark)|	collection of blood by ro bleeding facilitated measurement of mir-122 in a zebrafish model of paracetamol hepatotoxicity. the zebrafish represents a new species for measurement of circulating mirna biomarkers that are translational and can bridge between fish and humans.
miRNA	hsa-miR-425-5p	mir-425	MIMAT0003393	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	colorectal cancer cells	sw480	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-339-3p	mir-339	MIMAT0004702	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-744*	mir-744	MIMAT0004946	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-625*	mir-625	MIMAT0004808	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-339-5p	mir-339	MIMAT0000764	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-376a	mir-368	MIMAT0000729	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Zhu C et al.	Br J Cancer. 110(9):2291-9.	A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer.	24595006	2014	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
miRNA	hsa-miR-429	mir-8	MIMAT0001536	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	exosome	colorectal cancer cells	sw480	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	human mirna microarray kit	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-33a	mir-33	MIMAT0000091	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-760	mir-760	MIMAT0004957	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-635	mir-635	MIMAT0003305	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-33a	mir-33	MIMAT0000091	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-425*	mir-425	MIMAT0001343	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Zhu C et al.	Br J Cancer. 110(9):2291-9.	A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer.	24595006	2014	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
miRNA	hsa-miR-432	mir-432	MIMAT0002814	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-125a	mir-125	MIMAT0000443	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	colorectal cancer cells	sw620	ohshima k et al.	plos one.5(10):e13247.	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.	20949044	2010	rt-pcr	let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
miRNA	hsa-miR-126*	mir-126	MIMAT0000444	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-340	mir-340	MIMAT0004692	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-765	mir-765	MIMAT0003945	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-658	mir-658	MIMAT0003336	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-340	mir-340	MIMAT0004692	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-495	mir-329	MIMAT0002817	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Zhu C et al.	Br J Cancer. 110(9):2291-9.	A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer.	24595006	2014	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
miRNA	hsa-miR-452	mir-452	MIMAT0001635	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-1246	mir-1246	MIMAT0005898	Homo sapiens	1	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-340*	mir-340	MIMAT0000750	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-769-3p	mir-769	MIMAT0003887	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-659		MIMAT0003337	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-342-3p	mir-342	MIMAT0000753	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-572	mir-572	MIMAT0003237	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Zhu C et al.	Br J Cancer. 110(9):2291-9.	A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer.	24595006	2014	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
miRNA	hsa-miR-453	mir-154	MIMAT0001630	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-126*	mir-126	MIMAT0000444	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	1	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-342-3p	mir-342	MIMAT0000753	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-769-5p	mir-769	MIMAT0003886	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-664	mir-664	MIMAT0005949	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-342-5p	mir-342	MIMAT0004694	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-720	mir-720	MIMAT0005954	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Zhu C et al.	Br J Cancer. 110(9):2291-9.	A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer.	24595006	2014	qrt-pcr	five mirnas (mir-16, mir-25, mir-92a, mir-451 and mir-486-5p) showed consistently elevated levels in plasma of the gc patients as compared with controls, and were identified to be potential markers for gnca with area under the receiver operating characteristic (roc) curves (aucs) ranging from 0.850 to 0.925 and 0.694 to 0.790 in the training and validation phases, respectively. the five-mirna panel presented a high diagnostic accuracy for the early-stage gnca (aucs=0.989 and 0.812 for the training and validation phases, respectively). three mirnas (mir-16, mir-25 and mir-92a) were excreted into the culture media of gc cell lines. the five-mirna panel in plasma may serve as a potential non-invasive biomarker in detecting the early-stage gc.
miRNA	hsa-miR-454-3p	mir-454	MIMAT0003885	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-133b	mir-133	MIMAT0000770	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-494	mir-154	MIMAT0002816	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-342-5p	mir-342	MIMAT0004694	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-770-5p	mir-770	MIMAT0003948	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-921	mir-921	MIMAT0004971	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-345	mir-345	MIMAT0000772	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-206	mir-1	MIMAT0000462	Homo sapiens	1	circulating	serum	Amyotrophic lateral sclerosis (als)	Toivonen JM et al.	PLoS One. 9(2):e89065.	MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis.	24586506	2014	Quantitative PCR	authors conclude that mir-206 is elevated in the circulation of symptomatic sod1-g93a mice and possibly in human als patients. although larger scale studies on als patients are warranted, mir-206 is a promising candidate biomarker for this motor neuron disease.
miRNA	hsa-miR-454-5p	mir-454	MIMAT0003884	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-140	mir-140	MIMAT0000431	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-663	mir-663	MIMAT0003326	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-345	mir-345	MIMAT0000772	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-874	mir-874	MIMAT0004911	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-92a-2*	mir-25	MIMAT0004508	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-346	mir-346	MIMAT0000773	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	0	circulating	plasma	Colorectal cancer (crc)	Wang Q et al.	PLoS One. 7(9):e44398.	Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer.	22970209	2012	qrt-pcr	according to the results of mirna profiling performed on pooling plasma samples form 10 crc patients or 10 healthy controls, a panel of mirnas (hsa-mir-10a, -19a, -22*, -24, -92a, 125a-5p, -141, -150, -188-3p, -192, -210, -221, -224*, -376a, -425*, -495, -572, -601, -720, -760 and hsa-let-7a, -7e) were deregulated in crc plasma with fold changes >5. plasma mir-601 and mir-760 can potentially serve as promising non-invasive biomarkers for the early detection of crc.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	1	circulating	plasma	tachycardia	Sun L et al.	Mol Med Rep. 11(6):4039-46.	Expression of circulating microRNA-1 and microRNA-133 in pediatric patients with tachycardia.	25625292	2015	fluorescent quantitative pcr	authors demonstrated that mir-1 may be appropriate marker for pediatric tachycardia. mir-1 levels were decreased in the arrhythmia group compared with those in the healthy controls. in particular, patients with supraventricular tachycardia (svt) had lower mir‑1 expression levels.
miRNA	mmu-miR-424	miR-322	MIMAT0000548	Mus musculus	0	circulating	peri-infarct cortex	reperfusion injury	Liu P et al.	Stroke. 46(2):513-9.	MicroRNA-424 protects against focal cerebral ischemia and reperfusion injury in mice by suppressing oxidative stress.	25523055	2015	real-time pcr	authors demonstrated that mir-424 protects against transient cerebral ischemia/reperfusion injury by inhibiting oxidative stress.
miRNA	hsa-miR-483	mir-483	MIMAT0002173	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-483-5p	mir-483	MIMAT0004761	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-877	mir-877	MIMAT0004949	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-940	mir-940	MIMAT0004983	Homo sapiens	0	circulating	plasma	normal	duttagupta r et al.	plos one 6(6): e20769.	impact of cellular mirnas on circulating mirna biomarker signatures	21698099	2011	abi 7500 real-time pcr instrument and miscript quantitative pcr system (qiagen)	cellular mirna signatures in cohorts of normal individuals are catalogued and the abundance and gender specific expression of bona fide circulating markers explored after calibrating the signal for this interfering class. A map of differentially expressed profiles is presented and the intrinsic variability of circulating mirna species investigated in subsets of healthy males and females.
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	1	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	hsa-miR133a/b	mir-133		Homo sapiens	1	circulating	plasma	ventricular tachycardia (vt)	Sun L et al.	Mol Med Rep. 11(6):4039-46.	Expression of circulating microRNA-1 and microRNA-133 in pediatric patients with tachycardia.	25625292	2015	fluorescent quantitative pcr	authors demonstrated that mir-133 may be appropriate marker for pediatric tachycardia, in fact patients with ventricular tachycardia (vt) had higher mir‑133 expression levels.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-142-5p	mir-142	MIMAT0000433	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-1305	mir-1305	MIMAT0005893	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-34b*	mir-34	MIMAT0000685	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-887	mir-887	MIMAT0004951	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	1	circulating	plasma	st elevation myocardial infarction (stemi)	gidlof o et al.	cardiology. 118(4):217-26.	cardiospecific microrna plasma levels correlate with troponin and cardiac function in patients with st elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples.	21701171	2011	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
miRNA	hsa-miR-361-5p	mir-361	MIMAT0000703	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	hsa-miR-671-5p	mir-671	MIMAT0003880	Homo sapiens	0	microvesicle	blood	hepatocellular carcinoma (hcc)	Sun L et al.	Acta Gastroenterol Belg. 76(4):386-92.	MicroRNA expression profiles of circulating microvesicles in hepatocellular carcinoma.	24592541	2013	agilent mirna microarry	mirnas were differentially expressed in hcc-mvs compared with chb and normal controls. aberrant hcc-mvs mirnas may play important roles in the development of hcc.
miRNA	hsa-miR-485-5p	mir-485	MIMAT0002175	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-574-5p	mir-574	MIMAT0004795	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-361-3p	mir-361	MIMAT0004682	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-9	mir-9	MIMAT0000441	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	1	circulating	urine	st elevation myocardial infarction (stemi)	gidlof o et al.	cardiology. 118(4):217-26.	cardiospecific microrna plasma levels correlate with troponin and cardiac function in patients with st elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples.	21701171	2011	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
miRNA	hsa-miR-362-3p	mir-362	MIMAT0004683	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	hsa-miR-432	mir-432	MIMAT0002814	Homo sapiens	0	microvesicle	blood	hepatocellular carcinoma (hcc)	Sun L et al.	Acta Gastroenterol Belg. 76(4):386-92.	MicroRNA expression profiles of circulating microvesicles in hepatocellular carcinoma.	24592541	2013	agilent mirna microarry	mirnas were differentially expressed in hcc-mvs compared with chb and normal controls. aberrant hcc-mvs mirnas may play important roles in the development of hcc.
miRNA	hsa-miR-486	mir-486	MIMAT0002177	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-146b	mir-146	MIMAT0002809	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-149*	mir-149	MIMAT0004609	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-361-5p	mir-361	MIMAT0000703	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-9*	mir-9	MIMAT0000442	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	1	circulating	plasma	st elevation myocardial infarction (stemi)	gidlof o et al.	cardiology. 118(4):217-26.	cardiospecific microrna plasma levels correlate with troponin and cardiac function in patients with st elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples.	21701171	2011	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
miRNA	hsa-miR-363	mir-363	MIMAT0000707	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	0	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	hsa-miR-33a	mir-33	MIMAT0000091	Homo sapiens	0	circulating	plasma	patients with low hdl-c levels	Cao R et al.	Dis Markers. 2014:781780	Xuezhikang therapy increases miR-33 expression in patients with low HDL-C levels.	24591767	2014	quantitative real-time pcr	in patients with low hdl-c levels, xzk therapy raised plasma levels of mir-33a and mir-33b, which may inhibit cellular cholesterol export and limit the hdl-raising effect of xzk.
miRNA	hsa-miR-487b	mir-154	MIMAT0003180	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-575	mir-575	MIMAT0003240	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-362-3p	mir-362	MIMAT0004683	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-921	mir-921	MIMAT0004971	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	1	circulating	urine	st elevation myocardial infarction (stemi)	gidlof o et al.	cardiology. 118(4):217-26.	cardiospecific microrna plasma levels correlate with troponin and cardiac function in patients with st elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples.	21701171	2011	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	hsa-miR-33b	mir-33	MIMAT0003301	Homo sapiens	0	circulating	plasma	patients with low hdl-c levels	Cao R et al.	Dis Markers. 2014:781780	Xuezhikang therapy increases miR-33 expression in patients with low HDL-C levels.	24591767	2014	quantitative real-time pcr	in patients with low hdl-c levels, xzk therapy raised plasma levels of mir-33a and mir-33b, which may inhibit cellular cholesterol export and limit the hdl-raising effect of xzk.
miRNA	hsa-miR-494	mir-154	MIMAT0002816	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-151	mir-28	MIMAT0000757	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-923		MIMAT0004973	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-362-5p	mir-362	MIMAT0000705	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-208b	mir-208	MIMAT0004960	Homo sapiens	1	circulating	plasma	st elevation myocardial infarction (stemi)	gidlof o et al.	cardiology. 118(4):217-26.	cardiospecific microrna plasma levels correlate with troponin and cardiac function in patients with st elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples.	21701171	2011	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
miRNA	hsa-miR-378	mir-378	MIMAT0000732	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	0	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	oar-miR-9	mir-9		Ovis aries	1	circulating	plasma	maternal alcohol exposure	Balaraman S et al.	Alcohol Clin Exp Res. 38(5):1390-400.	Maternal and neonatal plasma microRNA biomarkers for fetal alcohol exposure in an ovine model.	24588274	2014	Quantitative PCR	shared profiles between pregnant dam and neonate suggest possible maternal-fetal mirna transfer. cir mirnas are biomarkers for alcohol exposure during pregnancy, in both mother and neonate, and may constitute an important shared endocrine biomarker that is vulnerable to the maternal environment.
miRNA	hsa-miR-500	mir-500	MIMAT0004773	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-363	mir-363	MIMAT0000707	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-208b	mir-208	MIMAT0004960	Homo sapiens	1	circulating	urine	st elevation myocardial infarction (stemi)	gidlof o et al.	cardiology. 118(4):217-26.	cardiospecific microrna plasma levels correlate with troponin and cardiac function in patients with st elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples.	21701171	2011	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
miRNA	hsa-miR-378*	mir-378	MIMAT0000731	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-558	mir-558	MIMAT0003222	Homo sapiens	0	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	oar-miR-15b	mir-15		Ovis aries	1	circulating	plasma	maternal alcohol exposure	Balaraman S et al.	Alcohol Clin Exp Res. 38(5):1390-400.	Maternal and neonatal plasma microRNA biomarkers for fetal alcohol exposure in an ovine model.	24588274	2014	Quantitative PCR	shared profiles between pregnant dam and neonate suggest possible maternal-fetal mirna transfer. cir mirnas are biomarkers for alcohol exposure during pregnancy, in both mother and neonate, and may constitute an important shared endocrine biomarker that is vulnerable to the maternal environment.
miRNA	hsa-miR-502	mir-500	MIMAT0002873	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-181d	mir-181	MIMAT0002821	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-1469	mir-1469	MIMAT0007347	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-30a	mir-30	MIMAT0000087	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-374a	mir-374	MIMAT0000727	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-93*	mir-17	MIMAT0004509	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-499-5p	mir-499	MIMAT0002870	Homo sapiens	1	circulating	plasma	st elevation myocardial infarction (stemi)	gidlof o et al.	cardiology. 118(4):217-26.	cardiospecific microrna plasma levels correlate with troponin and cardiac function in patients with st elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples.	21701171	2011	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
miRNA	hsa-miR-381	mir-154	MIMAT0000736	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-625	mir-625	MIMAT0003294	Homo sapiens	0	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	oar-miR-19b	mir-19	MIMAT0030041	Ovis aries	1	circulating	plasma	maternal alcohol exposure	Balaraman S et al.	Alcohol Clin Exp Res. 38(5):1390-400.	Maternal and neonatal plasma microRNA biomarkers for fetal alcohol exposure in an ovine model.	24588274	2014	Quantitative PCR	shared profiles between pregnant dam and neonate suggest possible maternal-fetal mirna transfer. cir mirnas are biomarkers for alcohol exposure during pregnancy, in both mother and neonate, and may constitute an important shared endocrine biomarker that is vulnerable to the maternal environment.
miRNA	hsa-miR-505	mir-505	MIMAT0002876	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-182*	mir-182	MIMAT0000260	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-1308		MIMAT0005947	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-374b	mir-374	MIMAT0004955	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-936	mir-936	MIMAT0004979	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-499-5p	mir-499	MIMAT0002870	Homo sapiens	1	circulating	urine	st elevation myocardial infarction (stemi)	gidlof o et al.	cardiology. 118(4):217-26.	cardiospecific microrna plasma levels correlate with troponin and cardiac function in patients with st elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples.	21701171	2011	steponeplus real-time pcr system (applied biosystems)	distinct and rapid increase in levels of cardiospecific mirna in the circulation after myocardial infarction. Release of mirnas correlated with cardiomyocyte necrosis markers, the ejection fraction, and the gfr, indicating a possible role for these molecules as biomarkers for the diagnosis of stemi as well as the prediction of long-term complications.
miRNA	hsa-miR-382	mir-154	MIMAT0000737	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-665	mir-665	MIMAT0004952	Homo sapiens	0	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	oar-miR-20a	mir-17		Ovis aries	1	circulating	plasma	maternal alcohol exposure	Balaraman S et al.	Alcohol Clin Exp Res. 38(5):1390-400.	Maternal and neonatal plasma microRNA biomarkers for fetal alcohol exposure in an ovine model.	24588274	2014	Quantitative PCR	shared profiles between pregnant dam and neonate suggest possible maternal-fetal mirna transfer. cir mirnas are biomarkers for alcohol exposure during pregnancy, in both mother and neonate, and may constitute an important shared endocrine biomarker that is vulnerable to the maternal environment.
miRNA	hsa-miR-512-3p	mir-506	MIMAT0002823	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-183	mir-183	MIMAT0000261	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-1275	mir-1275	MIMAT0005929	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-378	mir-378	MIMAT0000732	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-96	mir-96	MIMAT0000095	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	circulating	plasma	prostate cancer	gonzales jc et al.	clin genitourin cancer. 9(1):39-45.	comparison of circulating microrna 141 to circulating tumor cells, lactate dehydrogenase, and prostate-specific antigen for determining treatment response in patients with metastatic prostate cancer.	21723797	2011	qrt-pcr	levels of mir-141 in plasma of 21 patients with cap were measured by using quantitative reverse transcription-polymerase chain reaction. A total of 35 intervals were assessed. Directional changes (increasing or decreasing) in psa, ctc, and mir-141 had sensitivity in predicting clinical outcome (progression vs. nonprogressing) of 78.9%.
miRNA	hsa-miR-409-3p	mir-154	MIMAT0001639	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	circulating	serum	Breast cancer	Si H et al.	J Cancer Res Clin Oncol.	Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer.	23052693	2012	qrt-pcr	the level of mir-92a was significantly lower, while mir-21 was higher, as previous reports, in tissue and serum samples of bc than that of healthy controls (p < 0.001). many mirnas expressions are altered in bc, whose expression profiling may provide a useful clue for the pathophysiological research. circulating mir-92a has potential use as novel breast cancer biomarker, which is comparable to mir-21.
miRNA	mmu-miR-122	mir-122	MIMAT0000246	mouse xenograft model	1	exosome	conditioned medium (cm) of breast cell lines	Breast cancer	Fong MY et al.	Nat Cell Biol. 17(2):183-94.	Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis.	25621950	2015	real-time pcr	authors demonstrate that, by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular mir-122 is able to reprogram systemic energy metabolism to facilitate disease progression.
miRNA	hsa-miR-513	mir-506	MIMAT0002877	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-186	mir-186	MIMAT0000456	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-378*	mir-378	MIMAT0000731	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-98	let-7	MIMAT0000096	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	hepatocellular carcinoma (hcc)	tomimaru y et al.	j hepatol. 56(1):167-75.	circulating microrna-21 as a novel biomarker for hepatocellular carcinoma.	21749846	2012	qrt-pcr	in the 10-patient group, plasma microrna-21 levels significantly diminished after surgery compared with the pre-operative values. Plasma microrna-21 level in the 126 patients with hepatocellular carcinoma was significantly higher than in patients with chronic hepatitis and healthy volunteers.
miRNA	hsa-miR-423-3p	mir-423	MIMAT0001340	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	1	circulating	serum	Conventional renal cell cancer (crcc)	Zhao A et al.	Exp Mol Pathol.  pii: S0014-4800(12)00152-9	Serum miR-210 as a novel biomarker for molecular diagnosis of clear cell renal cell carcinoma.	23064048	2012	real-time pcr	serum mir-210 may have a potential as a novel noninvasive biomarker for the detection of crcc.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	1	circulating	blood	Atherosclerosis	Zuo K et al.	Cell Physiol Biochem. 35(2):477-88.	A dysregulated microRNA-26a/EphA2 axis impairs endothelial progenitor cell function via the p38 MAPK/VEGF pathway.	25613580	2015	qrt-pcr	authors showed that mir-26a is overexpressed in patients with atherosclerosis and associated with epc (circulating endothelial progenitor cells) dysfunction. epha2 was identified as a direct target of mir-26a.
miRNA	hsa-miR-517c	mir-515	MIMAT0002866	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-1268	mir-1268	MIMAT0005922	Homo sapiens	0	exosome	mammary epithelial cells	malignant mammary epithelial cells	pigati l et al.	plos one. 5(10):e13515.	selective release of microrna species from normal and malignant mammary epithelial cells.	20976003	2010	trizol procedure (invitrogen)|qrt-pcr|mirna microarrays	released mirnas do not necessarily reflect the abundance of mirna in the cell of origin. Authors find that release of mirnas from cells into blood, milk and ductal fluids is selective and that the selection of released mirnas may correlate with malignancy.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-424	mir-322	MIMAT0001341	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-99b*	mir-99	MIMAT0004678	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	circulating	plasma	pregnancy	ge q et al.	clin chim acta. 412(21-22):1989-94.	sequencing circulating mirna in maternal plasma with modified library preparation.	21806976	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
miRNA	hsa-miR-424	mir-322	MIMAT0001341	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	1	circulating	serum	Breast cancer	Sun Y et al.	PLoS One. 7(10):e47003.	Serum MicroRNA-155 as a Potential Biomarker to Track Disease in Breast Cancer.	23071695	2012	quantitative reverse transcription polymerase chain reaction (rt-qpcr)	serum mir-155 is a potential biomarker to discriminate breast cancer patients from healthy subjects. for the first time, authors demonstrated a declined trend of mir-155 after surgery and chemotherapy, which raises the possibility to use it as an indicator for treatment response.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	Allogeneic hematopoietic stem cell transplantation (hsct)	Pontoppidan PL et al.	Int Immunopharmacol. 25(1):180-8.	Associations between gastrointestinal toxicity, micro RNA and cytokine production in patients undergoing myeloablative allogeneic stem cell transplantation.	25614225	2015	qpcr	authors showed that chemotherapy-induced gi toxicity is associated with increased levels of mirna-155 in plasma, indicating that this mirna may have a pro-inflammatory role during immune reconstitution after hsct (allogeneic hematopoietic stem cell transplantation).
miRNA	hsa-miR-519b	mir-515	MIMAT0002837	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	Breast cancer	asaga s et al.	clin chem. 57(1):84-91 	direct serum assay for microrna-21 concentrations in early and advanced breast cancer	21036945	2011	rt-qpcr applied directly in serum (rt-qpcr-ds) assay	the assay was sensitive for detection of mir-21 in 0.625 microliter of serum from breast cancer patients. For differentiation of samples from patients with locoregional breast cancer from those from healthy donors, the odds ratio was 1.796 and the area under the curve was 0.721. In a multivariate analysis that included standard clinicopathologic prognostic factors, high circulating mir-21 concentrations correlated significantly (p < 0.001) with visceral metastasis.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	circulating	plasma	multiple myeloma (mm)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-425	mir-425	MIMAT0003393	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-10b	mir-10	MIMAT0000254	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	1	circulating	plasma	pregnancy	ge q et al.	clin chim acta. 412(21-22):1989-94.	sequencing circulating mirna in maternal plasma with modified library preparation.	21806976	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
miRNA	hsa-miR-424*	mir-322	MIMAT0004749	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-202	mir-202	MIMAT0002811	Homo sapiens	1	circulating	serum	pertussis	Ge Y et al.	Mol Biol Rep. 40(2):1325-32	Serum microRNA expression profile as a biomarker for the diagnosis of pertussis.	23073777	2013	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	Allogeneic hematopoietic stem cell transplantation (hsct)	Pontoppidan PL et al.	Int Immunopharmacol. 25(1):180-8.	Associations between gastrointestinal toxicity, micro RNA and cytokine production in patients undergoing myeloablative allogeneic stem cell transplantation.	25614225	2015	qpcr	authors showed that chemotherapy-induced gi toxicity is associated with reduced levels of mirna- 146a in plasma, indicating that this mirna may have an anti-inflammatory role during immune reconstitution after hsct (allogeneic hematopoietic stem cell transplantation).
miRNA	hsa-miR-521	mir-515	MIMAT0002854	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-196b	mir-196	MIMAT0001080	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-10b	mir-10	MIMAT0000254	Homo sapiens	0	circulating	serum	Breast cancer	roth c et al.	breast cancer res. 12(6):r90.	circulating micrornas as blood-based markers for patients with primary and metastatic breast cancer.	21047409	2010	quantitative real-time pcr taqman microrna assays (applied biosystems)	the relative concentrations of total rna (p = 0.0001) and mir155 (p = 0.0001) in serum significantly discriminated m0-patients (primary breast cancer) from healthy women, whereas mir10b (p = 0.005), mir34a (p = 0.001) and mir155 (p = 0.008) discriminated m1-patients (metastatic disease) from healthy controls.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-450a	mir-450	MIMAT0001545	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-10b*	mir-10	MIMAT0004556	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	1	circulating	plasma	pregnancy	ge q et al.	clin chim acta. 412(21-22):1989-94.	sequencing circulating mirna in maternal plasma with modified library preparation.	21806976	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
miRNA	hsa-miR-425	mir-425	MIMAT0003393	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-342-5p	mir-342	MIMAT0004694	Homo sapiens	1	circulating	serum	pertussis	Ge Y et al.	Mol Biol Rep. 40(2):1325-32	Serum microRNA expression profile as a biomarker for the diagnosis of pertussis.	23073777	2013	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
miRNA	hsa-miR-642b	mir-642	MIMAT0018444	Homo sapiens	1	circulating	plasma	pancreatic cancer	Ganepola GA et al.	World J Gastrointest Oncol. 6(1):22-33.	Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer.	24578785	2014	microarray|rt-qpcr	three micrornas, mir-642b, mir-885-5p, and mir-22, were confirmed to show consistent expression between microarray and rt-qpcr. these three micrornas were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity (91%) and specificity (91%) with an area under the curve of 0.97 (p < 0.001). compared to the ca19-9 marker at 73%, the three-microrna panel has higher sensitivity although ca19-9 has higher specificity of 100%. the identified panel of three microrna biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer.
miRNA	hsa-miR-522	mir-515	MIMAT0002868	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	serum	Breast cancer	roth c et al.	breast cancer res. 12(6):r90.	circulating micrornas as blood-based markers for patients with primary and metastatic breast cancer.	21047409	2010	quantitative real-time pcr taqman microrna assays (applied biosystems)	the relative concentrations of total rna (p = 0.0001) and mir155 (p = 0.0001) in serum significantly discriminated m0-patients (primary breast cancer) from healthy women, whereas mir10b (p = 0.005), mir34a (p = 0.001) and mir155 (p = 0.008) discriminated m1-patients (metastatic disease) from healthy controls.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-454	mir-454	MIMAT0003885	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-517c	mir-515	MIMAT0002866	Homo sapiens	1	circulating	plasma	pregnancy	ge q et al.	clin chim acta. 412(21-22):1989-94.	sequencing circulating mirna in maternal plasma with modified library preparation.	21806976	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
miRNA	hsa-miR-425*	mir-425	MIMAT0001343	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-206	mir-1	MIMAT0000462	Homo sapiens	1	circulating	serum	pertussis	Ge Y et al.	Mol Biol Rep. 40(2):1325-32	Serum microRNA expression profile as a biomarker for the diagnosis of pertussis.	23073777	2013	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
miRNA	hsa-miR-885-5p	mir-885	MIMAT0004947	Homo sapiens	1	circulating	plasma	pancreatic cancer	Ganepola GA et al.	World J Gastrointest Oncol. 6(1):22-33.	Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer.	24578785	2014	microarray|rt-qpcr	three micrornas, mir-642b, mir-885-5p, and mir-22, were confirmed to show consistent expression between microarray and rt-qpcr. these three micrornas were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity (91%) and specificity (91%) with an area under the curve of 0.97 (p < 0.001). compared to the ca19-9 marker at 73%, the three-microrna panel has higher sensitivity although ca19-9 has higher specificity of 100%. the identified panel of three microrna biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer.
miRNA	hsa-miR-526a	mir-515	MIMAT0002845	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-199a*	mir-199	MIMAT0000232	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	0	circulating	serum	Breast cancer	roth c et al.	breast cancer res. 12(6):r90.	circulating micrornas as blood-based markers for patients with primary and metastatic breast cancer.	21047409	2010	quantitative real-time pcr taqman microrna assays (applied biosystems)	the relative concentrations of total rna (p = 0.0001) and mir155 (p = 0.0001) in serum significantly discriminated m0-patients (primary breast cancer) from healthy women, whereas mir10b (p = 0.005), mir34a (p = 0.001) and mir155 (p = 0.008) discriminated m1-patients (metastatic disease) from healthy controls.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-494	mir-154	MIMAT0002816	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1225-5p	mir-1225	MIMAT0005572	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-144	mir-144	MIMAT0000436	Homo sapiens	0	circulating	plasma	pregnancy	ge q et al.	clin chim acta. 412(21-22):1989-94.	sequencing circulating mirna in maternal plasma with modified library preparation.	21806976	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
miRNA	hsa-miR-4286		MIMAT0016916	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-487b	mir-154	MIMAT0003180	Homo sapiens	1	circulating	serum	pertussis	Ge Y et al.	Mol Biol Rep. 40(2):1325-32	Serum microRNA expression profile as a biomarker for the diagnosis of pertussis.	23073777	2013	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	1	circulating	plasma	pancreatic cancer	Ganepola GA et al.	World J Gastrointest Oncol. 6(1):22-33.	Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer.	24578785	2014	microarray|rt-qpcr	three micrornas, mir-642b, mir-885-5p, and mir-22, were confirmed to show consistent expression between microarray and rt-qpcr. these three micrornas were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity (91%) and specificity (91%) with an area under the curve of 0.97 (p < 0.001). compared to the ca19-9 marker at 73%, the three-microrna panel has higher sensitivity although ca19-9 has higher specificity of 100%. the identified panel of three microrna biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer.
miRNA	hsa-miR-527	mir-515	MIMAT0002862	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	1	circulating	plasma	extra-nodal natural killer t-cell (nk/t-cell) lymphoma	guo hq et al.	dis markers. 29(5):251-8.	diagnostic and prognostic value of circulating mir-221 for extranodal natural killer/t-cell lymphoma.	21206010	2010	real-time pcr	to explore mirnas as potential diagnostic and/or prognostic markers of nk/t-cell lymphoma, were compared circulating mir-221 levels in 79 patients and 37 normal subjects by real-time pcr amplification directly from plasma samples, and correlated patient-s mir-221 levels with their clinic features and treatment outcomes.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-500	mir-500	MIMAT0004773	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-125a-3p	mir-125	MIMAT0004602	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	plasma	pregnancy	ge q et al.	clin chim acta. 412(21-22):1989-94.	sequencing circulating mirna in maternal plasma with modified library preparation.	21806976	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 (nanodrop, usa)|solid small rna expression kit|qpcr	in this present study, a modified library preparation method for solid sequencing technology was developed and maternal plasma mirna from single and twin pregnancies was analyzed. Quantitative pcr was carried out for comparison.
miRNA	hsa-miR-431	mir-431	MIMAT0001625	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-576-5p	mir-576	MIMAT0003241	Homo sapiens	1	circulating	serum	pertussis	Ge Y et al.	Mol Biol Rep. 40(2):1325-32	Serum microRNA expression profile as a biomarker for the diagnosis of pertussis.	23073777	2013	real-time quantitative rt-pcr	a panel of five mirnas (mir-202, mir-342-5p, mir-206, mir-487b, mir-576-5p) was confirmed overexpressed in pertussis patients (p < 0.05). these data suggest that the five-member serum mirna profile may serve as a new biomarker for pertussis diagnosis with high specificity and sensitivity.
miRNA	hsa-miR-224-5p	mir-224	MIMAT0000281	Homo sapiens	1	circulating	serum	Graves ophthalmopathy	Shen L et al.	Endocrine.	Circulating microRNA predicts insensitivity to glucocorticoid therapy in Graves' ophthalmopathy.	25588771	2015	Quantitative PCR	authors showed that baseline serum mir-224-5p was associated with gc sensitivity in go and in vitro overexpression of mir-224-5p restored gc sensitivity in a resistant cell model. a parameter combined serum mir-224-5p and trab could effectively predict gc sensitivity in go patients.
miRNA	hsa-miR-532	mir-188	MIMAT0002888	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	serum	Chronic type B hepatitis	xu j et al.	mol carcinog. 50(2):136-42.	circulating micrornas, mir-21, mir-122, and mir-223, in patients with hepatocellular carcinoma or chronic hepatitis.	21229610	2011	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-500*	mir-500	MIMAT0002871	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-125b-1*	mir-125	MIMAT0004592	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-521	mir-515	MIMAT0002854	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-199a	mir-199	MIMAT0000231	Homo sapiens	1	circulating	serum	endometriosis	Wang WT et al.	J Clin Endocrinol Metab. 98(1):281-9	Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis.	23118427	2013	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	1	circulating	serum	Chronic lymphocytic leukemia (cll)	Stamatopoulos B et al.	Mol Med. [Epub ahead of print]	Opposite prognostic significance of cellular and serum circulating microRNA-150 in Chronic Lymphocytic Leukemia patients.	25584781	2015	qpcr	authors found that cellular and serum mir-150 levels vary in an opposite manner during chronic lymphocytic leukemia (cll) progression and could be used to molecularly monitor disease evolution as a new prognostic factor in cll.
miRNA	hsa-miR-550	mir-550	MIMAT0004800	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-302b	mir-302	MIMAT0000715	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	Chronic type B hepatitis	xu j et al.	mol carcinog. 50(2):136-42.	circulating micrornas, mir-21, mir-122, and mir-223, in patients with hepatocellular carcinoma or chronic hepatitis.	21229610	2011	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-501-3p	mir-500	MIMAT0004774	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-520h	mir-515	MIMAT0002867	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	1	circulating	serum	endometriosis	Wang WT et al.	J Clin Endocrinol Metab. 98(1):281-9	Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis.	23118427	2013	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	1	circulating	chronic lymphocytic leukemia cells	Chronic lymphocytic leukemia (cll)	Stamatopoulos B et al.	Mol Med. [Epub ahead of print]	Opposite prognostic significance of cellular and serum circulating microRNA-150 in Chronic Lymphocytic Leukemia patients.	25584781	2015	qpcr	authors found that cellular and serum mir-150 levels vary in an opposite manner during chronic lymphocytic leukemia (cll) progression and could be used to molecularly monitor disease evolution as a new prognostic factor in cll.
miRNA	hsa-miR-557	mir-557	MIMAT0003221	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	serum	Chronic type B hepatitis	xu j et al.	mol carcinog. 50(2):136-42.	circulating micrornas, mir-21, mir-122, and mir-223, in patients with hepatocellular carcinoma or chronic hepatitis.	21229610	2011	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-502-3p	mir-500	MIMAT0004775	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-141*	mir-8	MIMAT0004598	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-517c	mir-515	MIMAT0002866	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-486-3p	mir-486	MIMAT0004762	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-145*	mir-145	MIMAT0004601	Homo sapiens	1	circulating	serum	endometriosis	Wang WT et al.	J Clin Endocrinol Metab. 98(1):281-9	Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis.	23118427	2013	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	HDL	blood	human coronary artery endothelial cells (hcaec)	Tabet F et al.	Nat Commun. 5:3292.	HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells.	24576947	2014	microarray|rt-qpcr	icam-1 is a direct target of hdl-transferred mir-223 and this is the first example of an extracellular mirna regulating gene expression in cells where it is not transcribed.
miRNA	hsa-miR-565			Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	xu j et al.	mol carcinog. 50(2):136-42.	circulating micrornas, mir-21, mir-122, and mir-223, in patients with hepatocellular carcinoma or chronic hepatitis.	21229610	2011	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-502-5p	mir-500	MIMAT0002873	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-519d	mir-515	MIMAT0002853	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-542-3p	mir-542	MIMAT0003389	Homo sapiens	1	circulating	serum	endometriosis	Wang WT et al.	J Clin Endocrinol Metab. 98(1):281-9	Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis.	23118427	2013	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	metastatic colorectal cancer (mcrc)	Hansen TF et al.	Br J Cancer. 112(4):624-9.	Changes in circulating microRNA-126 during treatment with chemotherapy and bevacizumab predicts treatment response in patients with metastatic colorectal cancer.	25584492	2015	qrt-pcr	authors demonstrated that changes in circulating mirna-126 during chemotherapy and bevacizumab treatment were predictive of  metastatic colorectal cancer (mcrc) response. non-responding patients had a median increase in cir-mirna-126 compared with a median decrease in a responding patients, thus representing a possible biomarker for the resistance to anti-angiogenic containing treatments.
miRNA	hsa-miR-571	mir-571	MIMAT0003236	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-331	mir-331	MIMAT0000760	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	xu j et al.	mol carcinog. 50(2):136-42.	circulating micrornas, mir-21, mir-122, and mir-223, in patients with hepatocellular carcinoma or chronic hepatitis.	21229610	2011	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-503	mir-503	MIMAT0002874	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-149*	mir-149	MIMAT0004609	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-520g	mir-515	MIMAT0002858	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-487b	mir-154	MIMAT0003180	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-141*	mir-8	MIMAT0004598	Homo sapiens	0	circulating	serum	endometriosis	Wang WT et al.	J Clin Endocrinol Metab. 98(1):281-9	Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis.	23118427	2013	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	microvesicle	plasma	healthy smokers	Badrnya S et al.	Thromb Haemost. 112(1):128-36.	Smoking alters circulating plasma microvesicle pattern and microRNA signatures.	24573468	2014		despite reduced total pmvs, pmv-derived microrna-profiling of six smoker/control pairs revealed a decrease of only a single microrna, the major platelet-derived microrna mir-223. conversely, mir-29b, a microrna associated with aortic aneurysm and fibrosis, and rnu6-2, a commonly used reference-rna, were significantly up-regulated. smoking leads to alterations in the circulating pmv profile and changes in the pmv-derived microrna signature already in young, healthy adults. these changes may contribute to the development of smoking-related cardiovascular pathologies. moreover, these smoking-related changes have to be considered when microrna or pmv profiles are used as disease-specific biomarkers.
miRNA	hsa-miR-574	mir-574	MIMAT0003239	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-340	mir-340	MIMAT0004692	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	serum	hepatocellular carcinoma (hcc)	xu j et al.	mol carcinog. 50(2):136-42.	circulating micrornas, mir-21, mir-122, and mir-223, in patients with hepatocellular carcinoma or chronic hepatitis.	21229610	2011	real-time quantitative rt-pcr	mir-21, mir-122 and mir-223 are elevated in patients with hepatocellular carcinoma (hcc) or chronic hepatitis
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-505	mir-505	MIMAT0002876	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-517b	mir-515	MIMAT0002857	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-495	mir-329	MIMAT0002817	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-9*	mir-9	MIMAT0000442	Homo sapiens	0	circulating	serum	endometriosis	Wang WT et al.	J Clin Endocrinol Metab. 98(1):281-9	Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis.	23118427	2013	taqman microrna array	the circulating mirnas mir-199a, mir-122, mir-145*, and mir-542-3p could potentially serve as noninvasive biomarkers for endometriosis. mir-199a may also play an important role in the progression of the disease. this is the first report that circulating mirnas serve as biomarkers of endometriosis.
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	0	microvesicle	plasma	healthy smokers	Badrnya S et al.	Thromb Haemost. 112(1):128-36.	Smoking alters circulating plasma microvesicle pattern and microRNA signatures.	24573468	2014		despite reduced total pmvs, pmv-derived microrna-profiling of six smoker/control pairs revealed a decrease of only a single microrna, the major platelet-derived microrna mir-223. conversely, mir-29b, a microrna associated with aortic aneurysm and fibrosis, and rnu6-2, a commonly used reference-rna, were significantly up-regulated. smoking leads to alterations in the circulating pmv profile and changes in the pmv-derived microrna signature already in young, healthy adults. these changes may contribute to the development of smoking-related cardiovascular pathologies. moreover, these smoking-related changes have to be considered when microrna or pmv profiles are used as disease-specific biomarkers.
miRNA	hsa-miR-578	mir-578	MIMAT0003243	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-342	mir-342	MIMAT0000753	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	serum	malignant melanoma (mm)	kanemaru h et al	j dermatol sci. 61(3):187-93.	the circulating microrna-221 level in patients with malignant melanoma as a new tumor marker.	21273047	2011	qrt-pcr	serum levels of mir-221 were significantly increased in mm patients and may be useful not only for the diagnosis of mm, but also for the differentiating mm in situ from stage i-iv mm, and for evaluating tumor progression and monitoring patients during the follow-up period. In addition, considering that the serum levels of mir-221 were correlated with tumor thickness, mir-221 might also be useful as a prognostic marker for patients with mm.
miRNA	hsa-miR-30a	mir-30	MIMAT0000087	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-532-3p	mir-188	MIMAT0004780	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-17*	mir-17	MIMAT0000071	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-542-3p	mir-542	MIMAT0003389	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-497	mir-497	MIMAT0002820	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	endurance exercise	Uhlemann M et al.	Eur J Prev Cardiol.	Circulating microRNA-126 increases after different forms of endurance exercise in healthy adults.	23150891	2012	qrt-pcr	different endurance exercise protocols lead to damage of the endothelial cell layer as evident by an increase in mirna-126. on the other hand, resistance exercise has no impact on the endothelial cells, but leads to a destruction of muscular cells.
miRNA	hsa-miR-31	mir-31	MIMAT0000089	Homo sapiens	1	circulating	plasma	Coronary artery disease	Wang HW et al.	Arterioscler Thromb Vasc Biol. 34(4):857-69.	Deficiency of the microRNA-31-microRNA-720 pathway in the plasma and endothelial progenitor cells from patients with coronary artery disease.	24558106	2014	real-time pcr	circulating levels of mir-31, mir-720, and vasohibin 1 have the potential to allow early diagnosis of cad and to act as prognosis biomarkers for cad and other epc-related diseases.
miRNA	hsa-miR-582	mir-582	MIMAT0003247	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-345	mir-345	MIMAT0000772	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	1	circulating	serum	plaque psoriasis	oyama r et al.	j dermatol sci. 61(3):209-11.	circulating microrna associated with tnf-a signaling pathway in patients with plaque psoriasis.	21277746	2011	mirneasy rna isolation kit (qiagen, valencia, ca, usa)|mir-x mirna first strand synthesis|sybr qrt-pcr kit (takara bio inc)	authors try to evaluate the possibility that serum levels of these mirnas can be disease markers for psoriasis, reflecting the activation of tnf signaling pathway. Serum levels of mir-19a and -29a, especially mir-19a, can be biomarkers for this disease, reflecting the activation of tnf signaling pathway.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-532-5p	mir-188	MIMAT0002888	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-181c*	mir-181	MIMAT0004559	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-136	mir-136	MIMAT0000448	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-499-3p	mir-499	MIMAT0004772	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-720	mir-720	MIMAT0005954	Homo sapiens	1	circulating	serum	multiple myeloma (mm)	Jones CI et al.	Br J Cancer.	Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.	23169280	2012	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
miRNA	hsa-miR-720	mir-720	MIMAT0005954	Homo sapiens	1	circulating	plasma	Coronary artery disease	Wang HW et al.	Arterioscler Thromb Vasc Biol. 34(4):857-69.	Deficiency of the microRNA-31-microRNA-720 pathway in the plasma and endothelial progenitor cells from patients with coronary artery disease.	24558106	2014	real-time pcr	circulating levels of mir-31, mir-720, and vasohibin 1 have the potential to allow early diagnosis of cad and to act as prognosis biomarkers for cad and other epc-related diseases.
miRNA	hsa-miR-584	mir-584	MIMAT0003249	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-374	mir-374	MIMAT0004688	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	1	circulating	serum	plaque psoriasis	oyama r et al.	j dermatol sci. 61(3):209-11.	circulating microrna associated with tnf-a signaling pathway in patients with plaque psoriasis.	21277746	2011	mirneasy rna isolation kit (qiagen, valencia, ca, usa)|mir-x mirna first strand synthesis|sybr qrt-pcr kit (takara bio inc)	authors try to evaluate the possibility that serum levels of these mirnas can be disease markers for psoriasis, reflecting the activation of tnf signaling pathway. Serum levels of mir-19a and -29a, especially mir-19a, can be biomarkers for this disease, reflecting the activation of tnf signaling pathway.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-542-3p	mir-542	MIMAT0003389	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-184	mir-184	MIMAT0000454	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7f-1*	let-7	MIMAT0004486	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-499-5p	mir-499	MIMAT0002870	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-1308		MIMAT0005947	Homo sapiens	1	circulating	serum	multiple myeloma (mm)	Jones CI et al.	Br J Cancer.	Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.	23169280	2012	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
miRNA	rno-miR-210	mir-210	MIMAT0000881	male f344 rats model	1	circulating	serum	lung cancer	Wu JJ et al.	Biomed Environ Sci. 27(1):10-6.	4-(Methylnitrosamino)-1-(3-pyridyl) -1-butanone induces circulating microRNA deregulation in early lung carcinogenesis.	24553369	2014	quantitative real-time pcr	the mir-210 was down-regulated and the mir-206 was up-regulated in nnk treatment group. the expression level of circulating mirnas changed from week 1 to week 20 following nnk treatment. the expression level of circulating mirnas is related to nnk-induced early stage lung carcinogenesis in rats and can therefore serve as its potential indicator.
miRNA	hsa-miR-585		MIMAT0003250	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-376a	mir-368	MIMAT0000729	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-542-5p	mir-542	MIMAT0003340	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-518e	mir-515	MIMAT0002861	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-500a*	mir-500	MIMAT0002871	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-1246	mir-1246	MIMAT0005898	Homo sapiens	1	circulating	serum	multiple myeloma (mm)	Jones CI et al.	Br J Cancer.	Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.	23169280	2012	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
miRNA	rno-miR-206	mir-1	MIMAT0000879	male f344 rats model	1	circulating	serum	lung cancer	Wu JJ et al.	Biomed Environ Sci. 27(1):10-6.	4-(Methylnitrosamino)-1-(3-pyridyl) -1-butanone induces circulating microRNA deregulation in early lung carcinogenesis.	24553369	2014	quantitative real-time pcr	the mir-210 was down-regulated and the mir-206 was up-regulated in nnk treatment group. the expression level of circulating mirnas changed from week 1 to week 20 following nnk treatment. the expression level of circulating mirnas is related to nnk-induced early stage lung carcinogenesis in rats and can therefore serve as its potential indicator.
miRNA	hsa-miR-590	mir-590	MIMAT0003258	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-423	mir-423	MIMAT0001340	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-551b	mir-551	MIMAT0003233	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-193a-3p	mir-193	MIMAT0000459	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7a*	let-7	MIMAT0004481	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-501-3p	mir-500	MIMAT0004774	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	serum	multiple myeloma (mm)	Jones CI et al.	Br J Cancer.	Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.	23169280	2012	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
miRNA	hsa-miR-34c	mir-34	MIMAT0000686	Homo sapiens	0	circulating	plasma	Alzheimer disease (AD)	Bhatnagar S et al.	Front Mol Neurosci. 7:2.	Increased microRNA-34c abundance in Alzheimer's disease circulating blood plasma.	24550773	2014	quantitative real-time pcr	these data show that plasma levels of microrna 34c are much more prominent in ad than those of its sister, mir-34a, or than its own level in pbmc. transfection studies show that mir-34c, as does its sister mir-34a, represses the expression of several selected genes involved in cell survival and oxidative defense pathways, such as bcl2, sirt1, and others, in cultured cells.
miRNA	hsa-miR-593	mir-593	MIMAT0004802	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-425-3p	mir-425	MIMAT0001343	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-564	mir-564	MIMAT0003228	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-505	mir-505	MIMAT0002876	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-638	mir-638	MIMAT0003308	Homo sapiens	0	circulating	serum	multiple myeloma (mm)	Jones CI et al.	Br J Cancer.	Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.	23169280	2012	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
miRNA	hsa-miR-99a	mir-99	MIMAT0000097	Homo sapiens	0	circulating	plasma	pregnancy	Kotlabova K et al.	Indian J Med Res. 138(6):935-43.	Extracellular chromosome 21-derived microRNAs in euploid & aneuploid pregnancies.	24521639	2013	real-time pcr	analysis of extracellular chromosome 21-derived micrornas has no benefit for screening programmes and non-invasive diagnosis of down syndrome.
miRNA	hsa-miR-594			Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-425-5p	mir-425	MIMAT0003393	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-590-5p	mir-590	MIMAT0003258	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-198	mir-198	MIMAT0000228	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-125a-5p	mir-125	MIMAT0000443	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-532-3p	mir-188	MIMAT0004780	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-1915	mir-1915	MIMAT0007892	Homo sapiens	0	circulating	serum	multiple myeloma (mm)	Jones CI et al.	Br J Cancer.	Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.	23169280	2012	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
miRNA	hsa-miR-28-5p	mir-28	MIMAT0000085	Homo sapiens	0	circulating	plasma	liver damage in hepatitis b e antigen positive (hbeag-positive) patients	Winther TN et al.	Int J Hepatol. 2014:791045.	Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes.	25580300	2014	qrt-pcr	authors demonstrated that three micrornas (mir-28-5p, -30a-5p, and -125b-5p) were significantly upregulated in hbeag-positive children when compared to hbeag-negative and healthy control children. the identified micrornas might impact the progression of chronic hepatitis b in children. 
miRNA	hsa-miR-595	mir-595	MIMAT0003263	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-630	mir-630	MIMAT0003299	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-199b-5p	mir-199	MIMAT0000263	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-519a	mir-515	MIMAT0002869	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-532-5p	mir-188	MIMAT0002888	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-1974		MIMAT0009449	Homo sapiens	0	circulating	serum	multiple myeloma (mm)	Jones CI et al.	Br J Cancer.	Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.	23169280	2012	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
miRNA	hsa-miR-125b-2	mir-10		Homo sapiens	0	circulating	plasma	pregnancy	Kotlabova K et al.	Indian J Med Res. 138(6):935-43.	Extracellular chromosome 21-derived microRNAs in euploid & aneuploid pregnancies.	24521639	2013	real-time pcr	analysis of extracellular chromosome 21-derived micrornas has no benefit for screening programmes and non-invasive diagnosis of down syndrome.
miRNA	hsa-miR-603	mir-548	MIMAT0003271	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-486	mir-486	MIMAT0002177	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-632	mir-632	MIMAT0003302	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200a*	mir-8	MIMAT0001620	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-543	mir-329	MIMAT0004954	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-574-5p	mir-574	MIMAT0004795	Homo sapiens	0	circulating	serum	multiple myeloma (mm)	Jones CI et al.	Br J Cancer.	Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.	23169280	2012	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
miRNA	hsa-miR-30a-5p	mir-30	MIMAT0000087	Homo sapiens	0	circulating	plasma	liver damage in hepatitis b e antigen positive (hbeag-positive) patients	Winther TN et al.	Int J Hepatol. 2014:791045.	Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes.	25580300	2014	qrt-pcr	authors demonstrated that three micrornas (mir-28-5p, -30a-5p, and -125b-5p) were significantly upregulated in hbeag-positive children when compared to hbeag-negative and healthy control children. the identified micrornas might impact the progression of chronic hepatitis b in children.
miRNA	hsa-miR-608	mir-608	MIMAT0003276	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-532	mir-188	MIMAT0002888	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	normal	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-652	mir-652	MIMAT0003322	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-219-5p	mir-219	MIMAT0000276	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-551b	mir-551	MIMAT0003233	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-762	mir-762	MIMAT0010313	Homo sapiens	0	circulating	serum	multiple myeloma (mm)	Jones CI et al.	Br J Cancer.	Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.	23169280	2012	taqman microrna reverse transcription kit (life technologies)|agilent human mirna 8 × 15k microarrays (agilent, santa clara, ca, usa, v3, mirbase version 12.0)|mirvana paris kit (life technologies, carlsbad, ca, usa)	three serum micrornas, mir-720, mir-1308 and mir-1246, were found to have potential as diagnostic biomarkers in myeloma.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	pregnancy	Kotlabova K et al.	Indian J Med Res. 138(6):935-43.	Extracellular chromosome 21-derived microRNAs in euploid & aneuploid pregnancies.	24521639	2013	real-time pcr	analysis of extracellular chromosome 21-derived micrornas has no benefit for screening programmes and non-invasive diagnosis of down syndrome.
miRNA	hsa-miR-612	mir-612	MIMAT0003280	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-574	mir-574	MIMAT0003239	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-654-5p	mir-654	MIMAT0003330	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-17-5p	mir-17	MIMAT0000070	Homo sapiens	1	circulating	plasma	endometriosis	Jia SZ et al.	Hum Reprod.	Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis.	23203215	2012	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
miRNA	hsa-miR-125b-5p	mir-10	MIMAT0000423	Homo sapiens	0	circulating	plasma	liver damage in hepatitis b e antigen positive (hbeag-positive) patients	Winther TN et al.	Int J Hepatol. 2014:791045.	Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes.	25580300	2014	qrt-pcr	authors demonstrated that three micrornas (mir-28-5p, -30a-5p, and -125b-5p) were significantly upregulated in hbeag-positive children when compared to hbeag-negative and healthy control children. the identified micrornas might impact the progression of chronic hepatitis b in children.
miRNA	hsa-miR-625	mir-625	MIMAT0003294	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-628	mir-628	MIMAT0003297	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-660	mir-188	MIMAT0003338	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1260	mir-1260	MIMAT0005911	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-584	mir-584	MIMAT0003249	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	1	circulating	plasma	endometriosis	Jia SZ et al.	Hum Reprod.	Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis.	23203215	2012	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
miRNA	hsa-let-7c	let-7	MIMAT0000064	Homo sapiens	0	circulating	plasma	pregnancy	Kotlabova K et al.	Indian J Med Res. 138(6):935-43.	Extracellular chromosome 21-derived microRNAs in euploid & aneuploid pregnancies.	24521639	2013	real-time pcr	analysis of extracellular chromosome 21-derived micrornas has no benefit for screening programmes and non-invasive diagnosis of down syndrome.
miRNA	hsa-miR-628	mir-628	MIMAT0003297	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-643	mir-643	MIMAT0003313	Homo sapiens	0	exosome	plasma	normal	hunter mp et al.	plos one. 3(11):e3694.	detection of microrna expression in human peripheral blood microvesicles.	19002258	2008	trizol (invitrogen, carlsbad, ca)|capillary electrophoresis on an agilent 2100 bioanalyzer (agilent technologies, inc, santa clara, ca)|real-time pcr using an applied biosystems 7900ht real-time pcr instrument|bd aria flow cytometer (bd biosciences)	microvesicles were isolated from the plasma of normal healthy individuals. RNA was isolated from both the microvesicles and matched mononuclear cells and profiled for 420 known mature mirnas by real-time pcr. Hierarchical clustering of the data sets indicated significant differences in mirna expression between peripheral blood mononuclear cells (pbmc) and plasma microvesicles. Authors observed 71 mirnas co-expressed between microvesicles and pbmc.
miRNA	hsa-miR-429	mir-8	MIMAT0001536	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-671-5p	mir-671	MIMAT0003880	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-629	mir-629	MIMAT0004810	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	1	circulating	plasma	endometriosis	Jia SZ et al.	Hum Reprod.	Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis.	23203215	2012	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
miRNA	hsa-miR-654-3p	mir-654	MIMAT0004814	Homo sapiens	0	circulating	plasma	liver damage in hepatitis b e antigen positive (hbeag-positive) patients	Winther TN et al.	Int J Hepatol. 2014:791045.	Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes.	25580300	2014	qrt-pcr	authors demonstrated that 654-3p was downregulated in hbeag-positive children when compared to hbeag-negative and healthy control children. the identified microrna might impact the progression of chronic hepatitis b in children.
miRNA	hsa-miR-629	mir-629	MIMAT0004810	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-17-3p	mir-17	MIMAT0000071	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-miR-429	mir-8	MIMAT0001536	Homo sapiens	0	circulating	serum	systemic lupus erythematosus (sle)	wang g et al.	lupus. 20(5):493-500.	serum and urinary free microrna level in patients with systemic lupus erythematosus.	21372198	2011		the serum levels of mir-200a, mir-200b, mir-200c, mir-429, mir-205 and mir-192, and urinary mir-200a, mir-200c, mir-141, mir-429 and mir-192 of sle patients were lower than those of controls.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-744	mir-744	MIMAT0004945	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-320c	mir-320	MIMAT0005793	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-675	mir-675	MIMAT0004284	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-15b-5p	mir-15	MIMAT0000417	Homo sapiens	0	circulating	plasma	endometriosis	Jia SZ et al.	Hum Reprod.	Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis.	23203215	2012	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
miRNA	hsa-miR-21-5p	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	subclinical hypothyroidism (sch)	Zhang X et al.	J Clin Endocrinol Metab. 99(5):E766-74.	Expression profiles of six circulating microRNAs critical to atherosclerosis in patients with subclinical hypothyroidism: a clinical study.	24517143	2014	real-time pcr	mir-21-5p showed the most specific expression patterns in all patients with subclinical hypothyroidism (sch and sch+ath groups). down-regulation of mir-125a-5p, mir-126-3p, mir-221-3p, and mir-222-3p may be a manifestation of atherosclerosis either in sch+ath or in ath-alone patients. mir-126-3p has the most specific expression patterns in all atherosclerosis patients (sch+ath and ath groups).
miRNA	hsa-miR-634	mir-634	MIMAT0003304	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-146	mir-146	MIMAT0000449	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-760	mir-760	MIMAT0004957	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30c-2*	mir-30	MIMAT0004550	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-7	mir-7	MIMAT0000252	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	endometriosis	Jia SZ et al.	Hum Reprod.	Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis.	23203215	2012	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
miRNA	hsa-miR-126-3p	mir-126	MIMAT0000445	Homo sapiens	0	circulating	serum	subclinical hypothyroidism (sch)	Zhang X et al.	J Clin Endocrinol Metab. 99(5):E766-74.	Expression profiles of six circulating microRNAs critical to atherosclerosis in patients with subclinical hypothyroidism: a clinical study.	24517143	2014	real-time pcr	mir-21-5p showed the most specific expression patterns in all patients with subclinical hypothyroidism (sch and sch+ath groups). down-regulation of mir-125a-5p, mir-126-3p, mir-221-3p, and mir-222-3p may be a manifestation of atherosclerosis either in sch+ath or in ath-alone patients. mir-126-3p has the most specific expression patterns in all atherosclerosis patients (sch+ath and ath groups).
miRNA	hsa-miR-637	mir-637	MIMAT0003307	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-769-5p	mir-769	MIMAT0003886	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-32	mir-32	MIMAT0000090	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-1272	mir-1272	MIMAT0005925	Homo sapiens	1	circulating	serum	preeclampsia	yang q et al.	clin chim acta. 412(23-24):2167-73.	application of next-generation sequencing technology to profile the circulating micrornas in the serum of preeclampsia versus normal pregnant women.	21840305	2011	mirvana mirna isolation kit (ambion, austin, tx)|nanodrop nd-1000 spectrophotometer (applied biosystems, foster city, ca)|solid small rna expression kit (srek, applied biosystems)	in this present study, authors analyzed the expression profiles of circulating mirnas in the serum of four pregnant women with preeclampsia (pe) and one normal control of pregnant women, by the next generation sequencing technology. 22 mirnas were found to be dys-regulated expressed with pe. Compared to the normal control, 15 and 7 mirnas were up-regulated and down-regulated respectively in each four pe samples.
miRNA	hsa-miR-744	mir-744	MIMAT0004945	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	circulating	plasma	endometriosis	Jia SZ et al.	Hum Reprod.	Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis.	23203215	2012	qrt-pcr	mir-17-5p, mir-20a and mir-22 were significantly down-regulated in women with endometriosis compared with controls (p = 0.011, 0.0020 and 0.0002, respectively), yielding an area under the receiver operator characteristics curve of 0.74
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	1	circulating	bladder cancer cells	Bladder cancer	Yu G et al.	J Exp Clin Cancer Res. 33(1):779.	MicroRNA-34a functions as an anti-metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44.	25551284	2014	quantitative real-time pcr	authors demonstrated that mir-34a functions as a tumor suppressor in bladder cancer by directly targeting cd44, which would be helpful as a therapeutic approach to block bladder cancer metastasis.
miRNA	hsa-miR-638	mir-638	MIMAT0003308	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-let-7d*	let-7	MIMAT0004484	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-886-3p		MIMAT0004906	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-324-5p	mir-324	MIMAT0000761	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	solitary pulmonary nodules (spns)	shen j et al.	bmc cancer. 11:374.	diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microrna biomarkers	21864403	2011	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
miRNA	hsa-miR-885-5p	mir-885	MIMAT0004947	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-195-5p	mir-15	MIMAT0000461	Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Gorur A et al.	Mol Biol Rep.	Determination of plasma microRNA for early detection of gastric cancer.	23212612	2012	high pure mirna isolation kit (roche)|biomark 96.96 dynamic array (fluidigm corporation)|real-time qpcr	in this study, among 740 mirnas that authors analyzed only mir-195-5p was significantly (p < 0.05, fold changes = 13, 3) down-regulated in gastric cancer patients compared with control. authors demonstrated that mir-195-5p is a novel tumor suppressor mirna and may contribute to gastric carcinogenesis.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	Breast cancer	Muller V et al.	Breast Cancer Res Treat. 147(1):61-8.	Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial.	25086636	2014	taqman human microrna arrays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21. 
miRNA	hsa-miR-642	mir-642	MIMAT0003312	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-892b	mir-743	MIMAT0004918	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-338-3p	mir-338	MIMAT0000763	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	1	circulating	plasma	solitary pulmonary nodules (spns)	shen j et al.	bmc cancer. 11:374.	diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microrna biomarkers	21864403	2011	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
miRNA	hsa-miR-9	mir-9	MIMAT0000441	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	serum	Bladder cancer	Scheffer AR et al.	World J Urol.	Circulating microRNAs in serum: novel biomarkers for patients with bladder cancer?	23266581	2012	qrt-pcr	the analysis of mir-141 and mir-639 in the validation cohort demonstrated that microrna levels were similar in bladder cancer patients and control subjects. furthermore, microrna levels were not correlated with clinicopathological parameters (pt-stage, metastasis, grading). the analysis of serum mir-141 and mir-639 levels does not seem to be helpful in the diagnosis or prognosis of bca.
miRNA	hsa-miR-29a/b/c	mir-29		Homo sapiens	0	circulating	human orbital fibroblasts	orbital fibrosis	Tan J et al.	Int J Clin Exp Pathol. 7(11):7571-7.	MicroRNA-29 mediates TGFβ1-induced extracellular matrix synthesis by targeting wnt/β-catenin pathway in human orbital fibroblasts.	25550793	2014	real-time pcr	authors demonstrated that mir-29 mediates tgfβ1-induced extracellular matrix synthesis through activation of wnt/β-catenin pathway in human orbital fibroblasts.
miRNA	hsa-miR-645	mir-645	MIMAT0003315	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-373*	mir-373	MIMAT0000725	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	1	circulating	plasma	solitary pulmonary nodules (spns)	shen j et al.	bmc cancer. 11:374.	diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microrna biomarkers	21864403	2011	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-639	mir-639	MIMAT0003309	Homo sapiens	0	circulating	serum	Bladder cancer	Scheffer AR et al.	World J Urol.	Circulating microRNAs in serum: novel biomarkers for patients with bladder cancer?	23266581	2012	qrt-pcr	the analysis of mir-141 and mir-639 in the validation cohort demonstrated that microrna levels were similar in bladder cancer patients and control subjects. furthermore, microrna levels were not correlated with clinicopathological parameters (pt-stage, metastasis, grading). the analysis of serum mir-141 and mir-639 levels does not seem to be helpful in the diagnosis or prognosis of bca.
miRNA	hsa-miR-18b	mir-17	MIMAT0001412	Homo sapiens	0	circulating	serum	triple-negative breast cancers (tnbc)	Kleivi Sahlberg K et al.	Clin Cancer Res. 21(5):1207-14.	A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients.	25547678	2015	real-time pcr	by cox regression analysis, authors identified a four-mirna signature (mir-18b, mir-103, mir-107, and mir-652) that predicted tumor relapse and overall survival for patients with triple-negative breast cancers (tnbc).
miRNA	hsa-miR-647	mir-647	MIMAT0003317	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-378*	mir-378	MIMAT0000731	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	solitary pulmonary nodules (spns)	shen j et al.	bmc cancer. 11:374.	diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microrna biomarkers	21864403	2011	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Giráldez MD et al.	Clin Gastroenterol Hepatol. pii: S1542-3565(12)015	Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study.	23267864	2012	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	circulating	serum	triple-negative breast cancers (tnbc)	Kleivi Sahlberg K et al.	Clin Cancer Res. 21(5):1207-14.	A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients.	25547678	2015	real-time pcr	by cox regression analysis, authors identified a four-mirna signature (mir-18b, mir-103, mir-107, and mir-652) that predicted tumor relapse and overall survival for patients with triple-negative breast cancers (tnbc).
miRNA	hsa-miR-649	mir-649	MIMAT0003319	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-98	let-7	MIMAT0000096	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-422a	mir-422	MIMAT0001339	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	circulating	plasma	solitary pulmonary nodules (spns)	shen j et al.	bmc cancer. 11:374.	diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microrna biomarkers	21864403	2011	mirvana mirna isolation kit (ambion, austin, tx)|qrt-pcr|taqman microrna rt kit (applied biosystems, foster city, ca)	in the training set, mir-21 and mir-210 display higher plasma expression levels, whereas mir-486-5p has lower expression level in patients with malignant spns, as compared to subjects with benign spns and healthy controls
miRNA	hsa-miR-98	let-7	MIMAT0000096	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Giráldez MD et al.	Clin Gastroenterol Hepatol. pii: S1542-3565(12)015	Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study.	23267864	2012	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	circulating	serum	triple-negative breast cancers (tnbc)	Kleivi Sahlberg K et al.	Clin Cancer Res. 21(5):1207-14.	A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients.	25547678	2015	real-time pcr	by cox regression analysis, authors identified a four-mirna signature (mir-18b, mir-103, mir-107, and mir-652) that predicted tumor relapse and overall survival for patients with triple-negative breast cancers (tnbc).
miRNA	hsa-miR-652	mir-652	MIMAT0003322	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-99a	mir-99	MIMAT0000097	Homo sapiens	0	exosome	dendritic cells	Dendritic cells	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-431*	mir-431	MIMAT0004757	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	serum	Chronic type C hepatitis	cermelli s et al.	plos one.6(8):e23937	circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.	21886843	2011	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
miRNA	hsa-miR-99a	mir-99	MIMAT0000097	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Giráldez MD et al.	Clin Gastroenterol Hepatol. pii: S1542-3565(12)015	Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study.	23267864	2012	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
miRNA	hsa-miR-652	mir-652	MIMAT0003322	Homo sapiens	0	circulating	serum	triple-negative breast cancers (tnbc)	Kleivi Sahlberg K et al.	Clin Cancer Res. 21(5):1207-14.	A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients.	25547678	2015	real-time pcr	by cox regression analysis, authors identified a four-mirna signature (mir-18b, mir-103, mir-107, and mir-652) that predicted tumor relapse and overall survival for patients with triple-negative breast cancers (tnbc).
miRNA	hsa-miR-660	mir-188	MIMAT0003338	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-212	mir-132	MIMAT0000269	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-376a	mir-368	MIMAT0000729	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	Chronic type C hepatitis	cermelli s et al.	plos one.6(8):e23937	circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.	21886843	2011	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
miRNA	hsa-miR-99b	mir-99	MIMAT0000689	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Giráldez MD et al.	Clin Gastroenterol Hepatol. pii: S1542-3565(12)015	Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study.	23267864	2012	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
miRNA	mmu-miR-126	mir-126		Mus musculus	1	circulating	vascular endothelium	kidney ischemia reperfusion injury	Bijkerk R et al.	Microrna. 3(3):144-9.	Silencing of miRNA-126 in kidney ischemia reperfusion is associated with elevated SDF-1 levels and mobilization of Sca-1+/Lin- progenitor cells.	25541911	2014	qrt-pcr	authors demonstrated that silencing of mir-126 can enhance renal expression of stromal cell-derived factor 1 (sdf-1) after ischemia/ reperfusion injury (iri), leading to the mobilization of vascular progenitor cells into the circulation.
miRNA	hsa-miR-663	mir-663	MIMAT0003326	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-203	mir-203	MIMAT0000264	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-483-5p	mir-483	MIMAT0004761	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	Chronic type C hepatitis	cermelli s et al.	plos one.6(8):e23937	circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.	21886843	2011	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Giráldez MD et al.	Clin Gastroenterol Hepatol. pii: S1542-3565(12)015	Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study.	23267864	2012	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	1	circulating	plasma	Coronary artery disease	Soeki T et al.	Circ J. 79(2):413-8.	Plasma microRNA-100 is associated with coronary plaque vulnerability.	25519160	2015	Quantitative PCR	authors showed that mir-100 might be released into the coronary circulation from vulnerable coronary plaques. this study provides insights into the role of mirnas in coronary atherosclerotic disease.
miRNA	hsa-miR-671	mir-671	MIMAT0003880	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-214	mir-214	MIMAT0000271	Homo sapiens	0	exosome	plasma	lung cancer	rabinowits g et al.	clin lung cancer. 10(1):42-6.	exosomal microrna: a diagnostic marker for lung cancer.	19289371	2009	size exclusion chromatography and magnetic activated cell sorting using anti epithelial cell adhesion molecule (epcam)|mirvana isolation kit (ambion, austin, tx)|mirvana mirna array labeling kit (ambion)|post labeling reactive dye kit (amersham biosciences, pittsburgh, pa)|mirna microarray chips	the significant difference in total exosome and mirna levels between lung cancer patients and controls, and the similarity between the circulating exosomal mirna and the tumor-derived mirna patterns, suggest that circulating exosomal mirna might be useful as a screening test for lung adenocarcinoma. No correlation between the exosomal mirna levels and the stage of disease can be made at this point.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-518f	mir-515	MIMAT0002842	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-let-7d*	let-7	MIMAT0004484	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-492	mir-492	MIMAT0002812	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	0	circulating	serum	Chronic type C hepatitis	cermelli s et al.	plos one.6(8):e23937	circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.	21886843	2011	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
miRNA	hsa-miR-320a	mir-320	MIMAT0000510	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-335	mir-335	MIMAT0000765	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Giráldez MD et al.	Clin Gastroenterol Hepatol. pii: S1542-3565(12)015	Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study.	23267864	2012	real-time quantitative rt-pcr	patients with crc have significantly different patterns of mirna expression than healthy individuals. these patterns might be developed as biomarkers for crc, although they have limited value in identifying patients with premalignant neoplastic lesions.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	1	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	Wang Y et al.	Cancer Biomark. 15(2):177-86. 	Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma.	25519019	2015	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
miRNA	hsa-miR-765	mir-765	MIMAT0003945	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	urine	urothelial bladder cancer (bca)	hanke m et al.	urol oncol. 28(6):655-61.	a robust methodology to study urine microrna as tumor marker: microrna-126 and microrna-182 are related to urinary bladder cancer.	19375957	2010	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-520c-3p	mir-515	MIMAT0002846	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-498	mir-498	MIMAT0002824	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	serum	non-alcoholic fatty liver disease (nafld)	cermelli s et al.	plos one.6(8):e23937	circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.	21886843	2011	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
miRNA	hsa-miR-423-5p	mir-423	MIMAT0004748	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	1	circulating	serum	serous epithelial ovarian cancer (seoc)	Kan CW et al.	BMC Cancer. 12(1):627	Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer.	23272653	2012	qrt-pcr	individually, mir-200a, mir-200b and mir-200c normalized to serum volume and mir-103 were significantly higher in serum of the seoc cohort (p < 0.05; 0.05; 0.0005 respectively) and in combination, mir-200b + mir-200c normalized to serum volume and mir-103 was the best predictive classifier of seoc (roc-auc = 0.784). this predictive model (mir-200b + mir-200c) was further confirmed by leave one out cross validation (auc = 0.784).
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	1	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	Wang Y et al.	Cancer Biomark. 15(2):177-86. 	Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma.	25519019	2015	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
miRNA	hsa-miR-766	mir-766	MIMAT0003888	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-182	mir-182	MIMAT0000259	Homo sapiens	1	circulating	urine	urothelial bladder cancer (bca)	hanke m et al.	urol oncol. 28(6):655-61.	a robust methodology to study urine microrna as tumor marker: microrna-126 and microrna-182 are related to urinary bladder cancer.	19375957	2010	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
miRNA	hsa-miR-126*	mir-126	MIMAT0000444	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-618	mir-618	MIMAT0003287	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-500*	mir-500	MIMAT0002871	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	non-alcoholic fatty liver disease (nafld)	cermelli s et al.	plos one.6(8):e23937	circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.	21886843	2011	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
miRNA	hsa-miR-92b	mir-25	MIMAT0003218	Homo sapiens	0	circulating	serum	Chronic systolic heart failure	goren y et al.	eur j heart fail. 14(2):147-54	serum levels of micrornas in patients with heart failure.	22120965	2012	qrt-pcr	elevated serum levels of specific micrornas: mir-423-5p, mir-320a, mir-22, and mir-92b, identify systolic heart failure patients and correlate with important clinical prognostic parameters.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	1	circulating	serum	serous epithelial ovarian cancer (seoc)	Kan CW et al.	BMC Cancer. 12(1):627	Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer.	23272653	2012	qrt-pcr	individually, mir-200a, mir-200b and mir-200c normalized to serum volume and mir-103 were significantly higher in serum of the seoc cohort (p < 0.05; 0.05; 0.0005 respectively) and in combination, mir-200b + mir-200c normalized to serum volume and mir-103 was the best predictive classifier of seoc (roc-auc = 0.784). this predictive model (mir-200b + mir-200c) was further confirmed by leave one out cross validation (auc = 0.784).
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	1	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	Wang Y et al.	Cancer Biomark. 15(2):177-86. 	Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma.	25519019	2015	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
miRNA	hsa-miR-768-3p			Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	urine	urothelial bladder cancer (bca)	hanke m et al.	urol oncol. 28(6):655-61.	a robust methodology to study urine microrna as tumor marker: microrna-126 and microrna-182 are related to urinary bladder cancer.	19375957	2010	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
miRNA	hsa-miR-130a	mir-130	MIMAT0000425	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-628-5p	mir-628	MIMAT0004809	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-let-7i	let-7	MIMAT0000415	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-502-3p	mir-500	MIMAT0004775	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	non-alcoholic fatty liver disease (nafld)	cermelli s et al.	plos one.6(8):e23937	circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.	21886843	2011	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
miRNA	hsa-miR-378	mir-378	MIMAT0000732	Homo sapiens	1	circulating	serum	gastric cancer (gc)	liu h et al.	cancer lett. 316(2):196-203.	genome-wide microrna profiles identify mir-378 as a serum biomarker for early detection of gastric cancer.	22169097	2012	qrt-pcr	genome-wide mirna expression profiles followed with real-time quantitative rt-pcr (qrt-pcr) assays revealed that mir-187(*), mir-371-5p and mir-378 were significantly elevated in gc patients. Further validation indicated that mir-378 alone could yields a roc curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating gc patients from healthy controls.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	circulating	serum	serous epithelial ovarian cancer (seoc)	Kan CW et al.	BMC Cancer. 12(1):627	Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer.	23272653	2012	qrt-pcr	individually, mir-200a, mir-200b and mir-200c normalized to serum volume and mir-103 were significantly higher in serum of the seoc cohort (p < 0.05; 0.05; 0.0005 respectively) and in combination, mir-200b + mir-200c normalized to serum volume and mir-103 was the best predictive classifier of seoc (roc-auc = 0.784). this predictive model (mir-200b + mir-200c) was further confirmed by leave one out cross validation (auc = 0.784).
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	1	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	Wang Y et al.	Cancer Biomark. 15(2):177-86. 	Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma.	25519019	2015	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
miRNA	hsa-miR-768-5p			Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	urine	urothelial bladder cancer (bca)	hanke m et al.	urol oncol. 28(6):655-61.	a robust methodology to study urine microrna as tumor marker: microrna-126 and microrna-182 are related to urinary bladder cancer.	19375957	2010	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
miRNA	hsa-miR-140-3p	mir-140	MIMAT0004597	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-646	mir-646	MIMAT0003316	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-513a-3p	mir-506	MIMAT0004777	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	0	circulating	serum	non-alcoholic fatty liver disease (nafld)	cermelli s et al.	plos one.6(8):e23937	circulating micrornas in patients with chronic hepatitis c and non-alcoholic fatty liver disease.	21886843	2011	taqman mirna qrt-pcr assay (applied biosystems, carlsbad, ca). Reverse transcription and pcr reactions were run in triplicate in the applied biosystems 7900 system.	serum levels of mir-34a and mir-122 may represent novel, noninvasive biomarkers of diagnosis and histological disease severity in patients with chc or nafld.
miRNA	hsa-miR-187*	mir-187	MIMAT0004561	Homo sapiens	0	circulating	serum	gastric cancer (gc)	liu h et al.	cancer lett. 316(2):196-203.	genome-wide microrna profiles identify mir-378 as a serum biomarker for early detection of gastric cancer.	22169097	2012	qrt-pcr	genome-wide mirna expression profiles followed with real-time quantitative rt-pcr (qrt-pcr) assays revealed that mir-187(*), mir-371-5p and mir-378 were significantly elevated in gc patients. Further validation indicated that mir-378 alone could yields a roc curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating gc patients from healthy controls.
miRNA	hsa-miR-9	mir-9	MIMAT0000441	Homo sapiens	0	circulating	cerebrospinal fluid	Alzheimer disease (AD)	Alexandrov PN et al.	Int J Biochem Mol Biol. 3(4):365-73.	microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF).	23301201	2012	fluorescent mirna-array-based analysis|led-northern dot-blot assay	the results indicate that mirna-9, mirna-125b, mirna-146a and mirna-155 are csf- and ecf-abundant, nf-кb-sensitive pro-inflammatory mirnas, and their enrichment in circulating csf and ecf suggest that they may be involved in the modulation or proliferation of mirna-triggered pathogenic signaling throughout the brain and central nervous system (cns).
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	1	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	Wang Y et al.	Cancer Biomark. 15(2):177-86. 	Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma.	25519019	2015	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
miRNA	hsa-miR-769-3p	mir-769	MIMAT0003887	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-17-5p	mir-17	MIMAT0000070	Homo sapiens	0	circulating	urine	urothelial bladder cancer (bca)	hanke m et al.	urol oncol. 28(6):655-61.	a robust methodology to study urine microrna as tumor marker: microrna-126 and microrna-182 are related to urinary bladder cancer.	19375957	2010	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems,darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-513a-5p	mir-506	MIMAT0002877	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	lung cancer	wang y et al.	nat nanotechnol. 6(10):668-74.	nanopore-based detection of circulating micrornas in lung cancer patients.	21892163	2011	nanopore sensor based on the alpha-hemolysin protein	authors show that a nanopore sensor based on the alpha-hemolysin protein selectively detected micrornas at the single molecular level in plasma samples from lung cancer patients without the need for labelling or amplification.
miRNA	hsa-miR-371-5p	mir-290	MIMAT0004687	Homo sapiens	0	circulating	serum	gastric cancer (gc)	liu h et al.	cancer lett. 316(2):196-203.	genome-wide microrna profiles identify mir-378 as a serum biomarker for early detection of gastric cancer.	22169097	2012	qrt-pcr	genome-wide mirna expression profiles followed with real-time quantitative rt-pcr (qrt-pcr) assays revealed that mir-187(*), mir-371-5p and mir-378 were significantly elevated in gc patients. Further validation indicated that mir-378 alone could yields a roc curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating gc patients from healthy controls.
miRNA	hsa-miR-125b	mir-125	MIMAT0000423	Homo sapiens	0	circulating	cerebrospinal fluid	Alzheimer disease (AD)	Alexandrov PN et al.	Int J Biochem Mol Biol. 3(4):365-73.	microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF).	23301201	2012	fluorescent mirna-array-based analysis|led-northern dot-blot assay	the results indicate that mirna-9, mirna-125b, mirna-146a and mirna-155 are csf- and ecf-abundant, nf-кb-sensitive pro-inflammatory mirnas, and their enrichment in circulating csf and ecf suggest that they may be involved in the modulation or proliferation of mirna-triggered pathogenic signaling throughout the brain and central nervous system (cns).
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	1	circulating	serum	hepatitis b virus (hbv)-positive small hepatocellular carcinoma (hcc)	Wang Y et al.	Cancer Biomark. 15(2):177-86. 	Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma.	25519019	2015	qpcr	authors demonstrated the presence of six differentially expressed serum micrornas in hbv-positive small hepatocellular carcinoma compared to other benign liver diseases associated with hbv.
miRNA	hsa-miR-769-5p	mir-769	MIMAT0003886	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	0	circulating	urine	urothelial bladder cancer (bca)	hanke m et al.	urol oncol. 28(6):655-61.	a robust methodology to study urine microrna as tumor marker: microrna-126 and microrna-182 are related to urinary bladder cancer.	19375957	2010	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-106a*	mir-17	MIMAT0004517	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-513b	mir-506	MIMAT0005788	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-423-5p	mir-423	MIMAT0004748	Homo sapiens	0	circulating	plasma	systemic right ventricle and reduced ejection fraction	tutarel o et al.	int j cardiol.	circulating mir-423_5p fails as a biomarker for systemic ventricular function in adults after atrial repair for transposition of the great arteries.	22188991	2011	quantitative reverse transcription pcr|master pure rna purification kit (epicentre biotechnologies)|iscript select cdna synthesis kit (bio-rad)|mirna-specific stem loop primers (applied biosystems)	levels of circulating mir-423-5p showed no difference between patients and controls. Further, there was no correlation between mir-423-5p and parameters of cardiopulmonary exercise testing or imaging findings. In patients with a systemic right ventricle and reduced ejection fraction mir-423-5p levels are not elevated. Therefore, circulating mir-423-5p is not a useful biomarker for heart failure in this patient group.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	cerebrospinal fluid	Alzheimer disease (AD)	Alexandrov PN et al.	Int J Biochem Mol Biol. 3(4):365-73.	microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF).	23301201	2012	fluorescent mirna-array-based analysis|led-northern dot-blot assay	the results indicate that mirna-9, mirna-125b, mirna-146a and mirna-155 are csf- and ecf-abundant, nf-кb-sensitive pro-inflammatory mirnas, and their enrichment in circulating csf and ecf suggest that they may be involved in the modulation or proliferation of mirna-triggered pathogenic signaling throughout the brain and central nervous system (cns).
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	0	circulating	serum	obesity and insulin resistance	Wang R et al.	Eur J Endocrinol. 172(3):291-300. 	Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults.	25515554	2015		authors demonstrated that elevated circulating mir-122 is positively associated with obesity and insulin resistance in young adults. these findings provide a better understanding regarding the role of mirnas in adiposity and insulin sensitivity.
miRNA	hsa-miR-801			Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-199a	mir-199	MIMAT0000231	Homo sapiens	0	circulating	urine	urothelial bladder cancer (bca)	hanke m et al.	urol oncol. 28(6):655-61.	a robust methodology to study urine microrna as tumor marker: microrna-126 and microrna-182 are related to urinary bladder cancer.	19375957	2010	mirneasy kit (qiagen, hilden, germany)|quantitative reverse transcriptase-polymerase chain reaction|taqman microrna assay kits (applied biosystems, darmstadt, germany)|taqman microrna reverse transcription kit (applied biosystems, darmstadt, germany)	this study describes a novel, robust, and useful technology platform that is suitable to analyze small rnas, including novel rna-based tumor markers, in urine samples. A detailed technical analysis of this methodology provides new insights into the characteristics of urine microrna such as composition and the donor-dependent variability.
miRNA	hsa-miR-142-5p	mir-142	MIMAT0000433	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-151-3p	mir-28	MIMAT0000757	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-513c	mir-506	MIMAT0005789	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	gastric cancer (gc)	song j et al.	dig dis sci. 57(4):897-904.	identification of suitable reference genes for qpcr analysis of serum microrna in gastric cancer patients.	22198701	2012	qpcr	authors recommend mir-16 and mir-93 as suitable reference genes for serum mirna analysis for gastric cancer patients and healthy controls.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	cerebrospinal fluid	Alzheimer disease (AD)	Alexandrov PN et al.	Int J Biochem Mol Biol. 3(4):365-73.	microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF).	23301201	2012	fluorescent mirna-array-based analysis|led-northern dot-blot assay	the results indicate that mirna-9, mirna-125b, mirna-146a and mirna-155 are csf- and ecf-abundant, nf-кb-sensitive pro-inflammatory mirnas, and their enrichment in circulating csf and ecf suggest that they may be involved in the modulation or proliferation of mirna-triggered pathogenic signaling throughout the brain and central nervous system (cns).
miRNA	hsa-miR-520h	mir-515	MIMAT0002867	Homo sapiens	1	circulating	plasma	gestational hypertension	Hromadnikova I et al.	PLoS One. 9(12):e113735. 	First trimester screening of circulating C19MC microRNAs can predict subsequent onset of gestational hypertension.	25502889	2014	real-time pcr	authors demonstrated that the first trimester screening of extracellular mir-520h alone or in combination with mir-518b identified a significant proportion of women with subsequent gestational hypertension.
miRNA	hsa-miR-9	mir-9	MIMAT0000441	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	0	circulating	serum	Breast cancer	zhu w et al.	bmc res notes. 2:89	circulating micrornas in breast cancer and healthy subjects.	19454029	2009	taqman microrna reverse transcription kit (applied biosystems catalog # 4366596)	the expression of mirnas was similar in samples from healthy women compared to those with breast cancer, women with progesterone receptor (pr, p = 0.016) positive tumors had higher mir-155 expression than tumors that were negative for these receptors.
miRNA	hsa-miR-143	mir-143	MIMAT0000435	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-518c*	mir-515	MIMAT0002847	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-126*	mir-126	MIMAT0000444	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	circulating	serum	gastric cancer (gc)	song j et al.	dig dis sci. 57(4):897-904.	identification of suitable reference genes for qpcr analysis of serum microrna in gastric cancer patients.	22198701	2012	qpcr	authors recommend mir-16 and mir-93 as suitable reference genes for serum mirna analysis for gastric cancer patients and healthy controls.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	1	circulating	plasma	thoracic aortic aneurysm (taa)	Ikonomidis JS et al.	J Thorac Cardiovasc Surg. pii: S0022-5223(12)01571	Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.	23312977	2013	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
miRNA	hsa-miR-518b	mir-515	MIMAT0002844	Homo sapiens	0	circulating	plasma	gestational hypertension	Hromadnikova I et al.	PLoS One. 9(12):e113735. 	First trimester screening of circulating C19MC microRNAs can predict subsequent onset of gestational hypertension.	25502889	2014	real-time pcr	authors demonstrated that mir-518b, particularly in combination with extracellular mir-520h, is associated with a risk of later development of gestational hypertension. 
miRNA	hsa-miR-92	mir-25	MIMAT0000092	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	serum	Breast cancer	zhu w et al.	bmc res notes. 2:89	circulating micrornas in breast cancer and healthy subjects.	19454029	2009	taqman microrna reverse transcription kit (applied biosystems catalog # 4366596)	the expression of mirnas was similar in samples from healthy women compared to those with breast cancer, women with progesterone receptor (pr, p = 0.016) positive tumors had higher mir-155 expression than tumors that were negative for these receptors.
miRNA	hsa-miR-144	mir-144	MIMAT0000436	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-10b	mir-10	MIMAT0000254	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-542-5p	mir-542	MIMAT0003340	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-1826			Homo sapiens	1	circulating	plasma	Multiple sclerosis (MS)	Siegel SR et al.	Mol Biol Rep. 39(5):6219-25.	Circulating microRNAs involved in multiple sclerosis.	22231906	2012	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	thoracic aortic aneurysm (taa)	Ikonomidis JS et al.	J Thorac Cardiovasc Surg. pii: S0022-5223(12)01571	Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.	23312977	2013	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	1	circulating	serum	osteoarthritis (oa)	Beyer C et al.	Ann Rheum Dis. 74(3):e18.	Signature of circulating microRNAs in osteoarthritis.	24515954	2015	real-time pcr	this is the first study that identifies differentially expressed circulating micrornas in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. among these micrornas, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.
miRNA	hsa-miR-92b	mir-25	MIMAT0003218	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	Breast cancer	zhu w et al.	bmc res notes. 2:89	circulating micrornas in breast cancer and healthy subjects.	19454029	2009	taqman microrna reverse transcription kit (applied biosystems catalog # 4366596)	the expression of mirnas was similar in samples from healthy women compared to those with breast cancer, women with progesterone receptor (pr, p = 0.016) positive tumors had higher mir-155 expression than tumors that were negative for these receptors.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-190b	mir-190	MIMAT0004929	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-10b*	mir-10	MIMAT0004556	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-134	mir-134	MIMAT0000447	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-1979		MIMAT0009454	Homo sapiens	1	circulating	plasma	Multiple sclerosis (MS)	Siegel SR et al.	Mol Biol Rep. 39(5):6219-25.	Circulating microRNAs involved in multiple sclerosis.	22231906	2012	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	circulating	plasma	thoracic aortic aneurysm (taa)	Ikonomidis JS et al.	J Thorac Cardiovasc Surg. pii: S0022-5223(12)01571	Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.	23312977	2013	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	blood	Asthma	Jiang R et al.	Part Fibre Toxicol. 11(1):71.	Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics.	25487561	2014		authors demonstrated that short-term exposure to diesel exhaust resulted in dna methylation changes at cpg sites residing in genes involved in inflammation and oxidative stress response, repetitive elements, and microrna.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	1	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-146b-5p	mir-146	MIMAT0002809	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-1224-5p	mir-1224	MIMAT0005458	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-575	mir-575	MIMAT0003240	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-139-3p	mir-139	MIMAT0004552	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	1	exosome	plasma	Multiple sclerosis (MS)	Siegel SR et al.	Mol Biol Rep. 39(5):6219-25.	Circulating microRNAs involved in multiple sclerosis.	22231906	2012	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	circulating	plasma	thoracic aortic aneurysm (taa)	Ikonomidis JS et al.	J Thorac Cardiovasc Surg. pii: S0022-5223(12)01571	Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.	23312977	2013	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
miRNA	hsa-miR-196a	mir-196	MIMAT0000226	Homo sapiens	1	circulating	plasma	oral cancer	Lu YC et al.	Clin Biochem. 48(3):115-21.	Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer.	25485932	2015		authors demonstrated that the combined determination of circulating mir-196a and mir-196b levels may serve as panel plasma biomarkers for the early detection of oral cancer.
miRNA	hsa-miR-95	mir-95	MIMAT0000094	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	1	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-1225-5p	mir-1225	MIMAT0005572	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-584	mir-584	MIMAT0003249	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-422a	mir-422	MIMAT0001339	Homo sapiens	1	circulating	plasma	Multiple sclerosis (MS)	Siegel SR et al.	Mol Biol Rep. 39(5):6219-25.	Circulating microRNAs involved in multiple sclerosis.	22231906	2012	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
miRNA	hsa-miR-143	mir-143	MIMAT0000435	Homo sapiens	0	circulating	plasma	thoracic aortic aneurysm (taa)	Ikonomidis JS et al.	J Thorac Cardiovasc Surg. pii: S0022-5223(12)01571	Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.	23312977	2013	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
miRNA	hsa-miR-196b	mir-196	MIMAT0001080	Homo sapiens	1	circulating	plasma	oral cancer	Lu YC et al.	Clin Biochem. 48(3):115-21.	Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer.	25485932	2015		authors demonstrated that the combined determination of circulating mir-196a and mir-196b levels may serve as panel plasma biomarkers for the early detection of oral cancer.
miRNA	hsa-miR-96	mir-96	MIMAT0000095	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-134	mir-134	MIMAT0000447	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-1226*	mir-1226	MIMAT0005576	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-590-5p	mir-590	MIMAT0003258	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-190	mir-190	MIMAT0000458	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-572	mir-572	MIMAT0003237	Homo sapiens	1	circulating	plasma	Multiple sclerosis (MS)	Siegel SR et al.	Mol Biol Rep. 39(5):6219-25.	Circulating microRNAs involved in multiple sclerosis.	22231906	2012	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	0	circulating	plasma	thoracic aortic aneurysm (taa)	Ikonomidis JS et al.	J Thorac Cardiovasc Surg. pii: S0022-5223(12)01571	Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.	23312977	2013	Quantitative PCR	significant (p < .05) differences in standardized mir-1 and mir-21 abundance between bav and tav aortic tissue samples and different tissue and plasma profiles of analyte differences from normal aorta where observed between the bav and tav groups.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	Breast cancer	Muller V et al.	Breast Cancer Res Treat. 147(1):61-8.	Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial.	25086636	2014	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
miRNA	hsa-miR-98	let-7	MIMAT0000096	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-125a-3p	mir-125	MIMAT0004602	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-610	mir-610	MIMAT0003278	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-614	mir-614	MIMAT0003282	Homo sapiens	1	circulating	plasma	Multiple sclerosis (MS)	Siegel SR et al.	Mol Biol Rep. 39(5):6219-25.	Circulating microRNAs involved in multiple sclerosis.	22231906	2012	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
miRNA	hsa-miR-34a	mir-34	MIMAT0000255	Homo sapiens	1	circulating	serum	Acute myocardial infarction (ami)	Fan F et al.	Curr Pharm Des.	MicroRNA-34a Promotes Cardiomyocyte Apoptosis Post Myocardial Infarction Through Down-regulating Aldehyde Dehydrogenase 2.	23323620	2013		serum mir-34a levels in acute myocardial infarction (ami) patients and rats were significantly higher than healthy subjects and sham rats. results proved that mir-34a could promote cardiomyocyte apoptosis via negatively regulating aldh2 and circulating mir-34a was increased in the condition of mi. thus, mir-34a may constitute a new therapeutic target and diagnostic marker for patients with mi.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	1	circulating	serum	Breast cancer	Muller V et al.	Breast Cancer Res Treat. 147(1):61-8.	Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial.	25086636	2014	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
miRNA	hsa-miR-99a	mir-99	MIMAT0000097	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-17-3p	mir-17	MIMAT0000071	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-125b-1*	mir-125	MIMAT0004592	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-632	mir-632	MIMAT0003302	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-20a*	mir-17	MIMAT0004493	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-648	mir-648	MIMAT0003318	Homo sapiens	1	circulating	plasma	Multiple sclerosis (MS)	Siegel SR et al.	Mol Biol Rep. 39(5):6219-25.	Circulating microRNAs involved in multiple sclerosis.	22231906	2012	MirVana Paris kit (Applied Biosystems, Foster City, CA, USA)|Nanodrop and the Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, A, USA)|real time PCR	Authors identified six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly downregulated in MS individuals. The present study is the first to show a circulating miRNA signature involved in MS that could serve as a potential prognostic and diagnostic biomarker for MS.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	serum	sepsis	Roderburg C et al.	PLoS One. 8(1):e54612.	Circulating MicroRNA-150 Serum Levels Predict Survival in Patients with Critical Illness and Sepsis.	23372743	2013	quantitative real-time pcr	measurements of mir-150 serum concentrations revealed only slightly reduced mir-150 serum levels in critically ill patients compared to healthy controls. furthermore mir-150 levels did not significantly differ in critically ill patients with our without sepsis, indicating that mir-150 serum levels are not suitable for diagnostic establishment of sepsis.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	1	circulating	serum	Breast cancer	Muller V et al.	Breast Cancer Res Treat. 147(1):61-8.	Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial.	25086636	2014	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
miRNA	hsa-miR-99b	mir-99	MIMAT0000689	Homo sapiens	0	exosome	serum	papillary adenocarcinoma of ovary	taylor dd et al.	gynecol oncol.110(1):13-21.	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.	18589210	2008	467microrna array	microrna signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
miRNA	hsa-miR-181d	mir-181	MIMAT0002821	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-30a	mir-30	MIMAT0000087	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-125b-2*	mir-125	MIMAT0004603	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-654-5p	mir-654	MIMAT0003330	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-301a	mir-130	MIMAT0000688	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-218	mir-218	MIMAT0000275	Homo sapiens	0	circulating	serum	Cervical cancer	yu j et al.	j cancer res clin oncol. 138(4):671-4.	circulating microrna-218 was reduced in cervical cancer and correlated with tumor invasion.	22237456	2012	quantitative real-time pcr	in the cancer group, microrna-218 was reduced significantly in the sera (p < 0.001). Moreover, decreased microrna-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	1	circulating	serum	Chronic type C hepatitis	van der Meer AJ et al.	J Viral Hepat. 20(3):158-66.	Sensitive detection of hepatocellular injury in chronic hepatitis C patients with circulating hepatocyte-derived microRNA-122.	23383654	2013		mir-122 is a sensitive marker to distinguish chronic hepatitis c patients from healthy controls.
miRNA	hsa-miR-373	mir-373	MIMAT0000726	Homo sapiens	1	circulating	serum	Breast cancer	Muller V et al.	Breast Cancer Res Treat. 147(1):61-8.	Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial.	25086636	2014	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	circulating	plasma	prostate cancer	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-128	mir-128	MIMAT0000424	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-658	mir-658	MIMAT0003336	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30a	mir-30	MIMAT0000087	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	1	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	circulating	serum	Chronic type C hepatitis	van der Meer AJ et al.	J Viral Hepat. 20(3):158-66.	Sensitive detection of hepatocellular injury in chronic hepatitis C patients with circulating hepatocyte-derived microRNA-122.	23383654	2013		mir-122 is a sensitive marker to distinguish chronic hepatitis c patients from healthy controls.
miRNA	hsa-miR-373	mir-373	MIMAT0000726	Homo sapiens	1	circulating	serum	Breast cancer	Muller V et al.	Breast Cancer Res Treat. 147(1):61-8.	Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial.	25086636	2014	taqman microrna assays	authors demonstrate a specific influence of neoadjuvant therapy on the serum levels of mir-21, mir-210, and mir-373 in breast cancer patients together with a prognostic value of mir-21.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-342-3p	mir-342	MIMAT0000753	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-129-5p	mir-129	MIMAT0000242	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-662	mir-662	MIMAT0003325	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30d	mir-30	MIMAT0000245	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	1	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	type 2 diabetes	de Boer HC et al.	Eur Heart J.	Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease.	23386708	2013	in vitro and in vivo platelet activation	in vitro platelet activation resulted in the transfer of mir-126 from the platelet to the plasma compartment, which was prevented by aspirin. in vivo platelet activation, monitored in patients with dm2 by measuring soluble p-selectin, correlated directly with circulating levels of mir-126. platelets are a major source of circulating mir-126. consequently, in patho-physiological conditions associated with platelet activation, such as diabetes type 2, the administration of aspirin may lead to reduced levels of circulating mir-126.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	1	circulating	serum	Cholangiocarcinoma	Silakit R et al.	J Hepatobiliary Pancreat Sci. 21(12):864-72.	Circulating miR-192 in liver fluke-associated cholangiocarcinoma patients: a prospective prognostic indicator.	25131257	2014	taqman microrna assays	authors indicate that elevated levels of mir-192 may be involved in cca genesis and have a potential utility as a noninvasive prognostic indicator for cca patients.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-130b	mir-130	MIMAT0000691	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-671-5p	mir-671	MIMAT0003880	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30e	mir-30	MIMAT0000692	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	1	exosome	urine	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	1	circulating	plasma	Chronic type C hepatitis	Shrivastava S et al.	Hepatology	Upregulation of circulating miR-20a is correlated with hepatitis C virus mediated liver disease progression.	23390075	2013		plasma/serum levels of mir-20a and mir-92a have potential as sensitive and cost effective biomarkers for early detection of hcv infection. the circulating mir-20a may serve as a potential for predictive biomarker in hcv mediated fibrosis.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	1	circulating	plasma	gastric cancer (gc)	Fu Z et al.	Med Oncol. 31(9):164.	Circulating miR-222 in plasma and its potential diagnostic and prognostic value in gastric cancer.	25129310	2014	qrt-pcr	authors suggest that circulating mir-222 in plasma might be a potential and useful noninvasive biomarker for the early detection and prognosis of gc.
miRNA	hsa-let-7c	let-7	MIMAT0000064	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-18b	mir-17	MIMAT0001412	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-520c-3p	mir-515	MIMAT0002846	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-132	mir-132	MIMAT0000426	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-744*	mir-744	MIMAT0004946	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	1	exosome	urine	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	1	circulating	plasma	Chronic type C hepatitis	Shrivastava S et al.	Hepatology	Upregulation of circulating miR-20a is correlated with hepatitis C virus mediated liver disease progression.	23390075	2013		plasma/serum levels of mir-20a and mir-92a have potential as sensitive and cost effective biomarkers for early detection of hcv infection. the circulating mir-20a may serve as a potential for predictive biomarker in hcv mediated fibrosis.
miRNA	hsa-miR-196a	mir-196	MIMAT0000226	Homo sapiens	1	circulating	serum	pancreatic cancer	Slater EP et al.	Transl Oncol. 7(4):464-71.	MicroRNA-196a and -196b as Potential Biomarkers for the Early Detection of Familial Pancreatic Cancer.	24956938	2014	real-time pcr	authors demonstrate that the combination of mir-196a and -196b may be a promising biomarker test for the screening of iar for fpc.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-601	mir-601	MIMAT0003269	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-134	mir-134	MIMAT0000447	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-760	mir-760	MIMAT0004957	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-340*	mir-340	MIMAT0000750	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	1	circulating	serum	Chronic type C hepatitis	Shrivastava S et al.	Hepatology	Upregulation of circulating miR-20a is correlated with hepatitis C virus mediated liver disease progression.	23390075	2013		plasma/serum levels of mir-20a and mir-92a have potential as sensitive and cost effective biomarkers for early detection of hcv infection. the circulating mir-20a may serve as a potential for predictive biomarker in hcv mediated fibrosis.
miRNA	hsa-miR-196b	mir-196	MIMAT0001080	Homo sapiens	1	circulating	serum	pancreatic cancer	Slater EP et al.	Transl Oncol. 7(4):464-71.	MicroRNA-196a and -196b as Potential Biomarkers for the Early Detection of Familial Pancreatic Cancer.	24956938	2014	real-time pcr	authors demonstrate that the combination of mir-196a and -196b may be a promising biomarker test for the screening of iar for fpc.
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-320a	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	Advanced colorectal neoplasia (carcinomas and advanced adenomas)	huang z et al.	int j cancer. 127(1):118-26.	plasma micrornas are promising novel biomarkers for early detection of colorectal cancer.	19876917	2010	real-time rt-pcr	the aim of this study was to investigate whether plasma mirnas can be used as biomarkers for the early detection of colorectal carcinoma (crc) and were measured the levels of 12 mirnas (mir-134, -146a, -17-3p, -181d, -191, -221, -222, -223, -25, -29a, -320a and -92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real-time rt-pcr.
miRNA	hsa-miR-193a-5p	mir-193	MIMAT0004614	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-618	mir-618	MIMAT0003287	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-135a*	mir-135	MIMAT0004595	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-769-5p	mir-769	MIMAT0003886	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-362-5p	mir-362	MIMAT0000705	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-198	mir-198	MIMAT0000228	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	1	circulating	serum	Chronic type C hepatitis	Shrivastava S et al.	Hepatology	Upregulation of circulating miR-20a is correlated with hepatitis C virus mediated liver disease progression.	23390075	2013		plasma/serum levels of mir-20a and mir-92a have potential as sensitive and cost effective biomarkers for early detection of hcv infection. the circulating mir-20a may serve as a potential for predictive biomarker in hcv mediated fibrosis.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	1	circulating	serum	non-alcoholic fatty liver disease (nafld)	Pirola CJ et al.	Gut. 64(5):800-12.	Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis.	24973316	2015	rt-pcr	authors demonstrate that nafld has a distinguishing circulating mirna profile associated with a global dysmetabolic disease state and cardiovascular risk.
miRNA	hsa-let-7g	let-7	MIMAT0000414	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	1	circulating	plasma	Acute myocardial infarction (ami)	ai j et al.	biochem biophys res commun.391(1):73-7.	circulating microrna-1 as a potential novel biomarker for acute myocardial infarction.	19896465	2010	real-time rt-pcr	in the present study, were recruited 159 patients with or without ami for quantification of mir-1 level in plasma using real-time rt-pcr method. Circulating mir-1 may be a novel, independent biomarker for diagnosis of ami.
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-628-5p	mir-628	MIMAT0004809	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-138-2*	mir-138	MIMAT0004596	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-885-5p	mir-885	MIMAT0004947	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-374a	mir-374	MIMAT0000727	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-326	mir-326	MIMAT0000756	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	1	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	1	circulating	serum	non-alcoholic fatty liver disease (nafld)	Pirola CJ et al.	Gut. 64(5):800-12.	Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis.	24973316	2015	rt-pcr	authors demonstrate that nafld has a distinguishing circulating mirna profile associated with a global dysmetabolic disease state and cardiovascular risk.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-208a	mir-208	MIMAT0000241	Homo sapiens	1	circulating	plasma	Acute myocardial infarction (ami)	wang gk et al.	eur heart j. 31(6):659-66.	circulating microrna: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans.	20159880	2010	taqman mirna quantitative reverse transcriptase polymerase chain reaction (qrt-pcr) assay	elevated cardiac-specific mir-208a in plasma may be a novel biomarker for early detection of myocardial injury in humans.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-646	mir-646	MIMAT0003316	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-140-3p	mir-140	MIMAT0004597	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-9	mir-9	MIMAT0000441	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-382	mir-154	MIMAT0000737	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-379	mir-379	MIMAT0000733	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt-pcr microarray|taqman human mir assays(life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	1	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	hsa-miR-379	mir-379	MIMAT0000733	Homo sapiens	0	circulating	cell lysates	Dysfunctional lipid homeostasis	de Guia RM et al.	EMBO J. 34(3):344-60. 	microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis.	25510864	2015	taqman real-time pcr microrna array	authors demonstrated that hepatic mir-379 levels were correlated with glucocorticoid (gc) and triglyceride (tg) levels in human obese patients. the identification of a gc/gr(glucocorticoid receptor)-controlled mirna cluster not only defines a novel layer of hormone-dependent metabolic control but also paves the way to alternative mirna-based therapeutic approaches in metabolic dysfunction.
miRNA	hsa-miR-101	mir-101	MIMAT0000099	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-1	mir-1	MIMAT0000416	Homo sapiens	0	circulating	serum	Acute myocardial infarction (ami)	cheng y et al.	clin sci (lond). 119(2):87-95.	a translational study of circulating cell-free microrna-1 in acute myocardial infarction.	20218970	2010	qrt-pcr with a roche lightcycler 480 detection system	the levels of circulating cell-free mir-1 were significantly increased in patients with ami (acute myocardial infarction) and had a positive correlation with serum ck-mb (creatine kinase-mb) levels.
miRNA	hsa-miR-1979		MIMAT0009454	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage i-ii)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-140-5p	mir-140	MIMAT0000431	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-936	mir-936	MIMAT0004979	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-410	mir-154	MIMAT0002171	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-432	mir-432	MIMAT0002814	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-30d	mir-30	MIMAT0000245	Homo sapiens	1	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	hsa-miR-454	mir-454	MIMAT0003885	Homo sapiens	0	circulating	serum	osteoarthritis (oa)	Beyer C et al.	Ann Rheum Dis. 74(3):e18.	Signature of circulating microRNAs in osteoarthritis.	24515954	2015	real-time pcr	this is the first study that identifies differentially expressed circulating micrornas in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. among these micrornas, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-let-7a	let-7	MIMAT0000062	Homo sapiens	0	circulating	plasma	gastric cancer (gc)	tsujiura m et al.	br j cancer. 102(7):1174-9 	circulating micrornas in plasma of patients with gastric cancers.	20234369	2010	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-939	mir-939	MIMAT0004982	Homo sapiens	0	exosome	b cells	raji	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-485-3p	mir-485	MIMAT0002176	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	hsa-miR-885-5p	mir-885	MIMAT0004947	Homo sapiens	0	circulating	serum	osteoarthritis (oa)	Beyer C et al.	Ann Rheum Dis. 74(3):e18.	Signature of circulating microRNAs in osteoarthritis.	24515954	2015	real-time pcr	this is the first study that identifies differentially expressed circulating micrornas in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. among these micrornas, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	gastric cancer (gc)	tsujiura m et al.	br j cancer. 102(7):1174-9 	circulating micrornas in plasma of patients with gastric cancers.	20234369	2010	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-141*	mir-8	MIMAT0004598	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7b	let-7	MIMAT0000063	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-489	mir-489	MIMAT0002805	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-572	mir-572	MIMAT0003237	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	hsa-miR-1254	mir-1254	MIMAT0005905	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Zhao Z et al.	Tumour Biol. 35(6):5227-35.	Dysregulated miR1254 and miR579 for cardiotoxicity in patients treated with bevacizumab in colorectal cancer.	24515657	2014	microrna array	authors identify two mirnas that are specifically elevated in patients with bevacizumab-induced cardiotoxicity, mir1254 and mirna579, and mirna1254 shows the strongest correlation to the clinical diagnosis of bevacizumab-induced cardiotoxicity.
miRNA	hsa-miR-107	mir-103	MIMAT0000104	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	circulating	plasma	gastric cancer (gc)	tsujiura m et al.	br j cancer. 102(7):1174-9 	circulating micrornas in plasma of patients with gastric cancers.	20234369	2010	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-520g	mir-515	MIMAT0002858	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-577	mir-577	MIMAT0003242	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	hsa-miR-579	mir-548	MIMAT0003244	Homo sapiens	1	circulating	plasma	Colorectal cancer (crc)	Zhao Z et al.	Tumour Biol. 35(6):5227-35.	Dysregulated miR1254 and miR579 for cardiotoxicity in patients treated with bevacizumab in colorectal cancer.	24515657	2014	microrna array	authors identify two mirnas that are specifically elevated in patients with bevacizumab-induced cardiotoxicity, mir1254 and mirna579, and mirna1254 shows the strongest correlation to the clinical diagnosis of bevacizumab-induced cardiotoxicity.
miRNA	hsa-miR-125a	mir-125	MIMAT0000443	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-17-5p	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	gastric cancer (gc)	tsujiura m et al.	br j cancer. 102(7):1174-9 	circulating micrornas in plasma of patients with gastric cancers.	20234369	2010	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-142-5p	mir-142	MIMAT0000433	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-140	mir-140	MIMAT0000431	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-548b-5p	mir-548	MIMAT0004798	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-609	mir-609	MIMAT0003277	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	mmu-miR-28-5p	mir-28	MIMAT0000653	Mus musculus	1	circulating	serum	perfluorooctanoic acid (pfoa) exposure	Yan S et al.	Toxicol Lett. pii: S0378-4274(13)01360-X.	Circulating MicroRNA Profiles Altered in Mice after 28 Days Exposure to Perfluorooctanoic Acid.	24513432	2013	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	gastric cancer (gc)	tsujiura m et al.	br j cancer. 102(7):1174-9 	circulating micrornas in plasma of patients with gastric cancers.	20234369	2010	qrt-pcr taqman microrna assay kits (applied biosystems, foster city, ca, usa)|taqman microrna reverse transcription kit (applied biosystems)	mirnas were stable and detectable in all plasma samples, and the plasma mirna levels reflected the tumour mirnas in most cases. The levels of these mirnas were significantly reduced in post-operative samples. In large-scale analysis, the plasma concentrations of mirnas (mir-17-5p, mir-21, mir-106a, mir-106b) were significantly higher in gc patients than controls (p=0.05, 0.006, 0.008 and <0.001 respectively), whereas let-7a was lower in gc patients (p=0.002).
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-619	mir-619	MIMAT0003288	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	mmu-miR-32-5p	mir-32	MIMAT0000654	Mus musculus	1	circulating	serum	perfluorooctanoic acid (pfoa) exposure	Yan S et al.	Toxicol Lett. pii: S0378-4274(13)01360-X.	Circulating MicroRNA Profiles Altered in Mice after 28 Days Exposure to Perfluorooctanoic Acid.	24513432	2013	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	plasma	pancreatic cancer	ho as et al.	transl oncol. 3(2):109-13.	circulating mir-210 as a novel hypoxia marker in pancreatic cancer.	20360935	2010	reverse transcription-pcr (qrt-pcr)|taqman microrna assays (applied biosystems, foster city, ca)	circulating mir-210 levels are elevated in pancreatic cancer patients and may potentially serve as a useful biomarker for pancreatic cancer diagnosis.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-146b-5p	mir-146	MIMAT0002809	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-610	mir-610	MIMAT0003278	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-1236	mir-1236	MIMAT0005591	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	mmu-miR-122-5p	mir-122	MIMAT0000246	Mus musculus	1	circulating	serum	perfluorooctanoic acid (pfoa) exposure	Yan S et al.	Toxicol Lett. pii: S0378-4274(13)01360-X.	Circulating MicroRNA Profiles Altered in Mice after 28 Days Exposure to Perfluorooctanoic Acid.	24513432	2013	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
miRNA	hsa-miR-127	mir-127	MIMAT0000446	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-134	mir-134	MIMAT0000447	Homo sapiens	1	circulating	plasma	Bipolar disorder (bd)	rong h et al.	j psychiatr res. 45(1):92-5.	microrna-134 plasma levels before and after treatment for bipolar mania.	20546789	2011	real-time rt-pcr	decreased plasma mir-134 levels may be directly associated with the pathophysiology and severity of manic symptoms in bipolar disorder (bd)
miRNA	hsa-miR-215	mir-192	MIMAT0000272	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-632	mir-632	MIMAT0003302	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-2110	mir-2110	MIMAT0010133	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	1	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	mmu-miR-192-5p	mir-192	MIMAT0000517	Mus musculus	1	circulating	serum	perfluorooctanoic acid (pfoa) exposure	Yan S et al.	Toxicol Lett. pii: S0378-4274(13)01360-X.	Circulating MicroRNA Profiles Altered in Mice after 28 Days Exposure to Perfluorooctanoic Acid.	24513432	2013	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
miRNA	hsa-miR-130a	mir-130	MIMAT0000425	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	circulating	serum	Chronic pancreatitis	li a et al.	cancer res. 70(13):5226-37	pancreatic cancers epigenetically silence sip1 and hypomethylate and overexpress mir-200a/200b in association with elevated circulating mir-200a and mir-200b levels.	20551052	2010	mirvana paris kit (ambion 1556)|taqman microrna assays and taqman microrna reverse transcription kit (applied biosystems)	both mir-200a and mir-200b were significantly elevated in the sera of pancreatic cancer and chronic pancreatitis patients compared with healthy controls (p < 0.0001).
miRNA	hsa-miR-22	mir-22	MIMAT0000077	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-148a*	mir-148	MIMAT0004549	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-7	mir-7	MIMAT0000252	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-130b	mir-130	MIMAT0000691	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	mmu-miR-26b-5p	mir-26	MIMAT0000534	Mus musculus	1	circulating	serum	perfluorooctanoic acid (pfoa) exposure	Yan S et al.	Toxicol Lett. pii: S0378-4274(13)01360-X.	Circulating MicroRNA Profiles Altered in Mice after 28 Days Exposure to Perfluorooctanoic Acid.	24513432	2013	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
miRNA	hsa-miR-130b	mir-130	MIMAT0000691	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	0	circulating	serum	Chronic pancreatitis	li a et al.	cancer res. 70(13):5226-37	pancreatic cancers epigenetically silence sip1 and hypomethylate and overexpress mir-200a/200b in association with elevated circulating mir-200a and mir-200b levels.	20551052	2010	mirvana paris kit (ambion 1556)|taqman microrna assays and taqman microrna reverse transcription kit (applied biosystems)	both mir-200a and mir-200b were significantly elevated in the sera of pancreatic cancer and chronic pancreatitis patients compared with healthy controls (p < 0.0001).
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-768-3p			Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-17*	mir-17	MIMAT0000071	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	mmu-miR-26b-5p	mir-26	MIMAT0000534	Homo sapiens	1	circulating	serum	perfluorooctanoic acid (pfoa) exposure	Yan S et al.	Toxicol Lett. pii: S0378-4274(13)01360-X.	Circulating MicroRNA Profiles Altered in Mice after 28 Days Exposure to Perfluorooctanoic Acid.	24513432	2013	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
miRNA	hsa-miR-133b	mir-133	MIMAT0000770	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	circulating	serum	pancreatic cancer	li a et al.	cancer res. 70(13):5226-37	pancreatic cancers epigenetically silence sip1 and hypomethylate and overexpress mir-200a/200b in association with elevated circulating mir-200a and mir-200b levels.	20551052	2010	mirvana paris kit (ambion 1556)|taqman microrna assays and taqman microrna reverse transcription kit (applied biosystems)	both mir-200a and mir-200b were significantly elevated in the sera of pancreatic cancer and chronic pancreatitis patients compared with healthy controls (p < 0.0001).
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-149*	mir-149	MIMAT0004609	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-30e	mir-30	MIMAT0000692	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-923		MIMAT0004973	Homo sapiens	0	circulating	plasma	Acute pulmonary embolism (ape)	xiao j et al.	j transl med. 9:159.	microrna-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.	21943159	2011	7900ht fast real-time pcr system (applied biosystems, foster city, ca)	alterations in plasma microrna levels in patients with an acute pulmonary embolism (ape) compared to healthy controls. Plasma mirna-134 (mir-134) level was significantly higher in the ape patients than in the healthy controls or non-ape patients.
miRNA	hsa-miR-181a-2*	mir-181	MIMAT0004558	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	malignant effusions	lung cancer	Xie L et al.	BMC Cancer. 10:591.	Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions.	21029414	2010	qRT-PCR	Authors compared the miRNA expression levels between benign and malignant effusions using a Mann-Whitney U test and found miR-24, miR-26a and miR-30d were expressed differently between the two groups (P = 0.006, 0.021 and 0.011, respectively). Cells isolated from effusions rich in cell-free miR-152 were more sensitive to docetaxel (r = 0.60, P = 0.016).
miRNA	mmu-miR-199a-3p	mir-199	MIMAT0000230	Homo sapiens	1	circulating	serum	perfluorooctanoic acid (pfoa) exposure	Yan S et al.	Toxicol Lett. pii: S0378-4274(13)01360-X.	Circulating MicroRNA Profiles Altered in Mice after 28 Days Exposure to Perfluorooctanoic Acid.	24513432	2013	taqman microrna array	circulating mirna profiles were altered after exposure to high concentrations of pfoa and mir-28-5p, mir-32-5p, mir-122-5p, mir-192-5p, and mir-26b-5p in serum may be linked to effects of pfoa, especially in occupationally exposed people.
miRNA	hsa-miR-134	mir-134	MIMAT0000447	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	0	circulating	serum	pancreatic cancer	li a et al.	cancer res. 70(13):5226-37	pancreatic cancers epigenetically silence sip1 and hypomethylate and overexpress mir-200a/200b in association with elevated circulating mir-200a and mir-200b levels.	20551052	2010	mirvana paris kit (ambion 1556)|taqman microrna assays and taqman microrna reverse transcription kit (applied biosystems)	both mir-200a and mir-200b were significantly elevated in the sera of pancreatic cancer and chronic pancreatitis patients compared with healthy controls (p < 0.0001).
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-499	mir-499	MIMAT0002870	Homo sapiens	1	circulating	plasma	troponin-positive acute coronary syndrome	de rosa s et al.	circulation. 124(18):1936-44.	transcoronary concentration gradients of circulating micrornas.	21969012	2011	taqman polymerase chain reaction in edta-plasma 	circulating levels of the muscle-enriched mir-499, mir-133a, and mir-208a were significantly elevated in the aorta of troponin-positive acute coronary syndrome patients compared with patients with coronary artery disease. In contrast, circulating levels of mir-126 decreased during transcoronary passage in patients with evidence of myocardial injury, suggesting consumption during transcoronary passage.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-122	mir-122	MIMAT0000421	Homo sapiens	1	circulating	serum	Acetaminophen-induced acute liver injury (APAP-ALI)	Starkey Lewis PJ et al.	Hepatology. 54(5):1767-76.	Circulating microRNAs as potential markers of human drug-induced liver injury.	22045675	2011	miRNeasy kit (Qiagen, Venlo, Netherlands)|Taqman-based quantitative polymerase chain reaction (PCR)|stem-loop reverse-transcription RT primers (Applied Biosystems, Foster City, CA)	Serum miR-122 and miR-192 were substantially higher in APAP-ALI patients, compared to healthy controls.
miRNA	mmu-miR-424	mir-322	MIMAT0000548	Mus musculus	0	circulating	peri-infarct cortex	Cerebral ischemia	Liu P et al.	Stroke. 46(2):513-9.	MicroRNA-424 protects against focal cerebral ischemia and reperfusion injury in mice by suppressing oxidative stress.	25523055	2015	real-time pcr	authors demonstrated that mir-424 protects against transient cerebral ischemia/reperfusion injury by inhibiting oxidative stress.
miRNA	hsa-miR-140	mir-140	MIMAT0000431	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-let-7f	let-7	MIMAT0000067	Homo sapiens	1	circulating	plasma	non small cell lung cancer (nsclc)	silva j et al.	eur respir j. 37(3):617-23.	vesicle-related micrornas in plasma of nonsmall cell lung cancer patients and correlation with survival.	20595154	2011	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-150*	mir-150	MIMAT0004610	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-93	mir-17	MIMAT0000093	Homo sapiens	1	circulating	serum	pediatric crohn disease	zahm am et al.	j pediatr gastroenterol nutr. 53(1):26-33.	circulating microrna is a biomarker of pediatric crohn disease.	21546856	2011	low-density array qrt-pcr	all of the candidate biomarker mirnas were confirmed in an independent cd sample set (n = 46). To explore the specificity of the cd-associated mirnas, they were measured in the sera of patients with celiac disease (n = 12); none were changed compared with healthy controls. 
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	1	circulating	plasma	troponin-positive acute coronary syndrome	de rosa s et al.	circulation. 124(18):1936-44.	transcoronary concentration gradients of circulating micrornas.	21969012	2011	taqman polymerase chain reaction in edta-plasma 	circulating levels of the muscle-enriched mir-499, mir-133a, and mir-208a were significantly elevated in the aorta of troponin-positive acute coronary syndrome patients compared with patients with coronary artery disease. In contrast, circulating levels of mir-126 decreased during transcoronary passage in patients with evidence of myocardial injury, suggesting consumption during transcoronary passage.
miRNA	hsa-miR-20a*	mir-17	MIMAT0004493	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	1	circulating	serum	Acetaminophen-induced acute liver injury (APAP-ALI)	Starkey Lewis PJ et al.	Hepatology. 54(5):1767-76.	Circulating microRNAs as potential markers of human drug-induced liver injury.	22045675	2011	miRNeasy kit (Qiagen, Venlo, Netherlands)|Taqman-based quantitative polymerase chain reaction (PCR)|stem-loop reverse-transcription RT primers (Applied Biosystems, Foster City, CA)	Serum miR-122 and miR-192 were substantially higher in APAP-ALI patients, compared to healthy controls.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	serum	endothelial dysfunction	Chen Z et al.	Circulation. 131(9):805-14. 	Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a.	25550450	2015	taqman mirna qpcr	authors demonstrated that oxidative stress induces sterol regulatory element-binding protein 2 (srebp2) and microrna-92a (mir-92a), which in turn activate endothelial innate immune response, leading to dysfunctional endothelium.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-30e-3p	mir-30	MIMAT0000693	Homo sapiens	1	circulating	plasma	non small cell lung cancer (nsclc)	silva j et al.	eur respir j. 37(3):617-23.	vesicle-related micrornas in plasma of nonsmall cell lung cancer patients and correlation with survival.	20595154	2011	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-30a	mir-30	MIMAT0000087	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-151-3p	mir-28	MIMAT0000757	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-26a	mir-26	MIMAT0000082	Homo sapiens	0	circulating	serum	hepatitis b virus-infected patients	zhu ht et al.	mol biotechnol. 50(1):49-56.	identification of suitable reference genes for qrt-pcr analysis of circulating micrornas in hepatitis b virus-infected patients.	21567136	2012	taqman low density array|mirvana paris kit (ambion)	this study describes the identification and characterization of an appropriate reference gene for the normalization of circulating mirna levels in hepatitis b virus (hbv)-infected patients and healthy people. The combination of mir-26a, mir-221, and mir-22* is recommended as the most stable set of reference genes for circulating mirna evaluation in hbv patients and healthy people.
miRNA	hsa-miR-208a	mir-208	MIMAT0000241	Homo sapiens	1	circulating	plasma	troponin-positive acute coronary syndrome	de rosa s et al.	circulation. 124(18):1936-44.	transcoronary concentration gradients of circulating micrornas.	21969012	2011	taqman polymerase chain reaction in edta-plasma 	circulating levels of the muscle-enriched mir-499, mir-133a, and mir-208a were significantly elevated in the aorta of troponin-positive acute coronary syndrome patients compared with patients with coronary artery disease. In contrast, circulating levels of mir-126 decreased during transcoronary passage in patients with evidence of myocardial injury, suggesting consumption during transcoronary passage.
miRNA	hsa-miR-23a*	mir-23	MIMAT0004496	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-95	mir-95	MIMAT0000094	Homo sapiens	1	circulating	serum		Cantara S et al.	J Clin Endocrinol Metab. 99(11):4190-8.	Circulating miRNA95 and miRNA190 are sensitive markers for the differential diagnosis of thyroid nodules in a Caucasian population.	25057879	2014	qrt-pcr	authors have identified for the first time two mirnas differently expressed in serum of ptc patients who in combination allow the differential diagnosis of thyroid nodules with great accuracy in their study population.
miRNA	hsa-miR-142-5p	mir-142	MIMAT0000433	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	circulating	plasma	non small cell lung cancer (nsclc)	silva j et al.	eur respir j. 37(3):617-23.	vesicle-related micrornas in plasma of nonsmall cell lung cancer patients and correlation with survival.	20595154	2011	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
miRNA	hsa-miR-26b	mir-26	MIMAT0000083	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-151-5p	mir-28	MIMAT0004697	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	0	circulating	serum	hepatitis b virus-infected patients	zhu ht et al.	mol biotechnol. 50(1):49-56.	identification of suitable reference genes for qrt-pcr analysis of circulating micrornas in hepatitis b virus-infected patients.	21567136	2012	taqman low density array|mirvana paris kit (ambion)	this study describes the identification and characterization of an appropriate reference gene for the normalization of circulating mirna levels in hepatitis b virus (hbv)-infected patients and healthy people. The combination of mir-26a, mir-221, and mir-22* is recommended as the most stable set of reference genes for circulating mirna evaluation in hbv patients and healthy people.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	troponin-positive acute coronary syndrome	de rosa s et al.	circulation. 124(18):1936-44.	transcoronary concentration gradients of circulating micrornas.	21969012	2011	taqman polymerase chain reaction in edta-plasma 	circulating levels of the muscle-enriched mir-499, mir-133a, and mir-208a were significantly elevated in the aorta of troponin-positive acute coronary syndrome patients compared with patients with coronary artery disease. In contrast, circulating levels of mir-126 decreased during transcoronary passage in patients with evidence of myocardial injury, suggesting consumption during transcoronary passage.
miRNA	hsa-miR-301a	mir-130	MIMAT0000688	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-494	mir-154	MIMAT0002816	Homo sapiens	1	circulating	plasma	hodgkin lymphoma (chl)	Jones KL et al.	Clin Cancer Res.	Plasma microRNA are disease response biomarkers in classical Hodgkin lymphoma.	24222179	2013	qrt-pcr	levels of mir-494, mir-1973 and mir-21 were higher in patients than control (n=20) plasma (p=0.004, p=0.007, p<0.0001, respectively).
miRNA	hsa-miR-190	mir-190	MIMAT0000458	Homo sapiens	1	circulating	serum		Cantara S et al.	J Clin Endocrinol Metab. 99(11):4190-8.	Circulating miRNA95 and miRNA190 are sensitive markers for the differential diagnosis of thyroid nodules in a Caucasian population.	25057879	2014	qrt-pcr	authors have identified for the first time two mirnas differently expressed in serum of ptc patients who in combination allow the differential diagnosis of thyroid nodules with great accuracy in their study population.
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	non small cell lung cancer (nsclc)	silva j et al.	eur respir j. 37(3):617-23.	vesicle-related micrornas in plasma of nonsmall cell lung cancer patients and correlation with survival.	20595154	2011	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
miRNA	hsa-miR-27a	mir-27	MIMAT0000084	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-342-3p	mir-342	MIMAT0000753	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-22*	mir-22	MIMAT0004495	Homo sapiens	0	circulating	serum	hepatitis b virus-infected patients	zhu ht et al.	mol biotechnol. 50(1):49-56.	identification of suitable reference genes for qrt-pcr analysis of circulating micrornas in hepatitis b virus-infected patients.	21567136	2012	taqman low density array|mirvana paris kit (ambion)	this study describes the identification and characterization of an appropriate reference gene for the normalization of circulating mirna levels in hepatitis b virus (hbv)-infected patients and healthy people. The combination of mir-26a, mir-221, and mir-22* is recommended as the most stable set of reference genes for circulating mirna evaluation in hbv patients and healthy people.
miRNA	hsa-miR-1233	mir-1233	MIMAT0005588	Homo sapiens	1	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-331-3p	mir-331	MIMAT0000760	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-1973		MIMAT0009448	Homo sapiens	1	circulating	plasma	hodgkin lymphoma (chl)	Jones KL et al.	Clin Cancer Res.	Plasma microRNA are disease response biomarkers in classical Hodgkin lymphoma.	24222179	2013	qrt-pcr	levels of mir-494, mir-1973 and mir-21 were higher in patients than control (n=20) plasma (p=0.004, p=0.007, p<0.0001, respectively).
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	nasopharyngeal carcinoma	Xiang M et al.	Biochem Biophys Res Commun. 454(1):210-4.	U6 is not a suitable endogenous control for the quantification of circulating microRNAs.	25450382	2014	real-time quantitative pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-301	mir-130	MIMAT0000688	Homo sapiens	0	circulating	plasma	non small cell lung cancer (nsclc)	silva j et al.	eur respir j. 37(3):617-23.	vesicle-related micrornas in plasma of nonsmall cell lung cancer patients and correlation with survival.	20595154	2011	taqman low-density arrays (applied biosystems, foster city, ca, usa)|real-time pcr	365 human mirnas were analysed by taqman low-density arrays (applied biosystems, foster city, ca, usa) in the plasma from 28 nsclc patients and 20 controls. Levels of let-7f, mir-20b and mir-30e-3p were decreased in plasma vesicles of nsclc patients. Moreover, levels of let-7f and mir-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. 
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-153	mir-153	MIMAT0000439	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	exosome	pleural effusions	Breast cancer	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-106b	mir-17	MIMAT0000680	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-513a-5p	mir-506	MIMAT0002877	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	plasma	hodgkin lymphoma (chl)	Jones KL et al.	Clin Cancer Res.	Plasma microRNA are disease response biomarkers in classical Hodgkin lymphoma.	24222179	2013	qrt-pcr	levels of mir-494, mir-1973 and mir-21 were higher in patients than control (n=20) plasma (p=0.004, p=0.007, p<0.0001, respectively).
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	serum	nasopharyngeal carcinoma	Xiang M et al.	Biochem Biophys Res Commun. 454(1):210-4.	U6 is not a suitable endogenous control for the quantification of circulating microRNAs.	25450382	2014	real-time quantitative pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
miRNA	hsa-miR-146b	mir-146	MIMAT0002809	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	0	circulating	plasma	Coronary artery disease	fichtlscherer s et al	circ res. 107(5):677-84.	circulating micrornas in patients with coronary artery disease.	20595655	2010	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
miRNA	hsa-miR-301a	mir-130	MIMAT0000688	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	exosome	pleural effusions	Breast cancer	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-1271	mir-1271	MIMAT0005796	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-138	mir-138	MIMAT0000430	Homo sapiens	1	circulating	serum	type 2 diabetes	Pescador N et al.	PLoS One. 8(10):e77251.	Serum Circulating microRNA Profiling for Identification of Potential Type 2 Diabetes and Obesity Biomarkers.	24204780	2013	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
miRNA	hsa-miR-142-3p	mir-142	MIMAT0000434	Homo sapiens	0	circulating	serum	nasopharyngeal carcinoma	Xiang M et al.	Biochem Biophys Res Commun. 454(1):210-4.	U6 is not a suitable endogenous control for the quantification of circulating microRNAs.	25450382	2014	quantitative real-time pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
miRNA	hsa-miR-148a	mir-148	MIMAT0000243	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	circulating	plasma	Coronary artery disease	fichtlscherer s et al	circ res. 107(5):677-84.	circulating micrornas in patients with coronary artery disease.	20595655	2010	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
miRNA	hsa-miR-30a	mir-30	MIMAT0000087	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-520c-3p	mir-515	MIMAT0002846	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-15a*	mir-15	MIMAT0004488	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	0	exosome	pleural effusions	Breast cancer	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-1290	mir-1290	MIMAT0005880	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-582-3p	mir-582	MIMAT0004797	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	1	circulating	serum	type 2 diabetes	Pescador N et al.	PLoS One. 8(10):e77251.	Serum Circulating microRNA Profiling for Identification of Potential Type 2 Diabetes and Obesity Biomarkers.	24204780	2013	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	serum	nasopharyngeal carcinoma	Xiang M et al.	Biochem Biophys Res Commun. 454(1):210-4.	U6 is not a suitable endogenous control for the quantification of circulating microRNAs.	25450382	2014	real-time quantitative pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-145	mir-145	MIMAT0000437	Homo sapiens	0	circulating	plasma	Coronary artery disease	fichtlscherer s et al	circ res. 107(5):677-84.	circulating micrornas in patients with coronary artery disease.	20595655	2010	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-646	mir-646	MIMAT0003316	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	exosome	pleural effusions	Breast cancer	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-130b	mir-130	MIMAT0000691	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-624*	mir-624	MIMAT0003293	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	circulating	serum	nasopharyngeal carcinoma	Xiang M et al.	Biochem Biophys Res Commun. 454(1):210-4.	U6 is not a suitable endogenous control for the quantification of circulating microRNAs.	25450382	2014	real-time quantitative pcr	authors demonstrated that ct values of mir-16, mir-24, mir-142-3p, mir-19b and mir-192 in serum samples of nasopharyngeal carcinoma were greater than control samples. u6 is unsuitable as an internal reference gene in the research of circulating mirnas.
miRNA	hsa-miR-151	mir-28	MIMAT0000757	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	Coronary artery disease	fichtlscherer s et al	circ res. 107(5):677-84.	circulating micrornas in patients with coronary artery disease.	20595655	2010	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
miRNA	hsa-miR-30d	mir-30	MIMAT0000245	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	zap-70 negative b-cll (stage iii-iv)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-15b*	mir-15	MIMAT0004586	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	exosome	ascites	liver cirrhosis (lc)	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-142-5p	mir-142	MIMAT0000433	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-625*	mir-625	MIMAT0004808	Homo sapiens	0	exosome	plasma	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-26a-1	mir-26		Homo sapiens	0	circulating	serum	prostate cancer	Westermann AM et al.	Anticancer Res. 34(2):665-9.	Serum microRNAs as biomarkers in patients undergoing prostate biopsy: results from a prospective multi-center study.	24510997	2014	real-time pcr	the analysis of circulating micrornas does not seem to help identify patients with cancer undergoing prostate biopsy. however, their levels may be useful to identify patients with high-risk prostate cancer.
miRNA	hsa-miR-152	mir-148	MIMAT0000438	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	Coronary artery disease	fichtlscherer s et al	circ res. 107(5):677-84.	circulating micrornas in patients with coronary artery disease.	20595655	2010	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
miRNA	hsa-miR-32	mir-32	MIMAT0000090	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-106a	mir-17	MIMAT0000103	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	exosome	ascites	liver cirrhosis (lc)	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	exosome	urine	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-376a	mir-368	MIMAT0000729	Homo sapiens	1	circulating	serum	type 2 diabetes	Pescador N et al.	PLoS One. 8(10):e77251.	Serum Circulating microRNA Profiling for Identification of Potential Type 2 Diabetes and Obesity Biomarkers.	24204780	2013	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	circulating	serum	prostate cancer	Westermann AM et al.	Anticancer Res. 34(2):665-9.	Serum microRNAs as biomarkers in patients undergoing prostate biopsy: results from a prospective multi-center study.	24510997	2014	real-time pcr	the analysis of circulating micrornas does not seem to help identify patients with cancer undergoing prostate biopsy. however, their levels may be useful to identify patients with high-risk prostate cancer.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-208a	mir-208	MIMAT0000241	Homo sapiens	0	circulating	plasma	Coronary artery disease	fichtlscherer s et al	circ res. 107(5):677-84.	circulating micrornas in patients with coronary artery disease.	20595655	2010	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
miRNA	hsa-miR-320a	mir-320	MIMAT0000510	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-146a	mir-146	MIMAT0000449	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-16-2*	mir-15	MIMAT0004518	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	0	exosome	ascites	liver cirrhosis (lc)	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-375	mir-375	MIMAT0000728	Homo sapiens	0	exosome	urine	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-138	mir-138	MIMAT0000430	Homo sapiens	1	circulating	serum	obesity	Pescador N et al.	PLoS One. 8(10):e77251.	Serum Circulating microRNA Profiling for Identification of Potential Type 2 Diabetes and Obesity Biomarkers.	24204780	2013	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	1	circulating	serum	myelodysplastic syndromes (mds)	Kim Y et al.	PLoS One. 9(2):e86933.	Serum microRNA-21 as a potential biomarker for response to hypomethylating agents in myelodysplastic syndromes.	24503739	2014	mirvana paris kit (ambion inc., austin, tx)|qrt-pcr	serum mir-21 is a potential biomarker of epigenetic therapy in mds patients.
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	0	circulating	plasma	Coronary artery disease	fichtlscherer s et al	circ res. 107(5):677-84.	circulating micrornas in patients with coronary artery disease.	20595655	2010	mirna isolation kit (mirneasy kit, qiagen)|quantitative (q)pcr using taqman microrna assay kits (abi)	circulating levels of mir-126, mir-17, mir-92a, and the inflammation-associated mir-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched mir-145 was significantly reduced. In contrast, cardiac muscle-enriched micrornas (mir-133a, mir-208a) tend to be higher in patients with coronary artery disease.
miRNA	hsa-miR-324-3p	mir-324	MIMAT0000762	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	exosome	ascites	liver cirrhosis (lc)	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-200b	mir-8	MIMAT0000318	Homo sapiens	0	exosome	urine	prostate cancer	bryant rj et al.	br j cancer. 106(4):768-74.	changes in circulating microrna levels associated with prostate cancer.	22240788	2012	qiagen mirneasy extraction protocol|exomir extraction kit (bioo scientific, austin, tx, usa)|mirvana kit (ambion)|mircury lna universal rt mir pcr|exiqon qrt pcr microarray|taqman human mir assays (life technologies, carlsbad, ca, usa)	the association of mir-141 and mir-375 with metastatic prostate cancer was confirmed using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following radical prostatectomy. An analysis of five selected mirs in urine samples found that mir-107 and mir-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	1	circulating	serum	obesity	Pescador N et al.	PLoS One. 8(10):e77251.	Serum Circulating microRNA Profiling for Identification of Potential Type 2 Diabetes and Obesity Biomarkers.	24204780	2013	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
miRNA	hsa-miR-505	mir-505	MIMAT0002876	Homo sapiens	1	circulating	blood	hypertension	Yang Q et al.	Int J Cardiol. 177(3):925-34. 	MicroRNA-505 identified from patients with essential hypertension impairs endothelial cell migration and tube formation.	25449503	2014	mirvana paris kit (ambion)|taqman mirna qrt-pcr assays	authors showed that hsa-mir-505 is a novel circulating signature of hypertension, which may play a role in angiogenesis.
miRNA	hsa-miR-15b	mir-15	MIMAT0000417	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-126	mir-126	MIMAT0000445	Homo sapiens	1	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-328	mir-328	MIMAT0000752	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-151-3p	mir-28	MIMAT0000757	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-17*	mir-17	MIMAT0000071	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200a	mir-8	MIMAT0000682	Homo sapiens	0	exosome	malignant ascites	ovarian cancer	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-let-7e	let-7	MIMAT0000066	Homo sapiens	1	circulating	plasma	prostate cancer	chen zh et al.	prostate. doi: 10.1002/pros.22495.	a panel of five circulating micrornas as potential biomarkers for prostate cancer.	22298030	2012	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102-1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followedby qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
miRNA	hsa-miR-376a	mir-368	MIMAT0000729	Homo sapiens	1	circulating	serum	obesity	Pescador N et al.	PLoS One. 8(10):e77251.	Serum Circulating microRNA Profiling for Identification of Potential Type 2 Diabetes and Obesity Biomarkers.	24204780	2013	rt-qpcr	three serum micrornas, mir-138, mir-15b and mir-376a, were found to have potential as predictive biomarkers in obesity. use of mir-138 or mir-376a provides a powerful predictive tool for distinguishing obese patients from normal healthy controls, diabetic patients, and obese diabetic patients. in addition, the combination of mir-503 and mir-138 can distinguish diabetic from obese diabetic patients.
miRNA	rno-miR-133a/b	mir-133		sprague dawley rats	1	circulating	fibrotic bladder tissues	Bladder outlet obstruction (boo)	Duan LJ et al.	Cell Signal. 27(2):215-27. 	MiR-133 modulates TGF-beta-1-induced bladder smooth muscle cell hypertrophic and fibrotic response: implication for a role of microRNA in bladder wall remodeling caused by bladder outlet obstruction.	25451078	2015	primescript mirna qrt-pcr detection kit (takara, dalian, china)|real-time qpcr with sybr green i	authors showed a novel antifibrotic functional role for mir-133, which may represent a potential target for diagnostic and therapeutic strategies in bladder fibrosis.
miRNA	hsa-miR-16	mir-15	MIMAT0000069	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-20b	mir-17	MIMAT0001413	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-342-3p	mir-342	MIMAT0000753	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-155	mir-155	MIMAT0000646	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-200c	mir-8	MIMAT0000617	Homo sapiens	0	exosome	malignant ascites	ovarian cancer	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-16-1*	mir-15	MIMAT0004489	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-let-7c	let-7	MIMAT0000064	Homo sapiens	1	circulating	plasma	prostate cancer	chen zh et al.	prostate. doi: 10.1002/pros.22495.	a panel of five circulating micrornas as potential biomarkers for prostate cancer.	22298030	2012	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102 1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followed by qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	1	circulating	plasma	troponin-negative non-st elevation acute coronary syndrome (nste-acs)	Zhang YY et al.	J Thromb Thrombolysis.	Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome.	24202700	2013	real-time pcr	circulating mir-223 may serve as a novel biomarker for assessment of clopidogrel responsiveness in troponin-negative nste-acs patients.
miRNA	hsa-miR-593	mir-593	MIMAT0004802	Homo sapiens	1	circulating	serum	Combined pituitary hormone deficiency (cphd)	Hu Y et al.	Int J Mol Med. 35(2):358-66. 	Circulating microRNA profiles and the identification of miR-593 and miR-511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency.	25434367	2015	rt-qpcr	authors demonstrated that the levels of mir-593 and mir-511, whose direct target is the prop1 gene, may serve as a non-invasive diagnostic biomarkers for children with combined pituitary hormone deficiency (cphd).
miRNA	hsa-miR-17-3p	mir-17	MIMAT0000071	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-363	mir-363	MIMAT0000707	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-17	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-181a*	mir-181	MIMAT0000270	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	0	exosome	malignant ascites	ovarian cancer	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-181a	mir-181	MIMAT0000256	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-30c	mir-30	MIMAT0000244	Homo sapiens	1	circulating	plasma	prostate cancer	chen zh et al.	prostate. doi: 10.1002/pros.22495.	a panel of five circulating micrornas as potential biomarkers for prostate cancer.	22298030	2012	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102 1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followed by qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
miRNA	hsa-miR-127-3p	mir-127	MIMAT0000446	Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	PLoS One. 8(10):e76729.	Plasma MicroRNA Panel for Minimally Invasive Detection of Breast Cancer.	24194846	2013	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
miRNA	hsa-miR-511	mir-506	MIMAT0002808	Homo sapiens	1	circulating	serum	Combined pituitary hormone deficiency (cphd)	Hu Y et al.	Int J Mol Med. 35(2):358-66. 	Circulating microRNA profiles and the identification of miR-593 and miR-511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency.	25434367	2015	rt-qpcr	authors demonstrated that the levels of mir-593 and mir-511, whose direct target is the prop1 gene, may serve as a non-invasive diagnostic biomarkers for children with combined pituitary hormone deficiency (cphd).
miRNA	hsa-miR-17-5p	mir-17	MIMAT0000070	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-24	mir-24	MIMAT0000080	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-374a	mir-374	MIMAT0000727	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-194	mir-194	MIMAT0000460	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-181b	mir-181	MIMAT0000257	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	exosome	malignant ascites	ovarian cancer	rupp ak et al.	gynecol oncol. 122(2):437-46. 	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.	21601258	2011	rt-pcr	loss of epcam expression in breast cancer derived serum exosomes: role of proteolytic cleavage.
miRNA	hsa-miR-190b	mir-190	MIMAT0004929	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-622	mir-622	MIMAT0003291	Homo sapiens	1	circulating	plasma	prostate cancer	chen zh et al.	prostate. doi: 10.1002/pros.22495.	a panel of five circulating micrornas as potential biomarkers for prostate cancer.	22298030	2012	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102 1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followed by qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
miRNA	hsa-miR-376a	mir-368	MIMAT0000729	Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	PLoS One. 8(10):e76729.	Plasma MicroRNA Panel for Minimally Invasive Detection of Breast Cancer.	24194846	2013	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
miRNA	hsa-miR-193b	mir-193	MIMAT0002819	Homo sapiens	0	circulating	epidermis (epi) and dermal inflammatory infiltrate	psoriasis	Løvendorf MB et al.	Exp Dermatol. 24(3):187-93.	Laser capture microdissection followed by next-generation sequencing identifies disease-related microRNAs in psoriatic skin that reflect systemic microRNA changes in psoriasis.	25431026	2015	qrt-pcr	authors showed that mir-193b and mir-223 were deregulated in the dermal inflammatory infiltrates (rd) of psoriatic plaque compared with normal psoriatic skin. these altered local mirna changes are reflected in the circulating immune cells, suggesting that mirnas may contribute to the pathogenesis of psoriasis.
miRNA	hsa-miR-181b	mir-181	MIMAT0000257	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-15a	mir-15	MIMAT0000068	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-374b	mir-374	MIMAT0004955	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-181c	mir-181	MIMAT0000258	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-let-7d	let-7	MIMAT0000065	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-193	mir-193	MIMAT0000459	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-1285	mir-1285	MIMAT0005876	Homo sapiens	1	circulating	plasma	prostate cancer	chen zh et al.	prostate. doi: 10.1002/pros.22495.	a panel of five circulating micrornas as potential biomarkers for prostate cancer.	22298030	2012	nanodrop 1000 (nanodrop, wilmington, delaware)|illumina mirna expression platform v2 (cat. no. mi-102 1024; illumina, san diego, ca)|sybr green-based qrt-pcr|miscript reverse transcription kit (qiagen)	using the illumina microarray platform, followed by qrt-pcr, authors identified and finally validated 5 mirnas with differential expression, 3 of which (let-7e, let-7c, and mir-30c) were downregulated and 2 (mir-622 and mir-1285) were upregulated in prostate cancer patients.
miRNA	hsa-miR-652	mir-652	MIMAT0003322	Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	PLoS One. 8(10):e76729.	Plasma MicroRNA Panel for Minimally Invasive Detection of Breast Cancer.	24194846	2013	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	epidermis (epi) and dermal inflammatory infiltrate	psoriasis	Løvendorf MB et al.	Exp Dermatol. 24(3):187-93.	Laser capture microdissection followed by next-generation sequencing identifies disease-related microRNAs in psoriatic skin that reflect systemic microRNA changes in psoriasis.	25431026	2015	qrt-pcr	authors showed that mir-193b and mir-223 were deregulated in the dermal inflammatory infiltrates (rd) of psoriatic plaque compared with normal psoriatic skin. these altered local mirna changes are reflected in the circulating immune cells, suggesting that mirnas may contribute to the pathogenesis of psoriasis.
miRNA	hsa-miR-181c	mir-181	MIMAT0000258	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-376a	mir-368	MIMAT0000729	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-181d	mir-181	MIMAT0002821	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-100	mir-99	MIMAT0000098	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-214	mir-214	MIMAT0000271	Homo sapiens	1	circulating	serum	Breast cancer	schwarzenbach h et al.	breast cancer res treat.	diagnostic potential of pten-targeting mir-214 in the blood of breast cancer patients.	22350790	2012	taqman microrna assays	the relative concentrations of four circulating micrornas (mir-19a, mir-20a, mir-21, and mir-214) in blood serum were measured by taqman microrna assays. Levels of preoperative serum mir-20a and mir-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum mir-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in roc analysis, respectively.
miRNA	hsa-miR-148b	mir-148	MIMAT0000759	Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	PLoS One. 8(10):e76729.	Plasma MicroRNA Panel for Minimally Invasive Detection of Breast Cancer.	24194846	2013	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
miRNA	hsa-miR-302c	mir-302	MIMAT0000717	Homo sapiens	0	circulating	serum	Adenocarcinomas of the gastroesophageal junction	Odenthal M et al.	Int J Cancer. 137(1):230-7.	Serum microRNA profiles as prognostic/predictive markers in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction.	25429911	2015	quantitative real-time pcr	depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction, a differential serum microrna profile was identified by the authors. in particular, there was a significant correlation between mir-302c and mir-222 expression with overall survival. 
miRNA	hsa-miR-181d	mir-181	MIMAT0002821	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-197	mir-197	MIMAT0000227	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-378	mir-378	MIMAT0000732	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-182	mir-182	MIMAT0000259	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-103	mir-103	MIMAT0000101	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	0	circulating	serum	Breast cancer	schwarzenbach h et al.	breast cancer res treat.	diagnostic potential of pten-targeting mir-214 in the blood of breast cancer patients.	22350790	2012	taqman microrna assays	the relative concentrations of four circulating micrornas (mir-19a, mir-20a, mir-21, and mir-214) in blood serum were measured by taqman microrna assays. Levels of preoperative serum mir-20a and mir-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum mir-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in roc analysis, respectively.
miRNA	hsa-miR-376c	mir-368	MIMAT0000720	Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	PLoS One. 8(10):e76729.	Plasma MicroRNA Panel for Minimally Invasive Detection of Breast Cancer.	24194846	2013	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
miRNA	hsa-miR-222	mir-221	MIMAT0000279	Homo sapiens	0	circulating	serum	Adenocarcinomas of the gastroesophageal junction	Odenthal M et al.	Int J Cancer. 137(1):230-7.	Serum microRNA profiles as prognostic/predictive markers in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction.	25429911	2015	quantitative real-time pcr	depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction a differential serum microrna profile was identified by the authors. in particular, there was a significant correlation between mir-302c and mir-222 expression with overall survival. 
miRNA	hsa-miR-183	mir-183	MIMAT0000261	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-423-5p	mir-423	MIMAT0004748	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-30a	mir-30	MIMAT0000087	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-183	mir-183	MIMAT0000261	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-10a	mir-10	MIMAT0000253	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	0	circulating	serum	Breast cancer	schwarzenbach h et al.	breast cancer res treat.	diagnostic potential of pten-targeting mir-214 in the blood of breast cancer patients.	22350790	2012	taqman microrna assays	the relative concentrations of four circulating micrornas (mir-19a, mir-20a, mir-21, and mir-214) in blood serum were measured by taqman microrna assays. Levels of preoperative serum mir-20a and mir-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum mir-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in roc analysis, respectively.
miRNA	hsa-miR-409-3p	mir-154	MIMAT0001639	Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	PLoS One. 8(10):e76729.	Plasma MicroRNA Panel for Minimally Invasive Detection of Breast Cancer.	24194846	2013	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
miRNA	hsa-miR-221	mir-221	MIMAT0000278	Homo sapiens	1	circulating	serum	hepatitis c virus (hcv)-related hepatocellular carcinoma (hcc)	El-Garem H et al.	World J Hepatol. 6(11):818-24. 	Circulating microRNA, miR-122 and miR-221 signature in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma.	25429320	2014	rt-pcr	authors demonstrated that serum mir-221 has a strong potential to serve as one of the novel non-invasive biomarkers of hcc.
miRNA	hsa-miR-186	mir-186	MIMAT0000456	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-424	mir-322	MIMAT0001341	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-320	mir-320	MIMAT0000510	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-184	mir-184	MIMAT0000454	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-10b*	mir-10	MIMAT0004556	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	serum	Breast cancer	schwarzenbach h et al.	breast cancer res treat.	diagnostic potential of pten-targeting mir-214 in the blood of breast cancer patients.	22350790	2012	taqman microrna assays	the relative concentrations of four circulating micrornas (mir-19a, mir-20a, mir-21, and mir-214) in blood serum were measured by taqman microrna assays. Levels of preoperative serum mir-20a and mir-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum mir-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in roc analysis, respectively.
miRNA	hsa-miR-801			Homo sapiens	1	circulating	plasma	Breast cancer	Cuk K et al.	PLoS One. 8(10):e76729.	Plasma MicroRNA Panel for Minimally Invasive Detection of Breast Cancer.	24194846	2013	mirna array-based screening	circulating mir-127-3p, mir-376a and mir-652, selected as candidates from a mirna array-based screening, were found to be associated with breast cancer for the first time (n‚=‚417). further authors validated their previously reported circulating mirnas (mir-148b, mir-376c, mir-409-3p and mir-801) in an independent cohort (n‚=‚210) as elevated in the plasma of breast cancer patients compared to healthy women.
miRNA	hsa-miR-320a/b	mir-320		Homo sapiens	1	circulating	serum	waldenström macroglobulinemia	Kubiczkova Besse L et al.	Am J Hematol. 90(3):E51-2. 	Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia.	25428891	2015	quantitative real-time pcr	authors focused on the role of circulating serum mirnas as biomarkers of waldenström macroglobulinemia (wm). they found that the combination of mir-320a and mir-320b served as the best indicator for wm.
miRNA	hsa-miR-189	mir-24	MIMAT0000079	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-486	mir-486	MIMAT0002177	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-425	mir-425	MIMAT0003393	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-185	mir-185	MIMAT0000455	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-127-3p	mir-127	MIMAT0000446	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-215	mir-192	MIMAT0000272	Homo sapiens	1	circulating	serum	Breast cancer	van schooneveld e et al.	breast cancer res. 14(1):r34.	expression profiling of cancerous and normal breast tissues identifies micrornas that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers.	22353773	2012	mirvana mirna isolation kit (ambion, austin, tx, usa)|microrna isolation kit (biochain institute inc, hayward, ca, usa)|nanodrop nd1000 (nanodrop technologies, waltham, ma, usa)|taqman microrna reverse transcription kit (applied biosystems)|qrt-pcr	mirna expression in cancerous samples tends to be repressed when compared with mirna expression in healthy controls (p = 0.0685). The four most discriminating mirnas by fold-change (mir-215, mir-299-5p, mir-411, and mir-452) were selected for further analysis on serum samples. All mirnas at least tended to be differentially expressed between serum samples from patients with cancer and serum samples from healthy controls 
miRNA	hsa-miR-205	mir-205	MIMAT0000266	Homo sapiens	1	exosome	plasma	lung squamous cell carcinoma (scc)	Aushev VN et al.	PLoS One. 8(10):e78649.	Comparisons of microRNA Patterns in Plasma before and after Tumor Removal Reveal New Biomarkers of Lung Squamous Cell Carcinoma.	24130905	2013	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
miRNA	hsa-miR-190a	mir-190	MIMAT0000458	Homo sapiens	0	circulating	plasma	heart failure (hf)	Wong LL et al.	Eur J Heart Fail. 17(4):393-404.	Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction.	25619197	2015		authors reported specific micrornas as potential biomarkers in distinguishing heart failure (hf) from non-hf controls and in differentiating between hf with reduced vs. preserved left ventricular ejection fraction (hfref and hfpef, respectively). of these, mir-190a distinguished hf from controls and hfref from hfpef.
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-28-3p	mir-28	MIMAT0004502	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-451	mir-451	MIMAT0001631	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-186	mir-186	MIMAT0000456	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-130a	mir-130	MIMAT0000425	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-223	mir-223	MIMAT0000280	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-299-5p	mir-299	MIMAT0002890	Homo sapiens	1	circulating	serum	Breast cancer	van schooneveld e et al.	breast cancer res. 14(1):r34.	expression profiling of cancerous and normal breast tissues identifies micrornas that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers.	22353773	2012	mirvana mirna isolation kit (ambion, austin, tx, usa)|microrna isolation kit (biochain institute inc, hayward, ca, usa)|nanodrop nd1000 (nanodrop technologies, waltham, ma, usa)|taqman microrna reverse transcription kit (applied biosystems)|qrt-pcr	mirna expression in cancerous samples tends to be repressed when compared with mirna expression in healthy controls (p = 0.0685). The four most discriminating mirnas by fold-change (mir-215, mir-299-5p, mir-411, and mir-452) were selected for further analysis on serum samples. All mirnas at least tended to be differentially expressed between serum samples from patients with cancer and serum samples from healthy controls 
miRNA	hsa-miR-19a	mir-19	MIMAT0000073	Homo sapiens	1	exosome	plasma	lung squamous cell carcinoma (scc)	Aushev VN et al.	PLoS One. 8(10):e78649.	Comparisons of microRNA Patterns in Plasma before and after Tumor Removal Reveal New Biomarkers of Lung Squamous Cell Carcinoma.	24130905	2013	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
miRNA	hsa-miR-1260	mir-1260	MIMAT0005911	Homo sapiens	1	circulating	blood	Breast cancer	Park IH et al.	Tumour Biol. 35(12):12173-80.	Identification and clinical implications of circulating microRNAs for estrogen receptor-positive breast cancer.	25179838	2014	qrt-pcr	authors found that mir-1280, mir-1260, and mir-720 were up-regulated in blood from breast cancer patience, mir-1280 may serve as a biomarker for er-positive breast cancer.
miRNA	hsa-miR-190	mir-190	MIMAT0000458	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-29b	mir-29	MIMAT0000100	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-484	mir-484	MIMAT0002174	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-188-3p	mir-188	MIMAT0004613	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-130b	mir-130	MIMAT0000691	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-23a	mir-23	MIMAT0000078	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-411	mir-379	MIMAT0003329	Homo sapiens	1	circulating	serum	Breast cancer	van schooneveld e et al.	breast cancer res. 14(1):r34.	expression profiling of cancerous and normal breast tissues identifies micrornas that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers.	22353773	2012	mirvana mirna isolation kit (ambion, austin, tx, usa)|microrna isolation kit (biochain institute inc, hayward, ca, usa)|nanodrop nd1000 (nanodrop technologies, waltham, ma, usa)|taqman microrna reverse transcription kit (applied biosystems)|qrt-pcr	mirna expression in cancerous samples tends to be repressed when compared with mirna expression in healthy controls (p = 0.0685). The four most discriminating mirnas by fold-change (mir-215, mir-299-5p, mir-411, and mir-452) were selected for further analysis on serum samples. All mirnas at least tended to be differentially expressed between serum samples from patients with cancer and serum samples from healthy controls 
miRNA	hsa-miR-19b	mir-19	MIMAT0000074	Homo sapiens	1	exosome	plasma	lung squamous cell carcinoma (scc)	Aushev VN et al.	PLoS One. 8(10):e78649.	Comparisons of microRNA Patterns in Plasma before and after Tumor Removal Reveal New Biomarkers of Lung Squamous Cell Carcinoma.	24130905	2013	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
miRNA	hsa-miR-1280	null	MIMAT0005946	Homo sapiens	1	circulating	blood	Breast cancer	Park IH et al.	Tumour Biol. 35(12):12173-80.	Identification and clinical implications of circulating microRNAs for estrogen receptor-positive breast cancer.	25179838	2014	qrt-pcr	authors found that mir-1280, mir-1260, and mir-720 were up-regulated in blood from breast cancer patience, mir-1280 may serve as a biomarker for er-positive breast cancer.
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-150	mir-150	MIMAT0000451	Homo sapiens	0	circulating	plasma	type 2 diabetes	zampetaki a et al.	circ res. 107(6):810-7.	plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes.	20651284	2010	quantitative pcr|mirneasy kit (qiagen)|taqman mirna arrays a and b (all from applied biosystems)	quantitative pcr assessment revealed lower plasma levels of mir-20b, mir-21, mir-24, mir-15a, mir-126, mir-191, mir-197, mir-223, mir-320, and mir-486 in prevalent dm, but a modest increase of mir-28-3p. Reduced mir-15a, mir-29b, mir-126, mir-223, and elevated mir-28-3p levels antedated the manifestation of disease.
miRNA	hsa-miR-486-5p	mir-486	MIMAT0002177	Homo sapiens	0	Ago2	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-520c-3p	mir-515	MIMAT0002846	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-188-5p	mir-188	MIMAT0000457	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-133a	mir-133	MIMAT0000427	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-25	mir-25	MIMAT0000081	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-452	mir-452	MIMAT0001635	Homo sapiens	1	circulating	serum	Breast cancer	van schooneveld e et al.	breast cancer res. 14(1):r34.	expression profiling of cancerous and normal breast tissues identifies micrornas that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers.	22353773	2012	mirvana mirna isolation kit (ambion, austin, tx, usa)|microrna isolation kit (biochain institute inc, hayward, ca, usa)|nanodrop nd1000 (nanodrop technologies, waltham, ma, usa)|taqman microrna reverse transcription kit (applied biosystems)|qrt-pcr	mirna expression in cancerous samples tends to be repressed when compared with mirna expression in healthy controls (p = 0.0685). The four most discriminating mirnas by fold-change (mir-215, mir-299-5p, mir-411, and mir-452) were selected for further analysis on serum samples. All mirnas at least tended to be differentially expressed between serum samples from patients with cancer and serum samples from healthy controls 
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	1	exosome	plasma	lung squamous cell carcinoma (scc)	Aushev VN et al.	PLoS One. 8(10):e78649.	Comparisons of microRNA Patterns in Plasma before and after Tumor Removal Reveal New Biomarkers of Lung Squamous Cell Carcinoma.	24130905	2013	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
miRNA	hsa-miR-720	mir-720	MIMAT0005954	Homo sapiens	1	circulating	blood	Breast cancer	Park IH et al.	Tumour Biol. 35(12):12173-80.	Identification and clinical implications of circulating microRNAs for estrogen receptor-positive breast cancer.	25179838	2014	qrt-pcr	authors found that mir-1280, mir-1260, and mir-720 were up-regulated in blood from breast cancer patience, mir-1280 may serve as a biomarker for er-positive breast cancer.
miRNA	hsa-miR-192	mir-192	MIMAT0000222	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-206	mir-1	MIMAT0000462	Homo sapiens	1	circulating	serum	rhabdomyosarcoma (rms)	miyachi m et al.	biochem biophys res commun. 400(1):89-93	circulating muscle-specific microrna, mir-206, as a potential diagnostic marker for rhabdomyosarcoma.	20696132	2010		authors evaluated the feasibility of using muscle-specific mirnas (mir-1, -133a, -133b and -206) as biomarkers of rms. Expression of muscle-specific mirnas, especially mir-206, was significantly higher in rms cell lines than in other tumor cell lines, as well as in rms tumor specimens. Further, serum levels of muscle-specific mirnas were significantly higher in patients with rms tumors than in patients with non-rms tumors.
miRNA	hsa-miR-491-3p	mir-491	MIMAT0004765	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-601	mir-601	MIMAT0003269	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-18a	mir-17	MIMAT0000072	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-139-5p	mir-139	MIMAT0000250	Homo sapiens	0	exosome	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-301b	mir-130	MIMAT0004958	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-210	mir-210	MIMAT0000267	Homo sapiens	1	circulating	plasma	Breast cancer	jung ej et al.	cancer. 	plasma microrna 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients.	22370716	2011	reverse transcriptase-polymerase chain reaction 	circulating mir-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma mir-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab. 
miRNA	hsa-miR-20a	mir-17	MIMAT0000075	Homo sapiens	1	exosome	plasma	lung squamous cell carcinoma (scc)	Aushev VN et al.	PLoS One. 8(10):e78649.	Comparisons of microRNA Patterns in Plasma before and after Tumor Removal Reveal New Biomarkers of Lung Squamous Cell Carcinoma.	24130905	2013	rt-pcr	the results revealed a specific panel of the mirnas (mir-205, -19a, -19b, -30b, and -20a) whose levels decreased strikingly in the blood of patients after lung scc surgery. interestingly, mirna profiling of plasma fractions of lung scc patients revealed high levels of these mirna species in tumor-specific exosomes; additionally, some of these mirnas were also found to be selectively secreted to the medium by cultivated lung cancer cells.
miRNA	hsa-miR-10a	mir-10	MIMAT0000253	Homo sapiens	1	circulating	serum	heart transplant rejection	Duong Van Huyen JP et al.	Eur Heart J. 35(45):3194-202.	MicroRNAs as non-invasive biomarkers of heart transplant rejection.	25176944	2014	real-time pcr	the study demonstrates that a differential expression of mirna occurs in rejecting allograft patients, not only at the tissue level but also in the serum, suggesting their potential relevance as non-invasive biomarkers in heart transplant rejection.
miRNA	hsa-miR-195	mir-15	MIMAT0000461	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-885-5p	mir-885	MIMAT0004947	Homo sapiens	1	circulating	serum	hepatocellular carcinoma (hcc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-501-5p	mir-500	MIMAT0002872	Homo sapiens	0	exosome	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-645	mir-645	MIMAT0003315	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-18b	mir-17	MIMAT0001412	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-141	mir-8	MIMAT0000432	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-30b	mir-30	MIMAT0000420	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-21	mir-21	MIMAT0000076	Homo sapiens	0	circulating	plasma	Breast cancer	jung ej et al.	cancer. 	plasma microrna 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients.	22370716	2011	reverse transcriptase-polymerase chain reaction 	circulating mir-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma mir-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab. 
miRNA	hsa-miR-483-5p	mir-483	MIMAT0004761	Homo sapiens	1	circulating	plasma	hepatocellular carcinoma (hcc)	Shen J et al.	Cancer Epidemiol Biomarkers Prev.	Exploration of Genome-wide Circulating MicroRNA in Hepatocellular Carcinoma (HCC): MiR-483-5p as a Potential Biomarker.	24127413	2013	qrt-pcr	mir-483-5p was statistically significantly over-expressed in hcc cases compared with controls (3.20 vs. 0.82, p<0.0001). hcc risk factors and clinic-pathological characteristics did not influence mir-483-5p expression.
miRNA	hsa-miR-31	mir-31	MIMAT0000089	Homo sapiens	1	circulating	serum	heart transplant rejection	Duong Van Huyen JP et al.	Eur Heart J. 35(45):3194-202.	MicroRNAs as non-invasive biomarkers of heart transplant rejection.	25176944	2014	real-time pcr	the study demonstrates that a differential expression of mirna occurs in rejecting allograft patients, not only at the tissue level but also in the serum, suggesting their potential relevance as non-invasive biomarkers in heart transplant rejection.
miRNA	hsa-miR-196b	mir-196	MIMAT0001080	Homo sapiens	0	circulating	plasma	normal	mitchell ps et al.	pnas 105(30):10513-8	circulating micrornas as stable blood-based markers for cancer detection.	18663219	2008	taqman low-density array qrt-pcr	mirnas are present in human plasma in a remarkably stable form that is protected from endogenous rnase activity.
miRNA	hsa-miR-885-5p	mir-885	MIMAT0004947	Homo sapiens	1	circulating	serum	liver cirrhosis (lc)	gui j et al.	clin sci (lond). 120(5):183-93.	serum microrna characterization identifies mir-885-5p as a potential marker for detecting liver pathologies.	20815808	2011	taqman microrna reverse transcription kit (applied biosystems) qpcr	mir-885-5p is significantly elevated in the sera of patients with liver pathologies. Data suggest that serum mirnas could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.
miRNA	hsa-miR-574-3p	mir-574	MIMAT0003239	Homo sapiens	0	circulating	plasma	normal	arroyo jd et al.	pnas 108(12):5003-8	argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma.	21383194	2011	size-exclusion chromatography|mirna ready-to-use pcr, human panel i, v2.m qrt-pcr arrays (exiqon)	the majority of circulating mirnas cofractionated with protein complexes rather than with vesicles. Argonaute2 (ago2), the key effector protein of mirna-mediated silencing, was present in human plasma and eluted with plasma mirnas in size-exclusion chromatography. Furthermore, immunoprecipitation of ago2 from plasma readily recovered non vesicle-associated plasma mirnas.
miRNA	hsa-miR-646	mir-646	MIMAT0003316	Homo sapiens	0	circulating	plasma	zap-70 positive b-cll (stage 0)	moussay e et al.	pnas 108(16):6573-8	microrna as biomarkers and regulators in b-cell chronic lymphocytic leukemia.	21460253	2011	mirneasy kit (qiagen)|taq mirna low-density array from applied biosystems	circulating mirnas can be sensitive biomarkers for cll, because certain extracellular mirnas are present in cll patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating mirnas also displayed significant differences between zeta-associated protein 70 (zap-70)(+) and zap-70(-) cll. 
miRNA	hsa-miR-191	mir-191	MIMAT0000440	Homo sapiens	0	exosome	t cells	j77	mittelbrunn m et al.	nat commun.2:282.	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.	21505438	2011	human mirna microarray kit	unidirectional transfer of microrna-loaded exosomes from t cells to antigen-presenting cells.
miRNA	hsa-miR-143	mir-143	MIMAT0000435	Homo sapiens	0	Ago2	plasma	normal	turchinovich a et al.	nucleic acids res. 39 (16): 7223-7233.	characterization of extracellular circulating microrna.	21609964	2011	ultracentrifugation|western blot immunoassay|real-time rt-pcr	here, authors confirmed that circulating mature mirna in contrast to mrna or snrna is strikingly stable in blood plasma and cell culture media. This is the first study to show that extracellular mirnas are predominantly exosomes/microvesicles free and are associated with ago proteins.
miRNA	hsa-miR-30d*	mir-30	MIMAT0004551	Homo sapiens	0	circulating	serum	renal cell carcinoma (rcc)	wulfken lm et al.	plos one. 6(9):e25787.	micrornas in renal cell carcinoma: diagnostic implications of serum mir-1233 levels.	21984948	2011	taqman low-density array qrt-pcr	microrna levels are distinctly increased in cancer patients, although only a small subset of circulating micrornas has a tumor-specific origin. Authors identify circulating mir-1233 as a potential biomarker for rcc patients.
miRNA	hsa-miR-29a	mir-29	MIMAT0000086	Homo sapiens	0	circulating	plasma	Breast cancer	jung ej et al.	cancer. 	plasma microrna 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients.	22370716	2011	reverse transcriptase-polymerase chain reaction 	circulating mir-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma mir-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab. 
miRNA	hsa-miR-214	mir-214	MIMAT0000271	Homo sapiens	0	exosome	hepatic stellate cells	steatotic liver	Chen L et al.	Hepatology.	Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells.	24122827	2013	rt-pcr	authors show that ccn2 up-regulation in fibrotic or steatotic livers, or in culture-activated or ethanol-treated primary mouse hsc is associated with a reciprocal down-regulation of microrna-214 (mir-214).
miRNA	hsa-miR-92a	mir-25	MIMAT0000092	Homo sapiens	1	circulating	serum	heart transplant rejection	Duong Van Huyen JP et al.	Eur Heart J. 35(45):3194-202.	MicroRNAs as non-invasive biomarkers of heart transplant rejection.	25176944	2014	real-time pcr	the study demonstrates that a differential expression of mirna occurs in rejecting allograft patients, not only at the tissue level but also in the serum, suggesting their potential relevance as non-invasive biomarkers in heart transplant rejection.